Fraunhofer Institute for Toxicology and Experimental Medicine
Fraunhofer Institute for Toxicology and Experimental Medicine

Publications of Fraunhofer ITEM

Publications 2019

  • Semi-automated detection, isolation and molecular analysis of single disseminated melanoma cells from lymph nodes.
  • Alberter, B., Scheitler, S., Feliciello, G., Ferrarini, A., Werner-Klein, M., Haferkamp, S., Klein, C. A., Polzer, B. (2019). Cancer Research 79(13 Supplement): Abstract 431. doi: 10.1158/1538-7445.AM2019-431 https://cancerres.aacrjournals.org/content/79/13_Supplement/431 - Abstract
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  • Ribosome-targeting antibiotics impair T cell effector function and ameliorate autoimmunity by blocking mitochondrial protein synthesis.
  • Almeida, L., Dhillon-LaBrooy, A., Castro, C. N., Ayele, N., Bartel, J., Carriche, G. M., Guderian, M., Lippens, S., Dennerlein, S., Hesse, C., Lambrecht, B. N., Schauser, L., Blazar, B. R., Kalesse, M., Müller, R., Moita, L. F., Sparwasser, T. (2019). bioRxiv - the preprint server for biology. doi: 10.1101/832956 https://www.biorxiv.org/content/10.1101/832956v1
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  • Geschlechtsspezifische Einflüsse auf die Lungenfibrose.
  • Apel, R. M., Prasse, A. (2019). Atemwegs- und Lungenkrankheiten 45(08): 407-411. doi: 10.5414/atx02373 https://www.dustri.com/nc/de/article-response-page.html?artId=185530&doi=10.5414%2FATX02373
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  • MicroRNA-144-3p targets relaxin/insulin-like family peptide receptor 1 (RXFP1) expression in lung fibroblasts from patients with idiopathic pulmonary fibrosis.
  • Bahudhanapati, H., Tan, J., Dutta, J. A., Strock, S. B., Sembrat, J., Alvarez, D., Rojas, M., Jäger, B., Prasse, A., Zhang, Y., Kass, D. J. (2019). Journal of Biological Chemistry 294(13): 5008-5022. doi: 10.1074/jbc.RA118.004910
  • http://www.jbc.org/content/294/13/5008
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  • Identification of potential emerging chemical risks in food from REACH registered chemicals.
  • Bitsch, A., Bohlen, M., Escher, S., Kass, G., Licht, O., MacLeod, M., Merten, C., Noteborn, H., Oltmanns, J., Schwarz, M., Silano, V. (2019). The Toxicologist Supplement to Toxicological Sciences 168(1): 386, Abstract PS 2637. - Abstract
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  • LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancer.
  • Blazquez, R., Rietkötter, E., Wenske, B., Wlochowitz, D., Sparrer, D., Vollmer, E., Müller, G., Seegerer, J., Sun, X., Dettmer, K., Barrantes-Freer, A., Stange, L., Utpatel, K., Bleckmann, A., Treiber, H., Bohnenberger, H., Lenz, C., Schulz, M., Reimelt, C., Hackl, C., Grade, M., Büyüktas, D., Siam, L., Balkenhol, M., Stadelmann, C., Kube, D., Krahn, M. P., Proescholdt, M. A., Riemenschneider, M. J., Evert, M., Oefner, P. J., Klein, C. A., Hanisch, U. K., Binder, C., Pukrop, T. (2019). International Journal of Cancer [Epub ahead of print]. doi: 10.1002/ijc.32742 https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32742 - Open Access
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  • Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma.
  • Brinkman, P., Wagener, A. H., Hekking, P. P., Bansal, A. T., Maitland-van der Zee, A. H., Wang, Y., Weda, H., Knobel, H. H., Vink, T. J., Rattray, N. J., D'Amico, A., Pennazza, G., Santonico, M., Lefaudeux, D., De Meulder, B., Auffray, C., Bakke, P. S., Caruso, M., Chanez, P., Chung, K. F., Corfield, J., Dahlen, S. E., Djukanovic, R., Geiser, T., Horvath, I., Krug, N., Musial, J., Sun, K., Riley, J. H., Shaw, D. E., Sandstrom, T., Sousa, A. R., Montuschi, P., Fowler, S. J., Sterk, P. J., Group, U. B. S. (2019). Journal of Allergy and Clinical Immunology 143(5): 1811-1820 e1817. doi: 10.1016/j.jaci.2018.10.058
  • https://www.sciencedirect.com/science/article/pii/S0091674918317226?via%3Dihub
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  • Novel ETV6-RUNX1 mouse model to study the role of ELF-MF in childhood B-acute lymphoblastic leukemia: a pilot study.
