Publications of Fraunhofer ITEM

Repeatability of Regional Lung Ventilation Quantification Using Fluorinated ((19)F) Gas Magnetic Resonance Imaging.
Gutberlet, M., Kaireit, T. F., Voskrebenzev, A., Kern, A. L., Obert, A., Wacker, F., Hohlfeld, J. M., Vogel-Claussen, J. (2019). Academic Radiology 26(3): 395-403. doi: 10.1016/j.acra.2018.10.021
https://www.sciencedirect.com/science/article/pii/S1076633218304859?via%3Dihub

Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans.
Heusser, K., Tank, J., Holz, O., May, M., Brinkmann, J., Engeli, S., Diedrich, A., Framke, T., Koch, A., Grosshennig, A., Jan Danser, A. H., Sweep, F., Schindler, C., Schwarz, K., Krug, N., Jordan, J., Hohlfeld, J. M. (2019). Scientific Reports 9(1): 3641. doi: 10.1038/s41598-019-40343-w
https://www.nature.com/articles/s41598-019-40343-w - Open Access

Regional investigation of lung function and microstructure parameters by localized (129) Xe chemical shift saturation recovery and dissolved-phase imaging: A reproducibility study.
Kern, A. L., Gutberlet, M., Qing, K., Voskrebenzev, A., Klimes, F., Kaireit, T. F., Czerner, C., Biller, H., Wacker, F., Ruppert, K., Hohlfeld, J. M., Vogel-Claussen, J. (2019). Magnetic Resonance in Medicine 81(1): 13-24. doi: 10.1002/mrm.27407
https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.27407

The clinical course of idiopathic pulmonary fibrosis and its association to quality of life over time: longitudinal data from the INSIGHTS-IPF registry.
Kreuter, M., Swigris, J., Pittrow, D., Geier, S., Klotsche, J., Prasse, A., Wirtz, H., Koschel, D., Andreas, S., Claussen, M., Grohe, C., Wilkens, H., Hagmeyer, L., Skowasch, D., Meyer, J. F., Kirschner, J., Glaser, S., Kahn, N., Welte, T., Neurohr, C., Schwaiblmair, M., Held, M., Bahmer, T., Oqueka, T., Frankenberger, M., Behr, J. (2019). Respiratory Research 20: 59. doi: 10.1186/s12931-019-1020-3
https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-019-1020-3 - Open Access

Contribution of airway eosinophils in airway wall remodeling in asthma: Role of MMP-10 and MET.
Kuo, C. S., Pavlidis, S., Zhu, J., Loza, M., Baribaud, F., Rowe, A., Pandis, I., Gibeon, D., Hoda, U., Sousa, A., Wilson, S. J., Howarth, P., Shaw, D., Fowler, S., Dahlen, B., Chanez, P., Krug, N., Sandstrom, T., Fleming, L., Corfield, J., Auffray, C., Djukanovic, R., Sterk, P. J., Guo, Y., Adcock, I. M., Chung, K. F., Team, U. B. P. (2019). Allergy [Epub ahead of print]. doi: 10.1111/all.13727 
https://onlinelibrary.wiley.com/doi/full/10.1111/all.13727

IL-17-high asthma with features of a psoriasis immunophenotype.
Ostling, J., van Geest, M., Schofield, J. P. R., Jevnikar, Z., Wilson, S., Ward, J., Lutter, R., Shaw, D. E., Bakke, P. S., Caruso, M., Dahlen, S. E., Fowler, S. J., Horvath, I., Krug, N., Montuschi, P., Sanak, M., Sandstrom, T., Sun, K., Pandis, I., Auffray, C., Sousa, A. R., Guo, Y., Adcock, I. M., Howarth, P., Chung, K. F., Bigler, J., Sterk, P. J., Skipp, P. J., Djukanovic, R., Vaarala, O., Group, U. B. S. (2019). Journal of Allergy and Clinical Immunology [Epub ahead of print]. doi: 10.1016/j.jaci.2019.03.027 https://www.sciencedirect.com/science/article/pii/S0091674919304841?via%3Dihub

Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux.
Perotin, J. M., Schofield, J. P. R., Wilson, S. J., Ward, J., Brandsma, J., Strazzeri, F., Bansal, A., Yang, X., Rowe, A., Corfield, J., Lutter, R., Shaw, D. E., Bakke, P. S., Caruso, M., Dahlen, B., Fowler, S. J., Horvath, I., Howarth, P., Krug, N., Montuschi, P., Sanak, M., Sandstrom, T., Sun, K., Pandis, I., Auffray, C., De Meulder, B., Lefaudeux, D., Riley, J. H., Sousa, A. R., Dahlen, S. E., Adcock, I. M., Chung, K. F., Sterk, P. J., Skipp, P. J., Collins, J. E., Davies, D. E., Djukanovic, R., Group, U. B. S. (2019). European Respiratory Journal [Epub ahead of print]. doi: 10.1183/13993003.00453-2019
https://erj.ersjournals.com/content/early/2019/03/15/13993003.00453-2019.long

