We are excited to be at this year’s SOT Annual Meeting and ToxExpo in Nashville, Tennessee, and will be very happy to share insights into our latest toxicology research with you.
Booth number: 1127
The development of in-vitro models of barrier organs for parameterizing next-generation PBK models
Tuesday, March 21, 10:05 a.m.-10:35 a.m.
Speaker: Dr. Sylvia Escher
New-approach model for volatile compounds: example of pulmonary fibrosis
Monday, March 20, 2023, 9:00-10:00 a.m., Room 101B, Music City Center
Speakers: Dr. Sylvia Escher, Christina Drake, Dr. Sebastian Konzok
New approaches to integrating transcriptomics in a read-across study on volatile compounds known to induce pulmonary fibrosis will be presented. Besides, knowledge can be transferred from amplifying receptor-mediated repair pathways to induce key cellular mechanisms and adverse outcomes.
Aggregating exposure: challenges and solution to link external and internal exposure using PBPK models
Tuesday, March 21, 2023, 3:00-4:00 p.m., Room 101B, Music City Center
Speakers: Dr. Annette Bitsch, Norman Nowak, Dr. Tanja Hansen
Protecting people from health risks in everyday life needs better understanding of exposure to chemical or biological stressors. Frameworks to combine aggregated exposure with reverse dosimetry are prerequisites for developing next generation risk assessments (NGRA). PBPK models link exposure and target organ toxicity.
Wednesday, March 22, 2023, 12:00 a.m - 1:00 p.m., Room 101B, Music City Center
Advanced In Vitro Models of Inhalation Toxicology
Speakers: Dr. Katharina Schwarz, Dr. Tanja Hansen
In this discussion, speakers will present tips to creating effective and reproducible particle deposition profiles, along with generating the most physiologically relevant exposure models and establishing in vitro/in vivo correlations with airway-liquid interface cultures. More details.
Nashville
Tennessee, USA
March 19, 2023 - March 23, 2023
English
Poster board P648: Zet-O-Map: identify principal molecular drivers of (dys)morphogenesis in zebrafish
Monday, March 20, 2023, 9:00-10:45 a.m.
Authors: M. Wehr, B. Schultz, H. Witters, M. Jacobs, S. E. Escher, A. Bitsch
Poster board P360: Optimization of the in-vitro alkaline comet assay with liver cells for genotoxicity testing of N-nitrosamines
Monday, March 20, 2023, 10:45 a.m.-12:30 p.m.
Authors: M. A. Djuari, L. Elenschneider, M. Engelke, T. Hansen, C. Ziemann, A. Bitsch
Poster board P410: Development of a database to derive inhalation TTC values for airborne compounds
Monday, March 20, 2023, 2:30-4:15 p.m.
Authors: M. Schwarz-Zocher, A. M. Api, K. Joshi, A. Giusti,4, J. Rose, S. Collins, G. Patlewicz, A. M. Bowden, F. Boisleve, M. Singal, N. Sadekar, S. E. Escher
Poster board P723: Toxicity of metal compounds in human precision-cut lung slices ex vivo
Tuesday, March 21, 2023, 9:00-10:45 a.m.
Authors: K. Grieger, O. Danov, H. Obernolte, M. Niehof, H. Fieguth, A. Braun, K. Sewald, F. Schulz, T. Hansen, A. Bitsch
Poster board P177: EMA MutAmind: data gap analysis of N-nitrosamines for structure-activity relationship
Tuesday, March 21, 2023, 9:00-10:45 a.m.
Authors: A. Londenberg, K. P. Cross, M. Christmann, M. Djuari, J. Fahrer, R. Frötschl, B. Haas, M. Vogel, C. Ziemann, S. Escher
Poster board P208: Co-expression networks to confirm the assessment of similar mechanisms of action in a context of compound-induced pulmonary fibrosis
Tuesday, March 21, 2023, 10:45 a.m.-12:30 p.m.
Authors: C. Drake, M. Wehr, W. Zobl, J. Koschmann, B. A. Kühne, D. De Luca, H. Vrieling, J. J. Boei, D. Ritter, J. Knebel, T. Hansen, A. Bitsch, S. E. Escher
Poster board P194: Occupational exposure to veterinary antibiotics: PBPK modeling of enrofloxacin in humans after inhalation uptake
Wednesday, March 22, 2023, 9:00-10:45 a.m.
Authors: K. Blümlein, N. Nowak, B. Ellinghusen, S. Gerling, P. Badorrek, T. Hansen, J. Hohlfeld, R. Paul, S. Schuchardt, A. Bitsch
Poster board P510: Quantitative ex-vivo to in-vivo extrapolation for respiratory toxicity of inhalable substances
Wednesday, March 22, 2023, 2:30-4:15 p.m.
Authors: K. Schwarz, H. Obernolte, D. Winterberg, D. Schaudien, S. Cleeves, K. Sewald, A. Braun, A. Bitsch
Fraunhofer ITEM
Fraunhofer Institute for Toxicology and Experimental Medicine