Fraunhofer Institute for Toxicology and Experimental Medicine
Fraunhofer Institute for Toxicology and Experimental Medicine

Fraunhofer ITEM publications

 

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All scientific Fraunhofer publications can be found via the publications database of the Fraunhofer-Gesellschaft.

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Fraunhofer ITEM publications per year

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Recent publications

Below please find recent publications by Fraunhofer ITEM scientists, sorted by subject area.

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R&D expertise "Lung research"

  • Behr, J., Prasse, A., Wirtz, H., Koschel, D., Pittrow, D., Held, M., Klotsche, J., Andreas, S., Claussen, M., Grohe, C., Wilkens, H., Hagmeyer, L., Skowasch, D., Meyer, J. F., Kirschner, J., Glaser, S., Neurohr, C., Schwaiblmair, M., Buschulte, K., Veit, T., Frankenberger, M., Ryerson, C. J., Johannson, K. A., Marcoux, V., Fisher, J. H., Assayag, D., Manganas, H., Khalil, N., Kolb, M., Kreuter, M. (2026). "Risk stratification as a guide to goal-oriented management of patients with fibrotic interstitial lung disease: a registry-based analysis." ERJ Open Res 12(1). doi: 10.1183/23120541.00570-2025 - Open Access 
  • Carstensen-Aureche, S., Litzenburger, T., De Sousa, D., Sailer, R., Benediktus, E., Delic, D., Müller, F., Müller, M., Hohlfeld, J. M. (2026). "Safety, tolerability, pharmacokinetics and pharmacodynamics of the spleen tyrosine kinase inhibitor BI 894416 in healthy volunteers and patients with asthma." British Journal of Pharmacology [Epub ahead of print]. doi: 10.1111/bph.70329  - Open Access
  • Christian, L., Yilmaz, H., Ruwisch, J., Giercke, L., Seeliger, B., Kamp, J. C., Bayraktar, S., Ewen, R., Graalmann, T., Fuge, J., Greer, M., Ius, F., Welte, T., Liao, S. Y., Yang, I. V., Hohlfeld, J. M., Hoeper, M. M., Gottlieb, J., Kaminski, N., Prasse, A., Jonigk, D., Li, Y., Falk, C., Neubert, L., Schupp, J. C. (2026). "Spatial Transcriptomics Uncovers Hybrid, Pro-Inflammatory and Pro-Fibrotic Cellular Niches in Pulmonary Granuloma of Patients with Chronic Sarcoidosis." American Journal of Respiratory and Critical Care Medicine [Epub ahead of print]. doi: 10.1093/ajrccm/aamaf089  - Open Access 
  • Gentemann, L., Ropken, F., Mroch, P. J., Noltemeyer, N., Donath, S., Seidler, A. E., Werlein, C., Zardo, P., Neubert, L., Jonigk, D., Fieguth, H. G., Heisterkamp, A., Sewald, K., Kalies, S. (2026). "Live imaging of human airway epithelial repair in precision-cut lung slices after targeted cell damage." Biochem Biophys Rep 45: 102470. doi: 10.1016/j.bbrep.2026.102470  - Open Access 
  • Glandorf, J., Klein, M. M., Klimes, F., Kern, A. L., Gutberlet, M., Hohlfeld, J. M., Hoeper, M. M., Olsson, K. M., Wacker, F., Vogel-Claussen, J., Voskrebenzev, A. (2026). "Analysis of Pulsatile Vessel Expansion in Healthy, COPD-and PH-Patients Using Dynamic Vessel Segmentation in Free-Breathing Lung MRI." Journal of Magnetic Resonance Imaging [Epub ahead of print]. doi: 10.1002/jmri.70249  - Open Access
  • Gress, C., Müller, M., Hohlfeld, J. M. (2026). "Proteomic profiling of bronchoalveolar lavage following human segmental endotoxin challenge-a potential exacerbation model." Scientific Reports 16(1): 6145. doi: 10.1038/s41598-026-39528-x - Open Access 
  • Leuschner, G., Prasse, A., Klotsche, J., Kreuter, M., Wirtz, H., Pittrow, D., Frankenberger, M., Behr, J. (2026). "Sex Differences in IPF: Data from the German INSIGHTS Registry." Respiration [Epub ahead of print]: 1-10. doi: 10.1159/000550309 
  • Struss, N., Badorrek, P., Schwarz, K., Windt, H., Straff, W., Hoflich, C., Hohlfeld, J. M. (2026). "Determining the Threshold Concentration of Birch Pollen for Inducing Allergic Symptoms Using an Allergen Challenge Chamber." International Archives of Allergy and Immunology 187(2): 103-112. doi: 10.1159/000545509 - Open Access 

