Fraunhofer ITEM publications

 

Fraunhofer-Publica

All scientific Fraunhofer publications can be found via the publications database of the Fraunhofer-Gesellschaft.

Fraunhofer ITEM publications per year

The below links give you quick access to publications by Fraunhofer ITEM scientists in the past few years.

Recent publications

Below please find recent publications by Fraunhofer ITEM scientists, sorted by subject area.

R&D expertise "Lung research"

  • Birker-Robaczewska, M., Boucher, M., Ranieri, G., Poirey, S., Studer, R., Freti, D., Schnoebelen, M., Froidevaux, S., Morrison, K., Wyss, C., Scherer, J., Lescop, C., Brotschi, C., Bolli, M. H., Kramberg, M., Di Stefano, S., Rey, M., Iglarz, M., Delahaye, S., Vezzali, E., Sieber, P., Schäfer, A., Caimi, S. L., Hesse, C., Nayler, O. (2025). "The novel lysophosphatidic acid receptor 1-selective antagonist, ACT-1016-0707, has unique binding properties that translate into effective anti-fibrotic and anti-inflammatory activity in different models of pulmonary fibrosis." The Journal of pharmacology and experimental therapeutics [Epub ahead of print]. doi: 10.1016/j.jpet.2025.103396  
  • Bouheraoua, S., Cleeves, S., Preusse, M., Musken, M., Braubach, P., Fuchs, M., Falk, C., Sewald, K., Haussler, S. (2025). "Establishment and characterization of persistent Pseudomonas aeruginosa infections in air-liquid interface cultures of human airway epithelial cells." Infection and Immunity 93(3): e0060324. doi: 10.1128/iai.00603-24 https://journals.asm.org/doi/10.1128/iai.00603-24  - Open Access
  • Burkle, M., Korf, I. H. E., Lippegaus, A., Krautwurst, S., Rohde, C., Weissfuss, C., Nouailles, G., Tene, X. M., Gaborieau, B., Ghigo, J. M., Ricard, J. D., Hocke, A. C., Papenfort, K., Debarbieux, L., Witzenrath, M., Wienhold, S. M., Krishnamoorthy, G. (2025). "Phage-phage competition and biofilms affect interactions between two virulent bacteriophages and Pseudomonas aeruginosa." ISME J 19(1). doi: 10.1093/ismejo/wraf065 https://academic.oup.com/ismej/advance-article/doi/10.1093/ismejo/wraf065/8106832 - Open Access
  • Holz, O., Sadiq, M. W., Gress, C., Struss, N., Stomilovic, S., Lundqvist, A., Hohlfeld, J. M. (2025). "Assessing Human Lung Pharmacokinetics Using Exhaled Breath Particles." Journal of Aerosol Medicine and Pulmonary Drug Delivery 38(1): 13-17. doi: 10.1089/jamp.2024.0032 
  • Kayser, T., Smulders, R., Kusawake, T., Wambre, E., Chichili, G. R., Blauwet, M. B., Spence, A., Patton, M., Tabash, R., DeBerg, H. A., Khosa, S., Badorrek, P., Hohlfeld, J. M., Ferslew, B. C. (2025). "Phase 1 study of safety, tolerability, and efficacy of intradermal DNA vaccine ASP2390 in adults allergic to house dust mites." Journal of Allergy and Clinical Immunology: Global 4(2). doi: 10.1016/j.jacig.2025.100404 https://www.jaci-global.org/article/S2772-8293(25)00005-0/fulltext - Open Access
  • Klimeš, F., Kern, A. L., Voskrebenzev, A., Gutberlet, M., Grimm, R., Müller, R. A., Behrendt, L., Kaireit, T. F., Glandorf, J., Alsady, T. M., Wacker, F., Hohlfeld, J. M., Vogel-Claussen, J. (2025). "Free-breathing 3D phase-resolved functional lung MRI vs breath-hold hyperpolarized (129)Xe ventilation MRI in patients with chronic obstructive pulmonary disease and healthy volunteers." European Radiology 35(2): 943-956. doi: 10.1007/s00330-024-10893-3 - Open Access 
  • Legchenko, E., Chouvarine, P., Hysko, K., Qadri, F., Wesolowski, R., Specker, E., Glage, S., Meier, M., Schwarz, K., Heineke, J., Pohlmann, G., Ramazanoglu, M., Bader, M., Hansmann, G. (2025). "Inhalation of the Novel Tryptophan Hydroxylase 1 Inhibitor TPT-004 Alleviates Pulmonary Arterial Hypertension." American Journal of Respiratory Cell and Molecular Biology [Epub ahead of print]. doi: 10.1165/rcmb.2024-0365OC  
