Alternative methods to animal testing are required to reduce animal tests, e.g. under REACH. Our working group QSAR/New Methodologies for Risk Assessment is involved in several projects developing strategies for human risk assessment within the European Framework Programs 6 and 7 and in projects sponsored by the chemical industry. In this context, two databases – RepDose and FeDTex – have been developed to address repeated-dose and reproductive toxicity.
RepDose – Repeated-Dose Toxicity:
RepDose, a database funded by Cefic LRI, contains peer-reviewed and confidential repeated-dose toxicity studies in rodents with subacute to chronic exposure durations. It is a continuously growing database and currently contains about 650 chemicals and 2500 studies. The database is available at: www.fraunhofer-repdose.de.
FeDTex – Reproductive and Developmental Toxicity:
FeDTex is a database on reproductive toxicity with a focus on one- and two-generation studies. Parameters and effects describing maternal toxicity, reproductive performance, and developmental toxicity are documented according to affected generation, developmental stage, and sex. The database can be used both for risk assessment and for structure-activity analyses.