Fraunhofer Institute for Toxicology and Experimental Medicine»Safe-by-design: Novel approaches for development of safe cosmetic spray products«
The ban on animal testing and increased requirements for inhalation exposure characterization have led to major challenges in the development and safety assessment of new cosmetic spray products. To support the industry, Fraunhofer ITEM has developed new methods for toxicological testing and exposure assessment aiming at an intrinsically safe design (Safe-by-design).
These methods include in-vitro inhalation testing to identify toxic substances, optimize ingredients and process conditions as well as estimate safety in humans during use by in vitro to in vivo correlation (QIVIVE). The approach is particularly useful for complex product compositions. In line with the safe-by-design approach, a methodology was developed that allows to minimize inhalation exposure to substances of concern.
Dr. Katharina Schwarz and Dr. Detlef Ritter will present case studies demonstrating the effectiveness of these integrated approaches to support the development of safe cosmetic spray products and risk assessment.
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- Read more about assessment and authorization of cosmetics at Fraunhofer ITEM
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- Project example: In-vitro inhalation methods help with safe product development of cosmetic sprays