Fraunhofer Institute for Toxicology and Experimental MedicineRecent publications
Behr, J., Gunther, A., Bonella, F., Geissler, K., Koschel, D., Kreuter, M., Prasse, A., Schonfeld, N., Sitter, H., Muller-Quernheim, J., Costabel, U.:
German Guideline for Idiopathic Pulmonary Fibrosis - Update on Pharmacological Therapies 2017.
Pneumologie (2018) [Epub ahead of print]
doi: 10.1055/s-0043-123035
https://www.thieme-connect.com/DOI/DOI?10.1055/s-0043-123035
Gutberlet, M., Kaireit, T. F., Voskrebenzev, A., Lasch, F., Freise, J., Welte, T., Wacker, F., Hohlfeld, J. M., Vogel-Claussen, J.:
Free-breathing Dynamic (19)F Gas MR Imaging for Mapping of Regional Lung Ventilation in Patients with COPD.
Radiology, Vol. 286 (2018), No. 3, pp. 1040-1051
doi: 10.1148/radiol.2017170591
http://pubs.rsna.org/doi/10.1148/radiol.2017170591
Happle, C., Jirmo, A. C., Meyer-Bahlburg, A., Habener, A., Hoymann, H. G., Hennig, C., Skuljec, J., Hansen, G.:
B cells control maternofetal priming of allergy and tolerance in a murine model of allergic airway inflammation.
Journal of Allergy and Clinical Immunology, Vol. 141 (2018), No. 2, pp. 685-696 e686.
doi: 10.1016/j.jaci.2017.03.051
https://www.sciencedirect.com/science/article/pii/S009167491730920X?via%3Dihub
Hohlfeld, J. M., Vogel-Claussen, J., Biller, H., Berliner, D., Berschneider, K., Tillmann, H. C., Hiltl, S., Bauersachs, J., Welte, T.:
Effect of lung deflation with indacaterol plus glycopyrronium on ventricular filling in patients with hyperinflation and COPD (CLAIM): a double-blind, randomised, crossover, placebo-controlled, single-centre trial.
Lancet Respir Med (2018) [Epub ahead of print].
doi: 10.1016/S2213-2600(18)30054-7
http://www.thelancet.com/journals/lanres/article/PIIS2213-2600(18)30054-7/fulltext
Hücker, S. M., Vanderhaeghen, S., Abellan-Schneyder, I., Wecko, R., Simon, S., Scherer, S., Neuhaus, K.:
A novel short L-arginine responsive protein-coding gene (laoB) antiparallel overlapping to a CadC-like transcriptional regulator in Escherichia coli O157:H7 Sakai originated by overprinting.
BMC Evolutionary Biology, Vol. 18 (2018), No. 1, p. 21
doi: 10.1186/s12862-018-1134-0
https://bmcevolbiol.biomedcentral.com/articles/10.1186/s12862-018-1134-0
Juling, S., Bohmert, L., Lichtenstein, D., Oberemm, A., Creutzenberg, O., Thunemann, A. F., Braeuning, A., Lampen, A.:
Comparative proteomic analysis of hepatic effects induced by nanosilver, silver ions and nanoparticle coating in rats.
Food and Chemical Toxicology, Vol. 113 (2018), pp. 255-266.
doi: 10.1016/j.fct.2018.01.056
https://www.sciencedirect.com/science/article/pii/S0278691518300620?via%3Dihub
Laux, P., Tentschert, J., Riebeling, C., Braeuning, A., Creutzenberg, O., Epp, A., Fessard, V., Haas, K. H., Haase, A., Hund-Rinke, K., Jakubowski, N., Kearns, P., Lampen, A., Rauscher, H., Schoonjans, R., Stormer, A., Thielmann, A., Muhle, U., Luch, A.:
Nanomaterials: certain aspects of application, risk assessment and risk communication.