  • Paillard, M., Abdellatif, M., Andreadou, I., Bar, C., Bertrand, L., Brundel, B., Chiva-Blanch, G., Davidson, S. M., Dawson, D., Di Lisa, F., Evans, P., Giricz, Z., Hausenloy, D. J., Kleinbongard, P., Lezoualc'h, F., Liehn, E., Maack, C., Maguy, A., Murphy, E., Perrino, C., Pesce, M., Rainer, P. P., Streckfuss-Bomeke, K., Thielmann, M., Tian, R., Tocchetti, C. G., Van Der Velden, J., Van Linthout, S., Zacchigna, S., Krieg, T. (2025). "Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function." European Journal of Heart Failure [Epub ahead of print]. doi: 10.1002/ejhf.3674 https://onlinelibrary.wiley.com/doi/full/10.1002/ejhf.3674 - Open Access
  • Pradhan, K., Neupane, B., Niehues, P., Kirschner, M., Beier, F., Kuo, C. C., Hilbold, E. A., Bär, C., Thoma, O. M., Waldner, M., Vieri, M., Brummendorf, T. H., Tharmapalan, V., Wagner, W., Kleines, M., Emrani, M., Zink, M. D., Napp, A., Marx, N., Gramlich, M. (2025). "Telomere Length Is Associated With Adverse Atrial Remodeling in Patients With Atrial Fibrillation." J Am Heart Assoc 14(3): e037512. doi: 10.1161/JAHA.124.037512 - Open Access  
  • Sadekar, N., Behrsing, H. P., Hansen, T., Patel, V., Paulo, H., Rae, A., Ritter, D., Schwarz, K., Api, A. M. (2025). "A Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods." Toxics 13(1). doi: 10.3390/toxics13010035  - Open Access
  • Santizo, K. Y., Mangold, H. S., Mirzaei, Z., Park, H., Kolan, R. R., Sarau, G., Kolle, S., Hansen, T., Christiansen, S., Wohlleben, W. (2025). "Microplastic Materials for Inhalation Studies: Preparation by Solvent Precipitation and Comprehensive Characterization." Small [Epub ahead of print]: e2405555. doi: 10.1002/smll.202405555   - Open Access 
  • Umeda, Y., Izawa, T., Kazama, K., Arai, S., Kamiie, J., Nakamura, S., Hano, K., Takasu, M., Hirata, A., Rittinghausen, S., Yamano, S. (2025). "Comparative anatomy of respiratory bronchioles and lobular structures in mammals." Journal of Toxicologic Pathology 38(2): 113-129. doi: 10.1293/tox.2024-0071 https://www.jstage.jst.go.jp/article/tox/38/2/38_2024-0071/_article - Open Access
  • Weber, N., Montag, J., Kowalski, K., Iorga, B., de la Roche, J., Holler, T., Wojciechowski, D., Wendland, M., Radocaj, A., Mayer, A. K., Brunkhorst, A., Osten, F., Burkart, V., Piep, B., Bodenschatz, A., Gibron, P., Schwanke, K., Franke, A., Thiemann, S., Koroleva, A., Pfanne, A., Konsanke, M., Fiedler, J., Hegermann, J., Wrede, C., Muhlfeld, C., Chichkov, B., Fischer, M., Thum, T., Francino, A., Martin, U., Meissner, J., Zweigerdt, R., Kraft, T. (2025). "Patient-specific hiPSC-derived cardiomyocytes indicate allelic and contractile imbalance as pathogenic factor in early-stage Hypertrophic Cardiomyopathy." Journal of Molecular and Cellular Cardiology 198: 112-125. doi: 10.1016/j.yjmcc.2024.11.007  - Open Access
  • Weissfuss, C., Li, J., Behrendt, U., Hoffmann, K., Burkle, M., Tan, C., Krishnamoorthy, G., Korf, I. H. E., Rohde, C., Gaborieau, B., Debarbieux, L., Ricard, J. D., Witzenrath, M., Felten, M., Nouailles, G. (2025). "Adjunctive phage therapy improves antibiotic treatment of ventilator-associated-pneumonia with Pseudomonas aeruginosa." Nat Commun 16(1): 4500. doi: 10.1038/s41467-025-59806-y https://www.nature.com/articles/s41467-025-59806-y - Open Access
  • Ye, J. L., Grieger, K., Lu, D., Brandenberger, C., Juchem, M., Jordan, M., Oehlsen, L., Zardo, P., Werlein, C., Hesse, C., Sewald, K., Tretbar, S., Thum, T., Chatterjee, S., Bär, C. (2025). "Telomerase modRNA offers a novel RNA-based approach to treat human pulmonary fibrosis." BioRxiv. doi: 10.1101/2025.02.19.639041 https://www.biorxiv.org/content/10.1101/2025.02.19.639041v1?med=mas - Preprint im Repositorium – Open Access

