"Maximizing drug development efficiency using predictive in vitro and ex vivo models"
Speaker: Dr. Katharina Schwarz
More information
The webinar deals with innovative strategies for enhancing drug development efficiency using predictive in vitro and ex vivo models. It focuses on the approach developed by the Fraunhofer ITEM, which streamlines drug development by offering faster, cost-effective, and predictive methods for developing new inhalable therapeutics.
Key highlights
- Precision-cut lung slices (PCLS): Used to study drug efficacy and respiratory toxicity of inhalable drugs
- Application of PRIT expoCube system: Enabling dose controlled air-liquid-interface exposure
- Therapeutic window: Identification of a therapeutic window between efficacy and local toxicity
- Integration of in vitro and in vivo Data: Using computational models to establish toxicity thresholds and first dose estimates