Publications of Fraunhofer ITEM

Publications 2022

  • Abdel-Aziz, M. I., Vijverberg, S. J. H., Neerincx, A. H., Brinkman, P., Wagener, A. H., Riley, J. H., Sousa, A. R., Bates, S., Wagers, S. S., De Meulder, B., Auffray, C., Wheelock, A. M., Bansal, A. T., Caruso, M., Chanez, P., Uddin, M., Corfield, J., Horvath, I., Krug, N., Musial, J., Sun, K., Shaw, D. E., Sandstrom, T., Montuschi, P., Fowler, S. J., Lutter, R., Djukanovic, R., Howarth, P., Skipp, P., Sanak, M., Adcock, I. M., Chung, K. F., Sterk, P. J., Kraneveld, A. D., Maitland-van der Zee, A. H., Group, U. B. S. (2022). "A multi-omics approach to delineate sputum microbiome-associated asthma inflammatory phenotypes." European Respiratory Journal 59(1). doi: 10.1183/13993003.02603-2021 https://erj.ersjournals.com/content/early/2021/10/19/13993003.02603-2021.long
  • Abdelhamid, M., Rosano, G., Metra, M., Adamopoulos, S., Bohm, M., Chioncel, O., Filippatos, G., Jankowska, E. A., Lopatin, Y., Lund, L., Milicic, D., Moura, B., Ben Gal, T., Ristic, A., Rakisheva, A., Savarese, G., Mullens, W., Piepoli, M., Bayes-Genis, A., Thum, T., Anker, S. D., Seferovic, P., Coats, A. J. S. (2022). "Prevention of sudden death in heart failure with reduced ejection fraction: do we still need an implantable cardioverter-defibrillator for primary prevention?" European Journal of Heart Failure [Epub ahead of print]. doi: 10.1002/ejhf.2594 https://onlinelibrary.wiley.com/doi/10.1002/ejhf.2594 - Open Access
  • Abdul Nabi Ali, A., Alam, M., Klein, S. C., Behmann, N., Krauss, J. K., Doll, T., Blume, H., Schwabe, K. (2022). "Predictive accuracy of CNN for cortical oscillatory activity in an acute rat model of parkinsonism." Neural Netw 146: 334-340. doi: 10.1016/j.neunet.2021.11.025 https://www.sciencedirect.com/science/article/abs/pii/S0893608021004664?via%3Dihub
  • Aimo, A., Vergaro, G., Gonzalez, A., Barison, A., Lupon, J., Delgado, V., Richards, A. M., de Boer, R. A., Thum, T., Arfsten, H., Hulsmann, M., Falcao-Pires, I., Diez, J., Foo, R. S. Y., Chan, M. Y. Y., Anene-Nzelu, C. G., Abdelhamid, M., Adamopoulos, S., Anker, S. D., Belenkov, Y., Gal, T. B., Cohen-Solal, A., Bohm, M., Chioncel, O., Jankowska, E. A., Gustafsson, F., Hill, L., Jaarsma, T., Januzzi, J. L., Jhund, P., Lopatin, Y., Lund, L. H., Metra, M., Milicic, D., Moura, B., Mueller, C., Mullens, W., Nunez, J., Piepoli, M. F., Rakisheva, A., Ristic, A. D., Rossignol, P., Savarese, G., Tocchetti, C. G., van Linthout, S., Volterrani, M., Seferovic, P., Rosano, G., Coats, A. J. S., Emdin, M., Bayes-Genis, A. (2022). "Cardiac remodelling - Part 2: Clinical, imaging and laboratory findings. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology." European Journal of Heart Failure 24(6): 944-958. doi: 10.1002/ejhf.2522 https://onlinelibrary.wiley.com/doi/10.1002/ejhf.2522  - Open Access
  • Arbustini, E., Behr, E. R., Carrier, L., van Duijn, C., Evans, P., Favalli, V., van der Harst, P., Haugaa, K. H., Jondeau, G., Kaab, S., Kaski, J. P., Kavousi, M., Loeys, B., Pantazis, A., Pinto, Y., Schunkert, H., Di Toro, A., Thum, T., Urtis, M., Waltenberger, J., Elliott, P. (2022). "Interpretation and actionability of genetic variants in cardiomyopathies: a position statement from the European Society of Cardiology Council on cardiovascular genomics." European Heart Journal 43(20): 1901-1916. doi: 10.1093/eurheartj/ehab895 https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehab895/6516788 - Open Access
  • Badi, Y. E., Pavel, A. B., Pavlidis, S., Riley, J. H., Bates, S., Kermani, N. Z., Knowles, R., Kolmert, J., Wheelock, C. E., Worsley, S., Uddin, M., Alving, K., Bakke, P. S., Behndig, A., Caruso, M., Chanez, P., Fleming, L. J., Fowler, S. J., Frey, U., Howarth, P., Horvath, I., Krug, N., Maitland-van der Zee, A. H., Montuschi, P., Roberts, G., Sanak, M., Shaw, D. E., Singer, F., Sterk, P. J., Djukanovic, R., Dahlen, S. E., Guo, Y. K., Chung, K. F., Guttman-Yassky, E., Adcock, I. M., Group, U. B. S. (2022). "Mapping atopic dermatitis and anti-IL-22 response signatures to type 2-low severe neutrophilic asthma." Journal of Allergy and Clinical Immunology 149(1): 89-101. doi: 10.1016/j.jaci.2021.04.010 https://www.sciencedirect.com/science/article/abs/pii/S0091674921006485?via%3Dihub
  • Baron, Y., Sens, J., Lange, L., Nassauer, L., Klatt, D., Hoffmann, D., Kleppa, M.-J., Barbosa, P. V., Keisker, M., Steinberg, V., Suerth, J. D., Vondran, F. W. R., Meyer, J., Morgan, M., Schambach, A., Galla, M. (2022). "Improved alpharetrovirus-based Gag.MS2 particles for efficient and transient delivery of CRISPR-Cas9 into target cells." Molecular Therapy - Nucleic Acids 27: 810-823. doi: 10.1016/j.omtn.2021.12.033 https://www.sciencedirect.com/science/article/pii/S216225312100336X?via%3Dihub - Open Access
  • Batke, M., Damm, G., Foth, H., Freyberger, A., Gebel, T., Gundert-Remy, U., Hengstler, J., Mangerich, A., Partosch, F., Rohl, C., Schupp, T., Wollin, K. M. (2022). "The EU chemicals strategy for sustainability: critical reflections on proposed regulatory changes for endocrine disruptors and mixture toxicity." Archives of Toxicology 96(4): 1133-1135. doi: 10.1007/s00204-022-03227-z https://link.springer.com/article/10.1007/s00204-022-03227-z - Open Access
  • Bei, Y., Lu, D., Bar, C., Chatterjee, S., Costa, A., Riedel, I., Mooren, F. C., Zhu, Y., Huang, Z., Wei, M., Hu, M., Liu, S., Yu, P., Wang, K., Thum, T., Xiao, J. (2022). "miR-486 attenuates cardiac ischemia/reperfusion injury and mediates the beneficial effect of exercise for myocardial protection." Molecular Therapy 30(4): 1675-1691. doi: 10.1016/j.ymthe.2022.01.031 https://www.sciencedirect.com/science/article/abs/pii/S1525001622000314?via%3Dihub
