Pathology database RITA (Registry of Industrial Toxicology Animal-data)
RITA is a database for the collection of peer-reviewed histopathological diagnoses on tumors and other proliferative lesions as well as study-associated information from control rats and mice. Since 1988, this database has been operated for major European chemical and / or pharmaceutical companies in collaboration with the Department of Pathology. See the RITA website for more information.
RITA CEPA – Cell Proliferation and Apoptosis
This RITA-associated project focuses on the development of a database and standardized procedures for applying cell proliferation techniques (e.g. BrdU and PCNA labeling) to toxicity testing. Please see the RITA CEPA website for more details.
goRENI – global open RENI
RENI is an information system for toxicologic pathology on the Web including a standardized nomenclature and diagnostic criteria for proliferative lesions in rats and mice together with images of histopathological slides and literature references. For further information, please visit the RENI website.
DevTox – Developmental Toxicology
The development of a database system for the evaluation of results from reproductive toxicology studies has been started in 1999. The project is carried out in cooperation with the working groups on General Toxicology and Reproductive Toxicology. For more details please see the related website.
FeDTex is a reproductive toxicology database with a focus on multi-generation studies. Affected parameters and effects are documented in relation to the developmental stage, gender, and generation. This database allows e.g. structureactivity relationships to be developed.
RepDose (repeated-dose toxicity) is a relational database on subacute to chronic toxicity and currently contains 655 chemicals. The toxicity of these chemicals has been documented in about 2280 studies, carried out in rats, mice or dogs with oral or inhalation exposure. The content and structure of the database RepDose provide a sound basis to perform analyses on repeated-dose toxicity. RepDose is used by the Department of Chemical Risk Assessment at the Fraunhofer ITEM to analyze and improve risk assessment strategies. Further information