Fraunhofer Institute for Toxicology and Experimental MedicineR&D expertise "Lung research"
- Abbas, N., Bentele, M., Waleczek, F. J. G., Fuchs, M., Just, A., Pfanne, A., Pich, A., Linke, S., Neumuller, S., Stucki-Koch, A., Jordan, M., Perbellini, F., Werlein, C., Korte, W., Ius, F., Ruhparwar, A., Weber, N., Fiedler, J., Thum, T. (2024). Ex vivo modelling of cardiac injury identifies ferroptosis-related pathways as a potential therapeutic avenue for translational medicine. Journal of Molecular and Cellular Cardiology 196: 125-140. doi: 10.1016/j.yjmcc.2024.09.012 https://www.sciencedirect.com/science/article/pii/S0022282824001615?via%3Dihub - Open Access
- Abbas, N., Haas, J. A., Xiao, K., Fuchs, M., Just, A., Pich, A., Perbellini, F., Werlein, C., Ius, F., Ruhparwar, A., Fiedler, J., Weber, N., Thum, T. (2024). Inhibition of miR-21: cardioprotective effects in human failing myocardium ex vivo. European Heart Journal 45(22): 2016-2018. doi: 10.1093/eurheartj/ehae102 https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehae102/7619354?login=true - Open Access
- Angeli, E., Jordan, M., Otto, M., Stojanović, S. D., Karsdal, M., Bauersachs, J., Thum, T., Fiedler, J., Genovese, F. (2024). The role of fibrosis in cardiomyopathies: an opportunity to develop novel biomarkers of disease activity. Matrix Biology 128: 65-78. doi: 10.1016/j.matbio.2024.02.008 https://www.sciencedirect.com/science/article/pii/S0945053X24000350?via%3Dihub - Open Access
- Badorrek, P., Diefenbach, C., Kogler, H., Eleftheraki, A., Seitz, F., Hohlfeld, J. M. (2024). Novel cathepsin C inhibitor, BI 1291583, intended for treatment of bronchiectasis: Phase I characterization in healthy volunteers. Clinical and Translational Science 17(8): e13891. doi: 10.1111/cts.13891 https://ascpt.onlinelibrary.wiley.com/doi/10.1111/cts.13891 - Open Access
- Bahudhanapati, H., Tan, J., Apel, R. M., Seeliger, B., Schupp, J., Li, X., Sullivan, D. I., Sembrat, J., Rojas, M., Tabib, T., Valenzi, E., Lafyatis, R., Mitash, N., Hernandez Pineda, R., Jawale, C., Peroumal, D., Biswas, P., Tedrow, J., Adams, T., Kaminski, N., Wuyts, W. A., McDyer, J. F., Gibson, K. F., Alder, J. K., Konigshoff, M., Zhang, Y., Nouraie, M., Prasse, A., Kass, D. J. (2024). Increased expression of CXCL6 in secretory cells drives fibroblast collagen synthesis and is associated with increased mortality in idiopathic pulmonary fibrosis. European Respiratory Journal 63(1). doi: 10.1183/13993003.00088-2023 https://erj.ersjournals.com/content/63/1/2300088.long - Article
- Barlang, L. A., Deimel, I., Mohl, B. P., Blaurock, C., Balkema-Buschmann, A., Weinbender, K., Hess, B., Obernolte, H., Merkel, O. M., Popp, A. (2024). Distribution and suitability of pulmonary surfactants as a vehicle for topically applied antibodies in healthy and SARS-CoV-2 infected rodent lungs. European Journal of Pharmaceutical Sciences 196: 106744. doi: 10.1016/j.ejps.2024.106744 https://www.sciencedirect.com/science/article/pii/S0928098724000551?via%3Dihub - Open Access
