Fraunhofer Institute for Toxicology and Experimental Medicine
Fraunhofer Institute for Toxicology and Experimental Medicine

Fraunhofer ITEM publications

 

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R&D expertise "Cardiopulmonary research": publications in 2023

  • Ahangari, F., Price, N. L., Malik, S., Chioccioli, M., Barnthaler, T., Adams, T. S., Kim, J., Pradeep, S. P., Ding, S., Cosmos, C., Jr., Rose, K. S., McDonough, J. E., Aurelien, N. R., Ibarra, G., Omote, N., Schupp, J. C., DeIuliis, G., Villalba Nunez, J. A., Sharma, L., Ryu, C., Dela Cruz, C. S., Liu, X., Prasse, A., Rosas, I., Bahal, R., Fernandez-Hernando, C., Kaminski, N. (2023). microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis. JCI Insight 8(4). doi: 10.1172/jci.insight.158100 https://insight.jci.org/articles/view/158100 - Open Access
  • Behr, J., Berger, M., Blum, T. G., Bonella, F., Dinkel, J., Glaser, S., Hagmeyer, L., Kneidinger, N., Koschel, D., Prasse, A., Slevogt, H., Stacher-Priehse, E., Woehrle, H., Kreuter, M. (2023). [SARS-CoV-2-Infection and Interstitial Lung Disease: Position paper of the German Respiratory Society]. SARS-CoV-2-Infektion und interstitielle Lungenerkrankungen – Positionspapier der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin. Pneumologie 77(3): 143-157. doi: 10.1055/a-2007-9845 https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2007-9845
  • Behr, J., Bonella, F., Frye, B. C., Gunther, A., Hagmeyer, L., Henes, J., Klemm, P., Koschel, D., Kreuter, M., Leuschner, G., Nowak, D., Prasse, A., Quadder, B., Sitter, H., Costabel, U. (2023). Erratum for [Pharmacological treatment of idiopathic pulmonary fibrosis (update) and progressive pulmonary fibrosis - S2k Guideline of the German Respiratory Society]. Erratum: Pharmakotherapie der idiopathischen Lungenfibrose (ein Update) und anderer progredienter pulmonaler Fibrosen. Pneumologie 77(2): e1. doi: 10.1055/a-2043-4482 https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-2043-4482
  • Behr, J., Bonella, F., Frye, B. C., Gunther, A., Hagmeyer, L., Henes, J., Klemm, P., Koschel, D., Kreuter, M., Leuschner, G., Nowak, D., Prasse, A., Quadder, B., Sitter, H., Costabel, U. (2023). [Pharmacological treatment of idiopathic pulmonary fibrosis (update) and progressive pulmonary fibrosis - S2k Guideline of the German Respiratory Society]. Pharmakotherapie der idiopathischen Lungenfibrose (ein Update) und anderer progredienter pulmonaler Fibrosen. Pneumologie 77(2): 94-119. doi: 10.1055/a-1983-6796 https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1983-6796
  • Biss, S., Teschler, M., Heimer, M., Thum, T., Bar, C., Mooren, F. C., Schmitz, B. (2023). A single session of EMS training induces long-lasting changes in circulating muscle but not cardiovascular miRNA levels - A randomized crossover study. J Appl Physiol. [Epub ahead of print]. doi: 10.1152/japplphysiol.00557.2022 https://journals.physiology.org/doi/abs/10.1152/japplphysiol.00557.2022
  • Borie, R., Kannengiesser, C., Antoniou, K., Bonella, F., Crestani, B., Fabre, A., Froidure, A., Galvin, L., Griese, M., Grutters, J. C., Molina-Molina, M., Poletti, V., Prasse, A., Renzoni, E., van der Smagt, J., van Moorsel, C. H. M. (2023). European Respiratory Society statement on familial pulmonary fibrosis. European Respiratory Journal 61(3). doi: 10.1183/13993003.01383-2022 https://erj.ersjournals.com/content/61/3/2201383.long
  • Brandsma, J., Schofield, J. P. R., Yang, X., Strazzeri, F., Barber, C., Goss, V. M., Koster, G., Bakke, P. S., Caruso, M., Chanez, P., Dahlen, S. E., Fowler, S. J., Horvath, I., Krug, N., Montuschi, P., Sanak, M., Sandstrom, T., Shaw, D. E., Chung, K. F., Singer, F., Fleming, L. J., Adcock, I. M., Pandis, I., Bansal, A. T., Corfield, J., Sousa, A. R., Sterk, P. J., Sanchez-Garcia, R. J., Skipp, P. J., Postle, A. D., Djukanovic, R., Group, U. B. S. (2023). Stratification of asthma by lipidomic profiling of induced sputum supernatant. Journal of Allergy and Clinical Immunology [Epub ahead of print]. doi: 10.1016/j.jaci.2023.02.032 https://www.sciencedirect.com/science/article/abs/pii/S0091674923002932?via%3Dihub
  • Davidson, S. M., Boulanger, C. M., Aikawa, E., Badimon, L., Barile, L., Binder, C. J., Brisson, A., Buzas, E., Emanueli, C., Jansen, F., Katsur, M., Lacroix, R., Lim, S. K., Mackman, N., Mayr, M., Menasche, P., Nieuwland, R., Sahoo, S., Takov, K., Thum, T., Vader, P., Wauben, M. H. M., Witwer, K., Sluijter, J. P. G. (2023). Methods for the identification and characterization of extracellular vesicles in cardiovascular studies: from exosomes to microvesicles. Cardiovascular Research 119(1): 45-63. doi: 10.1093/cvr/cvac031 https://academic.oup.com/cardiovascres/article/119/1/45/6553781?login=true  - Open Access
  • Gauvreau, G. M., Hohlfeld, J. M., FitzGerald, M. J., Boulet, L. P., Cockcroft, D. W., Davis, B. E., Korn, S., Kornmann, O., Leigh, R., Mayers, I., Watz, H., Grant, S. S., Jain, M., Cabanseki, M., Pertel, P. E., Jones, I., Lecot, J. R., Cao, H., O'Byrne, P. M. (2023). Inhaled anti-TSLP antibody fragment, ecleralimab, blocks responses to allergen in mild asthma. European Respiratory Journal 61(3): 10p. doi: 10.1183/13993003.01193-2022 https://erj.ersjournals.com/content/erj/61/3/2201193.full.pdf  - Open Access
