Between March 6 and 9, 2023, Fraunhofer ITEM scientists will present their current research at the 8th German Pharm-Tox Summit of the German Society for Experimental and Clinical Pharmacology and Toxicology.
Oral presentations:
“Sicherheitsfaktoren im regulatorischen Kontext: Status quo und Anpassungen an neue Entwicklungen“
(within the advanced course in toxicology “Moderne Ansätze in der Risikoabschätzung: Weight of Evidence und Unsicherheitsanalyse und -quantifizierung“)
Speaker: Annette Bitsch
Date and time: March 6, 2023, 11:45 a.m.-12:20 p.m., H2
“Establishment of an in vitro foreign body reaction model for medical device testing”
Speaker: Jan Sündermann
Date and time: March 8, 2023, 5:30-5:45 p.m., H4/5
“From bioinformatic profiling to the development of siRNA-loaded nanoparticle-based therapy against lung fibrosis”
Speaker: Mandy Otto
Date and time: March 9, 2023, 9:30-9:45 a.m., H2
“In vitro Inhalation – a brief overview on concepts, methods and perspectives for in vitro to in vivo extrapolation of results”
Speaker: Detlef Ritter
Date and time: March 9, 2023, 2:22-2:44 p.m., H4/5
“Aggregated exposure via two different routes of exposure – a case study on PBK modeling from the RISKHUNT3R project”
Speaker: Max Spänig
Date and time: March 9, 2023, 1:00-1:15 p.m., H4/5
Symposium 14: Respiratory Toxicology
Session Chair: Katharina Schwarz
Date and time: March 9, 2023, 2:00-3:30 p.m., H4/5
University of Ulm, Campus “Oberer Eselsberg”, Albert-Einstein-Allee 11, 89081 Ulm, Germany
March 06, 2023 - March 09, 2023
English
Poster Session 1: March 7, 2023, Foyer
P003: “Drug repurposing strategy for treatment of idiopathic pulmonary fibrosis”
Authors: Maria Jordan, Kevin Schmidt, Maximilian Fuchs, Thomas Thum, Jan Fiedler
P050: “Improving human relevance of Ames tests for regulatory use via in silico predicted metabolites”
Authors: Annika Dree, Victoria O. Jejeniwa, Abigail Schütte, Sylvia Escher, Monika Batke, Jochen vom Brocke
P052: “Optimization of the in vitro alkaline comet assay with HepG2 cells for genotoxicity testing of N-nitrosamines”
Authors: Michelle Djuari, Leroy Elenschneider, Martin Engelke, Christina Ziemann
P078: “Molecular fingerprints of SGLT2 inhibitors in non-myocyte cardiovascular cell models”
Authors: Kevin Schmidt, Arne Schmidt, Maximilian Fuchs, Sonja Groß, Annette Just, Angelika Pfanne, Andreas Pich, Thomas Thum, Jan Fiedler
Poster Session 2: March 8, 2023, Foyer
P115: "RNA-Analytics via Microscale Thermophoresis (MST) - A tool to study molecular interactions in solution"
Author: Markus Herkt
P118: “Determination of respiratory pharmacokinetic parameters using a combination of physiologically based pharmacokinetic modelling and an isolated perfused lung model”
Authors: Norman Nowak, Sylvia Escher, Katharina Blümlein, Katharina Schwarz
P132: “Suffocation through strong agglomeration of particles in the nose of test animals – new approaches for acute high-dose inhalation studies that only consider animal survival”
Authors: Gustav Bruer, Nils Krueger, Klaus Weber, Nils Warfing, Alex Vitali, Juergen Nolde, Tobias Schuster, Otto Creutzenberg, Paula Janssen, Benno Wessely, Michael Stintz
P140: “Development of RNA-based risk assessments for cardiotoxicity in rat cardiomyoblasts and living myocardial slices”
Authors: Anna-Leena Kassandra Heim, Mandy Otto, Leroy Elenschneider, Maximilian Fuchs, Marco Bentele, Naisam Abbas, Jan Weusthoff, Annette Just, Angelika Stucki-Koch, Sylvia Escher, Thomas Thum, Jan Fiedler
Fraunhofer ITEM
Fraunhofer Institute for Toxicology and Experimental Medicine