- Behr, J., Bonella, F., Frye, B. C., Gunther, A., Hagmeyer, L., Henes, J., Klemm, P., Koschel, D., Kreuter, M., Leuschner, G., Nowak, D., Prasse, A., Quadder, B., Sitter, H., Costabel, U. (2024). Pharmacological Treatment of Idiopathic Pulmonary Fibrosis (Update) and Progressive Pulmonary Fibroses: S2k Guideline of the German Respiratory Society. Respiration [Epub ahead of print]: 1-29. doi: 10.1159/000540856 https://karger.com/res/article/doi/10.1159/000540856/913020/Pharmacological-Treatment-of-Idiopathic-Pulmonary - Open Access
- Blumer, S., Khan, P., Artysh, N., Plappert, L., Savic, S., Knudsen, L., Jonigk, D., Kuehnel, M. P., Prasse, A., Hostettler, K. E. (2024). The use of cultured human alveolar basal cells to mimic honeycomb formation in idiopathic pulmonary fibrosis. Respiratory Research 25(1): 26. doi: 10.1186/s12931-024-02666-9 https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-024-02666-9 - Open Access
- Borisch, C., Thum, T., Bar, C., Hoepfner, J. (2024). Human in vitro models for Fabry disease: new paths for unravelling disease mechanisms and therapies. Journal of Translational Medicine 22(1): 965. doi: 10.1186/s12967-024-05756-w https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05756-w - Open Access
- Chalmers, J. D., Badorrek, P., Diefenbach, C., Kogler, H., Sauter, W., Kreideweiss, S., Hohlfeld, J. M. (2024). The preclinical and phase 1 development of the novel oral cathepsin C inhibitor BI 1291583. ERJ Open Res 10(2). doi: 10.1183/23120541.00725-2023 https://openres.ersjournals.com/content/10/2/00725-2023 - Open Access
- Chatterjee, S., Leach-Mehrwald, M., Huang, C. K., Xiao, K., Fuchs, M., Otto, M., Lu, D., Dang, V., Winkler, T., Dunbar, C. E., Thum, T., Bar, C. (2024). Telomerase is essential for cardiac differentiation and sustained metabolism of human cardiomyocytes. Cellular and Molecular Life Sciences 81(1): 196. doi: 10.1007/s00018-024-05239-7 https://link.springer.com/article/10.1007/s00018-024-05239-7 - Open Access
- Costa, A., Hunkler, H. J., Chatterjee, S., Cushman, S., Hilbold, E., Xiao, K., Lu, D., Leonardy, J., Juchem, M., Sansonetti, M., Hoepfner, J., Thum, T., Bar, C. (2024). A reporter system for live cell tracking of human cardiomyocyte proliferation. Cardiovascular Research 120(14): 1660-1663. doi: 10.1093/cvr/cvae175 https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvae175/7739742?login=true - Open Access
- Cunnion, K., Goss, J., Hair, P., Dell, L., Roberson, D., Thienel, U., Muller, M., Carstensen-Aureche, S., Badorrek, P., Holz, O., Hohlfeld, J. M. (2024). RLS-0071, a novel anti-inflammatory agent, significantly reduced inflammatory biomarkers in a randomised human evaluation of mechanisms and safety study. ERJ Open Res 10(4). doi: 10.1183/23120541.01006-2023 https://publications.ersnet.org/content/erjor/10/4/01006-2023 - Open Access
- Derda, A. A., Abelmann, M., Sieweke, J. T., Waleczek, F. J. G., Weber, N., Zehrfeld, N., Bar, C., Duncker, D., Bavendiek, U., Berliner, D., Bauersachs, J., Sonnenschein, K., Thum, T. (2024). A pilot study for risk stratification of ventricular tachyarrhythmia in hypertrophic cardiomyopathy with routine echocardiography parameters. Scientific Reports 14(1): 3799. doi: 10.1038/s41598-024-54153-2 https://www.nature.com/articles/s41598-024-54153-2 - Open Access