R&D expertise "Toxicology"

  • Bruer, G. G., Janssen, P., Schaudien, D., Ramazanoglu, M., Kryjewska, M., Hansen, T., de Aquino, E. L. S., Creutzenberg, O. (2026). "Identification of diniobium pentaoxide as a novel nuisance dust in a 90-day nose-only inhalation study." Inhalation Toxicology [Epub ahead of print]: 1-11. doi: 10.1080/08958378.2026.2625804 - Open Access
  • Hadrup, N., Sorli, J. B., Frederiksen, M., Sharma, A. K., Kafert-Kasting, S., Schuchardt, S., Bitsch, A., Clausen, P. A., Saber, A. T., Vogel, U., Hougaard, K. S. (2026). "Oil mists and vapours: A review of exposure and toxicity, with dose descriptors from inhalation studies." Toxicology 519: 154314. doi: 10.1016/j.tox.2025.154314  - Open Access 
  • Henning, T., Goerdeler, C., El-Khatib, A. H., Meyer, K., Bruer, G. G., Abraham, K., Monien, B. H. (2026). "Characterization and quantitation of urinary metabolites of 3-monochloropropane-1,2-diol (3-MCPD) in rats." Archives of Toxicology [Epub ahead of print]. doi: 10.1007/s00204-026-04318-x  - Open Access 
  • Irwan, J., Kass, G. E. N., Kellner, R., Nathanail, A. V., Simetska, N., Wehr, M. M., Escher, S. E. (2025). "Bridging the gap in chemical risk assessment: Leveraging metabolite similarity for enhanced read-across applications." Altex [Epub ahead of print]. doi: 10.14573/altex.2508271  - Open Access
  • Marx-Stoelting, P., Ritz, V., Herzler, M., Kneuer, C., Aiello-Holden, K., Brescia, S., Escher, S. E., Feustel, S., Fritsche, E., Gebel, J., Kenny, E. F., Landsiedel, R., Sanders, P., Schwarz, M., Streitz, M., Testai, E., van Ravenzwaay, B., Waetjen, W., Wend, K., Wilks, M., Luch, A., Tralau, T., Hensel, A. (2026). "Regulation of chemicals demands assessment of risks rather than identification of hazards only." Archives of Toxicology [Epub ahead of print]. doi: 10.1007/s00204-026-04307-0  - Open Access 
  • Moller, P., Ladeira, C., Ziemann, C., Knasmueller, S., Misik, M., Louro, H., Silva, M. J., Olsen, A. K., Azqueta, A., Langie, S. A. S., Bonassi, S., Dusinska, M., Gajski, G., Collins, A. (2026). "Towards a validation of the standard and enzyme-linked comet assay: a retrospective variability analysis." Archives of Toxicology 100(4): 1275-1300. doi: 10.1007/s00204-026-04317-y -
  • Ravi Shankar, A. L., Irwan, J., Spaenig, M., Carlier, M., Hansen, T., Zumbulte, N., Islam, B., Lundquist, P., Svensson, R., Gouin, T., Hamers, T., Escher, S. E. (2026). "Extrapolation of in vitro effect concentrations to in vivo bioavailable concentrations using PBK modelling in humans for two classes of persistent and mobile compounds: triazoles and triazines." Archives of Toxicology [Epub ahead of print]. doi: 10.1007/s00204-025-04268-w  - Open Access 
  • Spaenig, M., Vogel, M., Hansen, T., Elenschneider, L., Londenberg, A., Whomsley, R., Deppenmeier, U., Escher, S. E. (2026). "Estimation of bioavailable concentration of endogenously formed N-nitrosamines by physiologically based kinetic modelling." Altex 43(1): 49-64. doi: 10.14573/altex.2412061 - Open Access
  • Sündermann, J., Reamon-Buettner, S. M., Wilde, S., Bitsch, A., Ziemann, C. (2026). "The nitrovinyl moiety determines the cyto- and genotoxic profiles of beta-nitrostyrene derivatives: evidence from in silico and in vitro evaluation." Archives of Toxicology [Epub ahead of print]. doi: 10.1007/s00204-026-04349-4  - Open Access 
  • Wagner, A., Schulz, F., Meyer-Plath, A., Dahlmann, F., Rittinghausen, S., Schaudien, D. (2026). "Impact of carbon-based fibers morphologies on their carcinogenic potential." Particle and Fibre Toxicology [Epub ahead of print]. doi: 10.1186/s12989-026-00663-y  - Open Access   
  • Weber, K., Hayes, A. W., Schaudien, D., de Miguel, R. (2025). "Editorial: Advances in non-clinical and translational studies: cutting-edge study designs, special technologies, routine pitfalls, background findings and control data." Front Vet Sci 12: 1743861. doi: 10.3389/fvets.2025.1743861 - Open Access 
  • Yamano, S., Schaudien, D., Umeda, Y. (2026). "The Pneumoconiosis Renaissance: Revisiting the Pulmonary Pathology of Poorly Soluble Low Toxicity Particles: Insights from Rodent Inhalation Studies on Titanium Dioxide Nanoparticles." Nanomaterials (Basel) 16(4). doi: 10.3390/nano16040230  - Open Access 