  • Gauvreau, G. M., Hohlfeld, J. M., FitzGerald, J. M., Boulet, L. P., Cockcroft, D. W., Davis, B. E., Korn, S., Kornmann, O., Leigh, R., Mayers, I., Watz, H., Grant, S. S., Jain, M., Cabanski, M., Pertel, P. E., Jones, I., Lecot, J. R., Cao, H., O'Byrne, P. M. (2023). Inhaled anti-TSLP antibody fragment, ecleralimab, blocks responses to allergen in mild asthma. European Respiratory Journal 61(3). doi: 10.1183/13993003.01193-2022 https://erj.ersjournals.com/content/61/3/2201193.long - Open Access
  • Gress, C., Vogel-Claussen, J., Badorrek, P., Müller, M., Hohl, K., Konietzke, M., Litzenburger, T., Seibold, W., Gupta, A., Hohlfeld, J. M. (2023). The effect of bradykinin 1 receptor antagonist BI 1026706 on pulmonary inflammation after segmental lipopolysaccharide challenge in healthy smokers. Pulmonary Pharmacology and Therapeutics [Epub ahead of print]: 102246. doi: 10.1016/j.pupt.2023.102246 https://www.sciencedirect.com/science/article/abs/pii/S1094553923000585?via%3Dihub
  • Gustafsson, F., Damman, K., Nalbantgil, S., Van Laake, L. W., Tops, L. F., Thum, T., Adamopoulos, S., Bonios, M., Coats, A. J., Crespo-Leiro, M. G., Mehra, M. R., Filippatos, G., Hill, L., Metra, M., Jankowska, E., de Jonge, N., Kaye, D., Masetti, M., Parissis, J., Milicic, D., Seferovic, P., Rosano, G., Ben Gal, T. (2023). Inotropic therapy in patients with advanced heart failure. A clinical consensus statement from the Heart Failure Association of the European Society of Cardiology. European Journal of Heart Failure [Epub ahead of print]. doi: 10.1002/ejhf.2814 https://onlinelibrary.wiley.com/doi/10.1002/ejhf.2814 - Open Access
  • Hilbold, E., Bär, C., Thum, T. (2023). COVID-19: Insights into long-term manifestations and lockdown impacts. J Sport Health Sci [Epub ahead of print]. doi: 10.1016/j.jshs.2023.02.006 https://www.sciencedirect.com/science/article/pii/S2095254623000194?via%3Dihub - Open Access
  • Kandil, R., Baldassi, D., Bohlen, S., Muller, J. T., Jurgens, D. C., Bargmann, T., Dehmel, S., Xie, Y., Mehta, A., Sewald, K., Merkel, O. M. (2023). Targeted GATA3 knockdown in activated T cells via pulmonary siRNA delivery as novel therapy for allergic asthma. Journal of Controlled Release 354: 305-315. doi: 10.1016/j.jconrel.2023.01.014  https://www.sciencedirect.com/science/article/abs/pii/S0168365923000159?via%3Dihub
  • Kern, A. L., Gutberlet, M., Rumpel, R., Bruesch, I., Hohlfeld, J. M., Wacker, F., Hensen, B. (2023). Absolute thermometry using hyperpolarized (129) Xe free-induction decay and spin-echo chemical-shift imaging in rats. Magnetic Resonance in Medicine 89(1): 54-63. doi: 10.1002/mrm.29455 https://onlinelibrary.wiley.com/doi/10.1002/mrm.29455 - Open Access 
  • Kreuter, M., Behr, J., Bonella, F., Costabel, U., Gerber, A., Hamer, O. W., Heussel, C. P., Jonigk, D., Krause, A., Koschel, D., Leuschner, G., Markart, P., Nowak, D., Pfeifer, M., Prasse, A., Walscher, J., Winter, H., Kabitz, H. J. (2023). [Consensus guideline on the interdisciplinary diagnosis of interstitial lung diseases]. Pneumologie 77(5): 269-302. doi: 10.1055/a-2017-8971 https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-2017-8971
  • Lange, F., Koch, W. (2023). Application of Resuspension Data of Respirable Particles for Early Phase Inhalation Following Deposition Contamination in Radiological Emergencies. Health Physics 124(3): 155-165. doi: 10.1097/HP.0000000000001648 https://journals.lww.com/health-physics/Fulltext/2023/03000/Application_of_Resuspension_Data_of_Respirable.1.aspx - Open Access
  • Lu, D., Cushman, S., Thum, T., Bär, C. (2023). Gene Therapy and Cardiovascular Diseases. In: Genome Editing in Cardiovascular and Metabolic Diseases. Advances in Experimental Medicine and Biology. Xiao, J. (ed.) Springer, Singapore 1396: 235-254.
  • Lukovic, D., Hasimbegovic, E., Winkler, J., Mester-Tonczar, J., Muller-Zlabinger, K., Han, E., Spannbauer, A., Traxler-Weidenauer, D., Bergler-Klein, J., Pavo, N., Goliasch, G., Batkai, S., Thum, T., Zannad, F., Gyongyosi, M. (2023). Identification of Gene Expression Signatures for Phenotype-Specific Drug Targeting of Cardiac Fibrosis. Int J Mol Sci 24(8). doi: 10.3390/ijms24087461 https://www.mdpi.com/1422-0067/24/8/7461  - Open Access
  • McKinsey, T. A., Foo, R., Anene-Nzelu, C. G., Travers, J. G., Vagnozzi, R. J., Weber, N., Thum, T. (2023). Emerging epigenetic therapies of cardiac fibrosis and remodelling in heart failure: from basic mechanisms to early clinical development. Cardiovascular Research 118(18): 3482-3498. doi: 10.1093/cvr/cvac142 https://academic.oup.com/cardiovascres/article/118/18/3482/6675295?login=true - Open Access
  • Metra, M., Adamo, M., Tomasoni, D., Mebazaa, A., Bayes-Genis, A., Abdelhamid, M., Adamopoulos, S., Anker, S. D., Bauersachs, J., Belenkov, Y., Bohm, M., Gal, T. B., Butler, J., Cohen-Solal, A., Filippatos, G., Gustafsson, F., Hill, L., Jaarsma, T., Jankowska, E. A., Lainscak, M., Lopatin, Y., Lund, L. H., McDonagh, T., Milicic, D., Moura, B., Mullens, W., Piepoli, M., Polovina, M., Ponikowski, P., Rakisheva, A., Ristic, A., Savarese, G., Seferovic, P., Sharma, R., Thum, T., Tocchetti, C. G., Van Linthout, S., Vitale, C., Von Haehling, S., Volterrani, M., Coats, A. J. S., Chioncel, O., Rosano, G. (2023). Pre-discharge and early post-discharge management of patients hospitalized for acute heart failure: A scientific statement by the Heart Failure Association of the ESC. European Journal of Heart Failure 25(7): 1115-1131. doi: 10.1002/ejhf.2888 https://onlinelibrary.wiley.com/doi/10.1002/ejhf.2888  - Open Access
