Publications - Fraunhofer ITEM

Publications 2019

MicroRNA-144-3p targets relaxin/insulin-like family peptide receptor 1 (RXFP1) expression in lung fibroblasts from patients with idiopathic pulmonary fibrosis.
Bahudhanapati, H., Tan, J., Dutta, J. A., Strock, S. B., Sembrat, J., Alvarez, D., Rojas, M., Jager, B., Prasse, A., Zhang, Y., Kass, D. J. (2019). Journal of Biological Chemistry 294(13): 5008-5022. doi: 10.1074/jbc.RA118.004910
http://www.jbc.org/content/294/13/5008.long

Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma.
Brinkman, P., Wagener, A. H., Hekking, P. P., Bansal, A. T., Maitland-van der Zee, A. H., Wang, Y., Weda, H., Knobel, H. H., Vink, T. J., Rattray, N. J., D'Amico, A., Pennazza, G., Santonico, M., Lefaudeux, D., De Meulder, B., Auffray, C., Bakke, P. S., Caruso, M., Chanez, P., Chung, K. F., Corfield, J., Dahlen, S. E., Djukanovic, R., Geiser, T., Horvath, I., Krug, N., Musial, J., Sun, K., Riley, J. H., Shaw, D. E., Sandstrom, T., Sousa, A. R., Montuschi, P., Fowler, S. J., Sterk, P. J., Group, U. B. S. (2019). Journal of Allergy and Clinical Immunology 143(5): 1811-1820 e1817. doi: 10.1016/j.jaci.2018.10.058
https://www.sciencedirect.com/science/article/pii/S0091674918317226?via%3Dihub

Novel ETV6-RUNX1 Mouse Model to Study the Role of ELF-MF in Childhood B-Acute Lymphoblastic Leukemia: a Pilot Study.
Campos-Sanchez, E., Vicente-Duenas, C., Rodriguez-Hernandez, G., Capstick, M., Kuster, N., Dasenbrock, C., Sanchez-Garcia, I., Cobaleda, C. (2019). Bioelectromagnetics 40(5): 343-353. doi: 10.1002/bem.22193
https://onlinelibrary.wiley.com/doi/full/10.1002/bem.22193

In vivo detection of circulating tumor cells in high-risk non-metastatic prostate cancer patients undergoing radiotherapy.
Chen, S., Tauber, G., Langsenlehner, T., Schmölzer, L. M., Pötscher, M., Riethdorf, S., Kuske, A., Leitinger, G., Kashofer, K., Czyz, Z. T., Polzer, B., Pantel, K., Sedlmayr, P., Kroneis, T., El-Heliebi, A. (2019). Cancers 11(7): 933. doi: 10.3390/cancers1107093
https://www.mdpi.com/2072-6694/11/7/933 - Open Access

Use of nonhuman primates in obstructive lung disease research-Is it required?
Dahlmann, F., Sewald, K. (2017). Primate Biology 4(1): 131-142. doi: 10.5194/pb-4-131-2017
https://www.primate-biol.net/4/131/2017/

Targeted transcript quantification in single disseminated cancer cells after whole transcriptome amplification.
Durst, F. C., Grujovic, A., Ganser, I., Hoffmann, M., Ugocsai, P., Klein, C. A., Czyz, Z. T. (2019). PloS One 14(8): e0216442. doi: 10.1371/journal.pone.021644
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216442 - Open Access

Characterization of Aerosol Release during Spraying of Isocyanate Products.
Ehnes, C., Genz, M., Duwenhorst, J., Krasnow, J., Bleeke, J., Schwarz, K., Koch, W., Schuchardt, S. (2019). Ann Work Expo Health 63(7): 773-783. doi: 10.1093/annweh/wxz045
https://academic.oup.com/annweh/advance-article-abstract/doi/10.1093/annweh/wxz045/5513789?redirectedFrom=fulltext

Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop.
Ellison, C. A., Blackburn, K. L., Carmichael, P. L., Clewell, H. J., 3rd, Cronin, M. T. D., Desprez, B., Escher, S. E., Ferguson, S. S., Gregoire, S., Hewitt, N. J., Hollnagel, H. M., Klaric, M., Patel, A., Salhi, S., Schepky, A., Schmitt, B. G., Wambaugh, J. F., Worth, A. (2019). Regulatory Toxicology Pharmacology 103: 63-72. doi: 10.1016/j.yrtph.2019.01.016
https://www.sciencedirect.com/science/article/pii/S0273230019300169 - Open Access

Identification and quantification of synthetic cannabinoids in 'spice-like' herbal mixtures: Update of the German situation in summer 2018.
Ernst, L., Langer, N., Bockelmann, A., Salkhordeh, E., Beuerle, T. (2019). Forensic Science International 294: 96-102. doi: 10.1016/j.forsciint.2018.11.001
https://www.sciencedirect.com/science/article/pii/S0379073818307205?via%3Dihub

Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma.
George, L., Taylor, A. R., Esteve-Codina, A., Soler Artigas, M., Thun, G. A., Bates, S., Pavlidis, S., Wagers, S., Boland, A., Prasse, A., Boschetto, P., Parr, D. G., Nowinski, A., Barta, I., Hohlfeld, J., Greulich, T., van den Berge, M., Hiemstra, P. S., Timens, W., Hinks, T., Wenzel, S., Siddiqui, S., Richardson, M., Venge, P., Heath, S., Gut, I., Tobin, M. D., Edwards, L., Riley, J. H., Djukanovic, R., Auffray, C., De-Meulder, B., Erik-Dahlen, S., Adcock, I. M., Chung, K. F., Ziegler-Heitbrock, L., Sterk, P. J., Singh, D., Brightling, C. E., U, B., the Ev, A. s. t. (2019). Allergy [Epub ahead of print]. doi: 10.1111/all.14016
https://onlinelibrary.wiley.com/doi/full/10.1111/all.14016 - Open Access

Paradigm shift in safety assessment using new approach methods: The EU-ToxRisk strategy.
Graepel, R., Ter Braak, B., Escher, S. E., Fisher, C., Gardner, I., Kamp, H., Kroese, D., Leist, M., Moné, M. J., Pastor, M., van de Water, B. (2019). Current Opinion in Toxicology 15: 33-39. doi: 10.1016/j.cotox.2019.03.005
https://www.sciencedirect.com/science/article/pii/S2468202018300688?via%3Dihub

Repeatability of Regional Lung Ventilation Quantification Using Fluorinated ((19)F) Gas Magnetic Resonance Imaging.
Gutberlet, M., Kaireit, T. F., Voskrebenzev, A., Kern, A. L., Obert, A., Wacker, F., Hohlfeld, J. M., Vogel-Claussen, J. (2019). Academic Radiology 26(3): 395-403. doi: 10.1016/j.acra.2018.10.021
https://www.sciencedirect.com/science/article/pii/S1076633218304859?via%3Dihub

Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans.
Heusser, K., Tank, J., Holz, O., May, M., Brinkmann, J., Engeli, S., Diedrich, A., Framke, T., Koch, A., Grosshennig, A., Jan Danser, A. H., Sweep, F., Schindler, C., Schwarz, K., Krug, N., Jordan, J., Hohlfeld, J. M. (2019). Scientific Reports 9(1): 3641. doi: 10.1038/s41598-019-40343-w
https://www.nature.com/articles/s41598-019-40343-w - Open Access

Human ex vivo and in vitro disease models to study food allergy.
Hung, L., Obernolte, H., Sewald, K., Eiwegger, T. (2019). Asia Pac Allergy 9(1): e4. doi: 10.5415/apallergy.2019.9.e4
https://apallergy.org/DOIx.php?id=10.5415/apallergy.2019.9.e4 - Open Access

The rat bone marrow micronucleus test: Statistical considerations on historical negative control data.
Igl, B. W., Bitsch, A., Bringezu, F., Chang, S., Dammann, M., Frotschl, R., Harm, V., Kellner, R., Krzykalla, V., Lott, J., Nern, M., Pfuhler, S., Queisser, N., Schulz, M., Sutter, A., Vaas, L., Vonk, R., Zellner, D., Ziemann, C. (2019). Regulatory Toxicology and Pharmacology 102: 13-22. doi: 10.1016/j.yrtph.2018.12.009
https://www.sciencedirect.com/science/article/pii/S0273230018303167?via%3Dihub