R&D expertise "Malignant disease research"

  • Alves-de-Lima, J., Pukrop, T., Blazquez, R. (2026). "Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection." J Vis Exp227 [Epub ahead of print](227). doi: 10.3791/69415  - Open Access 
  • Böttcher, M., Reemts, L., Hengeveld, P. J., Bottcher-Loschinski, R., Bhuria, V., Lu, J., Materna-Reichelt, S., Das, D., Stojanovic Guzvic, N., Bruns, H., Huber, W., Zenz, T., Schanze, D., Zenker, M., Dietrich, S., Langerak, A. W., Mougiakakos, D. (2026). "Immunoglobulin heavy-chain status and stromal interactions shape ferroptosis sensitivity in chronic lymphocytic leukemia." Signal Transduct Target Ther 11(1): 3. doi: 10.1038/s41392-025-02535-x  - Open Access 
  • Harrer, D. C., Lüke, F., Pukrop, T., Ghibelli, L., Reichle, A., Heudobler, D. (2026). "Genome agnostic, multi-level non-oncogene addiction-based systems pharmacology for rescuing metastatic relapsed/refractory neoplasias." Frontiers in Pharmacology 17: 1629187. doi: 10.3389/fphar.2026.1629187  - Open Access 
  • Harrer, D. C., Lüke, F., Pukrop, T., Reichle, A., Heudobler, D. (2026). "Genome Agnostic Reprogramming of Acute Myelocytic Leukemia Hallmarks by Targeting Non-Oncogene Addictions with Azacitidine Plus Pioglitazone and All-Trans Retinoic Acid." Int J Mol Sci 27(2). doi: 10.3390/ijms27021067 - Open Access
  • Komljenovic, D., Bauerle, T., Alves-de-Lima, J., Trigueros, L., Dietz, C., Winter, Z., Araceli, T., Strotzer, Q., Wendl, C., Brendel, M., Proescholdt, M. A., Harter, P. N., Evert, K., Pukrop, T., Blazquez, R. (2026). "Local metastatic expansion versus secondary intra-organ dissemination: two causes of neurological death explained by fundamentally different metastatic colonization patterns." Molecular Cancer 25(1): 17. doi: 10.1186/s12943-026-02574-0  - Open Access 
  • Weidele, K., Werno, C., Treitschke, S., Botteron, C., Hoffmann, M., Scheitler, S., Wohrl, L., Czyz, Z., Feliciello, G., Weber, F., Ravikumar Varadarajan, A., Warfsmann, J., Materna-Reichelt, S., Katzer, M., Schreieder, L., Mohammadi, P., Hosseini, H., Honarnejad, K., Haferkamp, S., Werner-Klein, M., Klein, C. A. (2026). "Micrometastasis-derived models enable drug testing for early-stage, high-risk melanoma patients." EMBO Molecular Medicine 18(1): 297-324. doi: 10.1038/s44321-025-00339-8 - Open Access 