  • Nagai, M., Shityakov, S., Smetak, M., Hunkler, H. J., Bär, C., Schlegel, N., Thum, T., Forster, C. Y. (2023). Blood Biomarkers in Takotsubo Syndrome Point to an Emerging Role for Inflammaging in Endothelial Pathophysiology. Biomolecules 13(6) 955. doi: 10.3390/biom13060995 https://www.mdpi.com/2218-273X/13/6/995 - Open Access
  • Nehrig, J., Grosse, N., Hohenfeld, I. P., Hohlfeld, J. M., Badorrek, P. (2023). Efficacy and Safety of a Drug-Free, Barrier-Forming Nasal Spray for Allergic Rhinitis: Randomized, Open-Label, Crossover Noninferiority Trial. International Archives of Allergy and Immunology 184(2): 111-121. doi: 10.1159/000526423 https://www.karger.com/Article/Abstract/526423
  • Neufeldt, D., Cushman, S., Bär, C., Thum, T. (2023). Circular RNAs at the intersection of cancer and heart disease: potential therapeutic targets in cardio-oncology. Cardiovascular Research [Epub ahead of print]. doi: 10.1093/cvr/cvad013 https://academic.oup.com/cardiovascres/advance-article-abstract/doi/10.1093/cvr/cvad013/6991260?redirectedFrom=fulltext
  • Pham, Y. L., Holz, O., Beauchamp, J. (2023). Emissions and uptake of volatiles by sampling components in breath analysis. Journal of Breath Research 17(3): 037102. doi: 10.1088/1752-7163/acce34 https://iopscience.iop.org/article/10.1088/1752-7163/acce34  - Open Access
  • Seferovic, P. M., Polovina, M., Rosano, G., Bozkurt, B., Metra, M., Heymans, S., Mullens, W., Bauersachs, J., Sliwa, K., de Boer, R. A., Farmakis, D., Thum, T., Olivotto, I., Rapezzi, C., Linhart, A., Corrado, D., Tschope, C., Milinkovic, I., Bayes Genis, A., Filippatos, G., Keren, A., Asanin, M., Krljanac, G., Maksimovic, R., Skouri, H., Ben Gal, T., Moura, B., Volterrani, M., Abdelhamid, M., Lopatin, Y., Chioncel, O., Coats, A. J. (2023). State-of-the-art document on optimal contemporary management of cardiomyopathies. European Journal of Heart Failure [Epub ahead of print]. doi: 10.1002/ejhf.2979 https://onlinelibrary.wiley.com/doi/10.1002/ejhf.2979 - Open Access
  • Singh, S., Gaur, A., Kumari, R., Prakash, S., Kumari, S., Chaudhary, A. D., Sharma, R. K., Prasun, P., Pant, P., Thum, T., Jagavelu, K., Bharati, P., Hanif, K., Chitkara, P., Kumar, S., Mitra, K., Gupta, S. K. (2023). Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA. bioRxiv. doi: 10.1101/2023.03.01.530580 https://www.biorxiv.org/content/biorxiv/early/2023/03/02/2023.03.01.530580.full.pdf - Open Access
  • Sivaraman, K., Wrenger, S., Liu, B., Schaudien, D., Hesse, C., Gomez-Mariano, G., Perez-Luz, S., Sewald, K., DeLuca, D., Wurm, M. J., Pino, P., Welte, T., Martinez-Delgado, B., Janciauskiene, S. (2023). Mice inflammatory responses to inhaled aerosolized LPS: effects of various forms of human alpha1-antitrypsin. Journal of Leukocyte Biology 113(1): 58-70. doi: 10.1093/jleuko/qiac004 https://academic.oup.com/jleukbio/article/113/1/58/6979768?login=true - Open Access
  • Thum, T., Lam, C. S. P. (2023). Accelerating developments in heart failure. Cardiovascular Research 118(18): 3401-3402. doi: 10.1093/cvr/cvac185 https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvac185/6965791 - Open Access
  • van der Vis, J. J., Prasse, A., Renzoni, E. A., Stock, C. J. W., Caliskan, C., Maher, T. M., Bonella, F., Borie, R., Crestani, B., Petrek, M., Wuyts, W. A., Wind, A. E., Molyneaux, P. L., Grutters, J. C., van Moorsel, C. H. M. (2023). MUC5B rs35705950 minor allele associates with older age and better survival in idiopathic pulmonary fibrosis. Respirology 28(5): 455-464. doi: 10.1111/resp.14440 https://onlinelibrary.wiley.com/doi/10.1111/resp.14440  - Open Access
  • Wise, S. K., Damask, C., Roland, L. T., Ebert, C., Levy, J. M., Lin, S., Luong, A., Rodriguez, K., Sedaghat, A. R., Toskala, E., Villwock, J., Abdullah, B., Akdis, C., Alt, J. A., Ansotegui, I. J., Azar, A., Baroody, F., Benninger, M. S., Bernstein, J., Brook, C., Campbell, R., Casale, T., Chaaban, M., Chew, F. T., Chambliss, J., Cianferoni, A., Custovic, A., Davis, E. M., DelGaudio, J. M., Ellis, A. K., Flanagan, C., Fokkens, W. J., Franzese, C., Greenhawt, M., Gill, A., Halderman, A., Hohlfeld, J. M., Incorvaia, C., Joe, S. A., Joshi, S., Kuruvilla, M. E., Kim, J., Klein, A. M., Krouse, H. J., Kuan, E. C., Lang, D., Larenas-Linnemann, D., Laury, A. M., Lechner, M., Lee, S. E., Lee, V. S., Loftus, P., Marcus, S., Marzouk, H., Mattos, J., McCoul, E., Melen, E., Mims, J. W., Mullol, J., Nayak, J. V., Oppenheimer, J., Orlandi, R. R., Phillips, K., Platt, M., Ramanathan, M., Jr., Raymond, M., Rhee, C. S., Reitsma, S., Ryan, M., Sastre, J., Schlosser, R. J., Schuman, T. A., Shaker, M. S., Sheikh, A., Smith, K. A., Soyka, M. B., Takashima, M., Tang, M., Tantilipikorn, P., Taw, M. B., Tversky, J., Tyler, M. A., Veling, M. C., Wallace, D., Wang, Y., White, A., Zhang, L. (2023). International consensus statement on allergy and rhinology: Allergic rhinitis - 2023. Int Forum Allergy Rhinol [Epub ahead of print]. doi: 10.1002/alr.23090 https://onlinelibrary.wiley.com/doi/10.1002/alr.23090
  • Zannikos, P., Solanki, B., De Meulder, M., Badorrek, P., Hohlfeld, J. M., Singh, J. (2023). Pharmacokinetics of Nasal Esketamine in Patients with Allergic Rhinitis with and Without Nasal Decongestant Pretreatment and in Healthy Subjects with and Without Nasal Corticosteroid Pretreatment. Clinical Pharmacokinetics [Epub ahead of print]. doi: 10.1007/s40262-023-01273-z https://link.springer.com/article/10.1007/s40262-023-01273-z - 

