Fraunhofer Institute for Toxicology and Experimental Medicine
Fraunhofer Institute for Toxicology and Experimental Medicine

Fraunhofer ITEM publications

 

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All scientific Fraunhofer publications can be found via the publications database of the Fraunhofer-Gesellschaft.

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Fraunhofer ITEM publications per year

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Recent publications

Below please find recent publications by Fraunhofer ITEM scientists, sorted by subject area.

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R&D expertise "Lung research"

  • Birker-Robaczewska, M., Boucher, M., Ranieri, G., Poirey, S., Studer, R., Freti, D., Schnoebelen, M., Froidevaux, S., Morrison, K., Wyss, C., Scherer, J., Lescop, C., Brotschi, C., Bolli, M. H., Kramberg, M., Di Stefano, S., Rey, M., Iglarz, M., Delahaye, S., Vezzali, E., Sieber, P., Schäfer, A., Caimi, S. L., Hesse, C., Nayler, O. (2025). "The novel lysophosphatidic acid receptor 1-selective antagonist, ACT-1016-0707, has unique binding properties that translate into effective anti-fibrotic and anti-inflammatory activity in different models of pulmonary fibrosis." The Journal of pharmacology and experimental therapeutics [Epub ahead of print]. doi: 10.1016/j.jpet.2025.103396  
  • Bouheraoua, S., Cleeves, S., Preusse, M., Musken, M., Braubach, P., Fuchs, M., Falk, C., Sewald, K., Haussler, S. (2025). "Establishment and characterization of persistent Pseudomonas aeruginosa infections in air-liquid interface cultures of human airway epithelial cells." Infection and Immunity 93(3): e0060324. doi: 10.1128/iai.00603-24 https://journals.asm.org/doi/10.1128/iai.00603-24  - Open Access
  • Burkle, M., Korf, I. H. E., Lippegaus, A., Krautwurst, S., Rohde, C., Weissfuss, C., Nouailles, G., Tene, X. M., Gaborieau, B., Ghigo, J. M., Ricard, J. D., Hocke, A. C., Papenfort, K., Debarbieux, L., Witzenrath, M., Wienhold, S. M., Krishnamoorthy, G. (2025). "Phage-phage competition and biofilms affect interactions between two virulent bacteriophages and Pseudomonas aeruginosa." ISME J 19(1). doi: 10.1093/ismejo/wraf065 https://academic.oup.com/ismej/advance-article/doi/10.1093/ismejo/wraf065/8106832 - Open Access
  • Holz, O., Sadiq, M. W., Gress, C., Struss, N., Stomilovic, S., Lundqvist, A., Hohlfeld, J. M. (2025). "Assessing Human Lung Pharmacokinetics Using Exhaled Breath Particles." Journal of Aerosol Medicine and Pulmonary Drug Delivery 38(1): 13-17. doi: 10.1089/jamp.2024.0032 
  • Kayser, T., Smulders, R., Kusawake, T., Wambre, E., Chichili, G. R., Blauwet, M. B., Spence, A., Patton, M., Tabash, R., DeBerg, H. A., Khosa, S., Badorrek, P., Hohlfeld, J. M., Ferslew, B. C. (2025). "Phase 1 study of safety, tolerability, and efficacy of intradermal DNA vaccine ASP2390 in adults allergic to house dust mites." Journal of Allergy and Clinical Immunology: Global 4(2). doi: 10.1016/j.jacig.2025.100404 https://www.jaci-global.org/article/S2772-8293(25)00005-0/fulltext - Open Access
  • Klimeš, F., Kern, A. L., Voskrebenzev, A., Gutberlet, M., Grimm, R., Müller, R. A., Behrendt, L., Kaireit, T. F., Glandorf, J., Alsady, T. M., Wacker, F., Hohlfeld, J. M., Vogel-Claussen, J. (2025). "Free-breathing 3D phase-resolved functional lung MRI vs breath-hold hyperpolarized (129)Xe ventilation MRI in patients with chronic obstructive pulmonary disease and healthy volunteers." European Radiology 35(2): 943-956. doi: 10.1007/s00330-024-10893-3 - Open Access 
  • Legchenko, E., Chouvarine, P., Hysko, K., Qadri, F., Wesolowski, R., Specker, E., Glage, S., Meier, M., Schwarz, K., Heineke, J., Pohlmann, G., Ramazanoglu, M., Bader, M., Hansmann, G. (2025). "Inhalation of the Novel Tryptophan Hydroxylase 1 Inhibitor TPT-004 Alleviates Pulmonary Arterial Hypertension." American Journal of Respiratory Cell and Molecular Biology [Epub ahead of print]. doi: 10.1165/rcmb.2024-0365OC  