  • Biener, M., Giannitsis, E., Thum, T., Bar, C., Stoyanov, K. M., Salbach, C., de Gonzalo-Calvo, D., Frey, N., Mueller-Hennessen, M. (2022). "Prognostic value of circulating microRNAs compared to high-sensitivity troponin T in patients presenting with suspected acute coronary syndrome to the emergency department." Clinical Biochemistry 99: 9-16. doi: 10.1016/j.clinbiochem.2021.09.009 https://www.sciencedirect.com/science/article/abs/pii/S0009912021002502?via%3Dihub
  • Bohnke, J., Varghese, J., Elise Study Group, Karch, A., Rubsamen, N. (2022). "Systematic review identifies deficiencies in reporting of diagnostic test accuracy among clinical decision support systems." Journal of Clinical Epidemiology [Epub ahead of print]. doi: 10.1016/j.jclinepi.2022.08.003 https://www.sciencedirect.com/science/article/abs/pii/S0895435622001913?via%3Dihub
  • Brotzmann, K., Escher, S. E., Walker, P., Braunbeck, T. (2022). "Potential of the zebrafish (Danio rerio) embryo test to discriminate between chemicals of similar molecular structure-a study with valproic acid and 14 of its analogues." Archives of Toxicology [Epub ahead of print]. doi: 10.1007/s00204-022-03340-z https://link.springer.com/article/10.1007/s00204-022-03340-z - Open Access
  • Burzlaff, A., Creutzenberg, O., Schaudien, D., Viegas, V., Danzeisen, R., Warheit, D. (2022). "A tiered approach to investigate the inhalation toxicity of cobalt substances. Tier 4: Effects from a 28-day inhalation toxicity study with tricobalt tetraoxide in rats." Regulatory Toxicology and Pharmacology 130: 105129. doi: 10.1016/j.yrtph.2022.105129 https://www.sciencedirect.com/science/article/pii/S0273230022000162?via%3Dihub - Open Access
  • Carstensen, S., Benediktus, E., Litzenburger, T., Hohlfeld, J. M., Muller, M. (2022). "Basophil activation test: Assay precision and BI 1002494 SYK inhibition in healthy and mild asthmatics." Cytometry A 101(1): 86-94. doi: 10.1002/cyto.a.24338 https://onlinelibrary.wiley.com/doi/10.1002/cyto.a.24338 - Open Access
  • Chen, F., Elgaher, W. A. M., Winterhoff, M., Büssow, K., Waqas, F. H., Graner, E., Pires-Afonso, Y., Casares Perez, L., de la Vega, L., Sahini, N., Czichon, L., Zobl, W., Zillinger, T., Shehata, M., Pleschka, S., Bähre, H., Falk, C., Michelucci, A., Schuchardt, S., Blankenfeldt, W., Hirsch, A. K. H., Pessler, F. (2022). "Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism." Nature Metabolism 4(5): 534-546. doi: 10.1038/s42255-022-00577-x https://www.nature.com/articles/s42255-022-00577-x - Open Access
  • Costa, A., Cushman, S., Haubner, B. J., Derda, A. A., Thum, T., Bar, C. (2022). "Neonatal injury models: integral tools to decipher the molecular basis of cardiac regeneration." Basic Research in Cardiology 117(1): 26. doi: 10.1007/s00395-022-00931-w https://link.springer.com/article/10.1007/s00395-022-00931-w - Open Access
  • Couch, L. S., Fiedler, J., Chick, G., Clayton, R., Dries, E., Wienecke, L. M., Fu, L., Fourre, J., Pandey, P., Derda, A. A., Wang, B. X., Jabbour, R., Shanmuganathan, M., Wright, P., Lyon, A. R., Terracciano, C. M., Thum, T., Harding, S. E. (2022). "Circulating microRNAs predispose to takotsubo syndrome following high-dose adrenaline exposure." Cardiovascular Research 118(7): 1758-1770. doi: 10.1093/cvr/cvab210 https://academic.oup.com/cardiovascres/article/118/7/1758/6307454 - Open Access
  • Creutzenberg, O., Oliveira, H., Farcal, L., Schaudien, D., Mendes, A., Menezes, A. C., Tischler, T., Burla, S., Ziemann, C. (2022). "PLATOX: Integrated In Vitro/In Vivo Approach for Screening of Adverse Lung Effects of Graphene-Related 2D Nanomaterials." Nanomaterials (Basel) 12(8): 33 p. doi: 10.3390/nano12081254 https://www.mdpi.com/2079-4991/12/8/1254 - Open Access
  • Creutzenberg, O., Pohlmann, G., Schaudien, D., Kock, H. (2022). "Toxicokinetics of Nanoparticles Deposited in Lungs Using Occupational Exposure Scenarios." Front Public Health 10: 909247. doi: 10.3389/fpubh.2022.909247 https://www.frontiersin.org/articles/10.3389/fpubh.2022.909247/full - Open Access
  • Davidson, S. M., Boulanger, C. M., Aikawa, E., Badimon, L., Barile, L., Binder, C. J., Brisson, A., Buzas, E., Emanueli, C., Jansen, F., Katsur, M., Lacroix, R., Lim, S. K., Mackman, N., Mayr, M., Menasche, P., Nieuwland, R., Sahoo, S., Takov, K., Thum, T., Vader, P., Wauben, M. H. M., Witwer, K., Sluijter, J. P. G. (2022). "Methods for the identification and characterization of extracellular vesicles in cardiovascular studies - from exosomes to microvesicles." Cardiovascular Research [Epub ahead of print]. doi: 10.1093/cvr/cvac031 https://academic.oup.com/cardiovascres/advance-article-abstract/doi/10.1093/cvr/cvac031/6553781?redirectedFrom=fulltext
  • de Boer, R. A., Heymans, S., Backs, J., Carrier, L., Coats, A. J. S., Dimmeler, S., Eschenhagen, T., Filippatos, G., Gepstein, L., Hulot, J. S., Knoll, R., Kupatt, C., Linke, W. A., Seidman, C. E., Tocchetti, C. G., van der Velden, J., Walsh, R., Seferovic, P. M., Thum, T. (2022). "Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC)." European Journal of Heart Failure 24(3): 406-420. doi: 10.1002/ejhf.2414 https://onlinelibrary.wiley.com/doi/10.1002/ejhf.2414 - Open Access
  • De Sadeleer, L. J., Verleden, S. E., Schupp, J. C., McDonough, J. E., Goos, T., Yserbyt, J., Bargagli, E., Rottoli, P., Kaminski, N., Prasse, A., Wuyts, W. A. (2022). "BAL Transcriptomes Characterize Idiopathic Pulmonary Fibrosis Endotypes With Prognostic Impact." Chest 161(6): 1576-1588. doi: 10.1016/j.chest.2021.12.668 https://www.sciencedirect.com/science/article/abs/pii/S0012369222000538?via%3Dihub -
  • Diboun, I., Cyprian, F. S., Anwardeen, N. R., Yassine, H. M., Elrayess, M. A., Rahmoon, S. M., Sayed, S. K., Schuchardt, S., Khatib, M., Bansal, D., Farag, E., Emara, M. M., Abdallah, A. M. (2022). "Identification of Prognostic Metabolomic Biomarkers at the Interface of Mortality and Morbidity in Pre-Existing TB Cases Infected With SARS-CoV-2." Front Cell Infect Microbiol 12: 929689. doi: 10.3389/fcimb.2022.929689 https://www.frontiersin.org/articles/10.3389/fcimb.2022.929689/full - Open Access
