Publications of Fraunhofer ITEM

Recent publications in the 2nd quarter 2018

Bernstein, D. M., Toth, B., Rogers, R. A., Sepulveda, R., Kunzendorf, P., Phillips, J. I., Ernst, H. (2018).
Evaluation of the dose-response and fate in the lung and pleura of chrysotile-containing brake dust compared to chrysotile or crocidolite asbestos in a 28-day quantitative inhalation toxicology study.
Toxicology and Applied Pharmacology 351: 74-92.
doi: 10.1016/j.taap.2018.04.033

Burg, D., Schofield, J. P. R., Brandsma, J., Staykova, D., Folisi, C., Bansal, A., Nicholas, B., Xian, Y., Rowe, A., Corfield, J., Wilson, S., Ward, J., Lutter, R., Fleming, L., Shaw, D. E., Bakke, P. S., Caruso, M., Dahlen, S. E., Fowler, S. J., Hashimoto, S., Horvath, I., Howarth, P., Krug, N., Montuschi, P., Sanak, M., Sandstrom, T., Singer, F., Sun, K., Pandis, I., Auffray, C., Sousa, A. R., Adcock, I. M., Chung, K. F., Sterk, P. J., Djukanovic, R., Skipp, P. J., The, U. B. S. G. (2018).
Large-scale label-free quantitative mapping of the sputum proteome.
Journal of Proteome Research 17(6): 2072-2091.
doi: 10.1021/acs.jproteome.8b00018

Chen, S., El-Heliebi, A., Schmid, J., Kashofer, K., Czyz, Z. T., Polzer, B. M., Pantel, K., Kroneis, T., Sedlmayr, P. (2018).
Target Cell Pre-enrichment and Whole Genome Amplification for Single Cell Downstream Characterization.
doi: 10.3791/56394

De Meulder, B., Lefaudeux, D., Bansal, A. T., Mazein, A., Chaiboonchoe, A., Ahmed, H., Balaur, I., Saqi, M., Pellet, J., Ballereau, S., Lemonnier, N., Sun, K., Pandis, I., Yang, X., Batuwitage, M., Kretsos, K., van Eyll, J., Bedding, A., Davison, T., Dodson, P., Larminie, C., Postle, A., Corfield, J., Djukanovic, R., Chung, K. F., Adcock, I. M., Guo, Y. K., Sterk, P. J., Manta, A., Rowe, A., Baribaud, F., Auffray, C., Group, U. B. S., the e, T. C. (2018).
A computational framework for complex disease stratification from multiple large-scale datasets.
BMC Systems Biology 12(1): 60. 
doi: 10.1186/s12918-018-0556-z

Fayyad, A., Lapp, S., Risha, E., Pfankuche, V. M., Rohn, K., Barthel, Y., Schaudien, D., Baumgartner, W., Puff, C. (2018).
Matrix metalloproteinases expression in spontaneous canine histiocytic sarcomas and its xenograft model.
Veterinary Immunology and Immunopathology 198: 54-64.
doi: 10.1016/j.vetimm.2018.03.002

Feldmann, J., Bluemlein, K., Krupp, E. M., Mueller, M., Wood, B. A. (2018).
Metallomics study in plants exposed to arsenic, mercury, selenium and sulphur.
Advances in Experimental Medicine and Biology 1055: 67-100.
doi: 10.1007/978-3-319-90143-5_4

Gotzmann, G., Portillo, J., Wronski, S., Kohl, Y., Gorjup, E., Schuck, H., Rögner, F. H., Müller, M., Chaberny, I. F., Schönfelder, J., Wetzel, C. (2018).
Low-energy electron-beam treatment as alternative for on-site sterilization of highly functionalized medical products – A feasibility study.
Radiation Physics and Chemistry 150: 9-19.
doi: 10.1016/j.radphyschem.2018.04.008

