Human-based testing strategies for next generation risk assessment
A primary goal of modern risk assessment is to better understand the mechanisms leading to toxic effects in humans and susceptible human subpopulations. The animal tests used so far are, therefore, increasingly being replaced by human in-vitro and in-silico approaches, in line with the principle of the 3Rs (“reduce, refine and replace animal testing”).
The development and further improvement of these new integrated testing strategies is the focus of the European project RISK-HUNT3R. Coordinated by Prof. Bob van de Water of Leiden University (The Netherlands), 37 partners from industry (40%), academia (55%) and regulatory authorities (5%) are cooperating in the project consortium.