Two-day training and two-hour webinar  /  10/21/2019  -  10/23/2019

Training no. 3: Endocrine disruptors

Training topic

The European Commission has published scientific criteria for the identification of endocrine disruptors (EDs). These criteria will be used to identify EDs in the context of the EU legislation on pesticides and biocides. The criteria specify that a substance is considered to have endocrine disrupting properties if 1) it shows adverse effects in an intact organism or its progeny, 2) it has an endocrine mode of action, and 3) the adverse effect is a consequence of the endocrine mode of action. EDs will be identified based on the assessment of all relevant scientific information using a weight of evidence approach. A guidance document for the identification of substances with ED properties has been developed by the European Food Safety Authority (EFSA) and the European Chemicals Agency (ECHA) with the support of the European Commission’s Joint Research Centre (JRC).

The objective of this training course is to enable the understanding and practical implementation of the guidance document on ED hazard identification of plant protection products in the context of the EU legislation on pesticides amongst members of EFSA’s Scientific Committee/Panels, their working groups as well as EFSA staff.

By the end of the course, participants should be able to understand and describe:

  • The scope and applicability of this guidance document on ED hazard identification of plant protection products in the context of the EU legislation on pesticides
  • The general scheme of this guidance document and its interplay with already existing EFSA guidance documents per sector
  • The scientific information required to perform ED hazard identification of plant protection products in the context of the EU legislation on pesticides

The course will first introduce the principles and definitions of EDs, regulatory aspects, the scientific criteria and overview of the guidance document. Then the focus will be on two of the scientific criteria, adversity and mode of action. What type of scientific information is needed and how can it be used to assess these criteria? Subsequently, the third scientific criterion will be discussed, the link between the ED mode of action and the adverse effect. What type of scientific information is needed to demonstrate the link? Adverse Outcome Pathways (AOP) will be discussed as a concept to support the identification of EDs. Thereafter, the focus will be on how the relevant information is identified and assessed using systematic review and weight of evidence approaches. The knowledge will be applied to a practical case study that includes the whole process. EFSA-relevant examples will be used as cases and the participants will work them out and share and discuss the outcome. Throughout the course, discussions in small groups and plenum as well as practicals will be used to apply the knowledge.

 

Organizational details

As seating is limited for the two-day training course, some aspects of this topic will be trained in addition in a two-hour webinar held a few days after the two-day training course. You may register for the two-day training course or the webinar, or both.

EFSA staff is kindly asked to registered via the EFSA workflow, not via this website. EFSA reserves the right to select the participants of each course from all registered persons. After the registration deadline, all registrants will be informed whether they can actually attend the selected training.

Training materials will be sent to all participants a few days prior to the training/webinar.