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This training course will introduce the participants to three different in-silico approaches for estimation of human health toxicological endpoints, namely QSAR models, read-across, and the TTC (threshold of toxicological concern) concept. The application of in-silico approaches in ecotoxicology will not be addressed in this course.

Current topics, including new research results, challenges, solutions and perspectives in the field of immune-mediated diseases will be presented and discussed.

At the 61st Congress of the German Respiratory Society, taking place in Leipzig (Germany) from June 24 to 27, 2020, Fraunhofer ITEM scientists will make contributions to the scientific program.

This training course will introduce participants to three different in-silico approaches, namely QSAR models, read-across, and the TTC (threshold of toxicological concern) concept, including demonstrations and explanations of currently available predictive toxicology models.

This training course will provide a short review of the key terms, scientific basis for combined exposure risk assessment and approaches to assessing (eco)toxicology of combined exposures. Existing frameworks for risk assessment of combined exposure to multiple chemicals were evaluated by EFSA, resulting in a harmonized framework for risk assessment of combined exposure to multiple chemicals. The framework as published as EFSA Guidance in 2019 is based on the risk assessment steps (problem formulation, exposure assessment, hazard identification and characterization, and risk characterization including uncertainty analysis), with tiered and stepwise approaches for both whole-mixture approaches and component-based approaches.

The objective of this training course is to enable the understanding and practical implementation of the guidance document on ED hazard identification of plant protection products in the context of the EU legislation on pesticides amongst members of EFSA’s Scientific Committee/Panels, their working groups as well as EFSA staff.

This training course will give guidance to participants on how to evaluate study data on genotoxicity and how to integrate corresponding testing results in risk assessment.

Twenty years of clinical research at Fraunhofer ITEM is a great opportunity to discuss current issues in clinical lung research with internationally renowned experts. Please save the Dates November 12 and 13 for our symposium "Experimental Medicine in Lung Disease – 20 years of Fraunhofer ITEM Clinical Research".