  • Elrayess, M. A., Cyprian, F. S., Abdallah, A. M., Emara, M. M., Diboun, I., Anwardeen, N., Schuchardt, S., Yassine, H. M. (2022). "Metabolic Signatures of Type 2 Diabetes Mellitus and Hypertension in COVID-19 Patients With Different Disease Severity." Frontiers in Medicine 8: 788687. doi: 10.3389/fmed.2021.788687 https://www.frontiersin.org/articles/10.3389/fmed.2021.788687/full - Open Access
  • Escher, S. E., Aguayo-Orozco, A., Benfenati, E., Bitsch, A., Braunbeck, T., Brotzmann, K., Bois, F., van der Burg, B., Castel, J., Exner, T., Gadaleta, D., Gardner, I., Goldmann, D., Hatley, O., Golbamaki, N., Graepel, R., Jennings, P., Limonciel, A., Long, A., Maclennan, R., Mombelli, E., Norinder, U., Jain, S., Capinha, L. S., Taboureau, O. T., Tolosa, L., Vrijenhoek, N. G., van Vugt-Lussenburg, B. M. A., Walker, P., van de Water, B., Wehr, M., White, A., Zdrazil, B., Fisher, C. (2022). "Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action." Toxicology in Vitro 79: 105269. doi: 10.1016/j.tiv.2021.105269 https://www.sciencedirect.com/science/article/abs/pii/S0887233321001946
  • Farber, I., Kruger, J., Rocha, C., Armando, F., von Kockritz-Blickwede, M., Pohlmann, S., Braun, A., Baumgartner, W., Runft, S., Kruger, N. (2022). "Investigations on SARS-CoV-2 Susceptibility of Domestic and Wild Animals Using Primary Cell Culture Models Derived from the Upper and Lower Respiratory Tract." Viruses 14(4): 16 p. doi: 10.3390/v14040828 https://www.mdpi.com/1999-4915/14/4/828 - Open Access
  • Friedrich, M., Pfeifer, G., Binder, S., Aigner, A., Vollmer Barbosa, P., Makert, G. R., Fertey, J., Ulbert, S., Bodem, J., Konig, E. M., Geiger, N., Schambach, A., Schilling, E., Buschmann, T., Hauschildt, S., Koehl, U., Sewald, K. (2022). "Selection and Validation of siRNAs Preventing Uptake and Replication of SARS-CoV-2." Front Bioeng Biotechnol 10: 801870. doi: 10.3389/fbioe.2022.801870 https://www.frontiersin.org/articles/10.3389/fbioe.2022.801870/full - Open Access
  • Funk, J., Ruehl-Fehlert, C., Leonard, C., Kellner, R., Rittinghausen, S. (2022). "Immunohistochemical Characterization of Proliferative Lesions in the Thymus of Aging CD-1 Mice From Two Studies on the RITA Database, With Special Reference to the Perivascular Space." Toxicologic Pathology 50(3): 1926233221082972. doi: 10.1177/01926233221082972 https://journals.sagepub.com/doi/10.1177/01926233221082972 - Open Access
  • Gonzalez, A., Richards, A. M., de Boer, R. A., Thum, T., Arfsten, H., Hulsmann, M., Falcao-Pires, I., Diez, J., Foo, R. S. Y., Chan, M. Y., Aimo, A., Anene-Nzelu, C. G., Abdelhamid, M., Adamopoulos, S., Anker, S. D., Belenkov, Y., Gal, T. B., Cohen-Solal, A., Bohm, M., Chioncel, O., Delgado, V., Emdin, M., Jankowska, E. A., Gustafsson, F., Hill, L., Jaarsma, T., Januzzi, J. L., Jhund, P. S., Lopatin, Y., Lund, L. H., Metra, M., Milicic, D., Moura, B., Mueller, C., Mullens, W., Nunez, J., Piepoli, M. F., Rakisheva, A., Ristic, A. D., Rossignol, P., Savarese, G., Tocchetti, C. G., Van Linthout, S., Volterrani, M., Seferovic, P., Rosano, G., Coats, A. J. S., Bayes-Genis, A. (2022). "Cardiac remodelling - Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology." European Journal of Heart Failure 24(6): 927-943. doi: 10.1002/ejhf.2493 https://onlinelibrary.wiley.com/doi/10.1002/ejhf.2493 - Open Access
  • Grinberg, M., Stober, R. M., Edlund, K., Rempel, E., Godoy, P., Reif, R., Widera, A., Madjar, K., Schmidt-Heck, W., Marchan, R., Sachinidis, A., Spitkovsky, D., Hescheler, J., Carmo, H., Arbo, M. D., van de Water, B., Wink, S., Vinken, M., Rogiers, V., Escher, S., Hardy, B., Mitic, D., Apic, G., Myatt, G., Waldmann, T., Mardinoglu, A., Damm, G., Seehofer, D., Nussler, A., Weiss, T. S., Oberemm, A., Lampen, A., Schaap, M. M., Luijten, M., van Steeg, H., Thasler, W. E., Kleinjans, J. C. S., Stierum, R. H., Leist, M., Rahnenfuhrer, J., Hengstler, J. G. (2022). "Correction to: Toxicogenomics directory of chemically exposed human hepatocytes." Archives of Toxicology 96(3): 945-946. doi: 10.1007/s00204-021-03206-w https://link.springer.com/article/10.1007/s00204-021-03206-w - Open Access
  • Haase, L. M., Birk, T., Poland, C. A., Holz, O., Muller, M., Bachand, A. M., Mundt, K. A. (2022). "Cross-sectional Study of Workers Employed at a Copper Smelter-Effects of Long-term Exposures to Copper on Lung Function and Chronic Inflammation." Journal of Occupational and Environmental Medicine 64(9): e550-e558. doi: 10.1097/JOM.0000000000002610 https://journals.lww.com/joem/Abstract/9900/Cross_Sectional_Study_of_Workers_employed_at_a.100.aspx - Open Access
  • Harrer, D. C., Jakob, M., Vogelhuber, M., Lüke, F., Utpatel, K., Corbacioglu, S., Herr, W., Reichle, A., Heudobler, D. (2022). "Biomodulatory therapy induces durable remissions in multi-system Langerhans cell histiocytosis." Leukemia and Lymphoma [Epub ahead of print]: 1-11. doi: 10.1080/10428194.2022.2095627 https://www.tandfonline.com/doi/abs/10.1080/10428194.2022.2095627?journalCode=ilal20
  • Harrer, D. C., Lüke, F., Einspieler, I., Menhart, K., Hellwig, D., Utpatel, K., Herr, W., Reichle, A., Heudobler, D. (2022). "Case Report: Extramedullary Acute Promyelocytic Leukemia: An Unusual Case and Mini-Review of the Literature." Frontiers in Oncology 12: 886436. doi: 10.3389/fonc.2022.886436 https://www.frontiersin.org/articles/10.3389/fonc.2022.886436/full - Open Access
  • Henschenmacher, B., Bitsch, A., de Las Heras Gala, T., Forman, H. J., Fragoulis, A., Ghezzi, P., Kellner, R., Koch, W., Kuhne, J., Sachno, D., Schmid, G., Tsaioun, K., Verbeek, J., Wright, R. (2022). "The effect of radiofrequency electromagnetic fields (RF-EMF) on biomarkers of oxidative stress in vivo and in vitro: A protocol for a systematic review." Environ Int 158: 106932. doi: 10.1016/j.envint.2021.106932 https://www.sciencedirect.com/science/article/pii/S0160412021005572 - Open Access