R&D expertise "Toxicology"

  • Blum, J., Brull, M., Hengstler, J. G., Dietrich, D. R., Gruber, A. J., Dipalo, M., Kraushaar, U., Mangas, I., Terron, A., Fritsche, E., Marx-Stoelting, P., Hardy, B., Schepky, A., Escher, S., Hartung, T., Landsiedel, R., Odermatt, A., Sachana, M., Koch, K., Donmez, A., Masjosthusmann, S., Bothe, K., Schildknecht, S., Beilmann, M., Beltman, J. B., Fitzpatrick, S., Mangerich, A., Rehm, M., Tangianu, S., Zickgraf, F. M., Kamp, H., Burger, G., van de Water, B., Kleinstreuer, N., White, A., Leist, M. (2025). "The long way from raw data to NAM-based information: Overview on data layers and processing steps." Altex 42(1): 167-180. doi: 10.14573/altex.2412171 - Open Access
  • Bruer, G., Lombaert, N., Burzlaff, A., Spirlet, C., Gödecke, D., Ramazanoglu, M., Creutzenberg, O. (2025). "Considerations and Challenges for Acute Inhalation Toxicity Testing and Classification of Zinc Sulphide Under REACH." Toxics 13(1). doi: 10.3390/toxics13010027  - Open Access
  • Colbourne, J. K., Escher, S. E., Lee, R., Vinken, M., van de Water, B., Freedman, J. H. (2025). "ASPIS Definition of New Approach Methodologies." Environmental Toxicology and Chemistry [Epub ahead of print]. doi: 10.1093/etojnl/vgae093  - Open Access 
  • Cronin, M. T. D., Baltazar, M. T., Barton-Maclaren, T. S., Bercaru, O., De Abrew, K. N., Desaintes, C., Escher, S. E., Kern, P., Maxwell, G., Rogiers, V., Schutte, K., Sobanski, T. (2025). "Report on the European Partnership for Alternative Approaches to Animal Testing (EPAA) "New Approach Methodologies (NAMs) User Forum Kick-Off Workshop"." Regulatory Toxicology and Pharmacology 159: 105796. doi: 10.1016/j.yrtph.2025.105796 https://www.sciencedirect.com/science/article/pii/S0273230025000261?via%3Dihub - Open Access
  • Emwas, A. H., Zacharias, H. U., Alborghetti, M. R., Gowda, G. A. N., Raftery, D., McKay, R. T., Chang, C. K., Saccenti, E., Gronwald, W., Schuchardt, S., Leiminger, R., Merzaban, J., Madhoun, N. Y., Iqbal, M., Alsiary, R. A., Shivapurkar, R., Pain, A., Shanmugam, D., Ryan, D., Roy, R., Schirra, H. J., Morris, V., Zeri, A. C., Alahmari, F., Kaddurah-Daouk, R., Salek, R. M., LeVatte, M., Berjanskii, M., Lee, B., Wishart, D. S. (2025). "Recommendations for sample selection, collection and preparation for NMR-based metabolomics studies of blood." Metabolomics 21(3): 66. doi: 10.1007/s11306-025-02259-7 https://link.springer.com/article/10.1007/s11306-025-02259-7 - Open Access
  • Englisch, C. N., Diebolt, C. M., Kirstein, E., Wahl, V., Wartenberg, P., Schaudien, D., Beckmann, A., Laschke, M. W., Krasteva-Christ, G., Gudermann, T., Chubanov, V., Boehm, U., Tschernig, T. (2025). "TRPM6 in murine kidneys-of targets and antibodies." Naunyn-Schmiedebergs Archives of Pharmacology [Epub ahead of print]. doi: 10.1007/s00210-025-03951-0  - Open Access 