R&D expertise "Medical and pharmaceutical engineering"

  • Nguyen, M.-H., Singla, P., Dann, A., Tran, T. H., Sündermann, J., Kreienmeyer, M., Schmitt, H., Butterbrodt, T., Schwarz, T., Schwieger, J., Scheper, V., Peeters, M., Wagner, P., Warnecke, A., Kaulen, C., Körner, J., Lenarz, T., Doll, T. (2026). "Intra-cochlear detection of Interleukin-6 using nanoMIPs embedded in a biodegradable matrix." Sensing and Bio-Sensing Research 51. doi: 10.1016/j.sbsr.2026.100990 - Open Access 
  • Rahim, M. I., Baseer, S., Paasch, D., Steglich, M., Waqas, S. F. H., Lachmann, N., Falk, C. S., Stiesch, M. (2026). "Commensal microflora coating endows implants with biofilm-repellent, immunomodulatory and osteogenic properties." Acta Biomater [Epub ahead of print]. doi: 10.1016/j.actbio.2026.01.017  - Open Access  
  • Steinke, J. A., Destruel, P. L., Weiche, B., Dengl, S., Schwach, G., Pohlmann, G., Hinner, M. J. (2026). "Minimizing Aggregates when Nebulizing Antibody Fab Fragments: High Thermostability and High Concentration are Key." European Journal of Pharmaceutical Sciences [Epub ahead of print]: 107446. doi: 10.1016/j.ejps.2026.107446  - Open Access 

R&D expertise "Bioinformatics and AI"