A mouse model for intellectual disability caused by mutations in the X-linked 2'Omethyltransferase Ftsj1 gene.
Jensen, L. R., Garrett, L., Holter, S. M., Rathkolb, B., Racz, I., Adler, T., Prehn, C., Hans, W., Rozman, J., Becker, L., Aguilar-Pimentel, J. A., Puk, O., Moreth, K., Dopatka, M., Walther, D. J., von Bohlen Und Halbach, V., Rath, M., Delatycki, M., Bert, B., Fink, H., Blumlein, K., Ralser, M., Van Dijck, A., Kooy, F., Stark, Z., Muller, S., Scherthan, H., Gecz, J., Wurst, W., Wolf, E., Zimmer, A., Klingenspor, M., Graw, J., Klopstock, T., Busch, D., Adamski, J., Fuchs, H., Gailus-Durner, V., de Angelis, M. H., von Bohlen Und Halbach, O., Ropers, H. H., Kuss, A. W. (2019). Biochim Biophys Acta Mol Basis Dis 1865(9): 2083-2093. doi: 10.1016/j.bbadis.2018.12.011
https://www.sciencedirect.com/science/article/pii/S0925443918304976?via%3Dihub - Open Access

Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation.
Jevnikar, Z., Ostling, J., Ax, E., Calven, J., Thorn, K., Israelsson, E., Oberg, L., Singhania, A., Lau, L. C. K., Wilson, S. J., Ward, J. A., Chauhan, A., Sousa, A. R., De Meulder, B., Loza, M. J., Baribaud, F., Sterk, P. J., Chung, K. F., Sun, K., Guo, Y., Adcock, I. M., Payne, D., Dahlen, B., Chanez, P., Shaw, D. E., Krug, N., Hohlfeld, J. M., Sandstrom, T., Djukanovic, R., James, A., Hinks, T. S. C., Howarth, P. H., Vaarala, O., van Geest, M., Olsson, H., Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes study, g. (2019). Journal of Allergy and Clinical Immunology 143(2): 577-590. doi: 10.1016/j.jaci.2018.05.026
https://www.sciencedirect.com/science/article/pii/S0091674918308479

Regional investigation of lung function and microstructure parameters by localized (129) Xe chemical shift saturation recovery and dissolved-phase imaging: A reproducibility study.
Kern, A. L., Gutberlet, M., Qing, K., Voskrebenzev, A., Klimes, F., Kaireit, T. F., Czerner, C., Biller, H., Wacker, F., Ruppert, K., Hohlfeld, J. M., Vogel-Claussen, J. (2019). Magnetic Resonance in Medicine 81(1): 13-24. doi: 10.1002/mrm.27407
https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.27407

Mapping of regional lung microstructural parameters using hyperpolarized (129) Xe dissolved-phase MRI in healthy volunteers and patients with chronic obstructive pulmonary disease.
Kern, A. L., Gutberlet, M., Voskrebenzev, A., Klimes, F., Rotarmel, A., Wacker, F., Hohlfeld, J. M., Vogel-Claussen, J. (2019). Magnetic Resonance in Medicine 81(4): 2360-2373. doi: 10.1002/mrm.27559
https://onlinelibrary.wiley.com/doi/full/10.1002/mrm.27559

Targeted Repair of p47-CGD in iPSCs by CRISPR/Cas9: Functional Correction without Cleavage in the Highly Homologous Pseudogenes.
Klatt, D., Cheng, E., Philipp, F., Selich, A., Dahlke, J., Schmidt, R. E., Schott, J. W., Buning, H., Hoffmann, D., Thrasher, A. J., Schambach, A. (2019). Stem Cell Reports [Epub ahead of print]. doi: 10.1016/j.stemcr.2019.08.008
https://www.sciencedirect.com/science/article/pii/S2213671119303029?via%3Dihub - Open Access