Greulich, T., Hohlfeld, J. M., Neuser, P., Lueer, K., Klemmer, A., Schade-Brittinger, C., Harnisch, S., Garn, H., Renz, H., Homburg, U., Renz, J., Kirsten, A., Pedersen, F., Müller, M., Vogelmeier, C. F., Watz, H. (2018).
A GATA3-specific DNAzyme attenuates sputum eosinophilia in eosinophilic COPD patients: a feasibility randomized clinical trial.
Respiratory Research 19(1): 55.
doi: 10.1186/s12931-018-0751-x

Hoffmann, M., Galle, J. (2018).
Stochastic system identification without an a priori chosen kinetic model-exploring feasible cell regulation with piecewise linear functions.
NPJ Systems Biology and Applications 4: 15.
doi: 10.1038/s41540-018-0049-0

Holz, O., Heusser, K., Müller, M., Windt, H., Schwarz, K., Schindler, C., Tank, J., Hohlfeld, J. M., Jordan, J. (2018).
Airway and systemic inflammatory responses to ultrafine carbon black particles and ozone in older healthy subjects.
Journal of Toxicology and Environmental Health. Part A 81(13): 576-588.
doi: 10.1080/15287394.2018.1463331

Jevnikar, Z., Ostling, J., Ax, E., Calven, J., Thorn, K., Israelsson, E., Oberg, L., Singhania, A., Lau, L. C. K., Wilson, S. J., Ward, J. A., Chauhan, A., Sousa, A. R., De Meulder, B., Loza, M. J., Baribaud, F., Sterk, P. J., Chung, K. F., Sun, K., Guo, Y., Adcock, I. M., Payne, D., Dahlen, B., Chanez, P., Shaw, D. E., Krug, N., Hohlfeld, J. M., Sandstrom, T., Djukanovic, R., James, A., Hinks, T. S. C., Howarth, P. H., Vaarala, O., van Geest, M., Olsson, H. K., group, U. B. s. (2018).
Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation.
Journal of Allergy and Clinical Immunology [Epub ahead of print].
doi: 10.1016/j.jaci.2018.05.026

Konerding, W. S., Froriep, U. P., Kral, A., Baumhoff, P. (2018).
New thin-film surface electrode array enables brain mapping with high spatial acuity in rodents.
Scientific Reports 8(1): 3825. doi: 10.1038/s41598-018-22051-z

Küppers, L., Holz, O., Schuchardt, S., Gottlieb, J., Fuge, J., Greer, M., Hohlfeld, J. (2018).
Breath volatile organic compounds of lung transplant recipients with and without chronic lung allograft dysfunction.
J Breath Res [Epub ahead of print].
doi: 10.1088/1752-7163/aac5af

Laux, P., Riebeling, C., Booth, A. M., Brain, J. D., Brunner, J., Cerrillo, C., Creutzenberg, O., Estrela-Lopis, I., Gebel, T., Johanson, G., Jungnickel, H., Kock, H., Tentschert, J., Tlili, A., Schäffer, A., Sips, A. J. A. M., Yokel, R. A., Luch, A. (2018). 
Challenges in characterizing the environmental fate and effects of carbon nanotubes and inorganic nanomaterials in aquatic systems.
Environmental Science: Nano 5(1): 48-63.
doi: 10.1039/c7en00594f!divAbstract

Lindner, K., Webering, S., Stroebele, M., Bockhorn, H., Hansen, T., König, P., Fehrenbach, H. (2018). 
Low dose carbon black nanoparticle exposure does not aggravate allergic airway inflammation in mice irrespective of the presence of surface polycyclic aromatic hydrocarbons.
Nanomaterials (Basel) 8(4).
doi: 10.3390/nano8040213

Lorentzen, A., Becker, P. F., Kosla, J., Saini, M., Weidele, K., Ronchi, P., Klein, C., Wolf, M. J., Geist, F., Seubert, B., Ringelhan, M., Mihic-Probst, D., Esser, K., Roblek, M., Kuehne, F., Bianco, G., O'Connor, T., Müller, Q., Schuck, K., Lange, S., Hartmann, D., Spaich, S., Gross, O., Utikal, J., Haferkamp, S., Sprick, M. R., Damle-Vartak, A., Hapfelmeier, A., Hüser, N., Protzer, U., Trumpp, A., Saur, D., Vartak, N., Klein, C. A., Polzer, B., Borsig, L., Heikenwalder, M. (2018).
Single cell polarity in liquid phase facilitates tumour metastasis.
Nat Commun 9(1): 887.
doi: 10.1038/s41467-018-03139-6

