Toxicology testing of chemicals, pesticides, and biocides

Our focus is on toxicological and toxicokinetic studies in rodents and – in cooperation with other institutions – also in non-rodents, in addition to in-vitro studies, performed for risk assessment and registration. In compliance with international registration guidelines (OECD), these studies are performed under GLP conditions. We can furthermore support our clients by completing what has been demanded by the competent authorities for registration of chemicals, pesticides, and biocides and by preparing the necessary documentation.

Overview of our services

© Fraunhofer ITEM

In vivo

Subacute and subchronic studies using different routes of administration

Chronic toxicity and/or carcinogenicity studies

Toxicokinetic studies

Reproductive toxicity studies (studies on prenatal toxicity, one- and two-generation studies)

Evaluation of influences on lactation

Histopathological investigations


In vitro

Mikrokerntest in vitro und in vivo

Chromosomenaberrationstest in vitro (V79, Humanlymphozyten)

Säugerzell-Genmutationstest in vitro (Mauslymphom-TK-Test)

Rückmutationstest mit Bakterien (Ames-Test und Ames-Fluktuationstest)

Comet-Assay azellulär, in vitro und ex vivo (alkalisch, neutral, modifiziert zur Erkennung von Crosslinks oder oxidativen DNA-Schäden)

Nachweis der apoptotischen DNA-Fragmentierung

Erfassung der Toxizität durch Zytotoxizitätsassays (NRU, LDH, WST etc.)

Erfassung intrazellulärer Endpunkte mittels photometrischer, luminometrischer und fluorimetrischer Messmethoden in Multiwell-Systemen

Your benefits

Access to a comprehensive range of methods

Custom-made concept for registration

Many years of cooperation with clients from industry

Efficient cooperation with public authorities

Support throughout the entire registration process

By serving as advisors in various committees, we are always up to date on changes in the relevant guidelines

As a non-university research institution, we can be a partner in applying for public funding