R&D expertise "Toxicology": publications in 2023

  • Blümlein, K., Nowak, N., Ellinghusen, B., Gerling, S., Badorrek, P., Hansen, T., Hohlfeld, J. M., Paul, R., Schuchardt, S. (2023). Occupational exposure to veterinary antibiotics: Pharmacokinetics of enrofloxacin in humans after dermal, inhalation and oral uptake - A clinical study. Environmental Toxicology and Pharmacology 100: 104139. doi: 10.1016/j.etap.2023.104139 https://www.sciencedirect.com/science/article/abs/pii/S1382668923000819?via%3Dihub
  • Bowden, A., Escher, S., Rose, J., Sadekar, N., Patlewicz, G., O'Keeffe, L., Bury, D., Hewitt, N. J., Giusti, A., Rothe, H. (2023). Workshop report: Challenges faced in developing inhalation thresholds of Toxicological Concern (TTC) - State of the science and next steps. Regulatory Toxicology and Pharmacology 142: 105434. doi: 10.1016/j.yrtph.2023.105434 https://www.sciencedirect.com/science/article/abs/pii/S0273230023001022  - Open Access
  • Dekant, W., Antoniou, E. E., Bosch, A., Bruer, G. G., Colnot, T., Creutzenberg, O., Drexel, C. P., Duffin, R., Krueger, N., Nolde, J., Poland, C., Schaudien, D., Schuster, T. B., Stintz, M., Weber, K., Wessely, B., Zeegers, M. P. (2023). Issues in the inhalation toxicity testing and hazard assessment for low density particulate materials such as synthetic amorphous silica (SAS). Toxicology Letters [Epub ahead of print]. doi: 10.1016/j.toxlet.2023.02.002 https://www.sciencedirect.com/science/article/pii/S0378427423000905?via%3Dihub
  • Drake, C., Wehr, M. M., Zobl, W., Koschmann, J., De Lucca, D., Kühne, B. A., Hansen, T., Knebel, J., Ritter, D., Boei, J., Vrieling, H., Bitsch, A., Escher, S. E. (2023). Substantiate a read-across hypothesis by using transcriptome data—A case study on volatile diketones. Frontiers in Toxicology 5: 14p. doi: 10.3389/ftox.2023.1155645 https://www.frontiersin.org/articles/10.3389/ftox.2023.1155645/full  - Open Access
  • Escher, S. E., Felter, S. P., Hollnagel, H., Boobis, A. R., Yang, C., Rathman, J., Cronin, M. T. D., Batke, M. (2023). Workshop report on the evaluation of the updated and expanded carcinogen database to support derivation of threshold of toxicological concern values for DNA-reactive carcinogens. Altex 40(2): 341-349. doi: 10.14573/altex.2210111 https://www.altex.org/index.php/altex/article/view/2556/2489  - Open Access
  • Lange, F., Koch, W. (2023). Application of Resuspension Data of Respirable Particles for Early Phase Inhalation Following Deposition Contamination in Radiological Emergencies. Health Physics 124(3): 155-165. doi: 10.1097/HP.0000000000001648 https://journals.lww.com/health-physics/Fulltext/2023/03000/Application_of_Resuspension_Data_of_Respirable.1.aspx - Open Access
  • Licht, O., Breuer, F., Blümlein, K., Schwonbeck, S., Pallapies, D., Kellner, R., Wiedemeier, P., Bitsch, A. (2023). Extensive literature search on mineral oil hydrocarbons. EFSA Supporting Publications 20(2). doi: 10.2903/sp.efsa.2023.EN-7893 https://www.efsa.europa.eu/en/supporting/pub/en-7893  - Open Access
  • Nendza, M., Hahn, S., Klein, M., Klaschka, U., Gabbert, S. (2023). Scoring scheme for Comparative Ranking of impact potential of chemical Alternatives (SCoRA). Environmental Sciences Europe 35(1). doi: 10.1186/s12302-023-00718-3 https://enveurope.springeropen.com/articles/10.1186/s12302-023-00718-3 - Open Access
  • Rodríguez, J. M. M., Frisk, A.-L., Kreutzer, R., Lemarchand, T., Lezmi, S., Saravanan, C., Stierstorfer, B., Thuilliez, C., Vezzali, E., Wieczorek, G., Yun, S.-W., Schaudien, D. (2023). European Society of Toxicologic Pathology (Pathology 2.0 Molecular Pathology Special Interest Group): Review of In Situ Hybridization Techniques for Drug Research and Development. Toxicologic Pathology [Epub ahead of print]. doi: 10.1177/019262332311782 https://journals.sagepub.com/doi/10.1177/01926233231178282  - Open Access
  • Sanz, F., Pognan, F., Steger-Hartmann, T., Díaz, C., Asakura, S., Amberg, A., Bécourt-Lhote, N., Blomberg, N., Bosc, N., Briggs, K., Bringezu, F., Brulle-Wohlhueter, C., Brunak, S., Bueters, R., Callegaro, G., Capella-Gutierrez, S., Centeno, E., Corvi, J., Cronin, M. T. D., Drew, P., Duchateau-Nguyen, G., Ecker, G. F., Escher, S., Felix, E., Ferreiro, M., Frericks, M., Furlong, L. I., Geiger, R., George, C., Grandits, M., Ivanov-Draganov, D., Kilgour-Christie, J., Kiziloren, T., Kors, J. A., Koyama, N., Kreuchwig, A., Leach, A. R., Mayer, M.-A., Monecke, P., Muster, W., Nakazawa, C. M., Nicholson, G., Parry, R., Pastor, M., Piñero, J., Oberhauser, N., Ramírez-Anguita, J. M., Rodrigo, A., Smajic, A., Schaefer, M., Schieferdecker, S., Soininen, I., Terricabras, E., Trairatphisan, P., Turner, S. C., Valencia, A., van de Water, B., van der Lei, J. L., van Mulligen, E. M., Vock, E., Wilkinson, D. (2023). eTRANSAFE: data science to empower translational safety assessment. Nature Reviews Drug Discovery 22(8): 605-606. doi: 10.1038/d41573-023-00099-5 https://www.nature.com/articles/d41573-023-00099-5
  • Schäferhenrich, A., Blümlein, K., Koch, W., Hahn, S., Schwarz, K., Poppek, U., Hebisch, R., Schlüter, U., Krug, M., Göen, T. (2023). Inhalation and dermal exposure to biocidal products during foam and spray applications. Ann Work Expo Health 67(7): 858-875. doi: 10.1093/annweh/wxad037 https://academic.oup.com/annweh/advance-article/doi/10.1093/annweh/wxad037/7221563 - Open Access
  • Schwarz, K., Blumlein, K., Goen, T., Hahn, S., Hebisch, R., Koch, W., Poppek, U., Schaferhenrich, A., Schluter, U., Krug, M. (2023). Aerosol formation during foam application of non-volatile biocidal substances. Ann Work Expo Health 67(6): 731-743. doi: 10.1093/annweh/wxad031 https://academic.oup.com/annweh/article/67/6/731/7207786 - Open Access
  • Warner, L., Bach-Hagemann, A., Schmidt, T. P., Pinkernell, S., Schubert, G. A., Clusmann, H., Albanna, W., Lindauer, U., Conzen-Dilger, C. (2023). Opening a window to the acutely injured brain: Simultaneous retinal and cerebral vascular monitoring in rats. Frontiers in Molecular Neuroscience 16: 1116841. doi: 10.3389/fnmol.2023.1116841 https://www.frontiersin.org/articles/10.3389/fnmol.2023.1116841/full - Open Access