Archives of Toxicology, Vol. 92 (2018), No. 1, pp. 121-141
doi: 10.1007/s00204-017-2144-1
https://link.springer.com/article/10.1007%2Fs00204-017-2144-1
Neehus, A. L., Lam, J., Haake, K., Merkert, S., Schmidt, N., Mucci, A., Ackermann, M., Schubert, M., Happle, C., Kühnel, M. P., Blank, P., Philipp, F., Goethe, R., Jonigk, D., Martin, U., Kalinke, U., Baumann, U., Schambach, A., Roesler, J., Lachmann, N.:
Impaired IFNgamma-Signaling and Mycobacterial Clearance in IFNgammaR1-Deficient Human iPSC-Derived Macrophages.
Stem Cell Reports, Vol. 10 (2018), No. 1, pp. 7-16
doi: 10.1016/j.stemcr.2017.11.011 - Open Access
http://www.cell.com/stem-cell-reports/fulltext/S2213-6711(17)30518-0
Neuhaus, V., Danov, O., Konzok, S., Obernolte, H., Dehmel, S., Braubach, P., Jonigk, D., Fieguth, H.-G., Zardo, P., Warnecke, G., Martin, C., Braun, A., Sewald, K.:
Assessment of the cytotoxic and immunomodulatory effects of substances in human precision-cut lung slices.
JoVE (2017) [Epub ahead of print]
doi: https://www.jove.com/video/57042/assessment-cytotoxic-immunomodulatory-effects-substances-human
Schwotzer, D., Niehof, M., Schaudien, D., Kock, H., Hansen, T., Dasenbrock, C., Creutzenberg, O.:
Cerium oxide and barium sulfate nanoparticle inhalation affects gene expression in alveolar epithelial cells type II.
Journal of Nanobiotechnology, Vol. 16 (2018), Vol. 1, p. 16
doi: 10.1186/s12951-018-0343-4 - Open Access
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-018-0343-4
Toropova, A. P., Toropov, A. A., Marzo, M., Escher, S. E., Dorne, J. L., Georgiadis, N., Benfenati, E.:
The application of new HARD-descriptor available from the CORAL software to building up NOAEL models.
Food and Chemical Toxicology, Vol. 112 (2018), pp. 544-550
doi: 10.1016/j.fct.2017.03.060
https://www.sciencedirect.com/science/article/pii/S0278691517301631?via%3Dihub
Ulmer, A., Dietz, K., Werner-Klein, M., Hafner, H. M., Schulz, C., Renner, P., Weber, F., Breuninger, H., Rocken, M., Garbe, C., Fierlbeck, G., Klein, C. A.:
The sentinel lymph node spread determines quantitatively melanoma seeding to non-sentinel lymph nodes and survival.
European Journal of Cancer, Vol. 91 (2018), pp. 1-10
doi: 10.1016/j.ejca.2017.12.002
https://www.sciencedirect.com/science/article/pii/S0959804917314582?via%3Dihub
Werner-Klein, M., Scheitler, S., Hoffmann, M., Hodak, I., Dietz, K., Lehnert, P., Naimer, V., Polzer, B., Treitschke, S., Werno, C., Markiewicz, A., Weidele, K., Czyz, Z., Hohenleutner, U., Hafner, C., Haferkamp, S., Berneburg, M., Rummele, P., Ulmer, A., Klein, C. A.:
Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma.
