Publikationen des Fraunhofer ITEM

Aktuelle Publikationen

Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections.
Ackermann, M., Kempf, H., Hetzel, M., Hesse, C., Hashtchin, A. R., Brinkert, K., Schott, J. W., Haake, K., Kuhnel, M. P., Glage, S., Figueiredo, C., Jonigk, D., Sewald, K., Schambach, A., Wronski, S., Moritz, T., Martin, U., Zweigerdt, R., Munder, A., Lachmann, N. (2018). Nature Communications 9(1): 5088. doi: 10.1038/s41467-018-07570-7
https://www.nature.com/articles/s41467-018-07570-7 - Open Access

Digital microscopy, image analysis, and virtual slide repository.
Aeffner, F., Adissu, H. A., Boyle, M. C., Cardiff, R. D., Hagendorn, E., Hoenerhoff, M. J., Klopfleisch, R., Newbigging, S., Schaudien, D., Turner, O., Wilson, K. (2018). ILAR Journal[Epub ahead of print]. doi: 10.1093/ilar/ily007
https://academic.oup.com/ilarjournal/article-lookup/doi/10.1093/ilar/ily007

MicroRNA-144-3p targets relaxin/insulin-like family peptide receptor 1 (RXFP1) expression in lung fibroblasts from patients with idiopathic pulmonary fibrosis.
Bahudhanapati, H., Tan, J., Dutta, J. A., Strock, S. B., Sembrat, J., Alvarez, D., Rojas, M., Jager, B., Prasse, A., Zhang, Y., Kass, D. J. (2019). Journal of Biological Chemistry [Epub ahead of print]. doi: 10.1074/jbc.RA118.004910
http://www.jbc.org/content/early/2019/02/01/jbc.RA118.004910.long

An immune cell spray (ICS) formulation allows for the delivery of functional monocyte/macrophages.
Beneke, V., Kuster, F., Neehus, A. L., Hesse, C., Lopez-Rodriguez, E., Haake, K., Rafiei Hashtchin, A., Schott, J. W., Walter, D., Braun, A., Wolkers, W. F., Ackermann, M., Lachmann, N. (2018). Scientific Reports 8(1): 16281. doi: 10.1038/s41598-018-34524-2
https://www.nature.com/articles/s41598-018-34524-2- Open Access

Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers.
Brandsma, J., Goss, V. M., Yang, X., Bakke, P. S., Caruso, M., Chanez, P., Dahlén, S.-E., Fowler, S. J., Horvath, I., Krug, N., Montuschi, P., Sanak, M., Sandström, T., Shaw, D. E., Chung, K. F., Singer, F., Fleming, L. J., Sousa, A. R., Pandis, I., Bansal, A. T., Sterk, P. J., Djukanović, R., Postle, A. D. (2018). Metabolomics 14(10): 123. doi: 10.1007/s11306-018-1412-2
https://link.springer.com/content/pdf/10.1007%2Fs11306-018-1412-2.pdf- Open Access

Identification and prospective stability of eNose derived inflammatory phenotypes in severe asthma.
Brinkman, P., Wagener, A. H., Hekking, P. P., Bansal, A. T., Maitland-van der Zee, A. H., Wang, Y., Weda, H., Knobel, H. H., Vink, T. J., Rattray, N. J., D'Amico, A., Pennazza, G., Santonico, M., Lefaudeux, D., De Meulder, B., Auffray, C., Bakke, P. S., Caruso, M., Chanez, P., Chung, K. F., Corfield, J., Dahlen, S. E., Djukanovic, R., Geiser, T., Horvath, I., Krug, N., Musial, J., Sun, K., Riley, J. H., Shaw, D. E., Sandstrom, T., Sousa, A. R., Montuschi, P., Fowler, S. J., Sterk, P. J., U. Biopred Study Group (2018). Journal of Allergy and Clinical Immunology [Epub ahead of print]. doi: 10.1016/j.jaci.2018.10.058
https://www.sciencedirect.com/science/article/pii/S0091674918317226?via%3Dihub

Human lung tissue provides highly relevant data about efficacy of new anti-asthmatic drugs.
Danov, O., Jimenez Delgado, S. M., Obernolte, H., Seehase, S., Dehmel, S., Braubach, P., Fieguth, H. G., Matschiner, G., Fitzgerald, M., Jonigk, D., Knauf, S., Pfennig, O., Warnecke, G., Wichmann, J., Braun, A., Sewald, K. (2018). PloS One 13(11): e0207767. doi: 10.1371/journal.pone.0207767
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207767 - Open Access

Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop.
Ellison, C. A., Blackburn, K. L., Carmichael, P. L., Clewell, H. J., 3rd, Cronin, M. T. D., Desprez, B., Escher, S. E., Ferguson, S. S., Gregoire, S., Hewitt, N. J., Hollnagel, H. M., Klaric, M., Patel, A., Salhi, S., Schepky, A., Schmitt, B. G., Wambaugh, J. F., Worth, A. (2019). Regulatory Toxicology and Pharmacology 103: 63-72. doi: 10.1016/j.yrtph.2019.01.016
https://www.sciencedirect.com/science/article/pii/S0273230019300169  - Open Access

Identification and quantification of synthetic cannabinoids in 'spice-like' herbal mixtures: Update of the German situation in summer 2018.
Ernst, L., Langer, N., Bockelmann, A., Salkhordeh, E., Beuerle, T. (2019). Forensic Science International 294: 96-102. doi: 10.1016/j.forsciint.2018.11.001
https://www.sciencedirect.com/science/article/pii/S0379073818307205?via%3Dihub

Prenatal treatment with rosiglitazone attenuates vascular remodeling and pulmonary monocyte influx in experimental congenital diaphragmatic hernia.
Gosemann, J. H., Friedmacher, F., Hofmann, A., Zimmer, J., Kuebler, J. F., Rittinghausen, S., Suttkus, A., Lacher, M., Alvarez, L., Corcionivoschi, N., Puri, P. (2018). PloS One 13(11): e0206975. doi: 10.1371/journal.pone.0206975 https://www.ncbi.nlm.nih.gov/pubmed/30418988
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206975  - Open Access

Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes.
Grinberg, M., Stober, R. M., Albrecht, W., Edlund, K., Schug, M., Godoy, P., Cadenas, C., Marchan, R., Lampen, A., Braeuning, A., Buhrke, T., Leist, M., Oberemm, A., Hellwig, B., Kamp, H., Gardner, I., Escher, S., Taboureau, O., Aguayo-Orozco, A., Sachinidis, A., Ellinger-Ziegelbauer, H., Rahnenfuhrer, J., Hengstler, J. G. (2018). Archives of Toxicology 92(12): 3517-3533. doi: 10.1007/s00204-018-2352-3
https://link.springer.com/article/10.1007%2Fs00204-018-2352-3

Human ex vivo and in vitro disease models to study food allergy.
Hung, L., Obernolte, H., Sewald, K., Eiwegger, T. (2019). Asia Pac Allergy 9(1): e4. doi: 10.5415/apallergy.2019.9.e4
https://apallergy.org/DOIx.php?id=10.5415/apallergy.2019.9.e4  - Open Access

The rat bone marrow micronucleus test: Statistical considerations on historical negative control data.
Igl, B. W., Bitsch, A., Bringezu, F., Chang, S., Dammann, M., Frotschl, R., Harm, V., Kellner, R., Krzykalla, V., Lott, J., Nern, M., Pfuhler, S., Queisser, N., Schulz, M., Sutter, A., Vaas, L., Vonk, R., Zellner, D., Ziemann, C. (2019). Regulatory Toxicology and Pharmacology 102: 13-22. doi: 10.1016/j.yrtph.2018.12.009
https://www.sciencedirect.com/science/article/pii/S0273230018303167?via%3Dihub

A mouse model for intellectual disability caused by mutations in the X-linked 2'Omethyltransferase Ftsj1 gene.
Jensen, L. R., Garrett, L., Holter, S. M., Rathkolb, B., Racz, I., Adler, T., Prehn, C., Hans, W., Rozman, J., Becker, L., Aguilar-Pimentel, J. A., Puk, O., Moreth, K., Dopatka, M., Walther, D. J., von Bohlen Und Halbach, V., Rath, M., Delatycki, M., Bert, B., Fink, H., Blumlein, K., Ralser, M., Van Dijck, A., Kooy, F., Stark, Z., Muller, S., Scherthan, H., Gecz, J., Wurst, W., Wolf, E., Zimmer, A., Klingenspor, M., Graw, J., Klopstock, T., Busch, D., Adamski, J., Fuchs, H., Gailus-Durner, V., de Angelis, M. H., von Bohlen Und Halbach, O., Ropers, H. H., Kuss, A. W. (2018). Biochimica et biophysica acta: BBA. Molecular basis of disease [Epub ahead of print]. doi: 10.1016/j.bbadis.2018.12.011
https://www.sciencedirect.com/science/article/pii/S0925443918304976?via%3Dihub - Open Access

