This e-learning training course will introduce the main principles of different structure based in-silico approaches for estimation of mainly human health toxicological endpoints. Statistical and rule base quantitative structure activity models (QSARs) will be introduced and how to assess the outcome of these predictions by using expert review.
The second topic is read-across, which is usually applied in case that the toxicological properties of a data poor target compound is predicted from one or several data rich similar source compounds. Recent guidance documents such as the RAAF will be taken into account. The different options for similarity assessments will be outlined as well as the main assessment elements of a read-across assessment.
The third concept is TTC (threshold of toxicological concern). This concept is used for unknown compounds occurring at low levels in feed/food.
Exercises will give the opportunity to train on well-known tools such as the OECD QSAR toolbox or Vega. Three webinars will be offered within the e-learning period to discuss the exercise.
By the end of the course, participants will be able to:
- Understand the differences between QSAR, read-across and TTC approaches
- Understand the applicability domain of different models
- Apply QSAR models and understand the principle of combining evidence by using different QSAR model types
- Understand the principles of expert review to deal with conflicting data
- Have a first insight into different tools such as the OECD QSAR toolbox and Vega
Learners will have a two-month period to complete the self-study part of the course (presentations and quizzes). Within the training period three webinars will be offered to discuss the exercises. The course will not be fully completed until the second webinar provided is attended by the learner.
This course is delivered as a blended learning, a mix of instructor-led activities and e-learnings. It will start and end with a live webinar. Learners will have to complete four e-learnings modules in the meantime.
Who will be admitted?
This EFSA e-learning is open to members of organisations on the List of Competent Organisations (also known as Article 36 List) that are eligible to receive EFSA’s grants. Registrants from other affiliations are not eligible. EFSA reserves the right to select the trainees from all registered persons. If the number of eligible registrants exceeds the number of available places, the first-come, first served principle will be applied. After the registration deadline, all registrants will be informed, and the selected trainees will receive login data for the e-learning platform.