R&D expertise "Malignant disease research": publications in 2023

  • Adler, O., Zait, Y., Cohen, N., Blazquez, R., Doron, H., Monteran, L., Scharff, Y., Shami, T., Mundhe, D., Glehr, G., Kanner, A. A., Horn, S., Yahalom, V., Haferkamp, S., Hutchinson, J. A., Bleckmann, A., Nahary, L., Benhar, I., Katz, S. Y., Pukrop, T., Erez, N. (2023). Reciprocal interactions between innate immune cells and astrocytes facilitate neuroinflammation and brain metastasis via lipocalin-2. Nat Cancer [Epub ahead of print]. doi: 10.1038/s43018-023-00519-w https://www.nature.com/articles/s43018-023-00519-w
  • Asami, M., Lam, B. Y. H., Hoffmann, M., Suzuki, T., Lu, X., Yoshida, N., Ma, M. K., Rainbow, K., Guzvic, M., VerMilyea, M. D., Yeo, G. S. H., Klein, C. A., Perry, A. C. F. (2023). A program of successive gene expression in mouse one-cell embryos. Cell Rep 42(2): 112023. doi: 10.1016/j.celrep.2023.112023 https://www.sciencedirect.com/science/article/pii/S2211124723000347?via%3Dihub - Open Access
  • Bakhshandeh, S., Taïeb, H. M., Varadarajan, A. R., Lissek, S. M., Hücker, S. M., Lu, X., Garske, D. S., Young, S. A. E., Contzen, J., Gossen, M., Kirsch, S., Warfsmann, J., Honarnejad, K., Klein, C. A., Cipitria, A. (2023). Quiescence-inducing 3D-engineered matrix uncovers mechanosensitive and drug protective FHL2-p21 signaling axis. bioRxiv. doi: 10.1101/2023.01.25.525382 https://www.biorxiv.org/content/biorxiv/early/2023/01/25/2023.01.25.525382.full.pdf  - Open Access
  • Franken, A., Kraemer, A., Sicking, A., Watolla, M., Rivandi, M., Yang, L., Warfsmann, J., Polzer, B. M., Friedl, T. W. P., Meier-Stiegen, F., Stoecklein, N. H., Dayan, D., Riethdorf, S., Mueller, V., Pantel, K., Koch, A., Hartkopf, A. D., Krawczyk, N., Ruckhaeberle, E., Niederacher, D., Fehm, T., Neubauer, H. (2023). Comparative analysis of EpCAM high-expressing and low-expressing circulating tumour cells with regard to their clonal relationship and clinical value. British Journal of Cancer [Epub ahead of print]. doi: 10.1038/s41416-023-02179-0 https://www.nature.com/articles/s41416-023-02179-0 - Open Access
  • Klusa, D., Lohaus, F., Franken, A., Baumbach, M., Cojoc, M., Dowling, P., Linge, A., Offermann, A., Lock, S., Husman, D., Rivandi, M., Polzer, B., Freytag, V., Lange, T., Neubauer, H., Kucken, M., Perner, S., Holscher, T., Dubrovska, A., Krause, M., Kurth, I., Baumann, M., Peitzsch, C. (2023). Dynamics of CXCR4 positive circulating tumor cells in prostate cancer patients during radiotherapy. International Journal of Cancer [Epub ahead of print]. doi: 10.1002/ijc.34457 https://onlinelibrary.wiley.com/doi/10.1002/ijc.34457 - Open Access
  • Neufeldt, D., Cushman, S., Bär, C., Thum, T. (2023). Circular RNAs at the intersection of cancer and heart disease: potential therapeutic targets in cardio-oncology. Cardiovascular Research [Epub ahead of print]. doi: 10.1093/cvr/cvad013 https://academic.oup.com/cardiovascres/advance-article-abstract/doi/10.1093/cvr/cvad013/6991260?redirectedFrom=fulltext
  • Nowak, J., Bentele, M., Kutle, I., Zimmermann, K., Luhmann, J. L., Steinemann, D., Kloess, S., Koehl, U., Rossberg, W., Ahmed, A., Schaudien, D., Neubert, L., Kamp, J. C., Kuehnel, M. P., Warnecke, A., Schambach, A., Morgan, M. (2023). CAR-NK Cells Targeting HER1 (EGFR) Show Efficient Anti-Tumor Activity against Head and Neck Squamous Cell Carcinoma (HNSCC). Cancers 15(12): 3169. doi: 10.3390/cancers15123169 https://www.mdpi.com/2072-6694/15/12/3169  - Open Access
  • Scheiter, A., Hierl, F., Luke, F., Keil, F., Heudobler, D., Einhell, S., Klier-Richter, M., Konstandin, N. P., Weber, F., Scheiter, A., Kandulski, A., Schlosser, S., Cosma, L. S., Tews, H., Weiss, A. R. R., Grube, M., Bumes, E., Hau, P., Proescholdt, M., Steger, F., Troeger, A., Haferkamp, S., Reibenspies, L. E., Schnabel, M. J., Schulz, C., Drexler, K., Hatzipanagiotou, M. E., Seitz, S., Klinkhammer-Schalke, M., Unberath, P., Calvisi, D. F., Pukrop, T., Dietmaier, W., Evert, M., Utpatel, K. (2023). Critical evaluation of molecular tumour board outcomes following 2 years of clinical practice in a Comprehensive Cancer Centre. British Journal of Cancer 128(6): 1134-1147. doi: 10.1038/s41416-022-02120-x https://www.nature.com/articles/s41416-022-02120-x - Open Access
  • Treitschke, S., Weidele, K., Varadarajan, A. R., Feliciello, G., Warfsmann, J., Vorbeck, S., Polzer, B., Botteron, C., Hoffmann, M., Dechand, V., Mederer, T., Weber, F., Werner-Klein, M., Robold, T., Hofmann, H. S., Werno, C., Klein, C. A. (2023). Ex vivo expansion of lung cancer-derived disseminated cancer cells from lymph nodes identifies cells associated with metastatic progression. International Journal of Cancer [Epub ahead of print]. doi: 10.1002/ijc.34658 https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.34658 - Open Access