  • Heratizadeh, A., Roesner, L. M., Traidl, S., Moitinho-Silva, L., Ellinghusen, B., Rodriguez, E., Harder, I., Sapak, M., Weidinger, S., Badorrek, P., Hohlfeld, J. M., Werfel, T. (2022). "Basic skin therapy effects on skin inflammation and microbiome composition in patients with atopic dermatitis after challenges with grass pollen." Journal of the European Academy of Dermatology and Venereology 36(6): e480-e483. doi: 10.1111/jdv.17966 https://onlinelibrary.wiley.com/doi/10.1111/jdv.17966
  • Herrera, V. L. M., Walkey, A. J., Nguyen, M. Q., Gromisch, C. M., Mosaddhegi, J. Z., Gromisch, M. S., Jundi, B., Lukassen, S., Carstensen, S., Denis, R., Belkina, A. C., Baron, R. M., Pinilla-Vera, M., Mueller, M., Kimberly, W. T., Goldstein, J. N., Lehmann, I., Shih, A. R., Eils, R., Levy, B. D., Ruiz-Opazo, N. (2022). "A targetable 'rogue' neutrophil-subset, [CD11b+DEspR+] immunotype, is associated with severity and mortality in acute respiratory distress syndrome (ARDS) and COVID-19-ARDS." Scientific Reports 12(1): 5583. doi: 10.1038/s41598-022-09343-1 https://www.nature.com/articles/s41598-022-09343-1 - Open Access
  • Hesse, C., Beneke, V., Konzok, S., Diefenbach, C., Bulow Sand, J. M., Ronnow, S. R., Karsdal, M. A., Jonigk, D., Sewald, K., Braun, A., Leeming, D. J., Wollin, L. (2022). "Nintedanib modulates type III collagen turnover in viable precision-cut lung slices from bleomycin-treated rats and patients with pulmonary fibrosis." Respiratory Research 23(1): 201. doi: 10.1186/s12931-022-02116-4 https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-022-02116-4 - Open Access
  • Hoda, U., Pavlidis, S., Bansal, A. T., Takahashi, K., Hu, S., Ng Kee Kwong, F., Rossios, C., Sun, K., Bhavsar, P., Loza, M., Baribaud, F., Chanez, P., Fowler, S. J., Horvath, I., Montuschi, P., Singer, F., Musial, J., Dahlen, B., Krug, N., Sandstrom, T., Shaw, D. E., Lutter, R., Fleming, L. J., Howarth, P. H., Caruso, M., Sousa, A. R., Corfield, J., Auffray, C., De Meulder, B., Lefaudeux, D., Dahlen, S. E., Djukanovic, R., Sterk, P. J., Guo, Y., Adcock, I. M., Chung, K. F., group, U. B. s. (2022). "Clinical and transcriptomic features of persistent exacerbation-prone severe asthma in U-BIOPRED cohort." Clin Transl Med 12(4): e816. doi: 10.1002/ctm2.816 https://onlinelibrary.wiley.com/doi/10.1002/ctm2.816 - Open Access
  • Hoepfner, J., Leonardy, J., Lu, D., Schmidt, K., Hunkler, H. J., Biss, S., Foinquinos, A., Xiao, K., Regalla, K., Ramanujam, D., Engelhardt, S., Bar, C., Thum, T. (2022). "The long non-coding RNA NRON promotes the development of cardiac hypertrophy in the murine heart." Molecular Therapy 30(3): 1265-1274. doi: 10.1016/j.ymthe.2021.11.018 https://www.sciencedirect.com/science/article/abs/pii/S1525001621006353?via%3Dihub
  • Holz, O., Muller, M., Carstensen, S., Olin, A. C., Hohlfeld, J. M. (2022). "Inflammatory cytokines can be monitored in exhaled breath particles following segmental and inhalation endotoxin challenge in healthy volunteers." Scientific Reports 12(1): 5620. doi: 10.1038/s41598-022-09399-z https://www.nature.com/articles/s41598-022-09399-z - Open Access
  • Holz, O., van Vorstenbosch, R., Guenther, F., Schuchardt, S., Trinkmann, F., van Schooten, F. J., Smolinska, A., Hohlfeld, J. M. (2022). "Changes of breath volatile organic compounds in healthy volunteers following segmental and inhalation endotoxin challenge." Journal of Breath Research 16(3): 17 p. doi: 10.1088/1752-7163/ac6359 https://iopscience.iop.org/article/10.1088/1752-7163/ac6359 - Open Access
  • Janssen, P., Barton, G., Kietzmann, M., Meissner, J. (2022). "Treatment of pigs with enrofloxacin via different oral dosage forms - environmental contaminations and resistance development of Escherichia coli." Journal of Veterinary Science 23(2): e23. doi: 10.4142/jvs.21216 https://vetsci.org/DOIx.php?id=10.4142/jvs.21216 - Open Access
  • Kreutzer, F. P., Meinecke, A., Mitzka, S., Hunkler, H. J., Hobuss, L., Abbas, N., Geffers, R., Weusthoff, J., Xiao, K., Jonigk, D. D., Fiedler, J., Thum, T. (2022). "Development and characterization of anti-fibrotic natural compound similars with improved effectivity." Basic Research in Cardiology 117(1): 9. doi: 10.1007/s00395-022-00919-6 https://link.springer.com/article/10.1007/s00395-022-00919-6 - Open Access
  • Kreutzer, F. P., Meinecke, A., Schmidt, K., Fiedler, J., Thum, T. (2022). "Alternative strategies in cardiac preclinical research and new clinical trial formats." Cardiovascular Research 118(3): 746-762. doi: 10.1093/cvr/cvab075 https://academic.oup.com/cardiovascres/article/118/3/746/6162160 - Open Access
  • Krueger, N., Weber, K., Warfving, N., Vitali, A., Nolde, J., Schuster, T. B., Bruer, G. G., Creutzenberg, O., Wessely, B., Stintz, M., Moise, V., Kellert, M. (2022). "Physical Obstruction of Nasal Cavities With Subsequent Asphyxia, Causes Lethality of Rats in an Acute Inhalation Study With Hydrophobic HMDZ Surface-Treated Synthetic Amorphous Silica (SAS)." Front Public Health 10: 907078. doi: 10.3389/fpubh.2022.907078 https://www.frontiersin.org/articles/10.3389/fpubh.2022.907078/full - Open Access
  • Leonardy, J., Bar, C. (2022). "Editorial Research Topic: Non-coding RNA as Therapeutic Target: A Game Changer in Cardiac Regenerative Strategies?" Frontiers in Physiology 12: 822280. doi: 10.3389/fphys.2021.822280 https://www.frontiersin.org/articles/10.3389/fphys.2021.822280/full - Open Access
