20th Fraunhofer Seminar "Models of Lung Disease" and satellite workshop "Alternatives to Animal Testing"

Satellite workshop on day 1, two-day seminar on days 2 and 3 / June 22, 2022 - June 24, 2022

Models of Lung Disease 2022 and satellite workshop Alternatives to Animal Testing

The 20^th Fraunhofer Seminar "Models of Lung Disease" will be held in Hannover, Germany, on June 23 and 24, 2022, with a thematic focus on lung infection. An additional satellite workshop on June 22, dedicated to alternatives to animal testing, can be booked separately or in combination with the main event.

Fraunhofer seminar "Models of Lung Disease 2022"

Models of Lung Disease is a workshop for about 120 participants, organized by Fraunhofer ITEM in cooperation with the German Center for Lung Research (DZL). The event provides a highly interactive platform for exchange of experience and intense discussions between experts from different research fields and the pharmaceutical industry. This year's thematic focus will be on infection and lung disease.

In addition to top-level speakers, a special highlight of this year's seminar is the SPRIND session, presenting projects that have been successful in the current challenge targeting new antiviral agents. SPRIND is the German Federal Agency for Disruptive Innovation, creating spaces for innovators where they can take risks and think radically different. Under the banner of the SPRIND challenges, visionary teams are selected to work on cutting-edge new solutions.

Satellite workshop "Alternatives to Animal Testing"

The satellite workshop on June 22 will focus on alternative in-vitro and ex-vivo models for use in toxicology, pharmacology and infection research. It will provide an opportunity to meet experts in this subject area, listen to interesting lectures and connect with our network.

Guided tours – see how we work

In addition to oral and poster presentations in different thematic sessions at both events, Fraunhofer ITEM will offer several guided tours to selected departments of the institute on all three days, allowing visitors to get insights into different aspects of the research work performed by the Fraunhofer scientists.

Poster exhibitions – present your own research

Consecutive poster exhibitions – one per event – with up to 40 posters each and extra poster sessions will accompany the two events. A poster prize will be awarded for the best poster presented at Models of Lung Disease 2022. Poster authors will have to submit an abstract by e-mail to lung.ws@item.fraunhofer.de by May 30, 2022. Abstracts can be accepted only if at least one author of the poster has registered for the corresponding event.

Continuing medical education: Get CME (ÄKN) credit points

Models of Lung Disease 2022 is worth 16 credit points. The workshop Alternatives to Animal Testing is worth 8 credit points.

Stay posted

If you have any questions about the satellite workshop or the two-day seminar, please feel free to contact us. If you want us to keep you posted about our events, we will be happy to add you to our mailing list. Please contact us via e-mail.

Safety is a priority!

Due to the ongoing pandemic, we recommend that participants have a valid vaccination against COVID-19 or/and have recently recovered from COVID-19. In addition, we would kindly ask all participants to have a recent (< 24 hours ago) negative COVID-19 (self-)test prior to their arrival at the venue (certificates will not be checked).

Face masks (FFP2/KN95/N95) must be worn indoors during registration, guided tours, poster and oral sessions, but not when actively eating or drinking. There is a large outdoor terrace next to the conference area where for example the barbecue dinners on both evenings (June 22 and 23) will take place and where no face masks are required. FFP2 face masks (and a limited number of SARS-CoV-2 self-tests) will be available on site.

Looking back

Go to the 2020 summary

Important facts in brief

Alternatives to Animal Testing on June 22, Models of Lung Disease (focus: infection) on June 23+24 – register for one or both.
Ample opportunities for interaction between participants – expand your network.
Two consecutive poster exhibitions – present your own research.
Guided tours to selected Fraunhofer ITEM departments – see how we work.
Continued medical education program accredited by ÄKN – get CME/ÄKN credits.
Limited seating – register now!

Event details

Program

Please see below for details

Costs

Models of Lung Disease (June 23-24, 2022):
€250 for TRAIN members
€300 for participants from academia
€400 for participants from industry

Satellite workshop Alternatives to Animal Testing (June 22, 2022):
€100 if booked in combination with Models of Lung Disease
€200 if booked separately (reduced fee for students and TRAIN members: €100)

An extra fee of €50 will be charged in all categories for late registrations after May 30, 2022.

Location

CRC Hannover, Feodor-Lynen-Str. 15, 30625 Hannover, Germany

Date

June 22, 2022 - June 24, 2022

Language

English

Program

Click below on the blue bars to see a detailed agenda for each day (subject to change without notice).