- Gress, C., Fuchs, M., Carstensen-Aureche, S., Muller, M., Hohlfeld, J. M. (2024). Prostaglandin D2 receptor 2 downstream signaling and modulation of type 2 innate lymphoid cells from patients with asthma. PloS One 19(7): e0307750. doi: 10.1371/journal.pone.0307750 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0307750 - Open Access
- Gress, C., Litzenburger, T., Schmid, R., Xiao, K., Heissig, F., Muller, M., Gupta, A., Hohlfeld, J. M. (2024). Transcriptomic characterization of the human segmental endotoxin challenge model. Scientific Reports 14(1): 1721. doi: 10.1038/s41598-024-51547-0 https://www.nature.com/articles/s41598-024-51547-0 - Open Access
- Gyorfi, A. H., Filla, T., Dickel, N., Moller, F., Li, Y. N., Bergmann, C., Matei, A. E., Harrer, T., Kunz, M., Schett, G., Distler, J. H. W. (2024). Performance of serum biomarkers reflective of different pathogenic processes in systemic sclerosis-associated interstitial lung disease. Rheumatology 63(4): 962-969. doi: 10.1093/rheumatology/kead332 https://academic.oup.com/rheumatology/article-lookup/doi/10.1093/rheumatology/kead332?login=true -
- Kern, A. L., Pink, I., Bonifacius, A., Kaireit, T., Speth, M., Behrendt, L., Klimes, F., Voskrebenzev, A., Hohlfeld, J. M., Hoeper, M. M., Welte, T., Wacker, F., Eiz-Vesper, B., Vogel-Claussen, J. (2024). Alveolar membrane and capillary function in COVID-19 convalescents: insights from chest MRI. European Radiology 34(10): 6502-6513. doi: 10.1007/s00330-024-10669-9 https://link.springer.com/article/10.1007/s00330-024-10669-9 - Open Access
- Klimeš, F., Kern, A. L., Voskrebenzev, A., Gutberlet, M., Grimm, R., Müller, R. A., Behrendt, L., Kaireit, T. F., Glandorf, J., Alsady, T. M., Wacker, F., Hohlfeld, J. M., Vogel-Claussen, J. (2024). Free-breathing 3D phase-resolved functional lung MRI vs breath-hold hyperpolarized (129)Xe ventilation MRI in patients with chronic obstructive pulmonary disease and healthy volunteers. European Radiology [Epub ahead of print]. doi: 10.1007/s00330-024-10893-3 https://link.springer.com/article/10.1007/s00330-024-10893-3 - Open Access
- Koch, P. F., Garcia-Hidalgo, M. C., Labus, J., Biener, M., Thum, T., de Gonzalo-Calvo, D., Bar, C. (2024). Circulating long noncoding RNA PDE4DIPP6: A novel biomarker for improving the clinical management of non-ST-segment elevation myocardial infarction. Clinica Chimica Acta 561: 119840. doi: 10.1016/j.cca.2024.119840 https://www.sciencedirect.com/science/article/pii/S0009898124020928?via%3Dihub
- Lehmann, M., Krishnan, R., Sucre, J., Kulkarni, H. S., Pineda, R. H., Anderson, C., Banovich, N. E., Behrsing, H. P., Dean, C. H., Haak, A., Gosens, R., Kaminski, N., Zagorska, A., Koziol-White, C., Metcalf, J. P., Kim, Y. H., Loebel, C., Neptune, E., Noel, A., Raghu, G., Sewald, K., Sharma, A., Suki, B., Sperling, A., Tatler, A., Turner, S., Rosas, I. O., van Ry, P., Wille, T., Randell, S. H., Pryhuber, G., Rojas, M., Bourke, J., Konigshoff, M. (2024). Precision Cut Lung Slices: Emerging Tools for Preclinical and Translational Lung Research. An Official American Thoracic Society Workshop Report. American Journal of Respiratory Cell and Molecular Biology [Epub ahead of print]. doi: 10.1165/rcmb.2024-0479ST https://www.atsjournals.org/doi/10.1165/rcmb.2024-0479ST
