Toxicology testing of chemicals, pesticides, and biocides

Our focus is on toxicological and toxicokinetic studies in rodents and – in cooperation with other institutions – also in non-rodents, in addition to in-vitro studies, performed for risk assessment and registration. In compliance with international registration guidelines (OECD), these studies are performed under GLP conditions. We can furthermore support our clients by completing what has been demanded by the competent authorities for registration of chemicals, pesticides, and biocides and by preparing the necessary documentation.

Overview of our services

Toxicology testing of chemicals, pesticides, and biocides
© Fraunhofer ITEM

In vivo

  • Subacute and subchronic studies using different routes of administration
  • Chronic toxicity and/or carcinogenicity studies
  • Toxicokinetic studies
  • Reproductive toxicity studies (studies on prenatal toxicity, one- and two-generation studies)
  • Evaluation of influences on lactation
  • Histopathological investigations


In vitro

  • Micronucleus assay in vitro and in vivo
  • Chromosomal aberration test in vitro (V79, human lymphocytes)
  • Mammalian cell gene mutation test in vitro (mouse lymphoma TK assay)
  • Bacterial reverse mutation assay (Ames test and Ames fluctuation test)
  • Acelluar, in-vitro, and ex-vivo comet assay (alkaline, neutral, modified protocol for detection of cross-links or oxidative DNA damage)
  • Demonstration of apoptotic DNA fragmentation
  • Detection of toxicity by cytotoxicity assays (NRU, LDH, WST etc.)
  • Measurement of intracellular endpoints by photometric, luminometric, and fluorimetric methods in multi-well systems

Your benefits

  • Access to a comprehensive range of methods
  • Custom-made concept for registration
  • Many years of cooperation with clients from industry
  • Efficient cooperation with public authorities
  • Support throughout the entire registration process
  • By serving as advisors in various committees, we are always up to date on changes in the relevant guidelines
  • As a non-university research institution, we can be a partner in applying for public funding


Annette Bitsch

Contact Press / Media

Dr. Annette Bitsch

Division Director Chemical Safety and Toxicology

Phone +49 511 5350-302