The clinical course of idiopathic pulmonary fibrosis and its association to quality of life over time: longitudinal data from the INSIGHTS-IPF registry.
Kreuter, M., Swigris, J., Pittrow, D., Geier, S., Klotsche, J., Prasse, A., Wirtz, H., Koschel, D., Andreas, S., Claussen, M., Grohe, C., Wilkens, H., Hagmeyer, L., Skowasch, D., Meyer, J. F., Kirschner, J., Gläser, S., Kahn, N., Welte, T., Neurohr, C., Schwaiblmair, M., Held, M., Bahmer, T., Oqueka, T., Frankenberger, M., Behr, J. (2019). Respiratory Research 20: 59. doi: 10.1186/s12931-019-1020-3
https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-019-1020-3 - Open Access

Contribution of airway eosinophils in airway wall remodeling in asthma: Role of MMP-10 and MET.
Kuo, C. S., Pavlidis, S., Zhu, J., Loza, M., Baribaud, F., Rowe, A., Pandis, I., Gibeon, D., Hoda, U., Sousa, A., Wilson, S. J., Howarth, P., Shaw, D., Fowler, S., Dahlen, B., Chanez, P., Krug, N., Sandstrom, T., Fleming, L., Corfield, J., Auffray, C., Djukanovic, R., Sterk, P. J., Guo, Y., Adcock, I. M., Chung, K. F., Team, U. B. P. (2019). Allergy [Epub ahead of print]. doi: 10.1111/all.13727
https://onlinelibrary.wiley.com/doi/full/10.1111/all.13727

Fate of barium sulfate nanoparticles deposited in the lungs of rats.
Molina, R. M., Konduru, N. V., Queiroz, P. M., Figueroa, B., Fu, D., Ma-Hock, L., Groeters, S., Schaudien, D., Brain, J. D. (2019). Scientific Reports 9(1): 8163. doi: 10.1038/s41598-019-44551-2
https://www.nature.com/articles/s41598-019-44551-2 - Open Access

IL-17-high asthma with features of a psoriasis immunophenotype.
Ostling, J., van Geest, M., Schofield, J. P. R., Jevnikar, Z., Wilson, S., Ward, J., Lutter, R., Shaw, D. E., Bakke, P. S., Caruso, M., Dahlen, S. E., Fowler, S. J., Horvath, I., Krug, N., Montuschi, P., Sanak, M., Sandstrom, T., Sun, K., Pandis, I., Auffray, C., Sousa, A. R., Guo, Y., Adcock, I. M., Howarth, P., Chung, K. F., Bigler, J., Sterk, P. J., Skipp, P. J., Djukanovic, R., Vaarala, O., Group, U. B. S. (2019). Journal of Allergy and Clinical Immunology [Epub ahead of print]. doi: 10.1016/j.jaci.2019.03.027
https://www.sciencedirect.com/science/article/pii/S0091674919304841?via%3Dihub

Occupational exposure to antibiotics in poultry feeding farms.
Paul, R., Gerling, S., Berger, M., Blumlein, K., Jackel, U., Schuchardt, S. (2019). Annals of Work Exposures and Health [Epub ahead of print]. doi: 10.1093/annweh/wxz047
https://academic.oup.com/annweh/article-abstract/63/7/821/5528992

The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity?
Pavan, C., Delle Piane, M., Gullo, M., Filippi, F., Fubini, B., Hoet, P., Horwell, C. J., Huaux, F., Lison, D., Lo Giudice, C., Martra, G., Montfort, E., Schins, R., Sulpizi, M., Wegner, K., Wyart-Remy, M., Ziemann, C., Turci, F. (2019). Particle and Fibre Toxicology 16(1): 32. doi: 10.1186/s12989-019-0315-3 https://particleandfibretoxicology.biomedcentral.com/articles/10.1186/s12989-019-0315-3 - Open Access