(Last updated on: June 23, 2022)

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June 22: Alternatives to Animal Testing for Assessment of Inhalable Agents

Wednesday, June 22, 2022

Preliminary program (subject to change without notice)

Joint workshop: Launch event of the Fraunhofer CIMD platform Alternatives to Animal Testing & workshop 3R Alternatives to Animal Testing for Assessment of Inhalable Agents

09:15	Welcome
Session 1	Opportunities and challenges for integrating new in-vitro methodologies in hazard testing and risk assessment of chemicals Chair: Annette Bitsch, Fraunhofer ITEM
09:30	Paradigm shift in risk assessment of chemicals – activities in EU-wide projects Sylvia Escher, Fraunhofer ITEM
10:00	Public health protection in the 21^st century – new methods and novel concepts in toxicology: BfR workshop and European PARC initiative Philip Marx-Stölting, German Federal Institute for Risk Assessment, Berlin (Germany)
10:30	OECD 497 – defined approaches on skin sensitization Miriam Buchholzer, Henkel (Germany)
11:00	Coffee break
Session 2	Advanced in-vitro and ex-vivo systems to increase the physiological relevance of new methodologies in biomedical research Chair: Vanessa Neuhaus, Fraunhofer ITEM
11:30	Disease modeling using human (lung) tissue Vanessa Neuhaus, Fraunhofer ITEM
12:00	In-vitro disease models for the assessment of efficacy and safety of drugs Florian Groeber-Becker, Fraunhofer Translational Center Regenerative Therapies TLC-RT (Germany)
12:30	Replace alternatives to animal testing at Paul Ehrlich Institut – where are we? Zoe Waibler, Paul Ehrlich Institut (PEI), Berlin (Germany)
13:00	Lunch & coffee and poster session
14:30	Designer cancer immunotherapies: lessons learnt in bench-to-bedside (and back) translation Miriam Alb, University of Würzburg
Session 3	Advanced methods in non-clinical testing of inhalable anti-infectives Chair: Katharina Schwarz, Fraunhofer ITEM
15:00	In-vitro models of biological barriers und modern drug delivery research Claus-Michael Lehr, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrücken (Germany)
15:30	From in-vitro/ex-vivo to in-vivo: alternatives for testing of inhalable substances Katharina Schwarz, Fraunhofer ITEM
16:00	Coffee break
16:30	Physiologically based kinetic (PBK) modeling: utilizing in-vitro data to compute inhalation uptake Norman Nowak, Fraunhofer ITEM
17:00	An industries perspective for alternative assessment of inhalable pharmaceuticals for the treatment of primary ciliary dyskinesia Verena Mummert, Ethris (Germany)
17:30	Guided tours to different Fraunhofer ITEM departments: o PCLS o In-vitro testing (ALI) o IPL
18:30	Dinner at the CRC Hannover
21:00	Summary & conclusions

June 23: Models of Lung Disease (day 1)

Thursday, June 23, 2022

Preliminary program (subject to change without notice)

Models of Lung Disease – infection and lung disease (day 1)