- Mullens, W., Dauw, J., Gustafsson, F., Mebazaa, A., Steffel, J., Witte, K. K., Delgado, V., Linde, C., Vernooy, K., Anker, S. D., Chioncel, O., Milicic, D., Hasenfuss, G., Ponikowski, P., Stephan von Bardeleben, R., Koehler, F., Ruschitzka, F., Damman, K., Schwammenthal, E., Testani, J. M., Zannad, F., Bohm, M., Cowie, M. R., Dickstein, K., Jaarsma, T., Filippatos, G., Volterrani, M., Thum, T., Adamopoulos, S., Cohen-Solal, A., Moura, B., Rakisheva, A., Ristic, A., Bayes-Genis, A., Van Linthout, S., Tocchetti, C. G., Savarese, G., Skouri, H., Adamo, M., Amir, O., Yilmaz, M. B., Simpson, M., Tokmakova, M., Gonzalez, A., Piepoli, M., Seferovic, P., Metra, M., Coats, A. J. S., Rosano, G. M. C. (2024). Integration of implantable device therapy in patients with heart failure. A clinical consensus statement from the Heart Failure Association (HFA) and European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC). European Journal of Heart Failure 26(2): 483-501. doi: 10.1002/ejhf.3150 https://onlinelibrary.wiley.com/doi/10.1002/ejhf.3150 - Open Access
- Neufeldt, D., Schmidt, A., Mohr, E., Lu, D., Chatterjee, S., Fuchs, M., Xiao, K., Pan, W., Cushman, S., Jahn, C., Juchem, M., Hunkler, H. J., Cipriano, G., Jurgens, B., Schmidt, K., Gross, S., Jung, M., Hoepfner, J., Weber, N., Foo, R., Pich, A., Zweigerdt, R., Kraft, T., Thum, T., Bar, C. (2024). Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival. Basic Research in Cardiology 119(4): 613-632. doi: 10.1007/s00395-024-01048-y https://link.springer.com/article/10.1007/s00395-024-01048-y - Open Access
- Perez-Pons, M., Molinero, M., Benitez, I. D., Garcia-Hidalgo, M. C., Chatterjee, S., Bar, C., Gonzalez, J., Torres, A., Barbe, F., de Gonzalo-Calvo, D., Project, C. (2024). MicroRNA-centered theranostics for pulmoprotection in critical COVID-19. Mol Ther Nucleic Acids 35(1): 102118. doi: 10.1016/j.omtn.2024.102118 https://www.sciencedirect.com/science/article/pii/S2162253124000052?via%3Dihub
- Rodriguez Gonzalez, C., Schevel, H., Hansen, G., Schwerk, N., Lachmann, N. (2024). Correction: Pulmonary Alveolar Proteinosis and new therapeutic concepts. Klinische Padiatrie 236(2): e1. doi: 10.1055/a-2320-5286 https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-2320-5286
- Rodriguez Gonzalez, C., Schevel, H., Hansen, G., Schwerk, N., Lachmann, N. (2024). Pulmonary Alveolar Proteinosis and new therapeutic concepts. Klinische Padiatrie 236(2): 73-79. doi: 10.1055/a-2233-1243 https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-2233-1243 - Open Access