Lüke, F., Blazquez, R., Yamaci, R. F., Lu, X., Pregler, B., Hannus, S., Menhart, K., Hellwig, D., Wester, H. J., Kropf, S., Heudobler, D., Grosse, J., Moosbauer, J., Hutterer, M., Hau, P., Riemenschneider, M. J., Bayerlova, M., Bleckmann, A., Polzer, B., Beissbarth, T., Klein, C. A., Pukrop, T. (2018).
Isolated metastasis of an EGFR-L858R-mutated NSCLC of the meninges: the potential impact of CXCL12/CXCR4 axis in EGFRmut NSCLC in diagnosis, follow-up and treatment.
Oncotarget 9(27): 18844-18857.
doi: 10.18632/oncotarget.24787[]=24787&path[]=77733

Mang, S., Braun, A., Pairet, N., Lamb, D. J. (2018).
Importance of the IL-1 Axis in Haemophilus influenzae-stimulated M1 Macrophages Driving Transepithelial Signaling.
American Journal of Respiratory Cell and Molecular Biology 58(3): 412-415.
doi: 10.1165/rcmb.2017-0283LE 

Pohlmann, G., Hohlfeld, J. M., Haidl, P., Pankalla, J., Cloes, R. M. (2018).
Assessment of the power required for optimal use of current inhalation devices.
Journal of Aerosol Medicine and Pulmonary Drug Delivery [Epub ahead of print].
doi: 10.1089/jamp.2017.1376

Ritter, D., Bitsch, A., Elend, M., Schuchardt, S., Hansen, T., Brodbeck, C., Knebel, J., Fuchs, A., Gronewold, C., Fautz, R. (2018).
Development and evaluation of an in vitro test system for toxicity screening of aerosols released from consumer products and first application to aerosols from a hair straightening process.
Applied In Vitro Toxicology [Epub ahead of print].
doi: 10.1089/aivt.2017.0036

Rogol, A. D., Tkachenko, N., Badorrek, P., Hohlfeld, J. M., Bryson, N. (2018).
Phase 1 pharmacokinetics and phase 3 efficacy of testosterone nasal gel in subjects with seasonal allergies.
Can Urol Assoc J 12(7).
doi: 10.5489/cuaj.4898

Schwarz, K., Pappa, G., Miertsch, H., Scheel, J., Koch, W. (2018).
A methodology for the assessment of inhalation exposure to aluminium from antiperspirant sprays.
Archives of Toxicology 92(4): 1383-1392.
doi: 10.1007/s00204-017-2151-2

Takahashi, K., Pavlidis, S., Ng Kee Kwong, F., Hoda, U., Rossios, C., Sun, K., Loza, M., Baribaud, F., Chanez, P., Fowler, S. J., Horvath, I., Montuschi, P., Singer, F., Musial, J., Dahlen, B., Dahlen, S. E., Krug, N., Sandstrom, T., Shaw, D. E., Lutter, R., Bakke, P., Fleming, L. J., Howarth, P. H., Caruso, M., Sousa, A. R., Corfield, J., Auffray, C., De Meulder, B., Lefaudeux, D., Djukanovic, R., Sterk, P. J., Guo, Y., Adcock, I. M., Chung, K. F., group, o. b. o. t. U. B. s. (2018).
Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis.
European Respiratory Journal 51(5).
doi: 10.1183/13993003.02173-2017