  • Ghaffari, M. H., Ostendorf, C. S., Hemmert, K. J., Schuchardt, S., Koch, C., Sauerwein, H. (2025). "Longitudinal characterization of plasma and fecal bile acids in dairy heifers from birth to first calving in response to transition milk feeding." Journal of Dairy Science 108(5): 5475-5488. doi: 10.3168/jds.2025-26307 https://www.sciencedirect.com/science/article/pii/S0022030225002097?via%3Dihub - Open Access
  • Ghaffari, M. H., Sauerwein, H., Sadri, H., Schuchardt, S., Martin-Tereso, J., Doelman, J. H., Daniel, J. B. (2025). "Longitudinal characterization of the metabolome of dairy cows transitioning from one lactation to the next: Investigations in fecal samples." Journal of Dairy Science 108(5): 5405-5419. doi: 10.3168/jds.2025-26273 https://www.sciencedirect.com/science/article/pii/S0022030225001328?via%3Dihub - Open Access
  • Hansen, T., Tillmann, T., Wiench, K., Creutzenberg, O. (2025). "Studies on acute dermal toxicity and dermal absorption of a nanoform zinc oxide (ZnO; NM-111) in rats." Toxicology Letters 409: 42-49. doi: 10.1016/j.toxlet.2025.04.011 https://www.sciencedirect.com/science/article/pii/S0378427425000785?via%3Dihub - Open Access
  • Neu, F., Wacker, M., Schuchardt, S., Vargese, S., Awad, G., Wippermann, J., Peßler, F., Veluswamy, P. (2025). "Altered plasma metabolites as fingerprint of cardiac bypass surgery." medRxiv doi: 10.1101/2025.04.11.25325708 https://www.medrxiv.org/content/10.1101/2025.04.11.25325708v1 - Preprint im Repositorium - Open Access
  • Sadri, H., Ghaffari, M. H., Sauerwein, H., Schuchardt, S., Martin-Tereso, J., Doelman, J., Daniel, J. B. (2025). "Longitudinal characterization of the muscle metabolome in dairy cows during the transition from lactation cessation to lactation resumption." Journal of Dairy Science 108(1): 1062-1077. doi: 10.3168/jds.2024-25324 - Open Access 
  • Sadekar, N., Behrsing, H. P., Hansen, T., Patel, V., Paulo, H., Rae, A., Ritter, D., Schwarz, K., Api, A. M. (2025). "A Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods." Toxics 13(1). doi: 10.3390/toxics13010035  - Open Access
  • Schaudien, D., Hansen, T., Tillmann, T., Pohlmann, G., Kock, H., Creutzenberg, O. (2025). "Comparative toxicity study of three surface-modified titanium dioxide nanoparticles following subacute inhalation." Particle and Fibre Toxicology 22(1): 5. doi: 10.1186/s12989-025-00620-1  - Open Access 
  • Santizo, K. Y., Mangold, H. S., Mirzaei, Z., Park, H., Kolan, R. R., Sarau, G., Kolle, S., Hansen, T., Christiansen, S., Wohlleben, W. (2025). "Microplastic Materials for Inhalation Studies: Preparation by Solvent Precipitation and Comprehensive Characterization." Small [Epub ahead of print]: e2405555. doi: 10.1002/smll.202405555   - Open Access 
  • Wehr, M. M., Witters, H., Remy, S., Schultz, B., Jacobs, M., Escher, S. E. (2025). "Feasibility study on integrating morphological and transcriptomic data for identifying teratogenic molecular markers in zebrafish embryo toxicity testing." Computational Toxicology 34. doi: 10.1016/j.comtox.2025.100342 https://www.sciencedirect.com/science/article/pii/S2468111325000027?via%3Dihub