  • Christian, L., Yilmaz, H., Ruwisch, J., Giercke, L., Seeliger, B., Kamp, J. C., Bayraktar, S., Ewen, R., Graalmann, T., Fuge, J., Greer, M., Ius, F., Welte, T., Liao, S. Y., Yang, I. V., Hohlfeld, J. M., Hoeper, M. M., Gottlieb, J., Kaminski, N., Prasse, A., Jonigk, D., Li, Y., Falk, C., Neubert, L., Schupp, J. C. (2026). "Spatial Transcriptomics Uncovers Hybrid, Pro-Inflammatory and Pro-Fibrotic Cellular Niches in Pulmonary Granuloma of Patients with Chronic Sarcoidosis." American Journal of Respiratory and Critical Care Medicine [Epub ahead of print]. doi: 10.1093/ajrccm/aamaf089  - Open Access 
  • Ghaffari, M. H., Sadri, H., Hemmert, K. J., Ostendorf, C. S., Schuchardt, S., Koch, C., Sauerwein, H. (2026). "Longitudinal characterization of fecal lipids in dairy heifers from birth to first calving." Journal of Dairy Science 109(3): 3011-3033. doi: 10.3168/jds.2025-27816  - Open Access 
  • Gress, C., Müller, M., Hohlfeld, J. M. (2026). "Proteomic profiling of bronchoalveolar lavage following human segmental endotoxin challenge-a potential exacerbation model." Scientific Reports 16(1): 6145. doi: 10.1038/s41598-026-39528-x - Open Access 
  • Harrer, D. C., Lüke, F., Pukrop, T., Ghibelli, L., Reichle, A., Heudobler, D. (2026). "Genome agnostic, multi-level non-oncogene addiction-based systems pharmacology for rescuing metastatic relapsed/refractory neoplasias." Frontiers in Pharmacology 17: 1629187. doi: 10.3389/fphar.2026.1629187  - Open Access 
  • Irwan, J., Kass, G. E. N., Kellner, R., Nathanail, A. V., Simetska, N., Wehr, M. M., Escher, S. E. (2025). "Bridging the gap in chemical risk assessment: Leveraging metabolite similarity for enhanced read-across applications." Altex [Epub ahead of print]. doi: 10.14573/altex.2508271  - Open Access
  • Ravi Shankar, A. L., Irwan, J., Spaenig, M., Carlier, M., Hansen, T., Zumbulte, N., Islam, B., Lundquist, P., Svensson, R., Gouin, T., Hamers, T., Escher, S. E. (2026). "Extrapolation of in vitro effect concentrations to in vivo bioavailable concentrations using PBK modelling in humans for two classes of persistent and mobile compounds: triazoles and triazines." Archives of Toxicology [Epub ahead of print]. doi: 10.1007/s00204-025-04268-w  - Open Access 
  • Spaenig, M., Vogel, M., Hansen, T., Elenschneider, L., Londenberg, A., Whomsley, R., Deppenmeier, U., Escher, S. E. (2026). "Estimation of bioavailable concentration of endogenously formed N-nitrosamines by physiologically based kinetic modelling." Altex 43(1): 49-64. doi: 10.14573/altex.2412061 - Open Access
  • Sündermann, J., Reamon-Buettner, S. M., Wilde, S., Bitsch, A., Ziemann, C. (2026). "The nitrovinyl moiety determines the cyto- and genotoxic profiles of beta-nitrostyrene derivatives: evidence from in silico and in vitro evaluation." Archives of Toxicology [Epub ahead of print]. doi: 10.1007/s00204-026-04349-4  - Open Access 

R&D expertise "Immunology and and infection research"

  • Gross, C., Chatterjee, S., Nilsson-Payant, B. E., Stojanovic, S. D., Kefalakes, H., Bär, C., Thum, T., Pietschmann, T., Bauersachs, J., Amanakis, G. (2026). "SARS-CoV-2-infected cardiomyocytes exhibit upregulated necroptosis, but no evidence of mitochondrial permeability transition." J Mol Cell Cardiol Plus 15: 100833. doi: 10.1016/j.jmccpl.2025.100833  - Open Access  
  • La Rocca, V., Filipponi, C., Diesendorf, V., De Carli, A., Sciandrone, G., Nottoli, S., Plicanti, E., Fonnesu, R., Iacono, E., Mengozzi, A., Masi, S., Lenzi, P., Fornai, F., Sewald, K., Obernolte, H., Angelini, R., Bodem, J., Freer, G., Pistello, M., Lai, M. (2026). "N-Acylethanolamine Acid Amidase Inhibition Reduces SARS-CoV-2 Infection in Human Precision Cut-Lung Slices and Downregulates NF-KBB Signalling." Journal of Medical Virology 98(2): e70819. doi: 10.1002/jmv.70819
  • Paasch, D., Schevel, H., Riehle, A., Costa, B., Toufaili, H., Gehnen, T., Dahlmann, J., Pavlou, A., Neehus, A. L., Nguyen, A. H. H., Schiering, E., Buchegger, T., Bustamante, J., Hansen, G., Kalinke, U., Gulbins, E., Grassme, H., Lachmann, N. (2026). "Immune activation and response dynamics of human iPSC-derived macrophages in tuberculosis infection models." Clin Transl Immunology 15(1): e70071. doi: 10.1002/cti2.70071   - Open Access
  • Perkins, E., Cooper, C., Lund, E., Alb, M., Morgan, H., Fogal, B., Hewitt, P., Mazein, A., Ostaszewski, M., Sewald, K. (2025). "Perspective of using in vitro models to understand immunotherapy-induced cytokine release syndrome." Frontiers in Immunology 16: 1732193. doi: 10.3389/fimmu.2025.1732193 - Open Access 
  • Wronski, S., Obernolte, H., Schaudien, D., Braun, A., Sewald, K., Vaslin Chessex, A., Baulier, E., Pasquali, C. (2026). "Prophylactic intranasal administration of bacterial lysate OM-85 mitigates human rhinovirus (RV-A1b) lung infection and inflammation in mice." Antiviral Research [Epub ahead of print]: 106362. doi: 10.1016/j.antiviral.2026.106362  - Open Access  