Tamo, L., Simillion, C., Hibaoui, Y., Feki, A., Gugger, M., Prasse, A., Jager, B., Goldmann, T., Geiser, T., Gazdhar, A. (2017).
Gene network analysis of interstitial macrophages after treatment with induced pluripotent stem cells secretome (iPSC-cm) in the bleomycin injured rat lung.
Stem Cell Rev Rep [Epub ahead of print].
doi: 10.1007/s12015-017-9790-9

Wronski, S., Dannenmaier, J., Schild, S., Macke, O., Müller, L., Burmeister, Y., Seilheimer, B., Müller, M. (2018).
Engystol reduces onset of experimental respiratory syncytial virus-induced respiratory inflammation in mice by modulating macrophage phagocytic capacity.
PloS One 13(4): e0195822.
doi: 10.1371/journal.pone.0195822

Ziemann, S., van der Linde, K., Lahrmann, U., Acar, B., Kaschani, F., Colby, T., Kaiser, M., Ding, Y., Schmelz, E., Huffaker, A., Holton, N., Zipfel, C., Doehlemann, G. (2018).
An apoplastic peptide activates salicylic acid signalling in maize.
Nat Plants 4(3): 172-180.
doi: 10.1038/s41477-018-0116-y

Zind, L., Troyke, R., Turban, K., Schaudien, D., Baumgärtner, W., Hansmann, F. (2018).
Ein importierter Fall von feliner Leishmaniose in Deutschland und eine Literaturübersicht zur felinen Leishmaniose. [An imported case of feline leishmaniosis in Germany with a literature review on feline leishmaniosis]
Berliner und Munchener Tierarztliche Wochenschrift [Epub ahead of print].
doi: 10.2376/0005-9366-17061

Publications in the 1st quarter 2018

Behr, J., Gunther, A., Bonella, F., Geissler, K., Koschel, D., Kreuter, M., Prasse, A., Schonfeld, N., Sitter, H., Muller-Quernheim, J., Costabel, U.:
German Guideline for Idiopathic Pulmonary Fibrosis - Update on Pharmacological Therapies 2017.
Pneumologie (2018) [Epub ahead of print]
doi: 10.1055/s-0043-123035

Gutberlet, M., Kaireit, T. F., Voskrebenzev, A., Lasch, F., Freise, J., Welte, T., Wacker, F., Hohlfeld, J. M., Vogel-Claussen, J.:
Free-breathing Dynamic (19)F Gas MR Imaging for Mapping of Regional Lung Ventilation in Patients with COPD.
Radiology, Vol. 286 (2018), No. 3, pp. 1040-1051
doi: 10.1148/radiol.2017170591

Happle, C., Jirmo, A. C., Meyer-Bahlburg, A., Habener, A., Hoymann, H. G., Hennig, C., Skuljec, J., Hansen, G.:
B cells control maternofetal priming of allergy and tolerance in a murine model of allergic airway inflammation.
Journal of Allergy and Clinical Immunology, Vol. 141 (2018), No. 2, pp. 685-696 e686. 
doi: 10.1016/j.jaci.2017.03.051

Hohlfeld, J. M., Vogel-Claussen, J., Biller, H., Berliner, D., Berschneider, K., Tillmann, H. C., Hiltl, S., Bauersachs, J., Welte, T.:
Effect of lung deflation with indacaterol plus glycopyrronium on ventricular filling in patients with hyperinflation and COPD (CLAIM): a double-blind, randomised, crossover, placebo-controlled, single-centre trial.
Lancet Respir Med (2018) [Epub ahead of print]. 
doi: 10.1016/S2213-2600(18)30054-7

Hücker, S. M., Vanderhaeghen, S., Abellan-Schneyder, I., Wecko, R., Simon, S., Scherer, S., Neuhaus, K.:
A novel short L-arginine responsive protein-coding gene (laoB) antiparallel overlapping to a CadC-like transcriptional regulator in Escherichia coli O157:H7 Sakai originated by overprinting.
BMC Evolutionary Biology, Vol. 18 (2018), No. 1, p. 21
doi: 10.1186/s12862-018-1134-0