  • Paillard, M., Abdellatif, M., Andreadou, I., Bar, C., Bertrand, L., Brundel, B., Chiva-Blanch, G., Davidson, S. M., Dawson, D., Di Lisa, F., Evans, P., Giricz, Z., Hausenloy, D. J., Kleinbongard, P., Lezoualc'h, F., Liehn, E., Maack, C., Maguy, A., Murphy, E., Perrino, C., Pesce, M., Rainer, P. P., Streckfuss-Bomeke, K., Thielmann, M., Tian, R., Tocchetti, C. G., Van Der Velden, J., Van Linthout, S., Zacchigna, S., Krieg, T. (2025). "Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function." European Journal of Heart Failure [Epub ahead of print]. doi: 10.1002/ejhf.3674 https://onlinelibrary.wiley.com/doi/full/10.1002/ejhf.3674 - Open Access
  • Pradhan, K., Neupane, B., Niehues, P., Kirschner, M., Beier, F., Kuo, C. C., Hilbold, E. A., Bär, C., Thoma, O. M., Waldner, M., Vieri, M., Brummendorf, T. H., Tharmapalan, V., Wagner, W., Kleines, M., Emrani, M., Zink, M. D., Napp, A., Marx, N., Gramlich, M. (2025). "Telomere Length Is Associated With Adverse Atrial Remodeling in Patients With Atrial Fibrillation." J Am Heart Assoc 14(3): e037512. doi: 10.1161/JAHA.124.037512 - Open Access  
  • Sadekar, N., Behrsing, H. P., Hansen, T., Patel, V., Paulo, H., Rae, A., Ritter, D., Schwarz, K., Api, A. M. (2025). "A Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods." Toxics 13(1). doi: 10.3390/toxics13010035  - Open Access
  • Santizo, K. Y., Mangold, H. S., Mirzaei, Z., Park, H., Kolan, R. R., Sarau, G., Kolle, S., Hansen, T., Christiansen, S., Wohlleben, W. (2025). "Microplastic Materials for Inhalation Studies: Preparation by Solvent Precipitation and Comprehensive Characterization." Small [Epub ahead of print]: e2405555. doi: 10.1002/smll.202405555   - Open Access 
  • Umeda, Y., Izawa, T., Kazama, K., Arai, S., Kamiie, J., Nakamura, S., Hano, K., Takasu, M., Hirata, A., Rittinghausen, S., Yamano, S. (2025). "Comparative anatomy of respiratory bronchioles and lobular structures in mammals." Journal of Toxicologic Pathology 38(2): 113-129. doi: 10.1293/tox.2024-0071 https://www.jstage.jst.go.jp/article/tox/38/2/38_2024-0071/_article - Open Access
  • Weber, N., Montag, J., Kowalski, K., Iorga, B., de la Roche, J., Holler, T., Wojciechowski, D., Wendland, M., Radocaj, A., Mayer, A. K., Brunkhorst, A., Osten, F., Burkart, V., Piep, B., Bodenschatz, A., Gibron, P., Schwanke, K., Franke, A., Thiemann, S., Koroleva, A., Pfanne, A., Konsanke, M., Fiedler, J., Hegermann, J., Wrede, C., Muhlfeld, C., Chichkov, B., Fischer, M., Thum, T., Francino, A., Martin, U., Meissner, J., Zweigerdt, R., Kraft, T. (2025). "Patient-specific hiPSC-derived cardiomyocytes indicate allelic and contractile imbalance as pathogenic factor in early-stage Hypertrophic Cardiomyopathy." Journal of Molecular and Cellular Cardiology 198: 112-125. doi: 10.1016/j.yjmcc.2024.11.007  - Open Access
  • Weissfuss, C., Li, J., Behrendt, U., Hoffmann, K., Burkle, M., Tan, C., Krishnamoorthy, G., Korf, I. H. E., Rohde, C., Gaborieau, B., Debarbieux, L., Ricard, J. D., Witzenrath, M., Felten, M., Nouailles, G. (2025). "Adjunctive phage therapy improves antibiotic treatment of ventilator-associated-pneumonia with Pseudomonas aeruginosa." Nat Commun 16(1): 4500. doi: 10.1038/s41467-025-59806-y https://www.nature.com/articles/s41467-025-59806-y - Open Access
  • Ye, J. L., Grieger, K., Lu, D., Brandenberger, C., Juchem, M., Jordan, M., Oehlsen, L., Zardo, P., Werlein, C., Hesse, C., Sewald, K., Tretbar, S., Thum, T., Chatterjee, S., Bär, C. (2025). "Telomerase modRNA offers a novel RNA-based approach to treat human pulmonary fibrosis." BioRxiv. doi: 10.1101/2025.02.19.639041 https://www.biorxiv.org/content/10.1101/2025.02.19.639041v1?med=mas - Preprint im Repositorium – Open Access