  • Campos-Sanchez, E., Vicente-Duenas, C., Rodriguez-Hernandez, G., Capstick, M., Kuster, N., Dasenbrock, C., Sanchez-Garcia, I., Cobaleda, C. (2019). Bioelectromagnetics 40(5): 343-353. doi: 10.1002/bem.22193
  • https://onlinelibrary.wiley.com/doi/full/10.1002/bem.22193
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  • Eosinophil and neutrophil granulocyte immunophenotyping using chipcytometry.
  • Carstensen, S., Holz, O., Hohlfeld, J. M., Müller, M. (2019). American Journal of Respiratory and Critical Care Medicine 199: Abstract A2956. https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A2956 - Abstract
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  • Sputum analysis by chipcytometry following LPS inhalation challenge.
  • Carstensen, S., Holz, O., Müller, M., Hohlfeld, J. M. (2019). American Journal of Respiratory and Critical Care Medicine 199: Abstract A5742. https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A4535 - Abstract
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  • In vivo detection of circulating tumor cells in high-risk non-metastatic prostate cancer patients undergoing radiotherapy.
  • Chen, S., Tauber, G., Langsenlehner, T., Schmölzer, L. M., Pötscher, M., Riethdorf, S., Kuske, A., Leitinger, G., Kashofer, K., Czyz, Z. T., Polzer, B., Pantel, K., Sedlmayr, P., Kroneis, T., El-Heliebi, A. (2019). Cancers 11(7): 933. doi: 10.3390/cancers11070933 https://www.mdpi.com/2072-6694/11/7/933 - Open Access
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  • ICONS - Integrated testing strategy for mechanistically assessing the respiratory toxicity of functionalized MWCNT.
  • Creutzenberg, O. H., Lison, D., Van Den Brule, S., Simon, S., Bonner, J., Ziemann, C. (2019). The Toxicologist Supplement to Toxicological Sciences 168(1): 293, Abstract PS 2232. - Abstract
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  • A novel workflow for isolation and multi-omic profiling of DCCs derived from cerebrospinal fluid of patients with pediatric brain cancer.
  • Czyz, Z. T., Feliciello, G., Guzvic, M., Schamberger, T., Grunewald, S., Corbacioglu, S., Riemenschneider, M. J., Polzer, B., Klein., C. A. (2019). Cancer Research 79(13 Supplement): Abstract LB-239. doi: 10.1158/1538-7445.AM2019-LB-239 https://cancerres.aacrjournals.org/content/79/13_Supplement/LB-239 - Abstract
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  • Rupintrivir reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo.
  • Danov, O., Lasswitz, L., Obernolte, H., Hesse, C., Braun, A., Wronski, S., Sewald, K. (2019). Respiratory Research 20: 228, 229p. doi: 10.1186/s12931-019-1175-y https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-019-1175-y - Open Access
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  • Enhanced tissue damage following H1N1 infection in human precision-cut lung slices (PCLS).
  • Danov, O., Martin, G., Greif, A., Bailly, B., Braubach, P., Jonigk, D. D., Warnecke, G., von Itzstein, M., Sewald, K., Wronski, S., Braun, A. (2019). American Journal of Respiratory and Critical Care Medicine199: Abstract A5742. https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A5742 - Abstract
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  • Targeted transcript quantification in single disseminated cancer cells after whole transcriptome amplification.
  • Durst, F. C., Grujovic, A., Ganser, I., Hoffmann, M., Ugocsai, P., Klein, C. A., Czyz, Z. T. (2019). PloS One14(8): e0216442. doi: 10.1371/journal.pone.0216442 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216442 - Open Access
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  • Characterization of aerosol release during spraying of isocyanate products.
  • Ehnes, C., Genz, M., Duwenhorst, J., Krasnow, J., Bleeke, J., Schwarz, K., Koch, W., Schuchardt, S. (2019). Ann Work Expo Health 63(7): 773-783. doi: 10.1093/annweh/wxz045
  • https://academic.oup.com/annweh/advance-article-abstract/doi/10.1093/annweh/wxz045/5513789?redirectedFrom=fulltext
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  • Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop.