Juling, S., Bohmert, L., Lichtenstein, D., Oberemm, A., Creutzenberg, O., Thunemann, A. F., Braeuning, A., Lampen, A.:
Comparative proteomic analysis of hepatic effects induced by nanosilver, silver ions and nanoparticle coating in rats.
Food and Chemical Toxicology, Vol. 113 (2018), pp. 255-266. 
doi: 10.1016/j.fct.2018.01.056

Laux, P., Tentschert, J., Riebeling, C., Braeuning, A., Creutzenberg, O., Epp, A., Fessard, V., Haas, K. H., Haase, A., Hund-Rinke, K., Jakubowski, N., Kearns, P., Lampen, A., Rauscher, H., Schoonjans, R., Stormer, A., Thielmann, A., Muhle, U., Luch, A.:
Nanomaterials: certain aspects of application, risk assessment and risk communication.
Archives of Toxicology, Vol. 92 (2018), No. 1, pp. 121-141 
doi: 10.1007/s00204-017-2144-1

Neehus, A. L., Lam, J., Haake, K., Merkert, S., Schmidt, N., Mucci, A., Ackermann, M., Schubert, M., Happle, C., Kühnel, M. P., Blank, P., Philipp, F., Goethe, R., Jonigk, D., Martin, U., Kalinke, U., Baumann, U., Schambach, A., Roesler, J., Lachmann, N.:
Impaired IFNgamma-Signaling and Mycobacterial Clearance in IFNgammaR1-Deficient Human iPSC-Derived Macrophages.
Stem Cell Reports, Vol. 10 (2018), No. 1, pp. 7-16
doi: 10.1016/j.stemcr.2017.11.011 - Open Access

Neuhaus, V., Danov, O., Konzok, S., Obernolte, H., Dehmel, S., Braubach, P., Jonigk, D., Fieguth, H.-G., Zardo, P., Warnecke, G., Martin, C., Braun, A., Sewald, K.: 
Assessment of the cytotoxic and immunomodulatory effects of substances in human precision-cut lung slices.
JoVE (2017) [Epub ahead of print] 

Schwotzer, D., Niehof, M., Schaudien, D., Kock, H., Hansen, T., Dasenbrock, C., Creutzenberg, O.:
Cerium oxide and barium sulfate nanoparticle inhalation affects gene expression in alveolar epithelial cells type II.
Journal of Nanobiotechnology, Vol. 16 (2018), Vol. 1, p. 16 
doi: 10.1186/s12951-018-0343-4 - Open Access

Toropova, A. P., Toropov, A. A., Marzo, M., Escher, S. E., Dorne, J. L., Georgiadis, N., Benfenati, E.: 
The application of new HARD-descriptor available from the CORAL software to building up NOAEL models.
Food and Chemical Toxicology, Vol. 112 (2018), pp. 544-550 
doi: 10.1016/j.fct.2017.03.060

Ulmer, A., Dietz, K., Werner-Klein, M., Hafner, H. M., Schulz, C., Renner, P., Weber, F., Breuninger, H., Rocken, M., Garbe, C., Fierlbeck, G., Klein, C. A.:
The sentinel lymph node spread determines quantitatively melanoma seeding to non-sentinel lymph nodes and survival.
European Journal of Cancer, Vol. 91 (2018), pp. 1-10 
doi: 10.1016/j.ejca.2017.12.002

Werner-Klein, M., Scheitler, S., Hoffmann, M., Hodak, I., Dietz, K., Lehnert, P., Naimer, V., Polzer, B., Treitschke, S., Werno, C., Markiewicz, A., Weidele, K., Czyz, Z., Hohenleutner, U., Hafner, C., Haferkamp, S., Berneburg, M., Rummele, P., Ulmer, A., Klein, C. A.:
Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma.
Nat Commun, Vol. 9 (2018), No. 1, p. 595
doi: 10.1038/s41467-017-02674-y - Open Access