Rating sputum cell quality in clinical trials for asthma and COPD treatment.
Pedersen, F., Zissler, U. M., Watz, H., Rabe, K. F., Hohlfeld, J. M., Holz, O. (2019). The International journal of chronic obstructive pulmonary disease 14: 195-198. doi: 10.2147/COPD.S188033
https://www.dovepress.com/rating-sputum-cell-quality-in-clinical-trials-for-asthma-and-copd-trea-peer-reviewed-article-COPD - Open Access

Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux.
Perotin, J. M., Schofield, J. P. R., Wilson, S. J., Ward, J., Brandsma, J., Strazzeri, F., Bansal, A., Yang, X., Rowe, A., Corfield, J., Lutter, R., Shaw, D. E., Bakke, P. S., Caruso, M., Dahlen, B., Fowler, S. J., Horvath, I., Howarth, P., Krug, N., Montuschi, P., Sanak, M., Sandstrom, T., Sun, K., Pandis, I., Auffray, C., De Meulder, B., Lefaudeux, D., Riley, J. H., Sousa, A. R., Dahlen, S. E., Adcock, I. M., Chung, K. F., Sterk, P. J., Skipp, P. J., Collins, J. E., Davies, D. E., Djukanovic, R., Group, U. B. S. (2019). European Respiratory Journal 53(6). doi: 10.1183/13993003.00453-2019
https://www.ncbi.nlm.nih.gov/pubmed/31023846

POINT: Should Molecular and Genetic Biomarkers Be Used in the Initial Evaluation of Patients With Fibrotic ILD? Yes.
Prasse, A. (2019). Chest 156(2): 203-205. doi: 10.1016/j.chest.2019.03.026
https://www.sciencedirect.com/science/article/pii/S0012369219307573

Rebuttal From Dr Prasse.
Prasse, A. (2019). Chest 156(2): 208-209. doi: 10.1016/j.chest.2019.03.029
https://www.sciencedirect.com/science/article/pii/S0012369219307603

BAL cell gene expression is indicative of outcome and airway basal cell involvement in idiopathic pulmonary fibrosis.
Prasse, A., Binder, H., Schupp, J. C., Kayser, G., Bargagli, E., Jaeger, B., Hess, M., Rittinghausen, S., Vuga, L., Lynn, H., Violette, S., Jung, B., Quast, K., Vanaudenaerde, B., Xu, Y., Hohlfeld, J. M., Krug, N., Herazo-Maya, J. D., Rottoli, P., Wuyts, W. A., Kaminski, N. (2019). American Journal of Respiratory and Critical Care Medicine 199(5): 622-630. doi: 10.1164/rccm.201712-2551OC
https://www.atsjournals.org/doi/10.1164/rccm.201712-2551OC

Rhinovirus-16 induced temporal interferon responses in nasal epithelium links with viral clearance and symptoms.
Ravi, A., Chang, M., van de Pol, M., Yang, S., Aliprantis, A., Thornton, B., Carayannopoulos, L. N., Bautmans, A., Robberechts, M., De Lepeleire, I., Singh, D., Hohlfeld, J. M., Sterk, P. J., Krug, N., Lutter, R., Group, U. B. S. (2019). Clinical and Experimental Allergy [Epub ahead of print]. doi: 10.1111/cea.13481
https://onlinelibrary.wiley.com/doi/abs/10.1111/cea.13481

Surface defects reduce carbon nanotube toxicity in vitro.
Requardt, H., Braun, A., Steinberg, P., Hampel, S., Hansen, T. (2019). Toxicology in Vitro 60: 12-18. doi: 10.1016/j.tiv.2019.03.028
https://www.sciencedirect.com/science/article/pii/S0887233318305800?via%3Dihub

Analysis of human breath by millimeter-wave/terahertz spectroscopy.
Rothbart, N., Holz, O., Koczulla, R., Schmalz, K., Hübers, H. W. (2019). Sensors (Basel)19(12): 2719, 2712p. doi: 10.3390/s19122719
https://www.mdpi.com/1424-8220/19/12/2719 - Open Access

