R&D expertise "Lung research"
- Birker-Robaczewska, M., Boucher, M., Ranieri, G., Poirey, S., Studer, R., Freti, D., Schnoebelen, M., Froidevaux, S., Morrison, K., Wyss, C., Scherer, J., Lescop, C., Brotschi, C., Bolli, M. H., Kramberg, M., Di Stefano, S., Rey, M., Iglarz, M., Delahaye, S., Vezzali, E., Sieber, P., Schäfer, A., Caimi, S. L., Hesse, C., Nayler, O. (2025). "The novel lysophosphatidic acid receptor 1-selective antagonist, ACT-1016-0707, has unique binding properties that translate into effective anti-fibrotic and anti-inflammatory activity in different models of pulmonary fibrosis." The Journal of pharmacology and experimental therapeutics [Epub ahead of print]. doi: 10.1016/j.jpet.2025.103396
- Bouheraoua, S., Cleeves, S., Preusse, M., Musken, M., Braubach, P., Fuchs, M., Falk, C., Sewald, K., Haussler, S. (2025). "Establishment and characterization of persistent Pseudomonas aeruginosa infections in air-liquid interface cultures of human airway epithelial cells." Infection and Immunity 93(3): e0060324. doi: 10.1128/iai.00603-24 https://journals.asm.org/doi/10.1128/iai.00603-24 - Open Access
- Burkle, M., Korf, I. H. E., Lippegaus, A., Krautwurst, S., Rohde, C., Weissfuss, C., Nouailles, G., Tene, X. M., Gaborieau, B., Ghigo, J. M., Ricard, J. D., Hocke, A. C., Papenfort, K., Debarbieux, L., Witzenrath, M., Wienhold, S. M., Krishnamoorthy, G. (2025). "Phage-phage competition and biofilms affect interactions between two virulent bacteriophages and Pseudomonas aeruginosa." ISME J 19(1). doi: 10.1093/ismejo/wraf065 https://academic.oup.com/ismej/advance-article/doi/10.1093/ismejo/wraf065/8106832 - Open Access
- Holz, O., Sadiq, M. W., Gress, C., Struss, N., Stomilovic, S., Lundqvist, A., Hohlfeld, J. M. (2025). "Assessing Human Lung Pharmacokinetics Using Exhaled Breath Particles." Journal of Aerosol Medicine and Pulmonary Drug Delivery 38(1): 13-17. doi: 10.1089/jamp.2024.0032
- Kayser, T., Smulders, R., Kusawake, T., Wambre, E., Chichili, G. R., Blauwet, M. B., Spence, A., Patton, M., Tabash, R., DeBerg, H. A., Khosa, S., Badorrek, P., Hohlfeld, J. M., Ferslew, B. C. (2025). "Phase 1 study of safety, tolerability, and efficacy of intradermal DNA vaccine ASP2390 in adults allergic to house dust mites." Journal of Allergy and Clinical Immunology: Global 4(2). doi: 10.1016/j.jacig.2025.100404 https://www.jaci-global.org/article/S2772-8293(25)00005-0/fulltext - Open Access
- Klimeš, F., Kern, A. L., Voskrebenzev, A., Gutberlet, M., Grimm, R., Müller, R. A., Behrendt, L., Kaireit, T. F., Glandorf, J., Alsady, T. M., Wacker, F., Hohlfeld, J. M., Vogel-Claussen, J. (2025). "Free-breathing 3D phase-resolved functional lung MRI vs breath-hold hyperpolarized (129)Xe ventilation MRI in patients with chronic obstructive pulmonary disease and healthy volunteers." European Radiology 35(2): 943-956. doi: 10.1007/s00330-024-10893-3 - Open Access
- Legchenko, E., Chouvarine, P., Hysko, K., Qadri, F., Wesolowski, R., Specker, E., Glage, S., Meier, M., Schwarz, K., Heineke, J., Pohlmann, G., Ramazanoglu, M., Bader, M., Hansmann, G. (2025). "Inhalation of the Novel Tryptophan Hydroxylase 1 Inhibitor TPT-004 Alleviates Pulmonary Arterial Hypertension." American Journal of Respiratory Cell and Molecular Biology [Epub ahead of print]. doi: 10.1165/rcmb.2024-0365OC