  • Ellison, C. A., Blackburn, K. L., Carmichael, P. L., Clewell, H. J., 3rd, Cronin, M. T. D., Desprez, B., Escher, S. E., Ferguson, S. S., Gregoire, S., Hewitt, N. J., Hollnagel, H. M., Klaric, M., Patel, A., Salhi, S., Schepky, A., Schmitt, B. G., Wambaugh, J. F., Worth, A. (2019). Regulatory Toxicology Pharmacology103: 63-72. doi: 10.1016/j.yrtph.2019.01.016 https://www.sciencedirect.com/science/article/pii/S0273230019300169 - Open Access
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  • Identification and quantification of synthetic cannabinoids in 'spice-like' herbal mixtures: Update of the German situation in summer 2018.
  • Ernst, L., Langer, N., Bockelmann, A., Salkhordeh, E., Beuerle, T. (2019). Forensic Science International294: 96-102. doi: 10.1016/j.forsciint.2018.11.001 https://www.sciencedirect.com/science/article/pii/S0379073818307205?via%3Dihub
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  • Integration of NAMs in risk assessment: the read-across approach of the EU-ToxRisk project.
  • Escher, S. (2019). The Toxicologist Supplement to Toxicological Sciences 168(1): 150, Abstract S 1627. - Abstract
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  • Cefic LRI AIMT-8: Prediction of STOTRE classification by new approach methodologies.
  • Escher, S., Cronin, M., Firman, J., Magdziarz, T., Rathman, J., Yang, C. (2019). The Toxicologist Supplement to Toxicological Sciences 168(1): 202, Abstract PS 1861. - Abstract
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  • Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project.
  • Escher, S. E., Kamp, H., Bennekou, S. H., Bitsch, A., Fisher, C., Graepel, R., Hengstler, J. G., Herzler, M., Knight, D., Leist, M., Norinder, U., Ouedraogo, G., Pastor, M., Stuard, S., White, A., Zdrazil, B., van de Water, B., Kroese, D. (2019). Archives of Toxicology 93(12): 3643-3667. doi: 10.1007/s00204-019-02591-7
  • https://link.springer.com/article/10.1007%2Fs00204-019-02591-7
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  • Detection of ESR1 mutations in single circulating tumor cells upon estrogen deprivation therapy but not in primary tumors from metastatic luminal breast cancer patients.
  • Franken, A., Honisch, E., Reinhardt, F., Meier-Stiegen, F., Yang, L., Jaschinski, S., Esposito, I., Alberter, B., Polzer, B., Huebner, H., Fasching, P. A., Pancholi, S., Martin, L. A., Ruckhaeberle, E., Schochter, F., Tzschaschel, M., Hartkopf, A. D., Mueller, V., Niederacher, D., Fehm, T., Neubauer, H. (2019). J Mol Diagn [Epub ahead of print]. doi: 10.1016/j.jmoldx.2019.09.004 https://www.sciencedirect.com/science/article/abs/pii/S1525157819304027?via%3Dihub
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  • Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma.
  • George, L., Taylor, A. R., Esteve-Codina, A., Soler Artigas, M., Thun, G. A., Bates, S., Pavlidis, S., Wagers, S., Boland, A., Prasse, A., Boschetto, P., Parr, D. G., Nowinski, A., Barta, I., Hohlfeld, J., Greulich, T., van den Berge, M., Hiemstra, P. S., Timens, W., Hinks, T., Wenzel, S., Siddiqui, S., Richardson, M., Venge, P., Heath, S., Gut, I., Tobin, M. D., Edwards, L., Riley, J. H., Djukanovic, R., Auffray, C., De-Meulder, B., Erik-Dahlen, S., Adcock, I. M., Chung, K. F., Ziegler-Heitbrock, L., Sterk, P. J., Singh, D., Brightling, C. E. (2019). Allergy [Epub ahead of print]. doi: 10.1111/all.14016
  • https://onlinelibrary.wiley.com/doi/full/10.1111/all.14016 - Open Access
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  • Paradigm shift in safety assessment using new approach methods: The EU-ToxRisk strategy.
  • Graepel, R., Ter Braak, B., Escher, S. E., Fisher, C., Gardner, I., Kamp, H., Kroese, D., Leist, M., Moné, M. J., Pastor, M., van de Water, B. (2019). Current Opinion in Toxicology 15: 33-39. doi: 10.1016/j.cotox.2019.03.005 https://www.sciencedirect.com/science/article/pii/S2468202018300688?via%3Dihub
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  • Repeatability of regional lung ventilation quantification using fluorinated ((19)F) gas magnetic resonance imaging.