- Schmidt, K., Fuchs, M., Weber, N., Werlein, C., Schmitto, J. D., Ius, F., Ruhparwar, A., Bar, C., Fiedler, J., Thum, T. (2024). Single-nucleus RNA sequencing identifies cell-type-specific effects of sodium-glucose co-transporter 2 inhibitors in human myocardial slices. European Heart Journal 45(35): 3292-3295. doi: 10.1093/eurheartj/ehae472 https://pmc.ncbi.nlm.nih.gov/articles/PMC11400937/pdf/ehae472.pdf - Open Access
- Schmidt, K., Schmidt, A., Gross, S., Just, A., Pfanne, A., Fuchs, M., Jordan, M., Mohr, E., Pich, A., Fiedler, J., Thum, T. (2024). SGLT2 inhibitors attenuate endothelial to mesenchymal transition and cardiac fibroblast activation. Scientific Reports 14(1): 16459. doi: 10.1038/s41598-024-65410-9 https://www.nature.com/articles/s41598-024-65410-9 - Open Access
- Schnell, A., Tamm, S., Hedtfeld, S., Rodriguez Gonzalez, C., Hoerning, A., Lachmann, N., Stanke, F., Dittrich, A. M., Munder, A. (2024). Analysis of CFTR mRNA and Protein in Peripheral Blood Mononuclear Cells via Quantitative Real-Time PCR and Western Blot. Int J Mol Sci 25(12). doi: 10.3390/ijms25126367 https://www.mdpi.com/1422-0067/25/12/6367 - Open Access
- Schuetz, T., Dolejsi, T., Beck, E., Fugger, F., Bild, A., Duin, M. T., Gavranovic-Novakovic, J., Hilbold, E., Hoffmann, T., Zuber, J., Bauer, A., Ruschitzka, F., Bar, C., Penninger, J. M., Haubner, B. J. (2024). Murine neonatal cardiac regeneration depends on Insulin-like growth factor 1 receptor signaling. Scientific Reports 14(1): 22661. doi: 10.1038/s41598-024-72783-4 https://www.nature.com/articles/s41598-024-72783-4 - Open Access
- Schwarz, K., Struss, N., Banari, L., Hohlfeld, J. M. (2024). Quantifying Exhaled Particles in Healthy Humans During Various Respiratory Activities Under Realistic Conditions. Journal of Aerosol Medicine and Pulmonary Drug Delivery 37(2): 51-63. doi: 10.1089/jamp.2022.0076 https://www.liebertpub.com/doi/10.1089/jamp.2022.0076
- Simonenko, M., Hansen, D., Niebauer, J., Volterrani, M., Adamopoulos, S., Amarelli, C., Ambrosetti, M., Anker, S. D., Bayes-Genis, A., Gal, T. B., Bowen, T. S., Cacciatore, F., Caminiti, G., Cavaretta, E., Chioncel, O., Coats, A. J. S., Cohen-Solal, A., D'Ascenzi, F., de Pablo Zarzosa, C., Gevaert, A. B., Gustafsson, F., Kemps, H., Hill, L., Jaarsma, T., Jankowska, E., Joyce, E., Krankel, N., Lainscak, M., Lund, L. H., Moura, B., Nytroen, K., Osto, E., Piepoli, M., Potena, L., Rakisheva, A., Rosano, G., Savarese, G., Seferovic, P. M., Thompson, D. R., Thum, T., Van Craenenbroeck, E. M. (2024). Prevention and rehabilitation after heart transplantation: A clinical consensus statement of the European Association of Preventive Cardiology, Heart Failure Association of the ESC, and the European Cardio Thoracic Transplant Association, a section of ESOT. European Journal of Heart Failure 26(9): 1876-1892. doi: 10.1002/ejhf.3185 https://onlinelibrary.wiley.com/doi/full/10.1002/ejhf.3185 - Open Access