  • Lu, D., Chatterjee, S., Xiao, K., Riedel, I., Huang, C. K., Costa, A., Cushman, S., Neufeldt, D., Rode, L., Schmidt, A., Juchem, M., Leonardy, J., Buchler, G., Blume, J., Gern, O. L., Kalinke, U., Tan, W. L. W., Foo, R., Vink, A., van Laake, L. W., van der Meer, P., Bar, C., Thum, T. (2022). "A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity." European Heart Journal [Epub ahead of print]. doi: 10.1093/eurheartj/ehac337 https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehac337/6618365 - Open Access
  • Lüke, F., Harrer, D. C., Pantziarka, P., Pukrop, T., Ghibelli, L., Gerner, C., Reichle, A., Heudobler, D. (2022). "Drug Repurposing by Tumor Tissue Editing." Frontiers in Oncology 12: 900985. doi: 10.3389/fonc.2022.900985 https://www.frontiersin.org/articles/10.3389/fonc.2022.900985/ful - Open Access
  • Makarewich, C. A., Thum, T. (2022). "Exercise-Induced Long Noncoding RNAs As New Players in Cardiac Hypertrophy." Circulation 145(16): 1234-1237. doi: 10.1161/CIRCULATIONAHA.122.059278 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.059278
  • Malik, M. N. H., Waqas, S. F., Zeitvogel, J., Cheng, J., Geffers, R., Gouda, Z. A., Elsaman, A. M., Radwan, A. R., Schefzyk, M., Braubach, P., Auber, B., Olmer, R., Musken, M., Roesner, L. M., Gerold, G., Schuchardt, S., Merkert, S., Martin, U., Meissner, F., Werfel, T., Pessler, F. (2022). "Congenital deficiency reveals critical role of ISG15 in skin homeostasis." Journal of Clinical Investigation 132(3). doi: 10.1172/JCI141573 https://www.jci.org/articles/view/141573 - Open Access
  • McKinsey, T. A., Foo, R., Anene-Nzelu, C. G., Travers, J. G., Vagnozzi, R. J., Weber, N., Thum, T. (2022). "Emerging epigenetic therapies of cardiac fibrosis and remodeling in heart failure: from basic mechanisms to early clinical development." Cardiovascular Research [Epub ahead of print]. doi: 10.1093/cvr/cvac142 https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvac142/6675295 - Open Access
  • Mederer, T., Elsner, F., Robold, T., Grosser, C., Neu, R., Ried, M., Bleicher, S., Schamberger, T., Blochberger, I., Hofmann, H. S., Klein, C. A. (2022). "EpCAM-positive disseminated cancer cells in bone marrow impact on survival of early-stage NSCLC patients." Lung Cancer 167: 73-77. doi: 10.1016/j.lungcan.2022.02.008 https://www.sciencedirect.com/science/article/pii/S0169500222003646?via%3Dihub - Open Access
  • Metzenmacher, M., Hegedus, B., Forster, J., Schramm, A., Horn, P. A., Klein, C. A., Bielefeld, N., Ploenes, T., Aigner, C., Siveke, J. T., Schuler, M., Lueong, S. S. (2022). "The clinical utility of cfRNA for disease detection and surveillance: A proof of concept study in non-small cell lung cancer." Thorac Cancer 13(15): 2180-2191. doi: 10.1111/1759-7714.14540 https://onlinelibrary.wiley.com/doi/10.1111/1759-7714.14540 - Open Access
  • Metzenmacher, M., Hegedus, B., Forster, J., Schramm, A., Horn, P. A., Klein, C. A., Bielefeld, N., Ploenes, T., Aigner, C., Theegarten, D., Schildhaus, H. U., Siveke, J. T., Schuler, M., Lueong, S. S. (2022). "Combined multimodal ctDNA analysis and radiological imaging for tumor surveillance in Non-small cell lung cancer." Translational Oncology 15(1): 101279. doi: 10.1016/j.tranon.2021.101279 https://www.sciencedirect.com/science/article/pii/S1936523321002709?via%3Dihub - Open Access
  • Meumann, N., Schmithals, C., Elenschneider, L., Hansen, T., Balakrishnan, A., Hu, Q., Hook, S., Schmitz, J., Brasen, J. H., Franke, A. C., Olarewaju, O., Brandenberger, C., Talbot, S. R., Fangmann, J., Hacker, U. T., Odenthal, M., Ott, M., Piiper, A., Buning, H. (2022). "Hepatocellular Carcinoma Is a Natural Target for Adeno-Associated Virus (AAV) 2 Vectors." Cancers 14(2): 19 p. doi: 10.3390/cancers14020427 https://www.mdpi.com/2072-6694/14/2/427 - Open Access
  • Mohr, E., Thum, T., Bär, C. (2022). "Accelerating cardiovascular research: recent advances in translational 2D and 3D heart models." European Journal of Heart Failure [Epub ahead of print]. doi: 10.1002/ejhf.2631 https://onlinelibrary.wiley.com/doi/10.1002/ejhf.2631  - Open Access
  • Mullens, W., Martens, P., Testani, J. M., Tang, W. H. W., Skouri, H., Verbrugge, F. H., Fudim, M., Iacoviello, M., Franke, J., Flammer, A. J., Palazzuoli, A., Barragan, P. M., Thum, T., Marcos, M. C., Miro, O., Rossignol, P., Metra, M., Lassus, J., Orso, F., Jankowska, E. A., Chioncel, O., Milicic, D., Hill, L., Seferovic, P., Rosano, G., Coats, A., Damman, K. (2022). "Renal effects of guideline-directed medical therapies in heart failure: a consensus document from the Heart Failure Association of the European Society of Cardiology." European Journal of Heart Failure 24(4): 603-619. doi: 10.1002/ejhf.2471 https://onlinelibrary.wiley.com/doi/10.1002/ejhf.2471 - Open Access
  • Nunez, J., de la Espriella, R., Rossignol, P., Voors, A. A., Mullens, W., Metra, M., Chioncel, O., Januzzi, J. L., Mueller, C., Richards, A. M., de Boer, R. A., Thum, T., Arfsten, H., Gonzalez, A., Abdelhamid, M., Adamopoulos, S., Anker, S. D., Gal, T. B., Biegus, J., Cohen-Solal, A., Bohm, M., Emdin, M., Jankowska, E. A., Gustafsson, F., Hill, L., Jaarsma, T., Jhund, P. S., Lopatin, Y., Lund, L. H., Milicic, D., Moura, B., Piepoli, M. F., Ponikowski, P., Rakisheva, A., Ristic, A., Savarese, G., Tocchetti, C. G., Van Linthout, S., Volterrani, M., Seferovic, P., Rosano, G., Coats, A. J., Bayes-Genis, A. (2022). "Congestion in Heart Failure: a circulating biomarker-based perspective." European Journal of Heart Failure [Epub ahead of print]. doi: 10.1002/ejhf.2664 https://onlinelibrary.wiley.com/doi/abs/10.1002/ejhf.2664  - Open Access
  • Obernolte, H., Niehof, M., Braubach, P., Fieguth, H. G., Jonigk, D., Pfennig, O., Tschernig, T., Warnecke, G., Braun, A., Sewald, K. (2022). "Cigarette smoke alters inflammatory genes and the extracellular matrix - investigations on viable sections of peripheral human lungs." Cell and Tissue Research 387(2): 249-260. doi: 10.1007/s00441-021-03553-1 https://link.springer.com/article/10.1007/s00441-021-03553-1 - Open Access
