Preclinical Pharmacology and Toxicology at Fraunhofer ITEM

Our preclinical research focuses on respiratory diseases, including asthma, COPD, infections, pulmonary fibrosis and cancer. Test the safety and efficacy of your therapeutics, including small molecules, cell therapies, antibodies, and RNA therapies.

Through interdisciplinary and complementary expertise in-house we strive to provide a comprehensive portfolio to our customers and research partners. Strong scientific networks within the German Centre for Lung Research and international consortia bolster our scientific excellence and enable a unique infrastructure within the Hannover Medical Park. 

Models of acute and chronic lung diseases

• Human PCLS to enable studies of pathophysiological / immunological processes in living human tissue
• Rodent models for respiratory diseases
• Advanced lung function measurements
   

GLP-certified inhalation toxicology

• Air-liquid interface cultures using patented P.R.I.T. technology
• Custom-made, in-vivo toxicological testing
• Novel ex-vivo lung measurements, i.e. isolated perfused lung