R&D expertise "Medical and pharmaceutical engineering": publications in 2023

  • Abdulbaki, A., Doll, T., Helgers, S., Heissler, H. E., Voges, J., Krauss, J. K., Schwabe, K., Alam, M. (2023). Subthalamic Nucleus Deep Brain Stimulation Restores Motor and Sensorimotor Cortical Neuronal Oscillatory Activity in the Free-Moving 6-Hydroxydopamine Lesion Rat Parkinson Model. Neuromodulation [Epub ahead of print]. doi: 10.1016/j.neurom.2023.01.014 https://www.sciencedirect.com/science/article/abs/pii/S1094715923000235?via%3Dihub
  • Nguyen, M. H., Onken, A., Wulff, A., Foremny, K., Torgau, P., Schutte, H., Hild, S., Doll, T. (2023). Computational Modeling of Diffusion-Based Delamination for Active Implantable Medical Devices. Bioengineering (Basel) 10(5). doi: 10.3390/bioengineering10050625 https://www.mdpi.com/2306-5354/10/5/625  - Open Access
  • Weissfuss, C., Wienhold, S. M., Burkle, M., Gaborieau, B., Bushe, J., Behrendt, U., Bischoff, R., Korf, I. H. E., Wienecke, S., Dannheim, A., Ziehr, H., Rohde, C., Gruber, A. D., Ricard, J. D., Debarbieux, L., Witzenrath, M., Nouailles, G. (2023). Repetitive Exposure to Bacteriophage Cocktails against Pseudomonas aeruginosa or Escherichia coli Provokes Marginal Humoral Immunity in Naive Mice. Viruses 15(2). doi: 10.3390/v15020387 https://www.mdpi.com/1999-4915/15/2/387 - Open Access
  • Willy, C., Bugert, J. J., Classen, A. Y., Deng, L., Duchting, A., Gross, J., Hammerl, J. A., Korf, I. H. E., Kuhn, C., Lieberknecht-Jouy, S., Rohde, C., Rupp, M., Vehreschild, M., Vogele, K., Wienecke, S., Witzenrath, M., Wurstle, S., Ziehr, H., Moelling, K., Broecker, F. (2023). Phage Therapy in Germany-Update 2023. Viruses 15(2). doi: 10.3390/v15020588 https://www.mdpi.com/1999-4915/15/2/588 - Open Access
  • Wittmann, J., Bunk, B., Korf, I., Wienecke, S., Spröer, C. (2023). Therapie-Phagen: Voraussetzung für die Anwendung geschaffen. Biospektrum 29(2): 222-222. doi: 10.1007/s12268-023-1917-8 https://link.springer.com/content/pdf/10.1007/s12268-023-1917-8.pdf - Open Access

R&D expertise "Bioinformatics and AI": publications in 2023

  • Babayev, Rufat, and Lena Wiese. "Benchmarking Multi-instance Learning for Multivariate Time Series Analysis." Heterogeneous Data Management, Polystores, and Analytics for Healthcare: VLDB Workshops. Springer International Publishing, 2021.Das, Pronaya Prosun, Marcel Mast, Lena Wiese, Thomas Jack, Antje Wulff, ELISE STUDY GROUP. "Data Extraction for Associative Classification using Mined Rules in Pediatric Intensive Care Data." BTW 2023 (2023).
  • Das, Pronaya Prosun, Marcel Mast, Lena Wiese, Thomas Jack, Antje Wulff, ELISE STUDY GROUP. "Data Extraction for Associative Classification using Mined Rules in Pediatric Intensive Care Data." BTW 2023 (2023).
  • Das, P. P., Marcel Mast, Wiese, L., Jack, T., Wulff, A., ELISE STUDY GROUP (2023). Data Extraction for Associative Classification using Mined Rules in Pediatric Intensive Care Data. In: BTW 2023. Lecture Notes in Informatics (LNI), Gesellschaft für Informatik. König-Ries, B., Scherzinger, S., Lehner, W. & Vossen, G https://dl.gi.de/handle/20.500.12116/40376
  • Junger, H., Muhlbauer, M., Brennfleck, F. W., Schurr, L. A., Goetz, M., Eggenhofer, E., Kirchner, G., Evert, K., Fichtner-Feigl, S., Geissler, E. K., Schlitt, H. J., Brunner, S. M. (2023). Early gammaGT and bilirubin levels as biomarkers for regeneration and outcomes in damaged bile ducts after liver transplantation. Clinical Transplantation: e14880, doi: 10.1111/ctr.14880 https://onlinelibrary.wiley.com/doi/10.1111/ctr.14880 - Open Access
  • Kaltdorf, M., Breitenbach, T., Karl, S., Fuchs, M., Kessie, D. K., Psota, E., Prelog, M., Sarukhanyan, E., Ebert, R., Jakob, F., Dandekar, G., Naseem, M., Liang, C., Dandekar, T. (2023). Software JimenaE allows efficient dynamic simulations of Boolean networks, centrality and system state analysis. Scientific Reports 13(1): 1855. doi: 10.1038/s41598-022-27098-7 https://www.nature.com/articles/s41598-022-27098-7 - Open Access
  • Lietz, Kristina, Babak Saremi, and Lena Wiese. "Genealyzer: web application for the analysis and comparison of gene expression data." BMC bioinformatics 24.1 (2023): 150.
  • Lietz, K., Saremi, B., Wiese, L. (2023). Genealyzer: web application for the analysis and comparison of gene expression data. BMC Bioinformatics 24(1): 150. doi: 10.1186/s12859-023-05266-4 https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-023-05266-4  - Open Access
  • Nguyen, M. H., Onken, A., Wulff, A., Foremny, K., Torgau, P., Schutte, H., Hild, S., Doll, T. (2023). Computational Modeling of Diffusion-Based Delamination for Active Implantable Medical Devices. Bioengineering (Basel) 10(5). doi: 10.3390/bioengineering10050625 https://www.mdpi.com/2306-5354/10/5/625  - Open Access
  • Sanz, F., Pognan, F., Steger-Hartmann, T., Díaz, C., Asakura, S., Amberg, A., Bécourt-Lhote, N., Blomberg, N., Bosc, N., Briggs, K., Bringezu, F., Brulle-Wohlhueter, C., Brunak, S., Bueters, R., Callegaro, G., Capella-Gutierrez, S., Centeno, E., Corvi, J., Cronin, M. T. D., Drew, P., Duchateau-Nguyen, G., Ecker, G. F., Escher, S., Felix, E., Ferreiro, M., Frericks, M., Furlong, L. I., Geiger, R., George, C., Grandits, M., Ivanov-Draganov, D., Kilgour-Christie, J., Kiziloren, T., Kors, J. A., Koyama, N., Kreuchwig, A., Leach, A. R., Mayer, M.-A., Monecke, P., Muster, W., Nakazawa, C. M., Nicholson, G., Parry, R., Pastor, M., Piñero, J., Oberhauser, N., Ramírez-Anguita, J. M., Rodrigo, A., Smajic, A., Schaefer, M., Schieferdecker, S., Soininen, I., Terricabras, E., Trairatphisan, P., Turner, S. C., Valencia, A., van de Water, B., van der Lei, J. L., van Mulligen, E. M., Vock, E., Wilkinson, D. (2023). eTRANSAFE: data science to empower translational safety assessment. Nature Reviews Drug Discovery 22(8): 605-606. doi: 10.1038/d41573-023-00099-5 https://www.nature.com/articles/d41573-023-00099-5
  • Steinmeyer, Christian, et al. "Automating Bronchoconstriction Analysis based on U-Net." EDBT/ICDT Workshops. 2021.
  • Wiese, Lena, Ingmar Wiese, and Kristina Lietz. "Software quality assessment of a web application for biomedical data analysis." Proceedings of the 25th International Database Engineering & Applications Symposium. 2021.