R&D expertise "Toxicology"

  • Blum, J., Brull, M., Hengstler, J. G., Dietrich, D. R., Gruber, A. J., Dipalo, M., Kraushaar, U., Mangas, I., Terron, A., Fritsche, E., Marx-Stoelting, P., Hardy, B., Schepky, A., Escher, S., Hartung, T., Landsiedel, R., Odermatt, A., Sachana, M., Koch, K., Donmez, A., Masjosthusmann, S., Bothe, K., Schildknecht, S., Beilmann, M., Beltman, J. B., Fitzpatrick, S., Mangerich, A., Rehm, M., Tangianu, S., Zickgraf, F. M., Kamp, H., Burger, G., van de Water, B., Kleinstreuer, N., White, A., Leist, M. (2025). "The long way from raw data to NAM-based information: Overview on data layers and processing steps." Altex 42(1): 167-180. doi: 10.14573/altex.2412171 - Open Access
  • Bruer, G., Lombaert, N., Burzlaff, A., Spirlet, C., Gödecke, D., Ramazanoglu, M., Creutzenberg, O. (2025). "Considerations and Challenges for Acute Inhalation Toxicity Testing and Classification of Zinc Sulphide Under REACH." Toxics 13(1). doi: 10.3390/toxics13010027  - Open Access
  • Colbourne, J. K., Escher, S. E., Lee, R., Vinken, M., van de Water, B., Freedman, J. H. (2025). "ASPIS Definition of New Approach Methodologies." Environmental Toxicology and Chemistry [Epub ahead of print]. doi: 10.1093/etojnl/vgae093  - Open Access 
  • Cronin, M. T. D., Baltazar, M. T., Barton-Maclaren, T. S., Bercaru, O., De Abrew, K. N., Desaintes, C., Escher, S. E., Kern, P., Maxwell, G., Rogiers, V., Schutte, K., Sobanski, T. (2025). "Report on the European Partnership for Alternative Approaches to Animal Testing (EPAA) "New Approach Methodologies (NAMs) User Forum Kick-Off Workshop"." Regulatory Toxicology and Pharmacology 159: 105796. doi: 10.1016/j.yrtph.2025.105796 https://www.sciencedirect.com/science/article/pii/S0273230025000261?via%3Dihub - Open Access
  • Emwas, A. H., Zacharias, H. U., Alborghetti, M. R., Gowda, G. A. N., Raftery, D., McKay, R. T., Chang, C. K., Saccenti, E., Gronwald, W., Schuchardt, S., Leiminger, R., Merzaban, J., Madhoun, N. Y., Iqbal, M., Alsiary, R. A., Shivapurkar, R., Pain, A., Shanmugam, D., Ryan, D., Roy, R., Schirra, H. J., Morris, V., Zeri, A. C., Alahmari, F., Kaddurah-Daouk, R., Salek, R. M., LeVatte, M., Berjanskii, M., Lee, B., Wishart, D. S. (2025). "Recommendations for sample selection, collection and preparation for NMR-based metabolomics studies of blood." Metabolomics 21(3): 66. doi: 10.1007/s11306-025-02259-7 https://link.springer.com/article/10.1007/s11306-025-02259-7 - Open Access
  • Englisch, C. N., Diebolt, C. M., Kirstein, E., Wahl, V., Wartenberg, P., Schaudien, D., Beckmann, A., Laschke, M. W., Krasteva-Christ, G., Gudermann, T., Chubanov, V., Boehm, U., Tschernig, T. (2025). "TRPM6 in murine kidneys-of targets and antibodies." Naunyn-Schmiedebergs Archives of Pharmacology [Epub ahead of print]. doi: 10.1007/s00210-025-03951-0  - Open Access 
