Fraunhofer Institute for Toxicology and Experimental Medicine
EFSA training no. 1: Combined exposure to multiple chemicals
This online training course will provide a short review of the key terms, scientific basis for combined exposure risk assessment and approaches to assessing (eco)toxicology of combined exposures. Existing frameworks for risk assessment of combined exposure to multiple chemicals were evaluated by EFSA, resulting in a harmonized framework for risk assessment of combined exposure to multiple chemicals. The framework as published as EFSA Guidance in 2019 is based on the risk assessment steps (problem formulation, exposure assessment, hazard identification and characterization, and risk characterization including uncertainty analysis), with tiered and stepwise approaches for both whole-mixture approaches and component-based approaches.