Fraunhofer Institute for Toxicology and Experimental Medicine
Fraunhofer Institute for Toxicology and Experimental Medicine

Toxicology databases

© Fraunhofer ITEM, Ralf Mohr

To support the process of international standardization of nomenclature and diagnostic criteria a team of scientists at the Fraunhofer ITEM are engaged in establishing different toxicology databases. This multidisciplinary team has many years of experience in designing, developing, and operating databases and electronic information systems for current issues in toxicology and toxicologic pathology.

To provide the required technical support for the databases goReni and DevTox, the team cooperates with the Fraunhofer ITEM Department of Pathology and the Working Group on Reproductive Toxicology as well as with numerous national and international societies and organizations.

The databases for Repeated Dose Toxicity (RepDose) and Reprotoxicity (FeDTex) are used to develop risk assessment strategies and to identify (quantitative) structure-activity relationships ((Q)SAR).

Our Databases

Pathology Database RITA and RITA CEPA

RITA (Registry of Industrial Toxicology Animal-data)

RITA is a database for the collection of peer-reviewed histopathological diagnoses on tumors and other proliferative lesions as well as study-associated information from control rats and mice. Since 1988, this database has been operated for major European chemical and / or pharmaceutical companies in collaboration with the Department of Pathology.

 

Information system goRENI for toxicological pathology

The internet-based information system goRENI for toxicological pathology provides internationally standardized nomenclature, diagnostic criteria, and images of proliferative lesions in rats and mice.

In collaboration with the four largest toxicological pathology societies worldwide (INHAND – International Harmonization of Nomenclature and Diagnostic Criteria), it is being expanded to include non-proliferative lesions.

Database DevTox – Developmental Toxicology

As part of this project, a database is being developed to store and analyze information from reproductive toxicology studies.

The proposed harmonized nomenclature for external, skeletal, and visceral anomalies in laboratory animals is available online, featuring more than 1,000 images.

Database RepDose

RepDose, a database financially supported by Cefic LRI, is a relational database for repeated-dose toxicity, containing data from sub-acute to chronic studies.

Currently, the database includes information on 930 chemicals with over 3,100 publicly available studies in rats and mice. Developed by Fraunhofer ITEM as part of a CEFIC-LRI project, RepDose is continuously expanded and maintained. The database's content and structure provide the basis for deriving structure-activity relationships for repeated-dose toxicity. Additionally, RepDose serves as a valuable tool for improving risk assessment strategies.

Your contact for our toxicology databases

Rupert Kellner

Contact Press / Media

Dr. Rupert Kellner

Manager of the Working Group on Databases and Information Systems

Phone +49 511 5350-106

Sylvia Escher

Contact Press / Media

Dr. Sylvia Escher

Division Director of Safety Assessment and Toxicology & Head of Department of In-silico Toxicology

Phone +49 511 5350-330