  • Ghaffari, M. H., Ostendorf, C. S., Hemmert, K. J., Schuchardt, S., Koch, C., Sauerwein, H. (2025). "Longitudinal characterization of plasma and fecal bile acids in dairy heifers from birth to first calving in response to transition milk feeding." Journal of Dairy Science 108(5): 5475-5488. doi: 10.3168/jds.2025-26307 https://www.sciencedirect.com/science/article/pii/S0022030225002097?via%3Dihub - Open Access
  • Ghaffari, M. H., Sauerwein, H., Sadri, H., Schuchardt, S., Martin-Tereso, J., Doelman, J. H., Daniel, J. B. (2025). "Longitudinal characterization of the metabolome of dairy cows transitioning from one lactation to the next: Investigations in fecal samples." Journal of Dairy Science 108(5): 5405-5419. doi: 10.3168/jds.2025-26273 https://www.sciencedirect.com/science/article/pii/S0022030225001328?via%3Dihub - Open Access
  • Hansen, T., Tillmann, T., Wiench, K., Creutzenberg, O. (2025). "Studies on acute dermal toxicity and dermal absorption of a nanoform zinc oxide (ZnO; NM-111) in rats." Toxicology Letters 409: 42-49. doi: 10.1016/j.toxlet.2025.04.011 https://www.sciencedirect.com/science/article/pii/S0378427425000785?via%3Dihub - Open Access
  • Neu, F., Wacker, M., Schuchardt, S., Vargese, S., Awad, G., Wippermann, J., Peßler, F., Veluswamy, P. (2025). "Altered plasma metabolites as fingerprint of cardiac bypass surgery." medRxiv doi: 10.1101/2025.04.11.25325708 https://www.medrxiv.org/content/10.1101/2025.04.11.25325708v1 - Preprint im Repositorium - Open Access
  • Sadri, H., Ghaffari, M. H., Sauerwein, H., Schuchardt, S., Martin-Tereso, J., Doelman, J., Daniel, J. B. (2025). "Longitudinal characterization of the muscle metabolome in dairy cows during the transition from lactation cessation to lactation resumption." Journal of Dairy Science 108(1): 1062-1077. doi: 10.3168/jds.2024-25324 - Open Access 
  • Sadekar, N., Behrsing, H. P., Hansen, T., Patel, V., Paulo, H., Rae, A., Ritter, D., Schwarz, K., Api, A. M. (2025). "A Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods." Toxics 13(1). doi: 10.3390/toxics13010035  - Open Access
  • Schaudien, D., Hansen, T., Tillmann, T., Pohlmann, G., Kock, H., Creutzenberg, O. (2025). "Comparative toxicity study of three surface-modified titanium dioxide nanoparticles following subacute inhalation." Particle and Fibre Toxicology 22(1): 5. doi: 10.1186/s12989-025-00620-1  - Open Access 
  • Santizo, K. Y., Mangold, H. S., Mirzaei, Z., Park, H., Kolan, R. R., Sarau, G., Kolle, S., Hansen, T., Christiansen, S., Wohlleben, W. (2025). "Microplastic Materials for Inhalation Studies: Preparation by Solvent Precipitation and Comprehensive Characterization." Small [Epub ahead of print]: e2405555. doi: 10.1002/smll.202405555   - Open Access 
  • Wehr, M. M., Witters, H., Remy, S., Schultz, B., Jacobs, M., Escher, S. E. (2025). "Feasibility study on integrating morphological and transcriptomic data for identifying teratogenic molecular markers in zebrafish embryo toxicity testing." Computational Toxicology 34. doi: 10.1016/j.comtox.2025.100342 https://www.sciencedirect.com/science/article/pii/S2468111325000027?via%3Dihub