  • Obert, A. J., Gutberlet, M., Kern, A. L., Kaireit, T. F., Glandorf, J., Moher Alsady, T., Wacker, F., Hohlfeld, J. M., Vogel-Claussen, J. (2022). "Examining lung microstructure using (19) F MR diffusion imaging in COPD patients." Magnetic Resonance in Medicine 88(2): 860-870. doi: 10.1002/mrm.29237 https://onlinelibrary.wiley.com/doi/10.1002/mrm.29237 - Open Access
  • Pham, Y. L., Beauchamp, J., Clement, A., Wiegandt, F., Holz, O. (2022). "3D-printed mouthpiece adapter for sampling exhaled breath in medical applications." 3D Print Med 8(1): 27. doi: 10.1186/s41205-022-00150-y https://threedmedprint.biomedcentral.com/articles/10.1186/s41205-022-00150-y - Open Access
  • Preuss, E. B., Schubert, S., Werlein, C., Stark, H., Braubach, P., Hofer, A., Plucinski, E. K. J., Shah, H. R., Geffers, R., Sewald, K., Braun, A., Jonigk, D. D., Kuhnel, M. P. (2022). "The challenge of long-term cultivation of human precision-cut lung slices." American Journal of Pathology 192(2): 239-253. doi: 10.1016/j.ajpath.2021.10.020 https://www.sciencedirect.com/science/article/pii/S0002944021004818?via%3Dihub - Open Access
  • Raghu, G., Mouded, M., Prasse, A., Stebbins, C., Zhao, G., Song, G., Arefayene, M., Violette, S. M., Gallagher, D., Gibson, K. F. (2022). "Randomized Phase IIa Study of an Anti-alphavbeta6 Monoclonal Antibody in Idiopathic Pulmonary Fibrosis." American Journal of Respiratory and Critical Care Medicine [Epub ahead of print]. doi: 10.1164/rccm.202205-0868LE https://www.atsjournals.org/doi/10.1164/rccm.202205-0868LE
  • Reinke, S. N., Naz, S., Chaleckis, R., Gallart-Ayala, H., Kolmert, J., Kermani, N. Z., Tiotiu, A., Broadhurst, D. I., Lundqvist, A., Olsson, H., Strom, M., Wheelock, A. M., Gomez, C., Ericsson, M., Sousa, A. R., Riley, J. H., Bates, S., Scholfield, J., Loza, M., Baribaud, F., Bakke, P. S., Caruso, M., Chanez, P., Fowler, S. J., Geiser, T., Howarth, P., Horvath, I., Krug, N., Montuschi, P., Behndig, A., Singer, F., Musial, J., Shaw, D. E., Dahlen, B., Hu, S., Lasky-Su, J., Sterk, P. J., Chung, K. F., Djukanovic, R., Dahlen, S. E., Adcock, I. M., Wheelock, C. E., U Biopred Study Group (2022). "Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study." European Respiratory Journal 59(6). doi: 10.1183/13993003.01733-2021 https://erj.ersjournals.com/content/59/6/2101733.long - Open Access
  • Rode, L., Bar, C., Gross, S., Rossi, A., Meumann, N., Viereck, J., Abbas, N., Xiao, K., Riedel, I., Gietz, A., Zimmer, K., Odenthal, M., Buning, H., Thum, T. (2022). "AAV capsid engineering identified two novel variants with improved in vivo tropism for cardiomyocytes." Molecular Therapy [Epub ahead of print]. doi: 10.1016/j.ymthe.2022.07.003 https://www.sciencedirect.com/science/article/pii/S1525001622004245?via%3Dihub - Open Access
  • Rohl, C., Batke, M., Damm, G., Freyberger, A., Gebel, T., Gundert-Remy, U., Hengstler, J. G., Mangerich, A., Matthiessen, A., Partosch, F., Schupp, T., Wollin, K. M., Foth, H. (2022). "New aspects in deriving health-based guidance values for bromate in swimming pool water." Archives of Toxicology 96(6): 1623-1659. doi: 10.1007/s00204-022-03255-9 https://link.springer.com/article/10.1007/s00204-022-03255-9 - Open Access
  • Rothbart, N., Stanley, V., Koczulla, R., Jarosch, I., Holz, O., Schmalz, K., Huebers, H. W. (2022). "Millimeter-Wave Gas Spectroscopy for Breath Analysis of COPD patients in Comparison to GC-MS." Journal of Breath Research 16(4): 046001. doi: 10.1088/1752-7163/ac77aa https://iopscience.iop.org/article/10.1088/1752-7163/ac77aa - Open Access
  • Royzman, D., Andreev, D., Stich, L., Peckert-Maier, K., Wild, A. B., Zinser, E., Muhl-Zurbes, P., Jones, E., Adam, S., Frey, S., Fuchs, M., Kunz, M., Bauerle, T., Nagel, L., Schett, G., Bozec, A., Steinkasserer, A. (2022). "The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis." Frontiers in Immunology 13: 936995. doi: 10.3389/fimmu.2022.936995 https://www.frontiersin.org/articles/10.3389/fimmu.2022.936995/full - Open Access
  • Runft, S., Farber, I., Kruger, J., Kruger, N., Armando, F., Rocha, C., Pohlmann, S., Burigk, L., Leitzen, E., Ciurkiewicz, M., Braun, A., Schneider, D., Baumgartner, L., Freisleben, B., Baumgartner, W. (2022). "Alternatives to animal models and their application in the discovery of species susceptibility to SARS-CoV-2 and other respiratory infectious pathogens: A review." Veterinary Pathology 59(4): 3009858211073678. doi: 10.1177/03009858211073678 https://journals.sagepub.com/doi/10.1177/03009858211073678
  • Saeb, A., Grundmann, S. M., Gessner, D. K., Schuchardt, S., Most, E., Wen, G., Eder, K., Ringseis, R. (2022). "Feeding of cuticles from Tenebrio molitor larvae modulates the gut microbiota and attenuates hepatic steatosis in obese Zucker rats." Food & Function 13(3): 1421-1436. doi: 10.1039/d1fo03920b https://pubs.rsc.org/en/Content/ArticleLanding/2022/FO/D1FO03920B
  • Sauerhering, L., Kuznetsova, I., Kupke, A., Meier, L., Halwe, S., Rohde, C., Schmidt, J., Morty, R. E., Danov, O., Braun, A., Vadasz, I., Becker, S., Herold, S. (2022). "Cyclosporin A Reveals Potent Antiviral Effects in Preclinical Models of SARS-CoV-2 Infection." American Journal of Respiratory and Critical Care Medicine 205(8): 964-968. doi: 10.1164/rccm.202108-1830LE https://www.atsjournals.org/doi/10.1164/rccm.202108-1830LE - Open Access
  • Scheiter, A., Evert, K., Reibenspies, L., Cigliano, A., Annweiler, K., Muller, K., Pohmerer, L. M., Xu, H., Cui, G., Itzel, T., Materna-Reichelt, S., Coluccio, A., Honarnejad, K., Teufel, A., Brochhausen, C., Dombrowski, F., Chen, X., Evert, M., Calvisi, D. F., Utpatel, K. (2022). "RASSF1A independence and early galectin-1 upregulation in PIK3CA-induced hepatocarcinogenesis: new therapeutic venues." Molecular Oncology 16(5): 1091-1118. doi: 10.1002/1878-0261.13135 https://febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13135 - Open Access
