This lighthouse project focuses on developing bioprocessing methods and production technologies for the modular and automated manufacture of mRNAs, mRNA nanocarriers and mRNA-modified cells that can be scaled right up to industry level. For the automated manufacture of mRNA-based drugs to be successful, technical solutions will be established in the areas of bioreactors, fluid dynamics, quality control and automated data analysis. Core elements of the Industry 4.0 concept are to be deployed in order to digitally map and monitor the production processes.
The primary objective is to develop automated manufacturing processes for mRNA molecules that will smooth the way for sustainable and cost-efficient health care. In order to achieve its goal, the project brings together the expertise of various Fraunhofer institutes from the fields of vaccine development, cell and gene therapy, bioprocess development, smart sensor technology, and the automation and digitalization of production processes.