R&D expertise "Malignant disease research"

  • Basilio-Queiros, D., Lachmann, N. (2025). "In vivo macrophage engineering for renal cancer therapy." Nat Cancer 6(5): 743-745. doi: 10.1038/s43018-025-00912-7 https://www.nature.com/articles/s43018-025-00912-7
  • Dastagir, N., Liebsch, C., Kutz, J., Wronski, S., Pich, A., Obed, D., Vogt, P. M., Bucan, V., Strauss, S. (2025). "Identification of antimicrobial peptides from the Ambystoma mexicanum displaying antibacterial and antitumor activity." PloS One 20(3): e0316257. doi: 10.1371/journal.pone.0316257  - Open Access 
  • Gand, L. V., Lanzuolo, C., Li, M., Rosti, V., Weber, N., Lu, D., Bar, C., Thum, T., Pich, A., Kraft, T., Amrute-Nayak, M., Nayak, A. (2025). "Calcium Handling Machinery and Sarcomere Assembly are Impaired Through Multipronged Mechanisms in Cancer Cytokine-Induced Cachexia." J Cachexia Sarcopenia Muscle 16(2): e13776. doi: 10.1002/jcsm.13776 https://onlinelibrary.wiley.com/doi/10.1002/jcsm.13776 - Open Access
  • Harrer, D. C., Luke, F., Pukrop, T., Ghibelli, L., Reichle, A., Heudobler, D. (2025). "MEPED as salvage therapy for relapsed/refractory Hodgkin's lymphoma incorporating edited non-oncogene addiction: mTOR as a bottleneck." Frontiers in Pharmacology 16: 1553331. doi: 10.3389/fphar.2025.1553331 https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1553331/full - Open Access
  • Kitte, R., Serfling, R., Blache, U., Seitz, C., Schrader, S., Kohl, U., Fricke, S., Bar, C., Tretbar, U. S. (2025). "Optimal Chimeric Antigen Receptor (CAR)-mRNA for Transient CAR T Cell Generation." Int J Mol Sci 26(3). doi: 10.3390/ijms26030965 https://www.mdpi.com/1422-0067/26/3/965 - Open Access
  • Kutle, I., Polten, R., Stalp, J. L., Hachenberg, J., Todzey, F., Hass, R., Zimmermann, K., von der Ohe, J., von Kaisenberg, C., Neubert, L., Kamp, J. C., Schaudien, D., Seyda, A.-K., Hillemanns, P., Klapdor, R., Morgan, M. A., Schambach, A. (2024). "Anti-Mesothelin CAR-NK cells as a novel targeted therapy against cervical cancer." Frontiers in Immunology 15. doi: 10.3389/fimmu.2024.1485461 - Open Access
  • Niedermayer, K., Schaffler, H., Vlachos, G., Greco, S., Pfister, K., Volz, B., Ott, L., Neubauer, H., Polzer, B., Koch, A., Riethdorf, S., Fehm, T., Janni, W., Friedl, T. W. P., Rack, B., Heitzer, E., Schochter, F., Wiesmuller, L. (2025). "Mass cytometric detection of homologous recombination proficiency in circulating tumor cells to predict chemoresistance of metastatic breast cancer patients." International Journal of Cancer [Epub ahead of print]. doi: 10.1002/ijc.35498 https://onlinelibrary.wiley.com/doi/10.1002/ijc.35498 - Open Access

R&D expertise "Medical and pharmaceutical engineering"

