Fraunhofer Institute for Toxicology and Experimental Medicine

Replacing animal testing

Fraunhofer ITEM advances the development of new-approach methodologies. Our scientists Dr. Sylvia Escher and Dr. Tanja Hansen discussed the paradigm shift in chemical risk assessment.

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Cluster of Excellence for Immune-Mediated Diseases CIMD

By teaming up with Fraunhofer IME, Fraunhofer IZI and other partners, we aim to advance the translation of innovative ideas and identified targets into individualized therapies for immune-mediated diseases.

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Excellent stage for excellent research!

Fraunhofer ITEM is a part of the nationwide campaign “Hannover – city of excellence”

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Respiratory infections

Fraunhofer ITEM research teams are facing up to the challenges in infection research. Dr. Sabine Wronski, manager of the Working Group on Infection and Immunology, talks about this in an interview.

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New guidance for endocrine disruptors and biocides

We support our clients concerning the compilation of data for the evaluation of the endocrine potential of biocides.

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Gentle treatment for premature babies

Researchers at Fraunhofer ITEM are working on an intelligent inhalation system for babies with lung diseases.

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MDR – handicap for the innovation hotspot Germany

High-Performance Center Translational Biomedical Engineering is suggesting specific measures for a revision of the Medical Device Regulation.

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Chip-based cell analysis by chip cytometry

New technology at Fraunhofer ITEM enables sputum analysis by chip cytometry.

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Project EU-ToxRisk

Fraunhofer ITEM scientists will test new-approach methodologies for animal-free toxicity testing and risk assessment.

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Focus of research: Respiratory Infection Research

Simulation of infections in human precision-cut lung slices (PCLS) to test the efficacy of drugs

Respiratory infection research at Fraunhofer ITEM

Due to the institute’s proximity to the Hannover Medical School, researchers at Fraunhofer ITEM in Hannover have the opportunity to work directly with human lung tissue from operated patients, to extract living lung slices and cultivate these in the laboratory. These "mini-lung pieces" are used to simulate infections, to investigate interactions of the pathogens with human tissue and thus to test the efficacy of new drugs.

Here you can find more information about respiratory infections. 

Fraunhofer ITEM: News


News / 25.7.2019

Regensburg Oncology Award for Nataša Stojanović

Fraunhofer ITEM scientist received a prize for her research work.

Press Release / 29.5.2019

German-Australian iCAIR project

Fraunhofer iCAIR is breaking new ground in the development of antiviral drugs.

News / 8.7.2019

Removing hazardous substances from PVC

Fraunhofer ITEM is one of 15 project partners in the EU-project REMADYL. 


News / 28.5.2019

Models of Lung Disease 2020 - Save the date!

The 19th Fraunhofer Seminar “Models of Lung Disease” will take place from February 6 to 7, 2020.

News / 8.5.2019

EFSA training courses open for registration

The EFSA training courses no. 3, "Endocrine disruptors" and no. 4, "Principles of genotoxicity in scientific assessment" are now open for registration.

News / 5.6.2019

Founding of the German Society for Metabolome Research

Dr. Sven Schuchardt of Fraunhofer ITEM elected treasurer.


Fraunhofer ITEM

Fraunhofer Institute for Toxicology and Experimental Medicine ITEM

Nikolai-Fuchs-Strasse 1
30625 Hannover

Phone +49 511 5350-0



Models of Lung Disease 2020

The 19th Fraunhofer Seminar “Models of Lung Disease” will take place from February 6 to 7, 2020.
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Training course: In-silico toxicology

This training course will introduce the participants to three different in-silico approaches for estimation of human health toxicological endpoints, namely QSAR models, read-across, and the TTC (threshold of toxicological concern) concept. The application of in-silico approaches in ecotoxicology will not be addressed in this course.
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Open Session »TBMED«

Aiming to support European medtech companies in the global competition, the EU has initiated the project TBMED – An Open-Innovation Test Bed for the Development of High-Risk Medical Devices. Together with 12 project partners from Spain, France, Ireland and Germany, Fraunhofer ITEM is actively participating in the development of a test bed for medical devices of risk classification IIb and higher.
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JSOT Annual Meeting 2019

The 46th Annual Meeting of the Japanese Society of Toxicology will be held at the convention facility of Tokushima (ASTY Tokushima) in Tokushima City, Japan, from June 26 to 28 , 2019. The theme of the meeting is "Toxicology, the foundation of sustainable environment, society and industry".
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Our services and expertise


Drug Development

From drug candidate to proof of concept


Chemical Safety and Assessment

From risk analysis towards safe products


Translational Biomedical Engineering

From idea to safe medical device


Personalized Tumor Therapy

From molecular analysis to personalized therapy

About Fraunhofer ITEM

The Fraunhofer Institute for Toxicology and Experimental Medicine ITEM is one of approximately 70 institutions of the Fraunhofer-Gesellschaft, Europe's leading organization for applied research. Protecting man from health hazards in our industrialized world and contributing to the development of novel therapeutic approaches are the aims Fraunhofer ITEM is pursuing with its contract research. With a focus on airway research, our R&D portfolio includes three thematic areas: drug development, chemical safety, and translational biomedical engineering. In addition, our scientists in Regensburg do research in the field of personalized tumor therapy.

With a staff of approximately 300 at its locations in Hannover, Braunschweig and Regensburg, the institute cooperates with industry, service providers, and public authorities in projects that drive economic development and serve the wider benefit of society.

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