Stratification of asthma phenotypes by airway proteomic signatures.
Schofield, J. P. R., Burg, D., Nicholas, B., Strazzeri, F., Brandsma, J., Staykova, D., Folisi, C., Bansal, A. T., Xian, Y., Guo, Y., Rowe, A., Corfield, J., Wilson, S., Ward, J., Lutter, R., Shaw, D. E., Bakke, P. S., Caruso, M., Dahlen, S. E., Fowler, S. J., Horvath, I., Howarth, P., Krug, N., Montuschi, P., Sanak, M., Sandstrom, T., Sun, K., Pandis, I., Riley, J., Auffray, C., De Meulder, B., Lefaudeux, D., Sousa, A. R., Adcock, I. M., Chung, K. F., Sterk, P. J., Skipp, P. J., Djukanovic, R., Group, U. B. S. (2019). Journal of Allergy and Clinical Immunology [Epub ahead of print]. doi: 10.1016/j.jaci.2019.03.013
https://www.sciencedirect.com/science/article/pii/S0091674919304154?via%3Dihub

Cabin air quality – Quantitative comparison of volatile air contaminants at different flight phases during 177 commercial flights.
Schuchardt, S., Koch, W., Rosenberger, W. (2019). Building and Environment 148: 498-507. doi: 10.1016/j.buildenv.2018.11.028
https://www.sciencedirect.com/science/article/abs/pii/S0360132318307236?via%3Dihub

Treatable traits in the European U-BIOPRED adult asthma cohorts.
Simpson, A. J., Hekking, P. P., Shaw, D. E., Fleming, L. J., Roberts, G., Riley, J. H., Bates, S., Sousa, A. R., Bansal, A. T., Pandis, I., Sun, K., Bakke, P. S., Caruso, M., Dahlen, B., Dahlen, S. E., Horvath, I., Krug, N., Montuschi, P., Sandstrom, T., Singer, F., Adcock, I. M., Wagers, S. S., Djukanovic, R., Chung, K. F., Sterk, P. J., Fowler, S. J., Group, U. B. S. (2019). Allergy 74(2): 406-411. doi: 10.1111/all.13629
https://onlinelibrary.wiley.com/doi/full/10.1111/all.13629

Update of the DevTox data database for harmonized risk assessment and alternative methodologies in developmental toxicology: Report of the 9th Berlin Workshop on Developmental Toxicity.
Solecki, R., Rauch, M., Gall, A., Buschmann, J., Kellner, R., Kucheryavenko, O., Schmitt, A., Delrue, N., Li, W., Hu, J., Fujiwara, M., Kuwagata, M., Mantovani, A., Makris, S. L., Paumgartten, F., Schonfelder, G., Schneider, S., Vogl, S., Kleinstreuer, N., Schneider, M., Schulze, F., Fritsche, E., Clark, R., Shiota, K., Chahoud, I. (2019). Reproductive Toxicology 89: 124-129. doi: 10.1016/j.reprotox.2019.07.003
https://www.sciencedirect.com/science/article/pii/S0890623819301698?via%3Dihub

Mast cells within cellular networks.
Stassen, M., Hartmann, A. K., Delgado, S. J., Dehmel, S., Braun, A. (2019). Journal of Allergy and Clinical Immunology [Epub ahead of print]. doi: 10.1016/j.jaci.2019.01.031
https://www.sciencedirect.com/science/article/pii/S0091674919301885?via%3Dihub

Left heart function in COPD : Impact of lung deflation.
Struss, N., Bauersachs, J., Welte, T., Hohlfeld, J. M. (2019). Herz 44(6): 477-482. doi: 10.1007/s00059-019-4816-5
https://link.springer.com/article/10.1007%2Fs00059-019-4816-5

Statische Daten vs. dynamische Daten
[Static data versus dynamic data]Terhechte, A., Appel, B., Clevermann, K., Färber, C., Heina, M., Kwiatkowski, E., Klappauf, E., Layher, C. (2019). Datenintegrität in der pharmazeutischen Industrie. Anwendung – Praxisbeispiele – Audit Trail. Heidelberg, C., Editio Cantor Verlag1110, 182-191.