  • Gutberlet, M., Kaireit, T. F., Voskrebenzev, A., Kern, A. L., Obert, A., Wacker, F., Hohlfeld, J. M., Vogel-Claussen, J. (2019). Academic Radiology 26(3): 395-403. doi: 10.1016/j.acra.2018.10.021 https://www.sciencedirect.com/science/article/pii/S1076633218304859?via%3Dihub
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  • Molecular characterization of a human LPS challenge model.
  • Heissig, F., Litzenburger, T., Müller, M., Wetzel, K., Hohl, K., Schmid, R., Seibold, W., Sarno, M., Gupta, A., Badorrek, P., Faulenbach, C., Hohlfeld, J. M. (2019). American Journal of Respiratory and Critical Care Medicine 199: Abstract A4534. https://doi.org/10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A4534 - Abstract
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  • Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans.
  • Heusser, K., Tank, J., Holz, O., May, M., Brinkmann, J., Engeli, S., Diedrich, A., Framke, T., Koch, A., Grosshennig, A., Jan Danser, A. H., Sweep, F., Schindler, C., Schwarz, K., Krug, N., Jordan, J., Hohlfeld, J. M. (2019). Scientific Reports 9(1): 3641. doi: 10.1038/s41598-019-40343-w https://www.nature.com/articles/s41598-019-40343-w - Open Access
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  • BI 1026706, a bradykinin 1 antagonist, did not reduce pulmonary inflammation upon segmental endotoxin challenge in healthy current smoker subjects compared with placebo.
  • Hohlfeld, J. M., Badorrek, P., Faulenbach, C., Hohl, K., Litzenburger, T., Müller, M., Sarno, M., Seibold, W., Gupta, A. (2019). American Journal of Respiratory and Critical Care Medicine 199: Abstract A4874. https://doi.org/10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A4874 - Abstract
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  • Human ex vivo and in vitro disease models to study food allergy.
  • Hung, L., Obernolte, H., Sewald, K., Eiwegger, T. (2019). Asia Pac Allergy 9(1): e4. doi: 10.5415/apallergy.2019.9.e4
  • https://apallergy.org/DOIx.php?id=10.5415/apallergy.2019.9.e4 - Open Access
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  • The rat bone marrow micronucleus test: Statistical considerations on historical negative control data.
  • Igl, B. W., Bitsch, A., Bringezu, F., Chang, S., Dammann, M., Frotschl, R., Harm, V., Kellner, R., Krzykalla, V., Lott, J., Nern, M., Pfuhler, S., Queisser, N., Schulz, M., Sutter, A., Vaas, L., Vonk, R., Zellner, D., Ziemann, C. (2019). Regulatory Toxicology and Pharmacology 102: 13-22. doi: 10.1016/j.yrtph.2018.12.009
  • https://www.sciencedirect.com/science/article/pii/S0273230018303167?via%3Dihub
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  • CXCR4 Inhibition by the I-body ad-114 blocks bronchosphere formation in a 3d organoid model.
  • Jäger, B., Schambach, A., Denise, K., Foley, M., Prasse, A. (2019). American Journal of Respiratory and Critical Care Medicine 199: Abstract A5250. https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A5250 - Abstract
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  • A mouse model for intellectual disability caused by mutations in the X-linked 2'Omethyltransferase Ftsj1 gene.
  • Jensen, L. R., Garrett, L., Holter, S. M., Rathkolb, B., Racz, I., Adler, T., Prehn, C., Hans, W., Rozman, J., Becker, L., Aguilar-Pimentel, J. A., Puk, O., Moreth, K., Dopatka, M., Walther, D. J., von Bohlen Und Halbach, V., Rath, M., Delatycki, M., Bert, B., Fink, H., Blumlein, K., Ralser, M., Van Dijck, A., Kooy, F., Stark, Z., Muller, S., Scherthan, H., Gecz, J., Wurst, W., Wolf, E., Zimmer, A., Klingenspor, M., Graw, J., Klopstock, T., Busch, D., Adamski, J., Fuchs, H., Gailus-Durner, V., de Angelis, M. H., von Bohlen Und Halbach, O., Ropers, H. H., Kuss, A. W. (2019). Biochim Biophys Acta Mol Basis Dis 1865(9): 2083-2093. doi: 10.1016/j.bbadis.2018.12.011 https://www.sciencedirect.com/science/article/pii/S0925443918304976?via%3Dihub - Open Access
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  • Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation.