- Paillard, M., Abdellatif, M., Andreadou, I., Bar, C., Bertrand, L., Brundel, B., Chiva-Blanch, G., Davidson, S. M., Dawson, D., Di Lisa, F., Evans, P., Giricz, Z., Hausenloy, D. J., Kleinbongard, P., Lezoualc'h, F., Liehn, E., Maack, C., Maguy, A., Murphy, E., Perrino, C., Pesce, M., Rainer, P. P., Streckfuss-Bomeke, K., Thielmann, M., Tian, R., Tocchetti, C. G., Van Der Velden, J., Van Linthout, S., Zacchigna, S., Krieg, T. (2025). "Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function." European Journal of Heart Failure [Epub ahead of print]. doi: 10.1002/ejhf.3674 https://onlinelibrary.wiley.com/doi/full/10.1002/ejhf.3674 - Open Access
- Pradhan, K., Neupane, B., Niehues, P., Kirschner, M., Beier, F., Kuo, C. C., Hilbold, E. A., Bär, C., Thoma, O. M., Waldner, M., Vieri, M., Brummendorf, T. H., Tharmapalan, V., Wagner, W., Kleines, M., Emrani, M., Zink, M. D., Napp, A., Marx, N., Gramlich, M. (2025). "Telomere Length Is Associated With Adverse Atrial Remodeling in Patients With Atrial Fibrillation." J Am Heart Assoc 14(3): e037512. doi: 10.1161/JAHA.124.037512 - Open Access
- Sadekar, N., Behrsing, H. P., Hansen, T., Patel, V., Paulo, H., Rae, A., Ritter, D., Schwarz, K., Api, A. M. (2025). "A Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods." Toxics 13(1). doi: 10.3390/toxics13010035 - Open Access
- Santizo, K. Y., Mangold, H. S., Mirzaei, Z., Park, H., Kolan, R. R., Sarau, G., Kolle, S., Hansen, T., Christiansen, S., Wohlleben, W. (2025). "Microplastic Materials for Inhalation Studies: Preparation by Solvent Precipitation and Comprehensive Characterization." Small [Epub ahead of print]: e2405555. doi: 10.1002/smll.202405555 - Open Access
- Umeda, Y., Izawa, T., Kazama, K., Arai, S., Kamiie, J., Nakamura, S., Hano, K., Takasu, M., Hirata, A., Rittinghausen, S., Yamano, S. (2025). "Comparative anatomy of respiratory bronchioles and lobular structures in mammals." Journal of Toxicologic Pathology 38(2): 113-129. doi: 10.1293/tox.2024-0071 https://www.jstage.jst.go.jp/article/tox/38/2/38_2024-0071/_article - Open Access
- Weber, N., Montag, J., Kowalski, K., Iorga, B., de la Roche, J., Holler, T., Wojciechowski, D., Wendland, M., Radocaj, A., Mayer, A. K., Brunkhorst, A., Osten, F., Burkart, V., Piep, B., Bodenschatz, A., Gibron, P., Schwanke, K., Franke, A., Thiemann, S., Koroleva, A., Pfanne, A., Konsanke, M., Fiedler, J., Hegermann, J., Wrede, C., Muhlfeld, C., Chichkov, B., Fischer, M., Thum, T., Francino, A., Martin, U., Meissner, J., Zweigerdt, R., Kraft, T. (2025). "Patient-specific hiPSC-derived cardiomyocytes indicate allelic and contractile imbalance as pathogenic factor in early-stage Hypertrophic Cardiomyopathy." Journal of Molecular and Cellular Cardiology 198: 112-125. doi: 10.1016/j.yjmcc.2024.11.007 - Open Access
- Weissfuss, C., Li, J., Behrendt, U., Hoffmann, K., Burkle, M., Tan, C., Krishnamoorthy, G., Korf, I. H. E., Rohde, C., Gaborieau, B., Debarbieux, L., Ricard, J. D., Witzenrath, M., Felten, M., Nouailles, G. (2025). "Adjunctive phage therapy improves antibiotic treatment of ventilator-associated-pneumonia with Pseudomonas aeruginosa." Nat Commun 16(1): 4500. doi: 10.1038/s41467-025-59806-y https://www.nature.com/articles/s41467-025-59806-y - Open Access
- Ye, J. L., Grieger, K., Lu, D., Brandenberger, C., Juchem, M., Jordan, M., Oehlsen, L., Zardo, P., Werlein, C., Hesse, C., Sewald, K., Tretbar, S., Thum, T., Chatterjee, S., Bär, C. (2025). "Telomerase modRNA offers a novel RNA-based approach to treat human pulmonary fibrosis." BioRxiv. doi: 10.1101/2025.02.19.639041 https://www.biorxiv.org/content/10.1101/2025.02.19.639041v1?med=mas - Preprint im Repositorium – Open Access