R&D expertise "Immunology and and infection research": publications in 2023

  • Adler, O., Zait, Y., Cohen, N., Blazquez, R., Doron, H., Monteran, L., Scharff, Y., Shami, T., Mundhe, D., Glehr, G., Kanner, A. A., Horn, S., Yahalom, V., Haferkamp, S., Hutchinson, J. A., Bleckmann, A., Nahary, L., Benhar, I., Katz, S. Y., Pukrop, T., Erez, N. (2023). Reciprocal interactions between innate immune cells and astrocytes facilitate neuroinflammation and brain metastasis via lipocalin-2. Nat Cancer [Epub ahead of print]. doi: 10.1038/s43018-023-00519-w https://www.nature.com/articles/s43018-023-00519-w
  • Behr, J., Berger, M., Blum, T. G., Bonella, F., Dinkel, J., Glaser, S., Hagmeyer, L., Kneidinger, N., Koschel, D., Prasse, A., Slevogt, H., Stacher-Priehse, E., Woehrle, H., Kreuter, M. (2023). [SARS-CoV-2-Infection and Interstitial Lung Disease: Position paper of the German Respiratory Society]. SARS-CoV-2-Infektion und interstitielle Lungenerkrankungen – Positionspapier der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin. Pneumologie 77(3): 143-157. doi: 10.1055/a-2007-9845 https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2007-9845
  • Bierwagen, J., Wiegand, M., Laakmann, K., Danov, O., Limburg, H., Herbel, S. M., Heimerl, T., Dorna, J., Jonigk, D., Preusser, C., Bertrams, W., Braun, A., Sewald, K., Schulte, L. N., Bauer, S., Pogge von Strandmann, E., Bottcher-Friebertshauser, E., Schmeck, B., Jung, A. L. (2023). Bacterial vesicles block viral replication in macrophages via TLR4-TRIF-axis. Cell Commun Signal 21(1): 65. doi: 10.1186/s12964-023-01086-4 https://biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01086-4  - Open Access
  • Busche, S., Harris, D. M. M., Zimmermann, J., Schuchardt, S., Oumari, M., Frank, D., Bang, C., Rosenstiel, P., Schreiber, S., Frey, N., Franke, A., Aden, K., Waschina, S. (2023). Amino acid auxotrophies in human gut bacteria are linked to higher microbiome diversity and long-term stability. bioRxiv. doi: 10.1101/2023.03.23.532984 https://www.biorxiv.org/content/biorxiv/early/2023/03/23/2023.03.23.532984.full.pdf  - Open Access
  • Diesendorf, V., Roll, V., Geiger, N., Fähr, S., Obernolte, H., Sewald, K., Bodem, J. (2023). Drug-induced phospholipidosis is not correlated with the inhibition of SARS-CoV-2 - inhibition of SARS-CoV-2 is cell line-specific. Frontiers in Cellular and Infection Microbiology 13. doi: 10.3389/fcimb.2023.1100028 https://www.frontiersin.org/articles/10.3389/fcimb.2023.1100028/full  - Open Access
  • Dühring, L., Petry, J., Lilienthal, G. M., Bartsch, Y. C., Kubiak, M., Pfeufer, C., Lehrian, S., Buhre, J. S., Lunding, H. B., Kern, C., Behrends, J., Walsemann, T., Gädert, L., Sommer, C., Krüger, L., Blanchard, V., Dehmel, S., Jappe, U., Rahmoller, J., Ehlers, M. (2023). Sialylation of IgE reduces FcepsilonRIalpha interaction and mast cell and basophil activation in vitro and increases IgE half-life in vivo. Allergy [Epub ahead of print]. doi: 10.1111/all.15665 https://onlinelibrary.wiley.com/doi/10.1111/all.15665 - Open Access
  • Fleischauer, J., Bastone, A. L., Selich, A., John-Neek, P., Weisskoeppel, L., Schaudien, D., Schambach, A., Rothe, M. (2023). TGFβ Inhibitor A83-01 Enhances Murine HSPC Expansion for Gene Therapy. Cells 12(15): 1978. doi: 10.3390/cells12151978 https://www.mdpi.com/2073-4409/12/15/1978  - Open Access
  • Gauvreau, G. M., Hohlfeld, J. M., FitzGerald, J. M., Boulet, L. P., Cockcroft, D. W., Davis, B. E., Korn, S., Kornmann, O., Leigh, R., Mayers, I., Watz, H., Grant, S. S., Jain, M., Cabanski, M., Pertel, P. E., Jones, I., Lecot, J. R., Cao, H., O'Byrne, P. M. (2023). Inhaled anti-TSLP antibody fragment, ecleralimab, blocks responses to allergen in mild asthma. European Respiratory Journal 61(3). doi: 10.1183/13993003.01193-2022 https://erj.ersjournals.com/content/61/3/2201193.long - Open Access
  • Hilbold, E., Bär, C., Thum, T. (2023). COVID-19: Insights into long-term manifestations and lockdown impacts. J Sport Health Sci [Epub ahead of print]. doi: 10.1016/j.jshs.2023.02.006 https://www.sciencedirect.com/science/article/pii/S2095254623000194?via%3Dihub - Open Access
  • Hou, R., Ye, G., Cheng, X., Shaw, D. E., Bakke, P. S., Caruso, M., Dahlen, B., Dahlen, S. E., Fowler, S. J., Horvath, I., Howarth, P., Krug, N., Montuschi, P., Sanak, M., Sandstrom, T., Auffray, C., De Meulder, B., Sousa, A. R., Adcock, I. M., Fan Chung, K., Sterk, P. J., Skipp, P. J., Schofield, J., Djukanovic, R., U. Biopred Study Group (2023). The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts. Brain, Behavior, and Immunity 111: 249-258. doi: 10.1016/j.bbi.2023.04.011 https://www.sciencedirect.com/science/article/pii/S0889159123001095?via%3Dihub  - Open Access
  • Hung, L., Celik, A., Yin, X., Yu, K., Berenjy, A., Kothari, A., Obernolte, H., Upton, J. E. M., Lindholm Bogh, K., Somers, G. R., Siddiqui, I., Grealish, M., Quereshy, F. A., Sewald, K., Chiu, P. P. L., Eiwegger, T. (2023). Precision cut intestinal slices, a novel model of acute food allergic reactions. Allergy 78(2): 500-511. doi: 10.1111/all.15579 https://onlinelibrary.wiley.com/doi/10.1111/all.15579 - Open Access
  • Mazein, A., Shoaib, M., Alb, M., Sakellariou, C., Sommer, C., Sewald, K., Reiche, K., Gogesch, P., Roser, L. A., Iannazzo, S. O., Sheth, S., Schiffmann, S., Waibler, Z., Neuhaus, V., Dehmel, S., Satagopam, V., Schneider, R., Consortium, i., Ostaszewski, M., Gu, W. (2023). Using interactive platforms to encode, manage and explore immune-related adverse outcome pathways. bioRxiv doi: 10.1101/2023.03.21.533620 https://www.biorxiv.org/content/biorxiv/early/2023/03/23/2023.03.21.533620.full.pdf  - Open Access
  • Nowak, J., Bentele, M., Kutle, I., Zimmermann, K., Luhmann, J. L., Steinemann, D., Kloess, S., Koehl, U., Rossberg, W., Ahmed, A., Schaudien, D., Neubert, L., Kamp, J. C., Kuehnel, M. P., Warnecke, A., Schambach, A., Morgan, M. (2023). CAR-NK Cells Targeting HER1 (EGFR) Show Efficient Anti-Tumor Activity against Head and Neck Squamous Cell Carcinoma (HNSCC). Cancers 15(12): 3169. doi: 10.3390/cancers15123169 https://www.mdpi.com/2072-6694/15/12/3169  - Open Access
  • Rudolph, D., Redinger, N., Schwarz, K., Li, F., Hadrich, G., Cohrs, M., Dailey, L. A., Schaible, U. E., Feldmann, C. (2023). Amorphous Drug Nanoparticles for Inhalation Therapy of Multidrug-Resistant Tuberculosis. ACS Nano 17(10): 9478-9486. doi: 10.1021/acsnano.3c01664 https://pubs.acs.org/doi/10.1021/acsnano.3c01664
  • Sivaraman, K., Wrenger, S., Liu, B., Schaudien, D., Hesse, C., Gomez-Mariano, G., Perez-Luz, S., Sewald, K., DeLuca, D., Wurm, M. J., Pino, P., Welte, T., Martinez-Delgado, B., Janciauskiene, S. (2023). Mice inflammatory responses to inhaled aerosolized LPS: effects of various forms of human alpha1-antitrypsin. Journal of Leukocyte Biology 113(1): 58-70. doi: 10.1093/jleuko/qiac004 https://academic.oup.com/jleukbio/article/113/1/58/6979768?login=true - Open Access
  • Seeling, M., Pohnl, M., Kara, S., Horstmann, N., Riemer, C., Wohner, M., Liang, C., Bruckner, C., Eiring, P., Werner, A., Biburger, M., Altmann, L., Schneider, M., Amon, L., Lehmann, C. H. K., Lee, S., Kunz, M., Dudziak, D., Schett, G., Bauerle, T., Lux, A., Tuckermann, J., Vogtle, T., Nieswandt, B., Sauer, M., Bockmann, R. A., Nimmerjahn, F. (2023). Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1. Immunity 56(5): 1046-1063 e1047. doi: 10.1016/j.immuni.2023.02.019 https://www.sciencedirect.com/science/article/pii/S1074761323000936?via%3Dihub - Open Access
  • Weissfuss, C., Wienhold, S. M., Burkle, M., Gaborieau, B., Bushe, J., Behrendt, U., Bischoff, R., Korf, I. H. E., Wienecke, S., Dannheim, A., Ziehr, H., Rohde, C., Gruber, A. D., Ricard, J. D., Debarbieux, L., Witzenrath, M., Nouailles, G. (2023). Repetitive Exposure to Bacteriophage Cocktails against Pseudomonas aeruginosa or Escherichia coli Provokes Marginal Humoral Immunity in Naive Mice. Viruses 15(2). doi: 10.3390/v15020387 https://www.mdpi.com/1999-4915/15/2/387 - Open Access
  • Willy, C., Bugert, J. J., Classen, A. Y., Deng, L., Duchting, A., Gross, J., Hammerl, J. A., Korf, I. H. E., Kuhn, C., Lieberknecht-Jouy, S., Rohde, C., Rupp, M., Vehreschild, M., Vogele, K., Wienecke, S., Witzenrath, M., Wurstle, S., Ziehr, H., Moelling, K., Broecker, F. (2023). Phage Therapy in Germany-Update 2023. Viruses 15(2). doi: 10.3390/v15020588 https://www.mdpi.com/1999-4915/15/2/588 - Open Access
  • Wittmann, J., Bunk, B., Korf, I., Wienecke, S., Spröer, C. (2023). Therapie-Phagen: Voraussetzung für die Anwendung geschaffen. Biospektrum 29(2): 222-222. doi: 10.1007/s12268-023-1917-8 https://link.springer.com/content/pdf/10.1007/s12268-023-1917-8.pdf - Open Access