R&D expertise "Malignant disease research"

  • Basilio-Queiros, D., Lachmann, N. (2025). "In vivo macrophage engineering for renal cancer therapy." Nat Cancer 6(5): 743-745. doi: 10.1038/s43018-025-00912-7 https://www.nature.com/articles/s43018-025-00912-7
  • Dastagir, N., Liebsch, C., Kutz, J., Wronski, S., Pich, A., Obed, D., Vogt, P. M., Bucan, V., Strauss, S. (2025). "Identification of antimicrobial peptides from the Ambystoma mexicanum displaying antibacterial and antitumor activity." PloS One 20(3): e0316257. doi: 10.1371/journal.pone.0316257  - Open Access 
  • Gand, L. V., Lanzuolo, C., Li, M., Rosti, V., Weber, N., Lu, D., Bar, C., Thum, T., Pich, A., Kraft, T., Amrute-Nayak, M., Nayak, A. (2025). "Calcium Handling Machinery and Sarcomere Assembly are Impaired Through Multipronged Mechanisms in Cancer Cytokine-Induced Cachexia." J Cachexia Sarcopenia Muscle 16(2): e13776. doi: 10.1002/jcsm.13776 https://onlinelibrary.wiley.com/doi/10.1002/jcsm.13776 - Open Access
  • Harrer, D. C., Luke, F., Pukrop, T., Ghibelli, L., Reichle, A., Heudobler, D. (2025). "MEPED as salvage therapy for relapsed/refractory Hodgkin's lymphoma incorporating edited non-oncogene addiction: mTOR as a bottleneck." Frontiers in Pharmacology 16: 1553331. doi: 10.3389/fphar.2025.1553331 https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1553331/full - Open Access
  • Kitte, R., Serfling, R., Blache, U., Seitz, C., Schrader, S., Kohl, U., Fricke, S., Bar, C., Tretbar, U. S. (2025). "Optimal Chimeric Antigen Receptor (CAR)-mRNA for Transient CAR T Cell Generation." Int J Mol Sci 26(3). doi: 10.3390/ijms26030965 https://www.mdpi.com/1422-0067/26/3/965 - Open Access
  • Kutle, I., Polten, R., Stalp, J. L., Hachenberg, J., Todzey, F., Hass, R., Zimmermann, K., von der Ohe, J., von Kaisenberg, C., Neubert, L., Kamp, J. C., Schaudien, D., Seyda, A.-K., Hillemanns, P., Klapdor, R., Morgan, M. A., Schambach, A. (2024). "Anti-Mesothelin CAR-NK cells as a novel targeted therapy against cervical cancer." Frontiers in Immunology 15. doi: 10.3389/fimmu.2024.1485461 - Open Access
  • Niedermayer, K., Schaffler, H., Vlachos, G., Greco, S., Pfister, K., Volz, B., Ott, L., Neubauer, H., Polzer, B., Koch, A., Riethdorf, S., Fehm, T., Janni, W., Friedl, T. W. P., Rack, B., Heitzer, E., Schochter, F., Wiesmuller, L. (2025). "Mass cytometric detection of homologous recombination proficiency in circulating tumor cells to predict chemoresistance of metastatic breast cancer patients." International Journal of Cancer [Epub ahead of print]. doi: 10.1002/ijc.35498 https://onlinelibrary.wiley.com/doi/10.1002/ijc.35498 - Open Access

R&D expertise "Medical and pharmaceutical engineering"