  • Basilio-Queiros, D., Lachmann, N. (2025). "In vivo macrophage engineering for renal cancer therapy." Nat Cancer 6(5): 743-745. doi: 10.1038/s43018-025-00912-7 https://www.nature.com/articles/s43018-025-00912-7
  • Burkle, M., Korf, I. H. E., Lippegaus, A., Krautwurst, S., Rohde, C., Weissfuss, C., Nouailles, G., Tene, X. M., Gaborieau, B., Ghigo, J. M., Ricard, J. D., Hocke, A. C., Papenfort, K., Debarbieux, L., Witzenrath, M., Wienhold, S. M., Krishnamoorthy, G. (2025). "Phage-phage competition and biofilms affect interactions between two virulent bacteriophages and Pseudomonas aeruginosa." ISME J 19(1). doi: 10.1093/ismejo/wraf065 https://academic.oup.com/ismej/advance-article/doi/10.1093/ismejo/wraf065/8106832 - Open Access
  • Costa, A., Bär, C. (2025). "Heart to Heal: Unveiling Follistatin's Potential for Myocardial Regeneration." Circulation Research 136(2): 177-179. doi: 10.1161/CIRCRESAHA.124.325939  
  • Mattis, P. (2025). "Der Weg zur erstattungsfähigen Gesundheitsversorgung." Medizintechnik (Cologne) 2(2): 29-33.
  • Rieper, F., Wittmann, J., Bunk, B., Spröer, C., Häfner, M., Willy, C., Müsken, M., Ziehr, H., Korf, I. H. E., Jahn, D. (2025). "Systematic bacteriophage selection for the lysis of multiple strains." Frontiers in Cellular and Infection Microbiology 15. doi: ARTN 1597009 10.3389/fcimb.2025.1597009 https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2025.1597009/abstract - Open Access
  • Weissfuss, C., Li, J., Behrendt, U., Hoffmann, K., Burkle, M., Tan, C., Krishnamoorthy, G., Korf, I. H. E., Rohde, C., Gaborieau, B., Debarbieux, L., Ricard, J. D., Witzenrath, M., Felten, M., Nouailles, G. (2025). "Adjunctive phage therapy improves antibiotic treatment of ventilator-associated-pneumonia with Pseudomonas aeruginosa." Nat Commun 16(1): 4500. doi: 10.1038/s41467-025-59806-y https://www.nature.com/articles/s41467-025-59806-y - Open Access

R&D expertise "Bioinformatics and AI"

  • Blum, J., Brull, M., Hengstler, J. G., Dietrich, D. R., Gruber, A. J., Dipalo, M., Kraushaar, U., Mangas, I., Terron, A., Fritsche, E., Marx-Stoelting, P., Hardy, B., Schepky, A., Escher, S., Hartung, T., Landsiedel, R., Odermatt, A., Sachana, M., Koch, K., Donmez, A., Masjosthusmann, S., Bothe, K., Schildknecht, S., Beilmann, M., Beltman, J. B., Fitzpatrick, S., Mangerich, A., Rehm, M., Tangianu, S., Zickgraf, F. M., Kamp, H., Burger, G., van de Water, B., Kleinstreuer, N., White, A., Leist, M. (2025). "The long way from raw data to NAM-based information: Overview on data layers and processing steps." Altex 42(1): 167-180. doi: 10.14573/altex.2412171  - Open Access
  • Hilberink, L., Wehage, P., Pashai Fakhri, M., Gaedcke, S., DeLuca, D., Mattis, P., Rademacher, J. (2025). "Künstliche Intelligenz und Machine Learning in der Auskultation. [Artificial intelligence and machine learning in auscultation: prospects of the project DigitaLung]." Pneumologie 79(3): 229-235. doi: 10.1055/a-2507-1486 https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-2507-1486
  • Lange, M., Korte, A., Fuchs, M., Fekete, A., Mueller, C., Dierich, B., Witte, J., Dandekar, T., Mueller, M. J., Berger, S. (2025). "A CW-type zinc finger protein is involved in RES-oxylipin signaling and the response to abiotic stress in Arabidopsis thaliana." Front. Plant Sci 16. doi: 10.3389/fpls.2025.153564 https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2025.1535643/full - Open Access
  • Schönfeld, J., Brunst, S., Ciomirtan, L., Willmer, L., Chromik, M. A., Kumar, A., Froemel, T., Liebisch, N., Hackspacher, A., Ehrler, J. H. M., Wintermeier, L., Hesse, C., Fiedler, J., Heering, J., Freitag, H., Zardo, P., Fieguth, H.-G., Brüggerhoff, A., Jakob, J., Häupl, B., Weizel, L., Kaiser, A., Schubert-Zsilavecz, M., Oellerich, T., Fleming, I., Schebb, N. H., Fürst, R., Kannt, A., Knapp, S., Proschak, E., Hiesinger, K. (2025). "Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase." Journal of Medicinal Chemistry [Epub ahead of print]. doi: 10.1021/acs.jmedchem.5c00552 https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c00552 - Open Access
  • Wehr, M. M., Witters, H., Remy, S., Schultz, B., Jacobs, M., Escher, S. E. (2025). "Feasibility study on integrating morphological and transcriptomic data for identifying teratogenic molecular markers in zebrafish embryo toxicity testing." Computational Toxicology 34. doi: 10.1016/j.comtox.2025.100342

