CRC Hannover (Clinical Research Center Hannover)

Clinical expertise under one roof

The CRC Hannover, which opened in 2014, maximizes benefits for patients by enabling leading academic experts to pool their expertise and collaborate. Three legally independent research organizations are working at the CRC Hannover under one roof. While clinical investigators of Fraunhofer ITEM and the Hannover Medical School perform early-phase clinical trials with new drugs and medical devices, researchers of the Helmholtz Centre for Infection Research are conducting a part of Germany’s largest health study, known as “German National Cohort study”.

These three partners share CRC Hannover’s unique infrastructure, which includes outpatient clinics, overnight facilities, advanced medical equipment, magnetic resonance imaging systems, and a state-of-the art biobank for storing biological samples.

What unites us is our dedication to becoming one of Europe’s leading centers for patient-oriented translational medicine.

 

Methods and techniques of our clinical research

 

Challenge models

We have developed several challenge models and in particular our unique Fraunhofer Allergen Challenge Chambers, where pollen and other allergens can be distributed under controlled conditions.

Inflammation monitoring

Our repertoire includes a variety of invasive and non-invasive methods for detailed observation and monitoring of inflammatory processes in the lung.

 

Biomarkers

We process and analyze human biosamples using a variety of innovative technologies and methods, including in-vitro disease models with primary cells.

 

Chip cytometry

Chip-based cell recognition, i. e. chip cytometry, enables iterative staining of cellular markers, as with flow cytometry, and in addition allows analysis of stored samples.

Medical imaging

Modern imaging techniques (we have our own research MRI) offer non-invasive techniques which we use to monitor morphological and functional biomarkers for our clinical research.

 

Respiratory diagnostics

From spirometry, bronchoscopy, body plethysmography, and rhinomanometry to pulse oscillometry and other methods – we offer a wide range of methods that can be used in clinical trials.

 

Fraunhofer Sputum Core Facility

Our sputum center has comprehensive experience and offers validated analytical methods for sputum analysis in multicenter clinical trials.

Clinical studies at the CRC Hannover

At the CRC Hannover, Fraunhofer ITEM performs clinical studies with healthy volunteers and patients with certain pre-existing conditions.

Fraunhofer ITEM expertise

Our early-phase clinical trials department is a highly specialized, academia-affiliated clinical research unit that focuses on early-phase and proof-of-concept trials. We have comprehensive experience in conducting clinical trials with drugs to treat respiratory diseases such as asthma, allergic rhinitis, COPD, interstitial and diffuse parenchymal lung diseases (especially idiopathic pulmonary fibrosis (IPF), sarcoidosis, and other interstitial lung diseases). For full-service projects, we work with CROs that have extensive experience with respiratory indications.