  • Basilio-Queiros, D., Lachmann, N. (2025). "In vivo macrophage engineering for renal cancer therapy." Nat Cancer 6(5): 743-745. doi: 10.1038/s43018-025-00912-7 https://www.nature.com/articles/s43018-025-00912-7
  • Burkle, M., Korf, I. H. E., Lippegaus, A., Krautwurst, S., Rohde, C., Weissfuss, C., Nouailles, G., Tene, X. M., Gaborieau, B., Ghigo, J. M., Ricard, J. D., Hocke, A. C., Papenfort, K., Debarbieux, L., Witzenrath, M., Wienhold, S. M., Krishnamoorthy, G. (2025). "Phage-phage competition and biofilms affect interactions between two virulent bacteriophages and Pseudomonas aeruginosa." ISME J 19(1). doi: 10.1093/ismejo/wraf065 https://academic.oup.com/ismej/advance-article/doi/10.1093/ismejo/wraf065/8106832 - Open Access
  • Costa, A., Bär, C. (2025). "Heart to Heal: Unveiling Follistatin's Potential for Myocardial Regeneration." Circulation Research 136(2): 177-179. doi: 10.1161/CIRCRESAHA.124.325939  
  • Mattis, P. (2025). "Der Weg zur erstattungsfähigen Gesundheitsversorgung." Medizintechnik (Cologne) 2(2): 29-33.
  • Rieper, F., Wittmann, J., Bunk, B., Spröer, C., Häfner, M., Willy, C., Müsken, M., Ziehr, H., Korf, I. H. E., Jahn, D. (2025). "Systematic bacteriophage selection for the lysis of multiple strains." Frontiers in Cellular and Infection Microbiology 15. doi: ARTN 1597009 10.3389/fcimb.2025.1597009 https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2025.1597009/abstract - Open Access
  • Weissfuss, C., Li, J., Behrendt, U., Hoffmann, K., Burkle, M., Tan, C., Krishnamoorthy, G., Korf, I. H. E., Rohde, C., Gaborieau, B., Debarbieux, L., Ricard, J. D., Witzenrath, M., Felten, M., Nouailles, G. (2025). "Adjunctive phage therapy improves antibiotic treatment of ventilator-associated-pneumonia with Pseudomonas aeruginosa." Nat Commun 16(1): 4500. doi: 10.1038/s41467-025-59806-y https://www.nature.com/articles/s41467-025-59806-y - Open Access

R&D expertise "Bioinformatics and AI"

  • Blum, J., Brull, M., Hengstler, J. G., Dietrich, D. R., Gruber, A. J., Dipalo, M., Kraushaar, U., Mangas, I., Terron, A., Fritsche, E., Marx-Stoelting, P., Hardy, B., Schepky, A., Escher, S., Hartung, T., Landsiedel, R., Odermatt, A., Sachana, M., Koch, K., Donmez, A., Masjosthusmann, S., Bothe, K., Schildknecht, S., Beilmann, M., Beltman, J. B., Fitzpatrick, S., Mangerich, A., Rehm, M., Tangianu, S., Zickgraf, F. M., Kamp, H., Burger, G., van de Water, B., Kleinstreuer, N., White, A., Leist, M. (2025). "The long way from raw data to NAM-based information: Overview on data layers and processing steps." Altex 42(1): 167-180. doi: 10.14573/altex.2412171  - Open Access
  • Hilberink, L., Wehage, P., Pashai Fakhri, M., Gaedcke, S., DeLuca, D., Mattis, P., Rademacher, J. (2025). "Künstliche Intelligenz und Machine Learning in der Auskultation. [Artificial intelligence and machine learning in auscultation: prospects of the project DigitaLung]." Pneumologie 79(3): 229-235. doi: 10.1055/a-2507-1486 https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-2507-1486
  • Lange, M., Korte, A., Fuchs, M., Fekete, A., Mueller, C., Dierich, B., Witte, J., Dandekar, T., Mueller, M. J., Berger, S. (2025). "A CW-type zinc finger protein is involved in RES-oxylipin signaling and the response to abiotic stress in Arabidopsis thaliana." Front. Plant Sci 16. doi: 10.3389/fpls.2025.153564 https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2025.1535643/full - Open Access
  • Schönfeld, J., Brunst, S., Ciomirtan, L., Willmer, L., Chromik, M. A., Kumar, A., Froemel, T., Liebisch, N., Hackspacher, A., Ehrler, J. H. M., Wintermeier, L., Hesse, C., Fiedler, J., Heering, J., Freitag, H., Zardo, P., Fieguth, H.-G., Brüggerhoff, A., Jakob, J., Häupl, B., Weizel, L., Kaiser, A., Schubert-Zsilavecz, M., Oellerich, T., Fleming, I., Schebb, N. H., Fürst, R., Kannt, A., Knapp, S., Proschak, E., Hiesinger, K. (2025). "Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase." Journal of Medicinal Chemistry [Epub ahead of print]. doi: 10.1021/acs.jmedchem.5c00552 https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c00552 - Open Access
  • Wehr, M. M., Witters, H., Remy, S., Schultz, B., Jacobs, M., Escher, S. E. (2025). "Feasibility study on integrating morphological and transcriptomic data for identifying teratogenic molecular markers in zebrafish embryo toxicity testing." Computational Toxicology 34. doi: 10.1016/j.comtox.2025.100342

