Fraunhofer Institute for Toxicology and Experimental MedicineR&D expertise "Lung research"
- Adams, T. S., Schupp, J. C., Balayev, A., Khoury, J., Justet, A., Nikola, F., De Sadeleer, L. J., Cala-Garcia, J., Zapata-Ortega, M., Benos, P. V., McDonough, J. E., Ahangari, F., Konigshoff, M., Ding, J., Homer, R. J., Rosas, I., Yan, X., Vanaudenaerde, B. M., Wuyts, W. A., Kaminski, N. (2025). "Alveolar epithelial cell plasticity and injury memory in human pulmonary fibrosis." bioRxiv. doi: 10.1101/2025.06.10.658504 https://www.biorxiv.org/content/10.1101/2025.06.10.658504v2 - Preprint im Repositorium – Open Access
- Babl, S., Seidel, J. M., Kugler, F., Silberhorn, E., Ludwig, A., Abel, J., Winklbauer, S., Schaub, N., Materna-Reichelt, S., Honarnejad, K., Stojanovic Guzvic, N., Langst, G. (2025). "SARS-CoV-2 nucleocapsid protein variants have differential RNA chaperone activity." FEBS J [Epub ahead of print]. doi: 10.1111/febs.70329 https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.70329 - Open Access
- Bargmann, T., Sommer, C., Stowasser, L., Jacob, S., Jurgen, L., Konzok, S., Werlein, C., Zardo, P., Neubert, L., Jonigk, D., Fieguth, H. G., Dahlmann, F., Sewald, K., Dehmel, S., Braun, A. (2025). "Regulation of T cell tissue residency and activation in human PCLS." Respiratory Research 26(1): 319. doi: 10.1186/s12931-025-03397-1 https://link.springer.com/article/10.1186/s12931-025-03397-1 - Open Access
- Birker-Robaczewska, M., Boucher, M., Ranieri, G., Poirey, S., Studer, R., Freti, D., Schnoebelen, M., Froidevaux, S., Morrison, K., Wyss, C., Scherer, J., Lescop, C., Brotschi, C., Bolli, M. H., Kramberg, M., Di Stefano, S., Rey, M., Iglarz, M., Delahaye, S., Vezzali, E., Sieber, P., Schäfer, A., Caimi, S. L., Hesse, C., Nayler, O. (2025). "The novel lysophosphatidic acid receptor 1-selective antagonist, ACT-1016-0707, has unique binding properties that translate into effective anti-fibrotic and anti-inflammatory activity in different models of pulmonary fibrosis." The Journal of pharmacology and experimental therapeutics [Epub ahead of print]. doi: 10.1016/j.jpet.2025.103396
- Bouheraoua, S., Cleeves, S., Preusse, M., Musken, M., Braubach, P., Fuchs, M., Falk, C., Sewald, K., Haussler, S. (2025). "Establishment and characterization of persistent Pseudomonas aeruginosa infections in air-liquid interface cultures of human airway epithelial cells." Infection and Immunity 93(3): e0060324. doi: 10.1128/iai.00603-24 https://journals.asm.org/doi/10.1128/iai.00603-24 - Open Accesssuper
- Burkle, M., Korf, I. H. E., Lippegaus, A., Krautwurst, S., Rohde, C., Weissfuss, C., Nouailles, G., Tene, X. M., Gaborieau, B., Ghigo, J. M., Ricard, J. D., Hocke, A. C., Papenfort, K., Debarbieux, L., Witzenrath, M., Wienhold, S. M., Krishnamoorthy, G. (2025). "Phage-phage competition and biofilms affect interactions between two virulent bacteriophages and Pseudomonas aeruginosa." ISME J 19(1). doi: 10.1093/ismejo/wraf065 https://academic.oup.com/ismej/advance-article/doi/10.1093/ismejo/wraf065/8106832 - Open Access
- Danov, O., Vollmer Barbosa, P., Obernolte, H., Fuchs, M., Guillon, P., Dirr, L., El-Deeb, I., Kunz, M., Hose, L., Martin, G., Ropken, F., Zimmer, A., Neubert, L., Jonigk, D., Fieguth, H. G., Dahlmann, F., Wronski, S., von Itzstein, M., Tschernig, T., Braun, A., Sewald, K. (2025). "Leveraging human precision cut lung slices for the study of human parainfluenza virus 3 infection." Respiratory Research 26(1): 315. doi: 10.1186/s12931-025-03335-1 https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-025-03335-1 - Open Access