R&D expertise "Immunology and and infection research"

  • Basilio-Queiros, D., Lachmann, N. (2025). "In vivo macrophage engineering for renal cancer therapy." Nat Cancer 6(5): 743-745. doi: 10.1038/s43018-025-00912-7 https://www.nature.com/articles/s43018-025-00912-7
  • Bouheraoua, S., Cleeves, S., Preusse, M., Musken, M., Braubach, P., Fuchs, M., Falk, C., Sewald, K., Haussler, S. (2025). "Establishment and characterization of persistent Pseudomonas aeruginosa infections in air-liquid interface cultures of human airway epithelial cells." Infection and Immunity 93(3): e0060324. doi: 10.1128/iai.00603-24 https://journals.asm.org/doi/10.1128/iai.00603-24 - Open Access
  • Burkle, M., Korf, I. H. E., Lippegaus, A., Krautwurst, S., Rohde, C., Weissfuss, C., Nouailles, G., Tene, X. M., Gaborieau, B., Ghigo, J. M., Ricard, J. D., Hocke, A. C., Papenfort, K., Debarbieux, L., Witzenrath, M., Wienhold, S. M., Krishnamoorthy, G. (2025). "Phage-phage competition and biofilms affect interactions between two virulent bacteriophages and Pseudomonas aeruginosa." ISME J 19(1). doi: 10.1093/ismejo/wraf065 https://academic.oup.com/ismej/advance-article/doi/10.1093/ismejo/wraf065/8106832 - Open Access
  • Dastagir, N., Liebsch, C., Kutz, J., Wronski, S., Pich, A., Obed, D., Vogt, P. M., Bucan, V., Strauss, S. (2025). "Identification of antimicrobial peptides from the Ambystoma mexicanum displaying antibacterial and antitumor activity." PloS One 20(3): e0316257. doi: 10.1371/journal.pone.0316257 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0316257 - Open Access
  • Diesendorf, V., La Rocca, V., Teutsch, M., Alattar, H., Obernolte, H., Kenst, K., Seibel, J., Worsdorfer, P., Sewald, K., Steinke, M., Schneider-Schaulies, S., Lutz, M. B., Bodem, J. (2025). "AMPK Activation Downregulates TXNIP, Rab5, and Rab7 Within Minutes, Thereby Inhibiting the Endocytosis-Mediated Entry of Human Pathogenic Viruses." Cells 14(5). doi: 10.3390/cells14050334 https://www.mdpi.com/2073-4409/14/5/334 - Open Access
  • Jahn, K., Chatterjee, S., Sinke, C., Koberschinski, J. J. R., Junemann, K., James, C. E., Worschech, F., Marie, D., Altenmuller, E., Bar, C., Kruger, T. H. C. (2025). "An incidental finding during a brain plasticity study: substantial telomere length shortening after COVID-19 lockdown in the older population." Geroscience [Epub ahead of print]. doi: 10.1007/s11357-025-01602-z https://link.springer.com/article/10.1007/s11357-025-01602-z - Open Access
  • Kayser, T., Smulders, R., Kusawake, T., Wambre, E., Chichili, G. R., Blauwet, M. B., Spence, A., Patton, M., Tabash, R., DeBerg, H. A., Khosa, S., Badorrek, P., Hohlfeld, J. M., Ferslew, B. C. (2025). "Phase 1 study of safety, tolerability, and efficacy of intradermal DNA vaccine ASP2390 in adults allergic to house dust mites." Journal of Allergy and Clinical Immunology: Global 4(2). doi: 10.1016/j.jacig.2025.100404 https://www.jaci-global.org/article/S2772-8293(25)00005-0/fulltext - Open Access 