BAL cell gene expression is indicative of outcome and airway basal cell involvement in idiopathic pulmonary fibrosis.
Prasse, A., Binder, H., Schupp, J. C., Kayser, G., Bargagli, E., Jaeger, B., Hess, M., Rittinghausen, S., Vuga, L., Lynn, H., Violette, S., Jung, B., Quast, K., Vanaudenaerde, B., Xu, Y., Hohlfeld, J. M., Krug, N., Herazo-Maya, J. D., Rottoli, P., Wuyts, W. A., Kaminski, N. (2019). American Journal of Respiratory and Critical Care Medicine 199(5): 622-630. doi: 10.1164/rccm.201712-2551OC
ttps://www.atsjournals.org/doi/10.1164/rccm.201712-2551OC

Transcriptomic Analysis Reveals Priming of The Host Antiviral Interferon Signaling Pathway by Bronchobini((R)) Resulting in Balanced Immune Response to Rhinovirus Infection in Mouse Lung Tissue Slices.
Reamon-Buettner, S. M., Niehof, M., Hirth, N., Danov, O., Obernolte, H., Braun, A., Warnecke, J., Sewald, K., Wronski, S. (2019). International Journal of Molecular Sciences 20(9): 2242, 2225 p. doi: 10.3390/ijms20092242
https://www.mdpi.com/1422-0067/20/9/2242 - Open Access

Surface defects reduce carbon nanotube toxicity in vitro.
Requardt, H., Braun, A., Steinberg, P., Hampel, S., Hansen, T. (2019). Toxicology in Vitro [Epub ahead of print]. doi: 10.1016/j.tiv.2019.03.028
ttps://www.sciencedirect.com/science/article/pii/S0887233318305800?via%3Dihub

Stratification of asthma phenotypes by airway proteomic signatures.
Schofield, J. P. R., Burg, D., Nicholas, B., Strazzeri, F., Brandsma, J., Staykova, D., Folisi, C., Bansal, A. T., Xian, Y., Guo, Y., Rowe, A., Corfield, J., Wilson, S., Ward, J., Lutter, R., Shaw, D. E., Bakke, P. S., Caruso, M., Dahlen, S. E., Fowler, S. J., Horvath, I., Howarth, P., Krug, N., Montuschi, P., Sanak, M., Sandstrom, T., Sun, K., Pandis, I., Riley, J., Auffray, C., De Meulder, B., Lefaudeux, D., Sousa, A. R., Adcock, I. M., Chung, K. F., Sterk, P. J., Skipp, P. J., Djukanovic, R., Group, U. B. S. (2019). Journal of Allergy and Clinical Immunology [Epub ahead of print]. doi: 10.1016/j.jaci.2019.03.013
https://www.sciencedirect.com/science/article/pii/S0091674919304154?via%3Dihub

Mast cells within cellular networks.
Stassen, M., Hartmann, A. K., Delgado, S. J., Dehmel, S., Braun, A. (2019). Journal of Allergy and Clinical Immunology [Epub ahead of print]. doi: 10.1016/j.jaci.2019.01.031
https://www.sciencedirect.com/science/article/pii/S0091674919301885?via%3Dihub

Corrigendum to "The application of new HARD-descriptor available from the CORAL software to building up NOAEL models" [Food Chem. Toxicol. 112 (2018) 544-550].
Toropova, A. P., Toropov, A. A., Marzo, M., Escher, S. E., Dorne, J. L., Georgiadis, N., Benfenati, E. (2019). Food and Chemical Toxicology 128: 146. doi: 10.1016/j.fct.2019.04.004
ttps://www.sciencedirect.com/science/article/pii/S0278691519301887?via%3Dihub

Effect of Indacaterol/Glycopyrronium on Pulmonary Perfusion and Ventilation in Hyperinflated COPD Patients (CLAIM): A Double-Blind, Randomised, Crossover Trial.
Vogel-Claussen, J., Schonfeld, C. O., Kaireit, T. F., Voskrebenzev, A., Czerner, C. P., Renne, J., Tillmann, H. C., Berschneider, K., Hiltl, S., Bauersachs, J., Welte, T., Hohlfeld, J. M. (2019). American Journal of Respiratory and Critical Care Medicine [Epub ahead of print]. doi: 10.1164/rccm.201805-0995OC
https://www.atsjournals.org/doi/abs/10.1164/rccm.201805-0995OC

Randomized immunotherapy trial in dual-allergic patients using "active allergen placebo" as control.
Wagenmann, M., Worm, M., Akboga, Y., Karjalainen, M., Hohlfeld, J. M. (2019). Allergy [Epub ahead of print]. doi: 10.1111/all.13842
ttps://onlinelibrary.wiley.com/doi/abs/10.1111/all.13842

Therapy resistance beyond cellular dormancy.
Werner-Klein, M., Klein, C. A. (2019). Nature Cell Biology 21(2): 117-119. doi: 10.1038/s41556-019-0276-7
https://www.nature.com/articles/s41556-019-0276-7

Activation of Group 2 innate lymphoid cells after allergen challenge in asthmatics.
Winkler, C., Hochdorfer, T., Israelsson, E., Hasselberg, A., Cavallin, A., Thorn, K., Muthas, D., Shojaee, S., Lueer, K., Mueller, M., Mjosberg, J., Vaarala, O., Hohlfeld, J., Pardali, K. (2019). Journal of Allergy and Clinical Immunology [Epub ahead of print]. doi: 10.1016/j.jaci.2019.01.027
ttps://www.sciencedirect.com/science/article/pii/S0091674919301848?via%3Dihub