- Hohlfeld, J. M., Badorrek, P., Breuer, O., Hanrott, K., Kricker, J., Parnham, M. J., Norris, V. (2025). "Effect of EP395, a novel anti-inflammatory macrolide, in an inhaled lipopolysaccharide challenge model in healthy volunteers: a randomised controlled trial." Pulmonary Pharmacology and Therapeutics 90: 102365. doi: 10.1016/j.pupt.2025.102365 https://www.sciencedirect.com/science/article/pii/S1094553925000227?via%3Dihub - Open Access
- Holz, O., Sadiq, M. W., Gress, C., Struss, N., Stomilovic, S., Lundqvist, A., Hohlfeld, J. M. (2025). "Assessing Human Lung Pharmacokinetics Using Exhaled Breath Particles." Journal of Aerosol Medicine and Pulmonary Drug Delivery 38(1): 13-17. doi: 10.1089/jamp.2024.0032
- Jordan, M., Schmidt, K., Fuchs, M., Just, A., Pfanne, A., Willmer, L., Neubert, L., Werlein, C., Zardo, P., Pich, A., Thum, T., Fiedler, J. (2025). "Repurposing of the small-molecule adrenoreceptor-inhibitor carvedilol for treatment of the fibrotic lung." Frontiers in Pharmacology 16: 1534989. doi: 10.3389/fphar.2025.1534989 https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1534989/full - Open Access
- Justet, A., Schupp, J. C. (2025). "From spatial transcriptomics to mouse model: the (re-)emergence of ductal myofibroblasts as a new cellular target in idiopathic pulmonary fibrosis." European Respiratory Journal 66(4). doi: 10.1183/13993003.01466-2025 https://www.ncbi.nlm.nih.gov/pubmed/41057218
- Kayser, T., Smulders, R., Kusawake, T., Wambre, E., Chichili, G. R., Blauwet, M. B., Spence, A., Patton, M., Tabash, R., DeBerg, H. A., Khosa, S., Badorrek, P., Hohlfeld, J. M., Ferslew, B. C. (2025). "Phase 1 study of safety, tolerability, and efficacy of intradermal DNA vaccine ASP2390 in adults allergic to house dust mites." Journal of Allergy and Clinical Immunology: Global 4(2). doi: 10.1016/j.jacig.2025.100404 https://www.jaci-global.org/article/S2772-8293(25)00005-0/fulltext - Open Access
- Kern, A. L., Park, D. H., Fuge, J., Hohlfeld, J. M., Wacker, F., Hoeper, M. M., Olsson, K. M., Vogel-Claussen, J. (2025). "Loss of pulmonary capillaries in idiopathic pulmonary arterial hypertension with low diffusion capacity is accompanied by early diffuse emphysema detected by (129)Xe MRI." European Radiology 35(6): 3010-3020. doi: 10.1007/s00330-024-11209-1 https://link.springer.com/article/10.1007/s00330-024-11209-1 - Open Access
- Kim, S. H., Nouws, J., Ruwisch, J., Woodard, G. A., Cooley, J., Khoury, J., Sun, H., Doherty, E., Piecychna, M., Manning, E. P., Kang, M. J., Bruscia, E. M., Wei, H., Zhang, Y., Yarovinsky, T. O., Hwa, J., Zacharias, W. J., Ingram, J., Lee, C. G., Elias, J. A., Kaminski, N., Redente, E. F., Herzog, E. L., Prasse, A., Bucala, R., Sauler, M. (2025). "Dysregulated alveolar type 2 epithelial cell proteostasis promotes fibrogenic macrophage migration inhibitory factor-CD74 signaling." Science Translational Medicine 17(827): eadr2277. doi: 10.1126/scitranslmed.adr2277 https://www.science.org/doi/10.1126/scitranslmed.adr2277
- Klimeš, F., Kern, A. L., Voskrebenzev, A., Gutberlet, M., Grimm, R., Müller, R. A., Behrendt, L., Kaireit, T. F., Glandorf, J., Alsady, T. M., Wacker, F., Hohlfeld, J. M., Vogel-Claussen, J. (2025). "Free-breathing 3D phase-resolved functional lung MRI vs breath-hold hyperpolarized (129)Xe ventilation MRI in patients with chronic obstructive pulmonary disease and healthy volunteers." European Radiology 35(2): 943-956. doi: 10.1007/s00330-024-10893-3 - Open Access
- Legchenko, E., Chouvarine, P., Hysko, K., Qadri, F., Wesolowski, R., Specker, E., Glage, S., Meier, M., Schwarz, K., Heineke, J., Pohlmann, G., Ramazanoglu, M., Bader, M., Hansmann, G. (2025). "Inhalation of the Novel Tryptophan Hydroxylase 1 Inhibitor TPT-004 Alleviates Pulmonary Arterial Hypertension." American Journal of Respiratory Cell and Molecular Biology [Epub ahead of print]. doi: 10.1165/rcmb.2024-0365OC
