Concepts and scientific basic principles of risk assessment

Our services and expertise

Improvement of risk assessment methods:
Development of integrated testing strategies (e.g. for the endpoint repeated-dose toxicity within the EU projekt OSIRIS); verification of predictiveness of in-vitro/in-silico screening methods (e.g. within the EU project ChemScreen)

Scientific basic principles of risk assessment:
Enhancement and improvement of TTC concepts including inhalation, extrapolation factors, and concepts for (nano-)particles

Development and validation of models and scenarios (e.g. SprayExpo, ESDs); evaluation of risk mitigation measures; development of analytical methods

Toxicological databases:
We develop databases and perform database analyses, for example, with regard to repeated-dose toxicity (RepDose), reproductive and developmental toxicity (FeDTex), and inhalation studies with nanoparticles (PaFTox); we furthermore develop ontologies for databases to enable uniform description of effects

(Q)SAR and investigation of structurally related substances:
Models of qualitative or quantitative structure-activity relationship; investigation of structurally related substances (definition of groups or analogy); development and assessment of substance categories by using our own or third-party databases (e.g. OECD toolbox)

Expert reports:
In the form of expert reports, we document the (eco-)toxicological properties of substances and assess their risks to human health and the environment, for example, in the event of contamination or chemical residues in foods and products.