  • Scheiter, A., Hierl, F., Winkel, I., Keil, F., Klier-Richter, M., Coulouarn, C., Lüke, F., Kandulski, A., Evert, M., Dietmaier, W., Calvisi, D. F., Utpatel, K. (2022). "Wnt/beta-Catenin-Pathway Alterations and Homologous Recombination Deficiency in Cholangiocarcinoma Cell Lines and Clinical Samples: Towards Specific Vulnerabilities." J Pers Med 12(8): 23 p. doi: 10.3390/jpm12081270 https://www.mdpi.com/2075-4426/12/8/1270 - Open Access
  • Schluter, U., Meyer, J., Ahrens, A., Borghi, F., Clerc, F., Delmaar, C., Di Guardo, A., Dudzina, T., Fantke, P., Fransman, W., Hahn, S., Heussen, H., Jung, C., Koivisto, J., Koppisch, D., Paini, A., Savic, N., Spinazze, A., Zare Jeddi, M., von Goetz, N. (2022). "Exposure modelling in Europe: how to pave the road for the future as part of the European Exposure Science Strategy 2020-2030." J Expo Sci Environ Epidemiol 32(4): 499-512. doi: 10.1038/s41370-022-00455-4 https://www.nature.com/articles/s41370-022-00455-4 - Open Access
  • Schmidt, A., Fuchs, M., Stojanovic, S. D., Liang, C., Schmidt, K., Jung, M., Xiao, K., Weusthoff, J., Just, A., Pfanne, A., Distler, J. H. W., Dandekar, T., Fiedler, J., Thum, T., Kunz, M. (2022). "Deciphering Pro-angiogenic Transcription Factor Profiles in Hypoxic Human Endothelial Cells by Combined Bioinformatics and in vitro Modeling." Front Cardiovasc Med 9: 877450. doi: 10.3389/fcvm.2022.877450 https://www.frontiersin.org/articles/10.3389/fcvm.2022.877450/full - Open Access
  • Schreiner, T., Allnoch, L., Beythien, G., Marek, K., Becker, K., Schaudien, D., Stanelle-Bertram, S., Schaumburg, B., Mounogou Kouassi, N., Beck, S., Zickler, M., Gabriel, G., Baumgärtner, W., Armando, F., Ciurkiewicz, M. (2022). "SARS-CoV-2 Infection Dysregulates Cilia and Basal Cell Homeostasis in the Respiratory Epithelium of Hamsters." International Journal of Molecular Sciences 23(9): 20 p. doi: 10.3390/ijms23095124 https://www.mdpi.com/1422-0067/23/9/5124 - Open Access
  • Seferovic, P., Farmakis, D., Bayes-Genis, A., Ben Gal, T., Bohm, M., Chioncel, O., Ferrari, R., Filippatos, G., Hill, L., Jankowska, E., Lainscak, M., Lopatin, Y., Lund, L. H., Mebazaa, A., Metra, M., Moura, B., Rosano, G., Thum, T., Voors, A., Coats, A. J. (2022). "Biomarkers for the prediction of heart failure and cardiovascular events in patients with type 2 diabetes: A position statement from the Heart Failure Association of the European Society of Cardiology." European Journal of Heart Failure 24(7): 1162-1170. doi: 10.1002/ejhf.2575 https://onlinelibrary.wiley.com/doi/10.1002/ejhf.2575 - Open Access
  • Sewald, K., Danov, O. (2022). Infection of Human Precision-Cut Lung Slices with the Influenza Virus. Asthma: Methods and Protocols. Gorska, M. M. New York, NY, Humana 2506: 119-134.
  • Sparreman Mikus, M., Kolmert, J., Andersson, L. I., Ostling, J., Knowles, R. G., Gomez, C., Ericsson, M., Thorngren, J. O., Emami Khoonsari, P., Dahlen, B., Kupczyk, M., De Meulder, B., Auffray, C., Bakke, P. S., Beghe, B., Bel, E. H., Caruso, M., Chanez, P., Chawes, B., Fowler, S. J., Gaga, M., Geiser, T., Gjomarkaj, M., Horvath, I., Howarth, P. H., Johnston, S. L., Joos, G., Krug, N., Montuschi, P., Musial, J., Nizankowska-Mogilnicka, E., Olsson, H. K., Papi, A., Rabe, K. F., Sandstrom, T., Shaw, D. E., Siafakas, N. M., Uhlen, M., Riley, J. H., Bates, S., Middelveld, R. J. M., Wheelock, C. E., Chung, K. F., Adcock, I. M., Sterk, P. J., Djukanovic, R., Nilsson, P., Dahlen, S. E., James, A., U Biopred Study Group, BIOAIR Consortium (2022). "Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation." European Respiratory Journal 59(2). doi: 10.1183/13993003.00142-2021 https://erj.ersjournals.com/content/59/2/2100142.long - Open Access
  • Teigeler, M., Schaudien, D., Bohmer, W., Lange, R., Schafers, C. (2022). "Effects of the Gestagen Levonorgestrel in a Life Cycle Test with Zebrafish (Danio rerio)." Environmental Toxicology and Chemistry 41(3): 580-591. doi: 10.1002/etc.5008 https://setac.onlinelibrary.wiley.com/doi/10.1002/etc.5008 - Open Access
  • Thum, T. (2022). "Orchestration of vascular smooth muscle cell plasticity using epigenetic therapy." European Heart Journal [Epub ahead of print]. doi: 10.1093/eurheartj/ehac200 https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehac200/6572530 - Open Access
  • Tschiche, H. R., Bierkandt, F. S., Creutzenberg, O., Fessard, V., Franz, R., Giese, B., Greiner, R., Haas, K. H., Haase, A., Hartwig, A., Hund‑Rinke, K., Iden, P., Kromer, C., Loeschner, K., Mutz, D., Rakow, A., Rasmussen, K., Rauscher, H., Richter, H., Schoon, J., Schmid, O., Som, C., M.Tovar, G. E., Westerhoff, P., Wohlleben, W., Luch, A., Laux, P. (2022). "Environmental considerations and current status of grouping and regulation of engineered nanomaterials." Environmental Nanotechnology, Monitoring & Management 18: 100707. doi: 10.1016/j.enmm.2022.100707 https://www.sciencedirect.com/science/article/pii/S2215153222000678 - Open Access
  • Tschiche, H. R., Bierkandt, F. S., Creutzenberg, O., Fessard, V., Franz, R., Greiner, R., Gruber-Traub, C., Haas, K. H., Haase, A., Hartwig, A., Hesse, B., Hund-Rinke, K., Iden, P., Kromer, C., Loschner, K., Mutz, D., Rakow, A., Rasmussen, K., Rauscher, H., Richter, H., Schoon, J., Schmid, O., Som, C., Spindler, L. M., Tovar, G. E. M., Westerhoff, P., Wohlleben, W., Luch, A., Laux, P. (2022). "Analytical and toxicological aspects of nanomaterials in different product groups: Challenges and opportunities." NanoImpact [Epub ahead of print]: 100416. doi: 10.1016/j.impact.2022.100416 https://www.sciencedirect.com/science/article/pii/S2452074822000386?via%3Dihub - Open Access