Corrigendum to "The application of new HARD-descriptor available from the CORAL software to building up NOAEL models" [Food Chem. Toxicol. 112 (2018) 544-550].
Toropova, A. P., Toropov, A. A., Marzo, M., Escher, S. E., Dorne, J. L., Georgiadis, N., Benfenati, E. (2019). Food and Chemical Toxicology 128: 146. doi: 10.1016/j.fct.2019.04.004
https://www.sciencedirect.com/science/article/pii/S0278691519301887?via%3Dihub

Effect of Indacaterol/Glycopyrronium on Pulmonary Perfusion and Ventilation in Hyperinflated Patients with Chronic Obstructive Pulmonary Disease (CLAIM). A Double-Blind, Randomized, Crossover Trial.
Vogel-Claussen, J., Schonfeld, C. O., Kaireit, T. F., Voskrebenzev, A., Czerner, C. P., Renne, J., Tillmann, H. C., Berschneider, K., Hiltl, S., Bauersachs, J., Welte, T., Hohlfeld, J. M. (2019). American Journal of Respiratory and Critical Care Medicine 199(9): 1086-1096. doi: 10.1164/rccm.201805-0995OC https://www.atsjournals.org/doi/abs/10.1164/rccm.201805-0995OC

Randomized immunotherapy trial in dual-allergic patients using "active allergen placebo" as control.
Wagenmann, M., Worm, M., Akboga, Y., Karjalainen, M., Hohlfeld, J. M. (2019). Allergy74(8): 1480-1489. doi: 10.1111/all.13842
https://onlinelibrary.wiley.com/doi/abs/10.1111/all.13842 - Open Access

Microfluidic enrichment, isolation and characterization of disseminated melanoma cells from lymph node samples.
Weidele, K., Stojanovic, N., Feliciello, G., Markiewicz, A., Scheitler, S., Alberter, B., Renner, P., Haferkamp, S., Klein, C. A., Polzer, B. (2019). International Journal of Cancer 145(1): 232-241. doi: 10.1002/ijc.32092
https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32092

Allgemeiner Datenintegritätsstandard für LaborgerätesoftwareWeiser, D., Appel, B., Buschmann, C., Clevermann, K., Färber, C., Heina, M., Kühn, M., Kwiatkowski, E., Klappauf, E., Layher, C., Terhechte, A. (2019). Datenintegrität in der pharmazeutischen Industrie. Anwendung – Praxisbeispiele – Audit Trail. Heidelberg, C., Editio Cantor Verlag1110, 215-230.

Therapy resistance beyond cellular dormancy.
Werner-Klein, M., Klein, C. A. (2019). Nature Cell Biology 21(2): 117-119. doi: 10.1038/s41556-019-0276-7
https://www.nature.com/articles/s41556-019-0276-7

Differentiation of aneugens and clastogens in the in vitro micronucleus test by kinetochore scoring using automated image analysis.
Wilde, S., Queisser, N., Holz, C., Raschke, M., Sutter, A. (2019). Environmental and Molecular Mutagenesis 60(3): 227-242. doi: 10.1002/em.22259 https://onlinelibrary.wiley.com/doi/10.1002/em.22259

Activation of group 2 innate lymphoid cells after allergen challenge in asthmatic patients.
Winkler, C., Hochdorfer, T., Israelsson, E., Hasselberg, A., Cavallin, A., Thorn, K., Muthas, D., Shojaee, S., Luer, K., Muller, M., Mjosberg, J., Vaarala, O., Hohlfeld, J., Pardali, K. (2019). Journal of Allergy and Clinical Immunology 144(1): 61-69.e67. doi: 10.1016/j.jaci.2019.01.027
https://www.ncbi.nlm.nih.gov/pubmed/30731124

Decellularized equine carotid artery layers as matrix for regenerated neurites of spiral ganglion neurons.
Yilmaz-Bayraktar, S., Schwieger, J., Scheper, V., Lenarz, T., Boer, U., Kreienmeyer, M., Torrente, M., Doll, T. (2019). International Journal of Artificial Organs [Epub ahead of print] doi: 10.1177/0391398819868481
https://journals.sagepub.com/doi/10.1177/0391398819868481

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