R&D expertise "Immunology and and infection research"

  • Basilio-Queiros, D., Lachmann, N. (2025). "In vivo macrophage engineering for renal cancer therapy." Nat Cancer 6(5): 743-745. doi: 10.1038/s43018-025-00912-7 https://www.nature.com/articles/s43018-025-00912-7
  • Bouheraoua, S., Cleeves, S., Preusse, M., Musken, M., Braubach, P., Fuchs, M., Falk, C., Sewald, K., Haussler, S. (2025). "Establishment and characterization of persistent Pseudomonas aeruginosa infections in air-liquid interface cultures of human airway epithelial cells." Infection and Immunity 93(3): e0060324. doi: 10.1128/iai.00603-24 https://journals.asm.org/doi/10.1128/iai.00603-24 - Open Access
  • Burkle, M., Korf, I. H. E., Lippegaus, A., Krautwurst, S., Rohde, C., Weissfuss, C., Nouailles, G., Tene, X. M., Gaborieau, B., Ghigo, J. M., Ricard, J. D., Hocke, A. C., Papenfort, K., Debarbieux, L., Witzenrath, M., Wienhold, S. M., Krishnamoorthy, G. (2025). "Phage-phage competition and biofilms affect interactions between two virulent bacteriophages and Pseudomonas aeruginosa." ISME J 19(1). doi: 10.1093/ismejo/wraf065 https://academic.oup.com/ismej/advance-article/doi/10.1093/ismejo/wraf065/8106832 - Open Access
  • Dastagir, N., Liebsch, C., Kutz, J., Wronski, S., Pich, A., Obed, D., Vogt, P. M., Bucan, V., Strauss, S. (2025). "Identification of antimicrobial peptides from the Ambystoma mexicanum displaying antibacterial and antitumor activity." PloS One 20(3): e0316257. doi: 10.1371/journal.pone.0316257 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0316257 - Open Access
  • Diesendorf, V., La Rocca, V., Teutsch, M., Alattar, H., Obernolte, H., Kenst, K., Seibel, J., Worsdorfer, P., Sewald, K., Steinke, M., Schneider-Schaulies, S., Lutz, M. B., Bodem, J. (2025). "AMPK Activation Downregulates TXNIP, Rab5, and Rab7 Within Minutes, Thereby Inhibiting the Endocytosis-Mediated Entry of Human Pathogenic Viruses." Cells 14(5). doi: 10.3390/cells14050334 https://www.mdpi.com/2073-4409/14/5/334 - Open Access
  • Jahn, K., Chatterjee, S., Sinke, C., Koberschinski, J. J. R., Junemann, K., James, C. E., Worschech, F., Marie, D., Altenmuller, E., Bar, C., Kruger, T. H. C. (2025). "An incidental finding during a brain plasticity study: substantial telomere length shortening after COVID-19 lockdown in the older population." Geroscience [Epub ahead of print]. doi: 10.1007/s11357-025-01602-z https://link.springer.com/article/10.1007/s11357-025-01602-z - Open Access
  • Kayser, T., Smulders, R., Kusawake, T., Wambre, E., Chichili, G. R., Blauwet, M. B., Spence, A., Patton, M., Tabash, R., DeBerg, H. A., Khosa, S., Badorrek, P., Hohlfeld, J. M., Ferslew, B. C. (2025). "Phase 1 study of safety, tolerability, and efficacy of intradermal DNA vaccine ASP2390 in adults allergic to house dust mites." Journal of Allergy and Clinical Immunology: Global 4(2). doi: 10.1016/j.jacig.2025.100404 https://www.jaci-global.org/article/S2772-8293(25)00005-0/fulltext - Open Access 