- Simonenko, M., Hansen, D., Niebauer, J., Volterrani, M., Adamopoulos, S., Amarelli, C., Ambrosetti, M., Anker, S. D., Bayes-Genis, A., Gal, T. B., Bowen, T. S., Cacciatore, F., Caminiti, G., Cavarretta, E., Chioncel, O., Coats, A. J. S., Cohen-Solal, A., D'Ascenzi, F., de Pablo Zarzosa, C., Gevaert, A. B., Gustafsson, F., Kemps, H., Hill, L., Jaarsma, T., Jankowska, E., Joyce, E., Krankel, N., Lainscak, M., Lund, L. H., Moura, B., Nytroen, K., Osto, E., Piepoli, M., Potena, L., Rakisheva, A., Rosano, G., Savarese, G., Seferovic, P. M., Thompson, D. R., Thum, T., Van Craenenbroeck, E. M. (2024). Prevention and rehabilitation after heart transplantation: A clinical consensus statement of the European Association of Preventive Cardiology, Heart Failure Association of the ESC, and the European Cardio Thoracic Transplant Association, a section of ESOT. Eur J Prev Cardiol 31(11): 1385-1399. doi: 10.1093/eurjpc/zwae179 https://academic.oup.com/eurjpc/article/31/11/1385/7695524?login=true - Open Access
- Simonenko, M., Hansen, D., Niebauer, J., Volterrani, M., Adamopoulos, S., Amarelli, C., Ambrosetti, M., Anker, S. D., Bayes-Genis, A., Gal, T. B., Bowen, T. S., Cacciatore, F., Caminiti, G., Cavarretta, E., Chioncel, O., Coats, A. J. S., Cohen-Solal, A., D'Ascenzi, F., de Pablo Zarzosa, C., Gevaert, A. B., Gustafsson, F., Kemps, H., Hill, L., Jaarsma, T., Jankowska, E., Joyce, E., Krankel, N., Lainscak, M., Lund, L. H., Moura, B., Nytroen, K., Osto, E., Piepoli, M., Potena, L., Rakisheva, A., Rosano, G., Savarese, G., Seferovic, P. M., Thompson, D. R., Thum, T., Van Craenenbroeck, E. M. (2024). Prevention and rehabilitation after heart transplantation: A clinical consensus statement of the European Association of Preventive Cardiology, Heart Failure Association of the ESC, and the European Cardio Thoracic Transplant Association, a section of ESOT. Transplant International 37: 13191. doi: 10.3389/ti.2024.13191 https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2024.13191/full - Open Access
- Wachtel, H., Emerson-Stadler, R., Langguth, P., Hohlfeld, J. M., Ohar, J. (2024). Aerosol Plumes of Inhalers Used in COPD. Pulm Ther 10(1): 109-122. doi: 10.1007/s41030-023-00249-5 https://link.springer.com/article/10.1007/s41030-023-00249-5 - open Access
- Wernz, M. M., Voskrebenzev, A., Muller, R. A., Zubke, M., Klimes, F., Glandorf, J., Czerner, C., Wacker, F., Olsson, K. M., Hoeper, M. M., Hohlfeld, J. M., Vogel-Claussen, J. (2024). Feasibility, Repeatability, and Correlation to Lung Function of Phase-Resolved Functional Lung (PREFUL) MRI-derived Pulmonary Artery Pulse Wave Velocity Measurements. Journal of Magnetic Resonance Imaging 60(5): 2216-2228. doi: 10.1002/jmri.29337 https://onlinelibrary.wiley.com/doi/10.1002/jmri.29337 - Open Access
- Zhao, A. Y., Unterman, A., Abu Hussein, N. S., Sharma, P., Nikola, F., Flint, J., Yan, X., Adams, T. S., Justet, A., Sumida, T. S., Zhao, J., Schupp, J. C., Raredon, M. S. B., Ahangari, F., Deluliis, G., Zhang, Y., Buendia-Roldan, I., Adegunsoye, A., Sperling, A. I., Prasse, A., Ryu, C., Herzog, E., Selman, M., Pardo, A., Kaminski, N. (2024). Single Cell Analysis Reveals Novel Immune Perturbations in Fibrotic Hypersensitivity Pneumonitis. American Journal of Respiratory and Critical Care Medicine 210(10): 1252-1266. doi: 10.1164/rccm.202401-0078OC https://www.atsjournals.org/doi/10.1164/rccm.202401-0078OC