- Lehrich, T., Dierks, A., Plenge, M., Obernolte, H., Grieger, K., Sewald, K., Rodriguez, F., Malet, L., Braubach, P., Bedos-Belval, F., Ngezahayo, A. (2025). "Repression of Connexin26 hemichannel activity protects the barrier function of respiratory airway epithelial cells against LPS-induced alteration." Cell Commun Signal 23(1): 226. doi: 10.1186/s12964-025-02228-6 https://biosignaling.biomedcentral.com/articles/10.1186/s12964-025-02228-6 - Open Access
- Muller, R. A., Klimes, F., Voskrebenzev, A., Behrendt, L., Kaireit, T. F., Wernz, M., Zubke, M., Kern, A. L., Prince, M. R., Shen, W., Cooper, C. B., Barr, R. G., Hohlfeld, J. M., Vogel-Claussen, J. (2025). "Phase-Resolved Functional Lung MRI Evaluation of Dynamic Hyperinflation Induced by Metronome-Paced Tachypnea in Patients with Chronic Obstructive Pulmonary Disease." COPD 22(1): 2502671. doi: 10.1080/15412555.2025.2502671 https://www.tandfonline.com/doi/full/10.1080/15412555.2025.2502671 - Open Access
- Nowak, N., Escher, S. E., Schwarz, K. (2025). "A Unified Whole Lung PBK Model for Inhalational Uptake of Gases and Aerosols in Men." CPT Pharmacometrics Syst Pharmacol [Epub ahead of print]. doi: 10.1002/psp4.70117 https://ascpt.onlinelibrary.wiley.com/doi/10.1002/psp4.70117 - Open Access
- Paillard, M., Abdellatif, M., Andreadou, I., Bar, C., Bertrand, L., Brundel, B., Chiva-Blanch, G., Davidson, S. M., Dawson, D., Di Lisa, F., Evans, P., Giricz, Z., Hausenloy, D. J., Kleinbongard, P., Lezoualc'h, F., Liehn, E., Maack, C., Maguy, A., Murphy, E., Perrino, C., Pesce, M., Rainer, P. P., Streckfuss-Bomeke, K., Thielmann, M., Tian, R., Tocchetti, C. G., Van Der Velden, J., Van Linthout, S., Zacchigna, S., Krieg, T. (2025). "Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function." European Journal of Heart Failure [Epub ahead of print]. doi: 10.1002/ejhf.3674 https://onlinelibrary.wiley.com/doi/full/10.1002/ejhf.3674 - Open Access
- Pradhan, K., Neupane, B., Niehues, P., Kirschner, M., Beier, F., Kuo, C. C., Hilbold, E. A., Bär, C., Thoma, O. M., Waldner, M., Vieri, M., Brummendorf, T. H., Tharmapalan, V., Wagner, W., Kleines, M., Emrani, M., Zink, M. D., Napp, A., Marx, N., Gramlich, M. (2025). "Telomere Length Is Associated With Adverse Atrial Remodeling in Patients With Atrial Fibrillation." J Am Heart Assoc 14(3): e037512. doi: 10.1161/JAHA.124.037512 - Open Access
- Sadekar, N., Behrsing, H. P., Hansen, T., Patel, V., Paulo, H., Rae, A., Ritter, D., Schwarz, K., Api, A. M. (2025). "A Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods." Toxics 13(1). doi: 10.3390/toxics13010035 - Open Access
- Santizo, K. Y., Mangold, H. S., Mirzaei, Z., Park, H., Kolan, R. R., Sarau, G., Kolle, S., Hansen, T., Christiansen, S., Wohlleben, W. (2025). "Microplastic Materials for Inhalation Studies: Preparation by Solvent Precipitation and Comprehensive Characterization." Small [Epub ahead of print]: e2405555. doi: 10.1002/smll.202405555 - Open Access
- Seeliger, B., Ruwisch, J., Bulow Sand, J. M., Simoes, F. B., Jessen, H., Boerner, E., Fuge, J., Sewald, K., Welte, T., Wendel-Garcia, P. D., Schupp, J. C., Leeming, D. J., Bonella, F., Prasse, A. (2025). "Differential Effects of Antifibrotic Treatment on Outcome Prediction via Serial Matrix Metalloproteinase-Degraded C-Reactive Protein Neoepitope Levels in Idiopathic Pulmonary Fibrosis." Chest [Epub ahead of print]. doi: 10.1016/j.chest.2025.08.047 https://www.sciencedirect.com/science/article/pii/S0012369225053942?via%3Dihub - Open Access