Wise, S. K., Lin, S. Y., Toskala, E., Orlandi, R. R., Akdis, C. A., Alt, J. A., Azar, A., Baroody, F. M., Bachert, C., Canonica, G. W., Chacko, T., Cingi, C., Ciprandi, G., Corey, J., Cox, L. S., Creticos, P. S., Custovic, A., Damask, C., DeConde, A., DelGaudio, J. M., Ebert, C. S., Eloy, J. A., Flanagan, C. E., Fokkens, W. J., Franzese, C., Gosepath, J., Halderman, A., Hamilton, R. G., Hoffman, H. J., Hohlfeld, J. M., Houser, S. M., Hwang, P. H., Incorvaia, C., Jarvis, D., Khalid, A. N., Kilpelainen, M., Kingdom, T. T., Krouse, H., Larenas-Linnemann, D., Laury, A. M., Lee, S. E., Levy, J. M., Luong, A. U., Marple, B. F., McCoul, E. D., McMains, K. C., Melen, E., Mims, J. W., Moscato, G., Mullol, J., Nelson, H. S., Patadia, M., Pawankar, R., Pfaar, O., Platt, M. P., Reisacher, W., Rondon, C., Rudmik, L., Ryan, M., Sastre, J., Schlosser, R. J., Settipane, R. A., Sharma, H. P., Sheikh, A., Smith, T. L., Tantilipikorn, P., Tversky, J. R., Veling, M. C., Wang, Y., Westman, M., Wickman, M., Zacharek, M.:
International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis.
Int Forum Allergy Rhinol, Vol. 8 (2018), No. 2, pp. 108-352
doi: 10.1002/alr.22073

Yu, Y., Schleich, K., Yue, B., Ji, S., Lohneis, P., Kemper, K., Silvis, M. S., Qutob, N., van Rooijen, E., Werner-Klein, M., Li, L., Dhawan, D., Meierjohann, S., Reimann, M., Elkahloun, A., Treitschke, S., Dorken, B., Speck, C., Mallette, F. A., Zon, L. I., Holmen, S. L., Peeper, D. S., Samuels, Y., Schmitt, C. A., Lee, S.:
Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.
Cancer Cell, Vol. 33 (2018), No. 2, pp. 322-336 e328
doi: 10.1016/j.ccell.2018.01.002

Oltmanns, J., Licht, O., Bitsch, A., Bohlen, M. L., Escher, S. E., Silano, V., MacLeod, M., Serafimova, R., Kass, G. E. N., Merten, C.:
Development of a novel scoring system for identifying emerging chemical risks in the food chain.
Environ Sci Process Impacts, Vol. 20 (2018), No. 2, pp. 340-353 
doi: 10.1039/c7em00564d!divAbstract

Hoffmann, M., Pasch, S., Schamberger, T., Maneck, M., Möhlendick, B., Schumacher, S., Brockhoff, G., Knoefel, WT., Izbicki, J., Polzer, B., Stoecklein, N. H., Klein, C. A.:
Diagnostic pathology of early systemic cancer: ERBB2 gene amplification in single disseminated cancer cells determines patient survival in operable esophageal cancer.
Int J Cancer, Vol. 142 (2018), No. 4, pp. 833-843 
doi: 10.1002/ijc.31108
Epub 2017 Nov 30

Lorentzen, A., Becker, P. F., Kosla, J., Saini, M., Weidele, K., Ronchi, P., Klein, C., Wolf, M. J., Geist, F., Seubert, B., Ringelhan, M., Mihic-Probst, D., Esser, K., Roblek, M., Kuehne, F., Bianco, G., O´Connor, T., Müller, Q., Schuck, K., Lange, S., Hartmann, D., Spaich, S., Groß, O., Utikal, J., Haferkamp, S., Sprick, M. R., Damle-Vartak, A., Hapfelmeier, A., Hüser, N., Protzer, U., Trumpp, A., Saur, D., Vartak, N., Klein, C. A., Polzer, B., Borsig, L. & Heikenwalder, M.:
Single cell polarity in liquid phase facilitates tumour metastasis.
Nature Communications, Vol. 887 (2018), No. 9
doi: 10.1038/s41467-018-03139-6 (for pdf please see