Fraunhofer Institute for Toxicology and Experimental Medicine

Respiratory infections

Fraunhofer ITEM research teams are facing up to the challenges in infection research. Dr. Sabine Wronski, manager of the Working Group on Infection and Immunology, talks about this in an interview.

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Cluster of Excellence for Immune-Mediated Diseases CIMD

By teaming up with Fraunhofer IME, Fraunhofer IZI and other partners, we aim to advance the translation of innovative ideas and identified targets into individualized therapies for immune-mediated diseases.

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Excellent stage for excellent research!

Fraunhofer ITEM is a part of the nationwide campaign “Hannover – city of excellence”

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Replacing animal testing

Fraunhofer ITEM advances the development of new-approach methodologies. Our scientists Dr. Sylvia Escher and Dr. Tanja Hansen discussed the paradigm shift in chemical risk assessment.

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New guidance for endocrine disruptors and biocides

We support our clients concerning the compilation of data for the evaluation of the endocrine potential of biocides.

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Gentle treatment for premature babies

Researchers at Fraunhofer ITEM are working on an intelligent inhalation system for babies with lung diseases.

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MDR – handicap for the innovation hotspot Germany

High-Performance Center Translational Biomedical Engineering is suggesting specific measures for a revision of the Medical Device Regulation.

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Chip-based cell analysis by chip cytometry

New technology at Fraunhofer ITEM enables sputum analysis by chip cytometry.

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Project EU-ToxRisk

Fraunhofer ITEM scientists will test new-approach methodologies for animal-free toxicity testing and risk assessment.

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Focus of research: Respiratory Infection Research

Simulation of infections in human precision-cut lung slices (PCLS) to test the efficacy of drugs

Respiratory infection research at Fraunhofer ITEM

Due to the institute’s proximity to the Hannover Medical School, researchers at Fraunhofer ITEM in Hannover have the opportunity to work directly with human lung tissue from operated patients, to extract living lung slices and cultivate these in the laboratory. These "mini-lung pieces" are used to simulate infections, to investigate interactions of the pathogens with human tissue and thus to test the efficacy of new drugs.

Here you can find more information about respiratory infections. 

Fraunhofer ITEM: News


Press Release / 10.9.2019

EU project MDOT

Fraunhofer ITEM committed to simplifying the testing and increasing the safety of medical devices in the EU project MDOT.

News / 16.10.2019

EU project SILIFE

The aim of the SILIFE project was to produce commercial quartz that exhibits little or no toxicity owing to RCS, due to a dry surface-coating step.

News / 20.9.2019

Fraunhofer scientist was appointed Honorary Professor

Dr. Holger Ziehr was appointed Honorary Professor at TU Braunschweig.


News / 26.9.2019

Models of Lung Disease 2020 – register now!

The 19th Fraunhofer Seminar “Models of Lung Disease” will take place from February 6 to 7, 2020. Registration is open.

News / 19.9.2019

InnoHealth China 2020

Go China with InnoHealth China: Call for Ideas & Innovation

News / 25.7.2019

Regensburg Oncology Award for Nataša Stojanović

Fraunhofer ITEM scientist received a prize for her research work.


Fraunhofer ITEM

Fraunhofer Institute for Toxicology and Experimental Medicine ITEM

Nikolai-Fuchs-Strasse 1
30625 Hannover

Phone +49 511 5350-0



19th Fraunhofer Seminar "Models of Lung Disease"

On February 6 and 7, 2020, the 19th Fraunhofer Seminar "Models of Lung Disease" will take place at the CRC Hannover. Online registration is open.
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Cefic-LRI Workshop

Fraunhofer ITEM will participate in the Cefic-LRI workshop in Brussels with two contributions: Dr. Monika Batke will give an oral presentation on the topic ”Incorporation of repeated-dose study information for non-DNA-reactive carcinogens into CPDB database and analysis of threshold values“ and Dr. Katharina Schwarz will present a poster about the parameterization of PBPK models for inhalation exposure.
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SFT Congress 2019 in Paris

This year's annual congress of the French Society of Toxicology ("Société Française de Toxicologie", SFT in short) will be held in Paris from November 4 to 5. The aim of SFT is to bring together experts from the various areas of toxicology in order to facilitate and promote the exchange of new findings. The focus of this year's SFT Congress is on new models, new approaches, and new challenges in toxicological risk assessment. Fraunhofer ITEM scientist Tanja Hansen will contribute an oral presentation entitled "New concepts in inhalation toxicology: the in-vitro approach".
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The 19th European Society for Alternatives to Animal Testing (EUSAAT) will take place at the University of Linz (Austria) from October 10 to 13, 2019. This year’s EUSAAT congress will focus its activities on all areas in the life sciences that rely on the use of experimental animals including the pharmaceutical, cosmetics and chemical industries, regulatory and basic sciences.
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Our services and expertise


Drug Development

From drug candidate to proof of concept


Chemical Safety and Assessment

From risk analysis towards safe products


Translational Biomedical Engineering

From idea to safe medical device


Personalized Tumor Therapy

From molecular analysis to personalized therapy

About Fraunhofer ITEM

The Fraunhofer Institute for Toxicology and Experimental Medicine ITEM is one of approximately 70 institutions of the Fraunhofer-Gesellschaft, Europe's leading organization for applied research. Protecting man from health hazards in our industrialized world and contributing to the development of novel therapeutic approaches are the aims Fraunhofer ITEM is pursuing with its contract research. With a focus on airway research, our R&D portfolio includes three thematic areas: drug development, chemical safety, and translational biomedical engineering. In addition, our scientists in Regensburg do research in the field of personalized tumor therapy.

With a staff of approximately 300 at its locations in Hannover, Braunschweig and Regensburg, the institute cooperates with industry, service providers, and public authorities in projects that drive economic development and serve the wider benefit of society.

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