Exposure characterization

We characterize human exposure to gases and aerosols / particles at workplaces, in indoor air and in the environment, with a focus on inhalation exposure. For this purpose, we combine state-of-the-art measurement technology with mathematical modeling tools and provide necessary adaptations to customize a solution to a client's specific needs or guarantee its compliance with relevant regulations.

Model rooms of various sizes and with adjustable air exchange rates are available for the realistic simulation of aerosol release from spray products and measurement of inhalation exposure, as well as customized measurement technology and methods for analyzing aerosols and gases. 

The results serve to assess risks to human health and the environment, to support substance and product registration and authorization, and to improve product safety. The required studies are performed at the Fraunhofer ITEM in compliance with national and international regulations (both GLP and non-GLP).

A particular focus is on determining the inhalation exposure of cosmetic spray products. Increased requirements for inhalation exposure characterization have led to challenges in the exposure and safety assessment of new cosmetic spray products.

To support the industry, we have developed novel methods which, on the one hand, allow exposure to be determined efficiently under current directives and, on the other hand, allow the optimization of cosmetic spray products towards minimal inhalation exposure to substances of concern (Safe-by-Design).

In the sense of safe-by-design, the combination of exposure studies with in vitro inhalation toxicology studies can also be used as a supporting tool for the development of in vitro to in vivo extrapolation strategies already in the development phase of cosmetic products.