Toxicology databases

To support the process of international standardization of nomenclature and diagnostic criteria a team of scientists at the Fraunhofer ITEM are engaged in establishing different toxicology databases. This multidisciplinary team has many years of experience in designing, developing, and operating databases and electronic information systems for current issues in toxicology and toxicologic pathology.

To provide the required technical support for the databases goReni and DevTox, the team cooperates with the Fraunhofer ITEM Department of Pathology and the Working Group on Reproductive Toxicology as well as with numerous national and international societies and organizations.

The databases for Repeated Dose Toxicity (RepDose) and Reprotoxicity (FeDTex) are used to develop risk assessment strategies and to identify (quantitative) structure-activity relationships ((Q)SAR).

Methods and expertise

Database design and development

Technical support for standardization and international harmonization issues in toxicological pathology

Software development

Statistical analysis

Development and implementation of information systems for stand-alone usage or for the Internet

Image analysis: e.g. procedures for the quantitative evaluation of cell proliferation measurements

Pathology database RITA (Registry of Industrial Toxicology Animal-data)

RITA is a database for the collection of peer-reviewed histopathological diagnoses on tumors and other proliferative lesions as well as study-associated information from control rats and mice. Since 1988, this database has been operated for major European chemical and / or pharmaceutical companies in collaboration with the Department of Pathology. See the RITA website for more information.


RITA CEPA – Cell Proliferation and Apoptosis

This RITA-associated project focuses on the development of a database and standardized procedures for applying cell proliferation techniques (e.g. BrdU and PCNA labeling) to toxicity testing. Please see the RITA CEPA website for more details.


goRENI – global open RENI

RENI is an information system for toxicologic pathology on the Web including a standardized nomenclature and diagnostic criteria for proliferative lesions in rats and mice together with images of histopathological slides and literature references. For further information, please visit the RENI website.


DevTox – Developmental Toxicology

The development of a database system for the evaluation of results from reproductive toxicology studies has been started in 1999. The project is carried out in cooperation with the working groups on General Toxicology and Reproductive Toxicology. For more details please see the related website.



FeDTex is a reproductive toxicology database with a focus on multi-generation studies. Affected parameters and effects are documented in relation to the developmental stage, gender, and generation. This database allows e.g. structureactivity relationships to be developed.



RepDose (repeated-dose toxicity) is a relational database on subacute to chronic toxicity and currently contains 655 chemicals. The toxicity of these chemicals has been documented in about 2280 studies, carried out in rats, mice or dogs with oral or inhalation exposure. The content and structure of the database RepDose provide a sound basis to perform analyses on repeated-dose toxicity. RepDose is used by the Department of Chemical Risk Assessment at the Fraunhofer ITEM to analyze and improve risk assessment strategies. Further information