Enrichment, isolation and molecular analysis of rare cells

Enrichment of rare cell populations:

Marker-dependent enrichment  (including FDA-approved CellSearch^® technology for CTC detection), marker-independent enrichment (microfluidic and filtration-based technologies), fluorescence activated cell sorting, laser capture microdissection, application of established staining protocols or implementation of customized solutions for your target of interest

Isolation of pure single cells:
Single-cell micromanipulation, dielectric cell sorting of single cells (DEPArray^TM technology)

Molecular analysis of single cells and subpopulations:
Single-cell whole-genome and whole-transcriptome amplification technologies (Ampli1^TM WGA and WTA, developed for Silicon Biosystems by Fraunhofer ITEM’s team in Regensburg and the University of Regensburg, Germany), superior quality control assays for WGA and WTA samples to identify high-quality samples suited for your intended downstream analyses (developed for Silicon Biosystems by Fraunhofer ITEM’s team in Regensburg, Germany), application and development of targeted molecular assays for single-cell analysis, solutions for high-throughput analysis of nucleic acids (microarray analysis, RNA-sequencing, whole-exome sequencing and whole-genome sequencing of single cells)

Accredited lab for single-cell diagnostics (in cooperation with the University of Regensburg):
Access to a sample biobank generated from single CTCs/DCCs of patients with different cancer types for biomarker research and target validation, correlation with clinical follow-up possible for many samples, perfect environment for translational research within clinical studies