- Struss, N., Badorrek, P., Schwarz, K., Windt, H., Straff, W., Hoflich, C., Hohlfeld, J. M. (2025). "Determining the Threshold Concentration of Birch Pollen for Inducing Allergic Symptoms Using an Allergen Challenge Chamber." International Archives of Allergy and Immunology [Epub ahead of print]: 1-10. doi: 10.1159/000545509 https://karger.com/iaa/article/doi/10.1159/000545509/926707/Determining-the-Threshold-Concentration-of-Birch - Open Access
- Tocchetti, C. G., Gonzalez, A., Backs, J., Pollesello, P., Rainer, P. P., Schiattarella, G. G., Bellin, M., Begley, G., Bock Marquette, I., Balligand, J. L., Falcao-Pires, I., Gorczynski, R., Hirsch, E., Hulot, J. S., Klebl, B., Lyon, A. R., Maack, C., McKinsey, T. A., Muller, O. J., Lunde, I., Montgomery, R., Vergaro, G., Bayes-Genis, A., Thum, T., van der Meer, P., Van Laake, L., Ruschitzka, F., Seferovic, P., Coats, A. J., Metra, M., Rosano, G., Van Linthout, S., de Boer, R. A. (2025). "How to facilitate seamless translation from basic concepts to new heart failure drugs. A scientific statement of the Heart Failure Association of the ESC." European Journal of Heart Failure [Epub ahead of print]. doi: 10.1002/ejhf.3709 https://onlinelibrary.wiley.com/doi/10.1002/ejhf.3709 - Open Access
- Umeda, Y., Izawa, T., Kazama, K., Arai, S., Kamiie, J., Nakamura, S., Hano, K., Takasu, M., Hirata, A., Rittinghausen, S., Yamano, S. (2025). "Comparative anatomy of respiratory bronchioles and lobular structures in mammals." Journal of Toxicologic Pathology 38(2): 113-129. doi: 10.1293/tox.2024-0071 https://www.jstage.jst.go.jp/article/tox/38/2/38_2024-0071/_article - Open Access
- van der Vis, J. J., Prasse, A., Renzoni, E. A., Stock, C. J. W., Maher, T. M., Bonella, F., Borie, R., Crestani, B., Wuyts, W. A., Molyneaux, P. L., Kelder, J. C., Grutters, J. C., van Moorsel, C. H. M. (2025). "Stratifying GAP Stages by MUC5B rs35705950 T-Allele Carriage Refines Survival Prediction in IPF." Lung 203(1): 85. doi: 10.1007/s00408-025-00837-z https://link.springer.com/article/10.1007/s00408-025-00837-z
- Weber, N., Montag, J., Kowalski, K., Iorga, B., de la Roche, J., Holler, T., Wojciechowski, D., Wendland, M., Radocaj, A., Mayer, A. K., Brunkhorst, A., Osten, F., Burkart, V., Piep, B., Bodenschatz, A., Gibron, P., Schwanke, K., Franke, A., Thiemann, S., Koroleva, A., Pfanne, A., Konsanke, M., Fiedler, J., Hegermann, J., Wrede, C., Muhlfeld, C., Chichkov, B., Fischer, M., Thum, T., Francino, A., Martin, U., Meissner, J., Zweigerdt, R., Kraft, T. (2025). "Patient-specific hiPSC-derived cardiomyocytes indicate allelic and contractile imbalance as pathogenic factor in early-stage Hypertrophic Cardiomyopathy." Journal of Molecular and Cellular Cardiology 198: 112-125. doi: 10.1016/j.yjmcc.2024.11.007 - Open Access
- Weissfuss, C., Li, J., Behrendt, U., Hoffmann, K., Burkle, M., Tan, C., Krishnamoorthy, G., Korf, I. H. E., Rohde, C., Gaborieau, B., Debarbieux, L., Ricard, J. D., Witzenrath, M., Felten, M., Nouailles, G. (2025). "Adjunctive phage therapy improves antibiotic treatment of ventilator-associated-pneumonia with Pseudomonas aeruginosa." Nat Commun 16(1): 4500. doi: 10.1038/s41467-025-59806-y https://www.nature.com/articles/s41467-025-59806-y - Open Access
- Ye, J. L., Grieger, K., Lu, D., Brandenberger, C., Juchem, M., Jordan, M., Oehlsen, L., Zardo, P., Werlein, C., Hesse, C., Sewald, K., Tretbar, S., Thum, T., Chatterjee, S., Bär, C. (2025). "Telomerase modRNA offers a novel RNA-based approach to treat human pulmonary fibrosis." BioRxiv. doi: 10.1101/2025.02.19.639041 https://www.biorxiv.org/content/10.1101/2025.02.19.639041v1?med=mas - Preprint im Repositorium – Open Access
