Cluster of Excellence for Immune-Mediated Diseases CIMD

The primary goal of the Fraunhofer Cluster of Excellence for Immune-Mediated Diseases is the translation of innovative ideas and identified targets into individualized therapies for immune-mediated diseases. The collaborating institutes want to bridge the existing gap from research on novel medications to what is actually available to patients.

In forward-looking projects, three Fraunhofer Institutes – Fraunhofer IME, Fraunhofer IZI, and Fraunhofer ITEM – are pooling their expertise, thereby enabling efficient translation. A substantial gain of knowledge in the pathophysiology of immune diseases will thus be generated, innovative targets will be addressed, and new treatment categories in this therapeutic area will be introduced and established.

Project insights


Vaccine against asthma

Mucosal application of RSV antigens to prevent juvenile bronchial asthma 


Treatment of chronic immune diseases by targeted modulation of certain immune cells


Prevention of respiratory infections in chronic lung diseases

Protecting patients with chronic lung diseases against respiratory viral infections by inhalation of interferon nanocapsules


Restoring the immune tolerance through antibody-mediated microbiome correction


New therapeutic strategies for the treatment of chronic inflammatory bowel diseases


Early diagnosis of subclinical arthritis

Development of a combined biomarker profile from innovative imaging data and liquid biopsy-based RNA analyses for early diagnosis of subclinical arthritis in risk populations


New transport system for drug delivery in the treatment of rheumatoid arthritis


New test system for drugs to treat rheumatoid arthritis

A humanized murine arthritis model for the development of innovative immunotherapeutics for rheumatoid arthritis


App as treatment support for immune diseases

Development of an information system for the treatment of immune-mediated diseases

Fraunhofer clusters of excellence

In January 2018, the first four Fraunhofer clusters of excellence were launched, dedicated to the following topics: Programmable Materials, Advanced Photon Sources, Cognitive Internet Technologies, and Immune-Mediated Diseases. These clusters are aimed at promoting cutting-edge research at Fraunhofer.

Up to four core institutes and a variable number of partner institutes collaborate in a cluster of excellence, thereby further expanding the Fraunhofer network.

The clusters of excellence have no defined location, rather do the core institutes of each cluster form a virtual institute, giving them a high degree of flexibility.

Core institutes of the Fraunhofer Cluster of Excellence CIMD:

Fraunhofer Institute for Molecular Biology and Applied Ecology IME

Fraunhofer Institute for Cell Therapy and Immunology IZI

Fraunhofer Institute for Toxicology and Experimental Medicine ITEM