  • Vajen, B., Bhowmick, R., Greiwe, L., Schaffer, V., Eilers, M., Reinkens, T., Stalke, A., Schmidt, G., Fiedler, J., Thum, T., DeLuca, D. S., Hickson, I. D., Schlegelberger, B., Illig, T., Skawran, B. (2022). "MicroRNA-449a Inhibits Triple Negative Breast Cancer by Disturbing DNA Repair and Chromatid Separation." Int J Mol Sci 23(9): 14 p. doi: 10.3390/ijms23095131 https://www.mdpi.com/1422-0067/23/9/5131 - Open Access
  • van der Velden, J., Asselbergs, F. W., Bakkers, J., Batkai, S., Bertrand, L., Bezzina, C. R., Bot, I., Brundel, B., Carrier, L., Chamuleau, S., Ciccarelli, M., Dawson, D., Davidson, S. M., Dendorfer, A., Duncker, D. J., Eschenhagen, T., Fabritz, L., Falcao-Pires, I., Ferdinandy, P., Giacca, M., Girao, H., Gollmann-Tepekoylu, C., Gyongyosi, M., Guzik, T. J., Hamdani, N., Heymans, S., Hilfiker, A., Hilfiker-Kleiner, D., Hoekstra, A. G., Hulot, J. S., Kuster, D. W. D., van Laake, L. W., Lecour, S., Leiner, T., Linke, W. A., Lumens, J., Lutgens, E., Madonna, R., Maegdefessel, L., Mayr, M., van der Meer, P., Passier, R., Perbellini, F., Perrino, C., Pesce, M., Priori, S., Remme, C. A., Rosenhahn, B., Schotten, U., Schulz, R., Sipido, K., Sluijter, J. P. G., van Steenbeek, F., Steffens, S., Terracciano, C. M., Tocchetti, C. G., Vlasman, P., Yeung, K. K., Zacchigna, S., Zwaagman, D., Thum, T. (2022). "Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC working group on myocardial function and the ESC Working Group on Cellular Biology of the Heart." Cardiovascular Research [Epub ahead of print]. doi: 10.1093/cvr/cvab370 https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvab370/6499268
  • Voskrebenzev, A., Kaireit, T. F., Klimeš, F., Pöhler, G. H., Behrendt, L., Biller, H., Berschneider, K., Wacker, F., Welte, T., Hohlfeld, J. M., Vogel-Claussen, J. (2022). "PREFUL MRI Depicts Dual Bronchodilator Changes in COPD: A Retrospective Analysis of a Randomized Controlled Trial." Radiology: Cardiothoracic Imaging 4(2): e210147. doi: 10.1148/ryct.210147 https://pubs.rsna.org/doi/full/10.1148/ryct.210147 - Open Access
  • Vrijenhoek, N. G., Wehr, M. M., Kunnen, S. J., Wijaya, L. S., Callegaro, G., Mone, M. J., Escher, S. E., Van de Water, B. (2022). "Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid." Altex 39(2): 207-220. doi: 10.14573/altex.2107261 https://www.altex.org/index.php/altex/article/view/2334 - Open Access
  • Wall, J., Seleci, D. A., Schworm, F., Neuberger, R., Link, M., Hufnagel, M., Schumacher, P., Schulz, F., Heinrich, U., Wohlleben, W., Hartwig, A. (2022). "Comparison of Metal-Based Nanoparticles and Nanowires: Solubility, Reactivity, Bioavailability and Cellular Toxicity." Nanomaterials (Basel) 12(1): 147. doi: 10.3390/nano12010147 https://www.mdpi.com/2079-4991/12/1/147 - Open Access
  • Waqas, S. F., Sohail, A., Nguyen, A. H. H., Usman, A., Ludwig, T., Wegner, A., Malik, M. N. H., Schuchardt, S., Geffers, R., Winterhoff, M., Merkert, S., Martin, U., Olmer, R., Lachmann, N., Pessler, F. (2022). "ISG15 deficiency features a complex cellular phenotype that responds to treatment with itaconate and derivatives." Clin Transl Med 12(7): e931. doi: 10.1002/ctm2.931 https://onlinelibrary.wiley.com/doi/10.1002/ctm2.931 - Open Access
  • Wege, A. K., Rom-Jurek, E. M., Jank, P., Denkert, C., Ugocsai, P., Solbach, C., Blohmer, J. U., Sinn, B., van Mackelenbergh, M., Mobus, V., Trumpp, A., Marangoni, E., Pfarr, N., Irlbeck, C., Warfsmann, J., Polzer, B., Weber, F., Ortmann, O., Loibl, S., Vladimirova, V., Brockhoff, G. (2022). "mdm2 gene amplification is associated with luminal breast cancer progression in humanized PDX mice and a worse outcome of estrogen receptor positive disease." International Journal of Cancer 150(8): 1357-1372. doi: 10.1002/ijc.33911 https://onlinelibrary.wiley.com/doi/10.1002/ijc.33911 - Open Access
  • Wehr, M. M., Sarang, S. S., Rooseboom, M., Boogaard, P. J., Karwath, A., Escher, S. E. (2022). "RespiraTox - Development of a QSAR model to predict human respiratory irritants." Regulatory Toxicology and Pharmacology 128: 105089. doi: 10.1016/j.yrtph.2021.105089 https://www.sciencedirect.com/science/article/abs/pii/S0273230021002300?via%3Dihub
  • Wessely, B., Stintz, M., Nolde, J., Creutzenberg, O. (2022). "Experimental Study on the Transport and Alteration Behavior of Aerosols From Low Density Powders for Acute Inhalation Toxicology Studies." Front Public Health 10: 907202. doi: 10.3389/fpubh.2022.907202 https://www.frontiersin.org/articles/10.3389/fpubh.2022.907202/full - Open Access
  • Wienhold, S.-M., Brack, M. C., Nouailles, G., Krishnamoorthy, G., Korf, I. H. E., Seitz, C., Wienecke, S., Dietert, K., Gurtner, C., Kershaw, O., Gruber, A. D., Ross, A., Ziehr, H., Rohde, M., Neudecker, J., Lienau, J., Suttorp, N., Hippenstiel, S., Hocke, A. C., Rohde, C., Witzenrath, M. (2022). "Preclinical Assessment of Bacteriophage Therapy against Experimental Acinetobacter baumannii Lung Infection." Viruses 14(1): 33. doi: 10.3390/v14010033 https://www.mdpi.com/1999-4915/14/1/33 - Open Access
  • Wulff, A., Mast, M., Bode, L., Rathert, H., Jack, T., Elise Study Group (2022). Towards an Evolutionary Open Pediatric Intensive Care Dataset in the ELISE Project. In: Advances in Informatics, Management and Technology in Healthcare. Mantas, J., Gallos, P., Zoulias, E. et al., IOS Press. 295: 100-103. https://ebooks.iospress.nl/doi/10.3233/SHTI220670
  • Yang Zhou, J., Werner, J. M., Glehr, G., Geissler, E. K., Hutchinson, J. A., Kronenberg, K. (2022). "Identification and Isolation of Type II NKT Cell Subsets in Human Blood and Liver." Frontiers in Immunology 13: 898473. doi: 10.3389/fimmu.2022.898473 https://www.frontiersin.org/articles/10.3389/fimmu.2022.898473/full - Open Access
  • Yilmaz-Bayraktar, S., Foremny, K., Kreienmeyer, M., Warnecke, A., Doll, T. (2022). "Medical-Grade Silicone Rubber-Hydrogel-Composites for Modiolar Hugging Cochlear Implants." Polymers (Basel) 14(9): 19 p. doi: 10.3390/polym14091766 https://www.mdpi.com/2073-4360/14/9/1766 - Open Access