08:45	Welcome Norbert Krug and Armin Braun, Fraunhofer ITEM
Session 1	Understanding and fighting Covid-19 Chair: Katherina Sewald, Fraunhofer ITEM
09:00	Phenotypic characterization of variants of SARS-CoV-2 Christian Drosten, Charité Berlin (Germany)
09:30	Host cell entry and antibody evasion of emerging SARS-CoV-2 variants BA.2.12.1 and BA.4/5 Stefan Pöhlmann, German Primate Center (Germany)
10:00	More than two years in the Corona pandemic? What have we learned? Tobias Welte, Hannover Medical School (Germany)
10:30	Coffee break
11:00	Preclinical development of nafamostat for inhalation Armin Braun, Fraunhofer ITEM
11:30	The impact and mechanisms of SARS-COV-2 on the heart Thomas Thum, Fraunhofer ITEM
12:00	Lunch break
Session 2	SPRIND: A quantum shift for new antiviral agents Chair: Armin Braun, Fraunhofer ITEM
13:00	SPRIND Jano Costard, Federal Agency for Disruptive Innovation SPRIND, Leipzig (Germany)
13:15	ImmunoPEC – a platform for controlling cellular immune responses Nadja Berger, Belyntic (Germany)
13:30	BacDefense: Harnessing bacterial defenses for human antivirals BacDefense Chase Beisel, Helmholtz Institute for RNA-based Infection Research (HIRI), Würzburg (Germany)
13:45	PROTAC-powered antivirals – enabling a paradigm shift in antiviral drug discovery Katharina Rox, Helmholtz Centre for Infection Research, Braunschweig (Germany)
14:00	RNA-drugs: Small molecules targeting functional RNA structures in coronaviruses Julia Weigand, Technical University of Darmstadt (Germany)
14:15	iGUARD: integrated Guided Ultrafast Antiviral RNAi Drug development Philippe Vollmer Barbosa and Axel Schambach, Hannover Medical School (Germany)
14:30	VirusTrap – a novel antiviral platform based on encapsulating viral pathogens in de novo engineered macromolecular shells Christian Sigl, Capsitec (Germany)
14:45	MucBoost – mucus augmentation through bifunctional peptides to increase antiviral efficacy of the natural mucus barrier Daniel Christian Lauster, FU Berlin (Germany)
15:00	CRISPR antivirals: from antifibrotic to antiviral therapy Elisabeth Zeisberg, University of Göttingen (Germany)
15:30	Coffee break
Session 3	Understanding the role of infection in asthma and COPD Chair: Jens Hohlfeld, Fraunhofer ITEM
16:00	Immune responsiveness to LPS determines risk of childhood wheeze and asthma Erika von Mutius, Dr. von Hauner Children’s Hospital, Comprehensive Childhood Research Center, Munich (Germany)
16:30	The structure-guided journey from millimolar to nanomolar inhibitors in the development of antiviral drug candidates targeting human parainfluenza virus Mark von Itzstein, Griffith University (Australia)
17:00	Epigenetic regulation promotes extravasation of monocytes resulting in tissue injury in COPD Ali Önder Yildirim, Helmholtz Zentrum München (Germany)
Session 4	Understanding onset, development and exacerbation of fibrosis I Chair: Antje Prasse, Fraunhofer ITEM
17:30	Claudin-1 as a therapeutic target for fibrosis Thomas Baumert, INSERM Research Institute, University of Straßburg (France)
18:00	Wine & cheese poster session Chair: Thomas Tschernig, Saarland University (Germany)
18:00	Guided tours to different non-clinical and clinical departments of Fraunhofer ITEM: o PCLS o Lung function and IPL o CRC Hannover o Biomedical engineering
19:00	Food-for-thought talk: Abuse of power in science – prevention is the responsibility of us all Heinz Fehrenbach, Research Center Borstel (Germany)
19:30	Awarding of poster prizes
19:35	Outdoor barbecue at CRC Hannover
21:30	Summary & conclusions day 1 Armin Braun, Fraunhofer ITEM

June 24: Models of Lung Disease (day 2)

Friday, June 24, 2022

Preliminary program (subject to change without notice)

Models of Lung Disease – infection and lung disease (day 2)

08:00	Guided tours to different non-clinical and clinical departments of Fraunhofer ITEM: o PCLS o In-vitro testing (ALI) o Lung function and IPL o Biomedical engineering
Session 5	Understanding onset, development and exacerbation of fibrosis II Chair: Antje Prasse, Fraunhofer ITEM
09:00	Anti-fibrotic treatment strategies for cardiovascular disease Thomas Thum, Fraunhofer ITEM
09:30	Patient-derived alveolar spheroids to explore epithelial mesenchymal interactions in pulmonary homeostasis and fibrosis Felix Wolf, Boehringer Ingelheim (Germany)
10:00	Models to study aberrant repair in pulmonary fibrosis Antje Prasse, Fraunhofer ITEM
10:30	Coffee break
11:00	Development of PRS-220, an inhaled Anticalin^® protein targeting CTGF for the treatment of IPF Vanessa Neiens, Pieris Pharmaceuticals (Germany)
11:30	Transcriptomics in IPF “prime time”: from target and biomarker discovery to the benefits in clinical research Yasmina Bauer, Galápagos (Switzerland)
12:00	Insights in IPF based on single-cell RNA sequencing Jonas Schupp, Hannover Medical School (Germany)
12:30	Role of senescent epithelial cells in IPF – a new target Nicolas Mercado, Roche Pharma (Germany)
13:00	Coffee and snacks to go – end of seminar

Contact

Contact Press / Media

Prof. Dr. Armin Braun

Organizer of Models of Lung Disease

Phone +49 511 5350-263

Send email
armin.braun@item.fraunhofer.de
Follow me on LinkedIn

Contact Press / Media

Dr. Katherina Sewald

Organizer of Alternatives to Animal Testing

Phone +49 511 5350-323

Send email
katherina.sewald@item.fraunhofer.de
Follow me on LinkedIn

Contact Press / Media

Silvia Menezes

Workshop secretary

Phone +49 511 5350-262

Send email
lung.ws@item.fraunhofer.de