House dust mite (HDM)-induced severe asthma
House dust mite (HDM) is the most frequent in-house allergen known to induce allergic symptoms in humans. HDM-induced chronic allergic asthma in mouse is a state-of-the-art model, closely reflecting features of clinical asthma.
The chronic allergen challenge involves repeated exposure to HDM for a period of several weeks. This exposure treatment has been shown to reproduce hallmarks of human asthma, including Th2-driven allergic inflammation and pronounced airway hyperresponsiveness (AHR). The HDM model provides the opportunity to assess novel therapeutics for treatment of chronic asthma. Additional stimulation can be performed, e.g. with respiratory viruses, to investigate impaired antiviral host responses in allergic preconditions, which have been associated with asthma exacerbations.