  • Rieper, F., Wittmann, J., Bunk, B., Spröer, C., Häfner, M., Willy, C., Müsken, M., Ziehr, H., Korf, I. H. E., Jahn, D. (2025). "Systematic bacteriophage selection for the lysis of multiple strains." Frontiers in Cellular and Infection Microbiology 15. doi: ARTN 1597009 10.3389/fcimb.2025.1597009 https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2025.1597009/abstract - Open Access
  • Waschina, S., Harris, D., Starke, S., Homeister, L., Schuchardt, S., Tran, F., Verstockt, B., Ananthakrishnan, A., Vermeire, S., Rosenstiel, P., Schreiber, S., Aden, K. (2025). "DOP019 Reduced Gut Microbial Amino Acid Auxotrophies and Enhanced Tryptophan Degradation in Inflammatory Bowel Disease." Journal of Crohn's and Colitis 19(Supplement_1): i122-i123. doi: 10.1093/ecco-jcc/jjae190.0058 https://academic.oup.com/ecco-jcc/article/19/Supplement_1/i122/7967042 -
  • Weissfuss, C., Li, J., Behrendt, U., Hoffmann, K., Burkle, M., Tan, C., Krishnamoorthy, G., Korf, I. H. E., Rohde, C., Gaborieau, B., Debarbieux, L., Ricard, J. D., Witzenrath, M., Felten, M., Nouailles, G. (2025). "Adjunctive phage therapy improves antibiotic treatment of ventilator-associated-pneumonia with Pseudomonas aeruginosa." Nat Commun 16(1): 4500. doi: 10.1038/s41467-025-59806-y https://www.nature.com/articles/s41467-025-59806-y - Open Access
  • Welz, L., Harris, D., Schuchardt, S., Tran, F., Waschina, S., Verstockt, B., Vermeire, S., Rosenstiel, P., Schreiber, S., Aden, K. (2025). "DOP090 Serum metabolites predict endoscopic disease activity and clinical and endoscopic remission in Ulcerative Colitis." Journal of Crohn's and Colitis 19(Supplement_1): i248-i250. doi: 10.1093/ecco-jcc/jjae190.0129 https://academic.oup.com/ecco-jcc/article/19/Supplement_1/i248/7967053

R&D expertise "RNA technologies"

  • Kitte, R., Serfling, R., Blache, U., Seitz, C., Schrader, S., Kohl, U., Fricke, S., Bar, C., Tretbar, U. S. (2025). "Optimal Chimeric Antigen Receptor (CAR)-mRNA for Transient CAR T Cell Generation." Int J Mol Sci 26(3). doi: 10.3390/ijms26030965 https://www.mdpi.com/1422-0067/26/3/965 - Open Access
  • Ye, J. L., Grieger, K., Lu, D., Brandenberger, C., Juchem, M., Jordan, M., Oehlsen, L., Zardo, P., Werlein, C., Hesse, C., Sewald, K., Tretbar, S., Thum, T., Chatterjee, S., Bär, C. (2025). "Telomerase modRNA offers a novel RNA-based approach to treat human pulmonary fibrosis." BioRxiv. doi: 10.1101/2025.02.19.639041 https://www.biorxiv.org/content/10.1101/2025.02.19.639041v1?med=mas - Preprint im Repositorium – Open Access

Contact

Petra Wiedemeier

Contact Press / Media

Petra Wiedemeier

Head of Information Management

Phone +49 511 5350-327