Inflammation is an essential component of many respiratory diseases, including pneumonia, asthma and chronic obstructive lung disease (COPD). It can be classified as acute or chronic. Acute inflammation is a natural, self-protecting biological response of the body to harmful agents such as physical or chemical injury and pathogens. It is characterized by release of proinflammatory mediators, migration of leukocytes, and initiation of repair processes. These events help prevent bodily injury, eliminate the initial cause of injury, and clear out cell debris. In chronic inflammation, a prolonged inflammatory condition with a progressive shift towards tissue destruction, scarring and remodeling is observed. It is known that chronic inflammation underlies not only respiratory infectious diseases, but also cancer and autoimmune disorders such as asthma and COPD. This realization makes it possible to recognize chronic inflammation as a condition that should be treated by its own and opens new avenues for treatment.

At Fraunhofer ITEM, we have a broad range of different models to induce acute and chronic inflammation, from in-vitro models using primary cells and cell lines to ex-vivo human tissue models and in-vivo murine and non-human primate models. Please click below for a description of our acute and subacute respiratory inflammation models. Our chronic inflammation models are described under Asthma, COPD, and Infection.

Acute and subacute respiratory inflammation

LPS-induced respiratory inflammation

Fresh human lung tissue and cells

Innate immune response in human lung tissue