Fraunhofer IIS’s Medical Image Analysis group and Fraunhofer ITEM’s Personalized Tumor Therapy division attend the next annual meeting of the American Association of Cancer Research in 2024 and exhibit their technologies and services.
Plenary session "Evolution of the Genome, Microenvironment, and Host through Metastasis"
„Insights into the invisible phase of systemic cancer: Genomic evolution and phenotypic plasticity of the metastatic seed“
Speaker: Christoph A. Klein
Date and Time: Tuesday, April 9. 2024. 8:05 - 8:30 a.m.
Fraunhofer ITEM
Advance registration deadline: Friday, February 16
Onsite registration opens 12:00 p.m. PT April 5, 2024
San Diego Convention Center
111 W Harbor Drive
San Diego, CA 92101
April 07, 2024 - April 10, 2024
English
Our Regensburg-based division "Personalized Tumor Therapy" develops diagnostic tests for the detection of circulating and disseminated cancer cells early in the disease and prediction of the response to therapy of metastatic cells. Their services and expertise include multiomics single-cell analysis, patient-derived preclinical model generation and their use for drug screening and testing, as well as customized bioinformatics and mathematical modeling.
Fraunhofer IIS’s biomedical image analysis division exhibits their computational pathology & spatial biology solution MICAIA® (www.micaia.ai) as well as their preclinical CRO & pharma services. MICAIA® contains off-the-shelf apps (HE, IHC, mIF) and can be extended using the interactive AI Author or the “plug in your own AI” API.
"Tumor Microenvironment-Mediated Regulation of Early Dissemination and Colonization in Breast Cancer via BAZ2A-Containing Remodeling Complexes"
Presenter: Miriam Kokal-Ribaudo
Authors: Miriam Kokal-Ribaudo, Nora Jahnen, Saba Sameri, Fulvia Ferrazzi, Renato Liguori, Christoph A. Klein, Gernot Längst, Hedayatollah Hosseini
"Patient-derived ex vivo models to test drug response of disseminated cancer cells in various metastatic niches"
Presenter: Lukas Wöhrl
Authors: Lukas Wöhrl, Catherine Botteron, Kathrin Weidele, Steffi Treitschke, Durdam Das, Melanie Werner-Klein, Martin Hoffmann, Nataša Stojanović Gužvić, Silvia Materna-Reichelt, Florian Weber, Simon Engelmann, Roman Mayr, Miodrag Gužvić, Sebastian Haferkamp, Stephan Seitz, Christoph A. Klein, Christian Werno
"A targeted mutation calling workflow - end to end - from FASTQ to clinical report for single cells"
Presenter: Adithi Ravikumar Varadarajan
Authors: Adithi Ravikumar Varadarajan, Thomas Ragg, Jonas Grote, Vadim Dechand, Steffi Treitschke, Clara Chaiban, Christoph Klein, Zbigniew Czyz, Jens Warfsmann
"Whole genome and targeted proteome analysis of single cancer cells"
Presenter: Atieh Alyasin
Authors: Atieh Alyasin, Kathrin Weidele, Catherine Botteron, Christoph A. Klein, Zbigniew T. Czyż
"In Vitro Plasticity Profiling of Metastatic Cancer Cells with an Imaging-Based Pipeline"
Presenter: Saba Sameri
Authors: Saba Sameri, Durdam Das, Stefanie Michaelis, Joachim Wegener, Hedayatollah Hosseini, Martin Hoffmann
"Molecular characterization and prognostic evaluation of disseminated cancer cell subpopulations detected in bone marrow of non-small cell lung cancer patients"
Presenter: Daniel Spitzl
Authors: Daniel Spitzl, Tobias Mederer, Julius Zank, Severin Gütter, Michael Ried, Hans-Stefan Hofmann, Christoph A. Klein
"Cell-Cell contacts regulate HER2 cellular localization and the transitions between migration and proliferation in breast cancer cells"
Presenter: Hedayatollah Hosseini
Authors: Saba Sameri, Durdam Das, Shabnam Shahrivari, Vladan Milosevic, Shamim Sarhadi, Carolina Fisch, Miriam Kokal, Michael Schletter, Paul S. Hahn, Lisa Seider, Marisa Schübel, Stefanie Michaelis, Joachim Wegener, Florian Weber, Martin Hoffmann, Christian Werno, Kathrin Weidele, Astrid Bruckmann, Arne Östman, Ernst R. Tamm, Yuting Li, Christoph A. Klein, Hedayatollah Hosseini
"Genomic profiling of single cancer cells using the novel single-cell integrated mutational profiling of actionable cancer targets (scIMPACT) assay"
Presenter: Clara Chaiban
Authors: Clara Chaiban, Adithi Ravikumar Varadarajan, Jonas Grote, Thomas Ragg, Isabell Blochberger, Vadim Dechand, Jens Warfsmann, Christoph A. Klein, Zbigniew T. Czyż
"Genomic profiling with the novel single-cell IMPACT assay reveals evidence of genetic heterogeneity among CTCs in late-stage breast cancer patients"
Presenter: Zbigniew Czyz
Authors: Zbigniew T. Czyż, Clara Chaiban, Adithi Ravikumar Varadarajan, Cäcilia Köstler, Vadim Dechand, Jonas Grote, Thomas Ragg, Bernhard Polzer, Jens Warfsmann, Christoph A. Klein
"Characterization of EpCAM-positive cells for specific detection of disseminated cancer cells in bone marrow of early breast cancer patients"
Presenter: Jonas Roth
Authors: Jonas Roth, Elia Raya, Sarah Hücker, Huiqin Koerkel-Qu, Stephan Seitz, Christoph A. Klein
"EpCAM+ DCCs isolated from bone marrow of breast cancer patients display high stemness and potency scores"
Presenter: Elia Raya
Authors: Elia Raya, Huiqin Koerkel-Qu, Laura Rudhart , Lisa Marie Köhler, Anna Damböck, Christoph Irlbeck, Catherine Botteron, Melanie Werner-Klein, Stephan Seitz, Christoph A. Klein
"Metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization"
Presenter: Melanie Werner-Klein
Authors: Severin Guetter, Courtney König, Huiqin Koerkel-Qu, Aleksandra Markiewicz, Sebastian Scheitler, Marie Katzer, Mark Berneburg, Philipp Renner, Beatrix Cucuruz, Leonhard Guttenberger, Veronika Naimer, Kathrin Weidele, Steffi Treitschke, Christian Werno, Hanna Jaser, Tonia Bargmann, Armin Braun, Florian Weber, Katharina Limm, Reinhard Rachel, Felix Baumann, Lisa Schmidleithner, Kathrin Schambeck, Parvaneh Mohammadi, Anja Ulmer, Sebastian Haferkamp, Christoph A. Klein, Melanie Werner-Klein
Fraunhofer ITEM, Germany
Fraunhofer Institute for Toxicology and Experimental Medicine