  • Rieper, F., Wittmann, J., Bunk, B., Spröer, C., Häfner, M., Willy, C., Müsken, M., Ziehr, H., Korf, I. H. E., Jahn, D. (2025). "Systematic bacteriophage selection for the lysis of multiple strains." Frontiers in Cellular and Infection Microbiology 15. doi: ARTN 1597009 10.3389/fcimb.2025.1597009 https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2025.1597009/abstract - Open Access
  • Waschina, S., Harris, D., Starke, S., Homeister, L., Schuchardt, S., Tran, F., Verstockt, B., Ananthakrishnan, A., Vermeire, S., Rosenstiel, P., Schreiber, S., Aden, K. (2025). "DOP019 Reduced Gut Microbial Amino Acid Auxotrophies and Enhanced Tryptophan Degradation in Inflammatory Bowel Disease." Journal of Crohn's and Colitis 19(Supplement_1): i122-i123. doi: 10.1093/ecco-jcc/jjae190.0058 https://academic.oup.com/ecco-jcc/article/19/Supplement_1/i122/7967042 -
  • Weissfuss, C., Li, J., Behrendt, U., Hoffmann, K., Burkle, M., Tan, C., Krishnamoorthy, G., Korf, I. H. E., Rohde, C., Gaborieau, B., Debarbieux, L., Ricard, J. D., Witzenrath, M., Felten, M., Nouailles, G. (2025). "Adjunctive phage therapy improves antibiotic treatment of ventilator-associated-pneumonia with Pseudomonas aeruginosa." Nat Commun 16(1): 4500. doi: 10.1038/s41467-025-59806-y https://www.nature.com/articles/s41467-025-59806-y - Open Access
  • Welz, L., Harris, D., Schuchardt, S., Tran, F., Waschina, S., Verstockt, B., Vermeire, S., Rosenstiel, P., Schreiber, S., Aden, K. (2025). "DOP090 Serum metabolites predict endoscopic disease activity and clinical and endoscopic remission in Ulcerative Colitis." Journal of Crohn's and Colitis 19(Supplement_1): i248-i250. doi: 10.1093/ecco-jcc/jjae190.0129 https://academic.oup.com/ecco-jcc/article/19/Supplement_1/i248/7967053

R&D expertise "RNA technologies"

  • Kitte, R., Serfling, R., Blache, U., Seitz, C., Schrader, S., Kohl, U., Fricke, S., Bar, C., Tretbar, U. S. (2025). "Optimal Chimeric Antigen Receptor (CAR)-mRNA for Transient CAR T Cell Generation." Int J Mol Sci 26(3). doi: 10.3390/ijms26030965 https://www.mdpi.com/1422-0067/26/3/965 - Open Access
  • Ye, J. L., Grieger, K., Lu, D., Brandenberger, C., Juchem, M., Jordan, M., Oehlsen, L., Zardo, P., Werlein, C., Hesse, C., Sewald, K., Tretbar, S., Thum, T., Chatterjee, S., Bär, C. (2025). "Telomerase modRNA offers a novel RNA-based approach to treat human pulmonary fibrosis." BioRxiv. doi: 10.1101/2025.02.19.639041 https://www.biorxiv.org/content/10.1101/2025.02.19.639041v1?med=mas - Preprint im Repositorium – Open Access

Contact

Petra Wiedemeier

Contact Press / Media

Petra Wiedemeier

Head of Information Management

Phone +49 511 5350-327