  • Jevnikar, Z., Ostling, J., Ax, E., Calven, J., Thorn, K., Israelsson, E., Oberg, L., Singhania, A., Lau, L. C. K., Wilson, S. J., Ward, J. A., Chauhan, A., Sousa, A. R., De Meulder, B., Loza, M. J., Baribaud, F., Sterk, P. J., Chung, K. F., Sun, K., Guo, Y., Adcock, I. M., Payne, D., Dahlen, B., Chanez, P., Shaw, D. E., Krug, N., Hohlfeld, J. M., Sandstrom, T., Djukanovic, R., James, A., Hinks, T. S. C., Howarth, P. H., Vaarala, O., van Geest, M., Olsson, H., Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes study, g. (2019). Journal of Allergy and Clinical Immunology 143(2): 577-590. doi: 10.1016/j.jaci.2018.05.026 https://www.sciencedirect.com/science/article/pii/S0091674918308479
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  • Disruptive anti-IgE inhibitors prevent mast cell-dependent early airway response in viable atopic lung tissue.
  • Jimenez-Delgado, S. M., Dehmel, S., Twisterling, E., Wichmann, J., Jonigk, D., Warnecke, G., Braubach, P., Fieguth, H. G., Wilkens, L., Dahlmann, F., Kaup, F. J., Eggel, A., Knauf, S., Sewald, K., Braun, A. (2019). Journal of Allergy and Clinical Immunology [Epub ahead of print]. doi: 10.1016/j.jaci.2019.11.002 https://www.sciencedirect.com/science/article/abs/pii/S009167491931485X?via%3Dihub
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  • Long noncoding RNA-enriched vesicles secreted by hypoxic cardiomyocytes drive cardiac fibrosis.
  • Kenneweg, F., Bang, C., Xiao, K., Boulanger, C. M., Loyer, X., Mazlan, S., Schroen, B., Hermans-Beijnsberger, S., Foinquinos, A., Hirt, M. N., Eschenhagen, T., Funcke, S., Stojanovic, S., Genschel, C., Schimmel, K., Just, A., Pfanne, A., Scherf, K., Dehmel, S., Reamon-Buettner, S. M., Fiedler, J., Thum, T. (2019). Mol Ther Nucleic Acids 18: 363-374. doi: 10.1016/j.omtn.2019.09.003 https://www.sciencedirect.com/science/article/pii/S2162253119302483?via%3Dihub - Open Access
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  • Challenges of screening applications for early detection of cancer using liquid biopsy.
  • Kermani, B. G., Hücker, S., Kirsch, S., Polzer, B. (2019). Cancer Research 79(13 Supplement): Abstract 1625. 10.1158/1538-7445.AM2019-1625 https://cancerres.aacrjournals.org/content/79/13_Supplement/1625 - Abstract
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  • Noninvasive monitoring of the response of human lungs to low-dose lipopolysaccharide inhalation challenge using MRI: A feasibility study.
  • Kern, A. L., Biller, H., Klimes, F., Voskrebenzev, A., Gutberlet, M., Renne, J., Muller, M., Holz, O., Wacker, F., Hohlfeld, J. M., Vogel-Claussen, J. (2019). Journal of Magnetic Resonance Imaging [Epub ahead of print]. doi: 10.1002/jmri.27000
  • https://onlinelibrary.wiley.com/doi/full/10.1002/jmri.27000 - Open Access
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  • Regional investigation of lung function and microstructure parameters by localized (129) Xe chemical shift saturation recovery and dissolved-phase imaging: A reproducibility study.
  • Kern, A. L., Gutberlet, M., Qing, K., Voskrebenzev, A., Klimes, F., Kaireit, T. F., Czerner, C., Biller, H., Wacker, F., Ruppert, K., Hohlfeld, J. M., Vogel-Claussen, J. (2019). Magnetic Resonance in Medicine81(1): 13-24. doi: 10.1002/mrm.27407
  • https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.27407
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  • Mapping of regional lung microstructural parameters using hyperpolarized (129) Xe dissolved-phase MRI in healthy volunteers and patients with chronic obstructive pulmonary disease.
  • Kern, A. L., Gutberlet, M., Voskrebenzev, A., Klimes, F., Rotarmel, A., Wacker, F., Hohlfeld, J. M., Vogel-Claussen, J. (2019). Magnetic Resonance in Medicine 81(4): 2360-2373. doi: 10.1002/mrm.27559
  • https://onlinelibrary.wiley.com/doi/full/10.1002/mrm.27559
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  • Targeted repair of p47-CGD in iPSCs by CRISPR/Cas9: Functional correction without cleavage in the highly homologous pseudogenes.
