For over 20 years, we have conducted inhalation studies in rodents and thus are experienced also in complex studies. Thanks to our cutting-edge equipment, not only standard fiber and (nano-)particle aerosols can be generated, but also sophisticated exposure atmospheres, such as occupationally relevant bitumen aerosols. We study above all poorly soluble particles in environmentally relevant atmospheres and in occupational exposure scenarios, but also the toxicokinetics of retained particles in the lung and the mechanisms of toxic effects. Over the past years, the focus of interest in toxicology has expanded and is no longer on fine particulate matter only, but because of their wide range of applications now also includes engineered nanoparticles (< 0.1 µm). This is why cross-departmental pilot projects have been initiated at the institute, aimed at establishing robust, validated screening assays that allow the toxic potential of this type of particles to be evaluated. Substance categories currently under investigation are carbon nanotubes (CNT) and graphenes.