R&D expertise "RNA technologies"

  • Costa, A., Bär, C. (2026). "piRNA-mediated RNA oxidation as a new route to heart regeneration." Cardiovascular Research [Epub ahead of print]. doi: 10.1093/cvr/cvag005  - Open Access
  • Kiselev, E., Agyapong, W., Jurgens, B., Mohr, E., Chatterjee, S., Hunkler, H. J., Salman, J., Cipriano, G., Bentele, M., Liu, J., Specht, J., Menge, K. S., Waleczek, F. J. G., Haas, J. A., Derda, A. A., Sonnenschein, K., Gietz, A., Neumuller, S., Pfanne, A., Beetz, O., Pflaum, M., Wiegmann, B., Psaras, Y., Toepfer, C., Zweigerdt, R., Radocaj, A., Kraft, T., Zeug, A., Ponimaskin, E., Korte, W., Horke, A., Ruhparwar, A., Fuchs, M., Xiao, K., Bär, C., Weber, N., Thum, T. (2026). "Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy." British Journal of Pharmacology 183(5): 1122-1139. doi: 10.1111/bph.70247 - Open Access 

R&D expertise "Stem Cell Technologies"

  • Fleischauer, J., John-Neek, P., Ha, T. C., Mansel, F., Kosanke, M., Selich, A., Hagedorn, M., Bastone, A. L., Schinke, M., Dziadek, V., Dittrich-Breiholz, O., von Kaisenberg, C., Schambach, A., Rothe, M. (2026). "Ex vivo long-term expansion of human hematopoietic stem and progenitor cells as a tool for modeling vector integration sites and clonality." Journal of Translational Medicine 24(1). doi: 10.1186/s12967-026-07700-6   - Open Access 
  • Paasch, D., Schevel, H., Riehle, A., Costa, B., Toufaili, H., Gehnen, T., Dahlmann, J., Pavlou, A., Neehus, A. L., Nguyen, A. H. H., Schiering, E., Buchegger, T., Bustamante, J., Hansen, G., Kalinke, U., Gulbins, E., Grassme, H., Lachmann, N. (2026). "Immune activation and response dynamics of human iPSC-derived macrophages in tuberculosis infection models." Clin Transl Immunology 15(1): e70071. doi: 10.1002/cti2.70071   - Open Access
  • Saleh, F., Valdivia Malqui, E. E., Gensch, I., Schinke, M., Kappelhoj, M., Nikolouli, E., Nguyen, A. H. H., Jang, M. S., Basilio-Queiros, D., Lachmann, N. (2026). "Harnessing intermediate-scale bioreactors for next-generation macrophage production and application." Nature Protocols [Epub ahead of print]. doi: 10.1038/s41596-025-01313-x 

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