Nat Commun, Vol. 9 (2018), No. 1, p. 595
doi: 10.1038/s41467-017-02674-y - Open Access
https://www.nature.com/articles/s41467-017-02674-y
Wise, S. K., Lin, S. Y., Toskala, E., Orlandi, R. R., Akdis, C. A., Alt, J. A., Azar, A., Baroody, F. M., Bachert, C., Canonica, G. W., Chacko, T., Cingi, C., Ciprandi, G., Corey, J., Cox, L. S., Creticos, P. S., Custovic, A., Damask, C., DeConde, A., DelGaudio, J. M., Ebert, C. S., Eloy, J. A., Flanagan, C. E., Fokkens, W. J., Franzese, C., Gosepath, J., Halderman, A., Hamilton, R. G., Hoffman, H. J., Hohlfeld, J. M., Houser, S. M., Hwang, P. H., Incorvaia, C., Jarvis, D., Khalid, A. N., Kilpelainen, M., Kingdom, T. T., Krouse, H., Larenas-Linnemann, D., Laury, A. M., Lee, S. E., Levy, J. M., Luong, A. U., Marple, B. F., McCoul, E. D., McMains, K. C., Melen, E., Mims, J. W., Moscato, G., Mullol, J., Nelson, H. S., Patadia, M., Pawankar, R., Pfaar, O., Platt, M. P., Reisacher, W., Rondon, C., Rudmik, L., Ryan, M., Sastre, J., Schlosser, R. J., Settipane, R. A., Sharma, H. P., Sheikh, A., Smith, T. L., Tantilipikorn, P., Tversky, J. R., Veling, M. C., Wang, Y., Westman, M., Wickman, M., Zacharek, M.:
International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis.
Int Forum Allergy Rhinol, Vol. 8 (2018), No. 2, pp. 108-352
doi: 10.1002/alr.22073
http://onlinelibrary.wiley.com/doi/10.1002/alr.22073/abstract
Yu, Y., Schleich, K., Yue, B., Ji, S., Lohneis, P., Kemper, K., Silvis, M. S., Qutob, N., van Rooijen, E., Werner-Klein, M., Li, L., Dhawan, D., Meierjohann, S., Reimann, M., Elkahloun, A., Treitschke, S., Dorken, B., Speck, C., Mallette, F. A., Zon, L. I., Holmen, S. L., Peeper, D. S., Samuels, Y., Schmitt, C. A., Lee, S.:
Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.
Cancer Cell, Vol. 33 (2018), No. 2, pp. 322-336 e328
doi: 10.1016/j.ccell.2018.01.002
https://www.sciencedirect.com/science/article/pii/S1535610818300023?via%3Dihub
Oltmanns, J., Licht, O., Bitsch, A., Bohlen, M. L., Escher, S. E., Silano, V., MacLeod, M., Serafimova, R., Kass, G. E. N., Merten, C.:
Development of a novel scoring system for identifying emerging chemical risks in the food chain.
Environ Sci Process Impacts, Vol. 20 (2018), No. 2, pp. 340-353
doi: 10.1039/c7em00564d
http://pubs.rsc.org/en/Content/ArticleLanding/2018/EM/C7EM00564D#!divAbstract
Hoffmann, M., Pasch, S., Schamberger, T., Maneck, M., Möhlendick, B., Schumacher, S., Brockhoff, G., Knoefel, WT., Izbicki, J., Polzer, B., Stoecklein, N. H., Klein, C. A.:
Diagnostic pathology of early systemic cancer: ERBB2 gene amplification in single disseminated cancer cells determines patient survival in operable esophageal cancer.
Int J Cancer, Vol. 142 (2018), No. 4, pp. 833-843
doi: 10.1002/ijc.31108
Epub 2017 Nov 30
Lorentzen, A., Becker, P. F., Kosla, J., Saini, M., Weidele, K., Ronchi, P., Klein, C., Wolf, M. J., Geist, F., Seubert, B., Ringelhan, M., Mihic-Probst, D., Esser, K., Roblek, M., Kuehne, F., Bianco, G., O´Connor, T., Müller, Q., Schuck, K., Lange, S., Hartmann, D., Spaich, S., Groß, O., Utikal, J., Haferkamp, S., Sprick, M. R., Damle-Vartak, A., Hapfelmeier, A., Hüser, N., Protzer, U., Trumpp, A., Saur, D., Vartak, N., Klein, C. A., Polzer, B., Borsig, L. & Heikenwalder, M.:
Single cell polarity in liquid phase facilitates tumour metastasis.
Nature Communications, Vol. 887 (2018), No. 9
doi: 10.1038/s41467-018-03139-6
https://www.nature.com/articles/s41467-018-03139-6 (for pdf please see http://rdcu.be/HYBy)