R&D expertise "RNA technologies": publications in 2023

  • Ahangari, F., Price, N. L., Malik, S., Chioccioli, M., Barnthaler, T., Adams, T. S., Kim, J., Pradeep, S. P., Ding, S., Cosmos, C., Jr., Rose, K. S., McDonough, J. E., Aurelien, N. R., Ibarra, G., Omote, N., Schupp, J. C., DeIuliis, G., Villalba Nunez, J. A., Sharma, L., Ryu, C., Dela Cruz, C. S., Liu, X., Prasse, A., Rosas, I., Bahal, R., Fernandez-Hernando, C., Kaminski, N. (2023). microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis. JCI Insight 8(4). doi: 10.1172/jci.insight.158100 https://insight.jci.org/articles/view/158100 - Open Access
  • Biss, S., Teschler, M., Heimer, M., Thum, T., Bar, C., Mooren, F. C., Schmitz, B. (2023). A single session of EMS training induces long-lasting changes in circulating muscle but not cardiovascular miRNA levels - A randomized crossover study. J Appl Physiol. [Epub ahead of print]. doi: 10.1152/japplphysiol.00557.2022 https://journals.physiology.org/doi/abs/10.1152/japplphysiol.00557.2022
  • Kandil, R., Baldassi, D., Bohlen, S., Muller, J. T., Jurgens, D. C., Bargmann, T., Dehmel, S., Xie, Y., Mehta, A., Sewald, K., Merkel, O. M. (2023). Targeted GATA3 knockdown in activated T cells via pulmonary siRNA delivery as novel therapy for allergic asthma. Journal of Controlled Release 354: 305-315. doi: 10.1016/j.jconrel.2023.01.014  https://www.sciencedirect.com/science/article/abs/pii/S0168365923000159?via%3Dihub
  • Lu, D., Cushman, S., Thum, T., Bär, C. (2023). Gene Therapy and Cardiovascular Diseases. In: Genome Editing in Cardiovascular and Metabolic Diseases. Advances in Experimental Medicine and Biology. Xiao, J. (ed.) Springer, Singapore 1396: 235-254.
  • Neufeldt, D., Cushman, S., Bär, C., Thum, T. (2023). Circular RNAs at the intersection of cancer and heart disease: potential therapeutic targets in cardio-oncology. Cardiovascular Research [Epub ahead of print]. doi: 10.1093/cvr/cvad013 https://academic.oup.com/cardiovascres/advance-article-abstract/doi/10.1093/cvr/cvad013/6991260?redirectedFrom=fulltext
  • Thum, T., Lam, C. S. P. (2023). Accelerating developments in heart failure. Cardiovascular Research 118(18): 3401-3402. doi: 10.1093/cvr/cvac185 https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvac185/6965791 - Open Access

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