  • Klatt, D., Cheng, E., Philipp, F., Selich, A., Dahlke, J., Schmidt, R. E., Schott, J. W., Buning, H., Hoffmann, D., Thrasher, A. J., Schambach, A. (2019). Stem Cell Reports 13(4): 590-598. doi: 10.1016/j.stemcr.2019.08.008 https://www.sciencedirect.com/science/article/pii/S2213671119303029?via%3Dihub - Open Access
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  • Targeted repair of p47-CGD restores the ability of iPSC-derived macrophages to kill bacteria.
  • Klatt, D., Cheng, E., Philipp, F., Selich, A., Dahlke, J., Schmidt, R. E., Schott, J. W., Hoffmann, D., Thrasher, A. J., Schambach, A. (2019). Molecular Therapy 27(4 Supplement 1): 338, Abstract 713. - Abstract
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  • The clinical course of idiopathic pulmonary fibrosis and its association to quality of life over time: longitudinal data from the INSIGHTS-IPF registry.
  • Kreuter, M., Swigris, J., Pittrow, D., Geier, S., Klotsche, J., Prasse, A., Wirtz, H., Koschel, D., Andreas, S., Claussen, M., Grohe, C., Wilkens, H., Hagmeyer, L., Skowasch, D., Meyer, J. F., Kirschner, J., Gläser, S., Kahn, N., Welte, T., Neurohr, C., Schwaiblmair, M., Held, M., Bahmer, T., Oqueka, T., Frankenberger, M., Behr, J. (2019). Respiratory Research 20: 59. doi: 10.1186/s12931-019-1020-3 https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-019-1020-3 - Open Access
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  • A read-across study on diketones.
  • Kühne, B., Ritter, D., Knebel, J., Boei, J., Vrieling, H., Hiemstra, P., Escher, S., Hansen, T. (2019). The Toxicologist Supplement to Toxicological Sciences 168(1): 243, Abstract PS 2029. - Abstract
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  • Contribution of airway eosinophils in airway wall remodeling in asthma: Role of MMP-10 and MET.
  • Kuo, C. S., Pavlidis, S., Zhu, J., Loza, M., Baribaud, F., Rowe, A., Pandis, I., Gibeon, D., Hoda, U., Sousa, A., Wilson, S. J., Howarth, P., Shaw, D., Fowler, S., Dahlen, B., Chanez, P., Krug, N., Sandstrom, T., Fleming, L., Corfield, J., Auffray, C., Djukanovic, R., Sterk, P. J., Guo, Y., Adcock, I. M., Chung, K. F., U. Biopred Project Team (2019). Allergy [Epub ahead of print]. doi: 10.1111/all.13727 https://onlinelibrary.wiley.com/doi/full/10.1111/all.13727
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  • Long-term effects of inhaled nanoparticles in rats: ceriumdioxide and bariumsulphate.
  • Landsiedel, R., Ma-Hock, L., Wiench, K., Gröters, S., van Ravenzwaay, B., Ernst, H., Schaudien, D. (2019). The Toxicologist Supplement to Toxicological Sciences 168(1): 289, Abstract PS 2217. - Abstract
  •  
  • Comparative study of multiwalled carbon nanotubes and pro-inflammatory IL-1 beta production: the role of purification and surface functionalization.
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  • Identification of potential emerging chemical risks in food from REACH registered chemicals.
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  • Long-term effects of inhaled nanoparticles in rats – Ceriumdioxide and Bariumsulphate.
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  • Fate of barium sulfate nanoparticles deposited in the lungs of rats.
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  • Fate of barium sulfate nanoparticles deposited in the lungs of rats.
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  • Analyses of frequency and sensitivity of affected organs in preclinical studies from RepDose and eTOX database.
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  • Development of a physiologically based pharmacokinetic (PBPK) model for the inhalationale route.
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  • Cigarette smoke induced pathophysiological changes in the extracellular matrix but not inflammation as early events in fresh human lung tissue.
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  • IL-17-high asthma with features of a psoriasis immunophenotype.
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  • Occupational exposure to antibiotics in poultry feeding farms.
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  • The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity?
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  • Rating sputum cell quality in clinical trials for asthma and COPD treatment.
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  • Interferon response genes in nasal epithelium to rhinovirus16 challenge in asthma patients links to viral clearance and common cold scores.
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