Mapping of regional lung microstructural parameters using hyperpolarized (129) Xe dissolved-phase MRI in healthy volunteers and patients with chronic obstructive pulmonary disease.
Kern, A. L., Gutberlet, M., Voskrebenzev, A., Klimes, F., Rotarmel, A., Wacker, F., Hohlfeld, J. M., Vogel-Claussen, J. (2019). Magnetic Resonance in Medicine 81(4): 2360-2373. doi: 10.1002/mrm.27559
https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.27559

Air–liquid interface in vitro models for respiratory toxicology research: consensus workshop and recommendations.
Lacroix, G., Koch, W., Ritter, D., Gutleb, A. C., Larsen, S. T., Loret, T., Zanetti, F., Constant, S., Chortarea, S., Rothen-Rutishauser, B., Hiemstra, P. S., Frejafon, E., Hubert, P., Gribaldo, L., Kearns, P., Aublant, J.-M., Diabaté, S., Weiss, C., de Groot, A., Kooter, I. (2018). Applied In Vitro Toxicology 4(2): 91-106. doi: 10.1089/aivt.2017.0034 https://www.liebertpub.com/doi/abs/10.1089/aivt.2017.0034

Rating sputum cell quality in clinical trials for asthma and COPD treatment.
Pedersen, F., Zissler, U. M., Watz, H., Rabe, K. F., Hohlfeld, J. M., Holz, O. (2019). International Journal of Chronic Obstructive Pulmonary Disease 14: 195-198. doi: 10.2147/COPD.S188033
https://www.dovepress.com/rating-sputum-cell-quality-in-clinical-trials-for-asthma-and-copd-trea-peer-reviewed-article-COPD  - Open Access

Human teratoma-derived hematopoiesis is a highly polyclonal process supported by human umbilical vein endothelial cells.
Philipp, F., Selich, A., Rothe, M., Hoffmann, D., Rittinghausen, S., Morgan, M. A., Klatt, D., Glage, S., Lienenklaus, S., Neuhaus, V., Sewald, K., Braun, A., Schambach, A. (2018). Stem Cell Reports 11(5): 1051-1060. doi: 10.1016/j.stemcr.2018.09.010
https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(18)30395-3  - Open Access

VIII – 7.3 Innenraumluftqualität in VerkehrsflugzeugenRosenberger, W., Schuchardt, S., Baumstark-Khan, C., A., H. (2018). Handbuch der Umweltmedizin. Wichmann, E., Fromme, H., ecomed Medizin. 62. Ergänzungslieferung.

Treatable traits in the European U-BIOPRED adult asthma cohorts.
Simpson, A. J., Hekking, P. P., Shaw, D. E., Fleming, L. J., Roberts, G., Riley, J. H., Bates, S., Sousa, A. R., Bansal, A. T., Pandis, I., Sun, K., Bakke, P. S., Caruso, M., Dahlen, B., Dahlen, S. E., Horvath, I., Krug, N., Montuschi, P., Sandstrom, T., Singer, F., Adcock, I. M., Wagers, S. S., Djukanovic, R., Chung, K. F., Sterk, P. J., Fowler, S. J., U. Biopred Study Group (2018). Allergy[Epub ahead of print]. doi: 10.1111/all.13629
https://onlinelibrary.wiley.com/doi/full/10.1111/all.13629

Signatures of T and B cell development, functional responses and PD-1 upregulation after HCMV latent infections and reactivations in Nod.Rag.Gamma mice humanized with cord blood CD34(+) cells.
Theobald, S. J., Khailaie, S., Meyer-Hermann, M., Volk, V., Olbrich, H., Danisch, S., Gerasch, L., Schneider, A., Sinzger, C., Schaudien, D., Lienenklaus, S., Riese, P., Guzman, C. A., Figueiredo, C., von Kaisenberg, C., Spineli, L. M., Glaesener, S., Meyer-Bahlburg, A., Ganser, A., Schmitt, M., Mach, M., Messerle, M., Stripecke, R. (2018). Frontiers in Immunology 9: 2734, 2721 p. doi: 10.3389/fimmu.2018.02734
https://www.frontiersin.org/articles/10.3389/fimmu.2018.02734/full  - Open Access

Isolated aggregates of lymphoid cells in the inner bronchial wall in asthma patients.
Tschernig, T., Pabst, R., Prenzler, F., Rittinghausen, S., Braun, A., Hohlfeld, J. M. (2018). Cell and Tissue Research 374(2): 423-425. doi: 10.1007/s00441-018-2936-5
https://link.springer.com/article/10.1007%2Fs00441-018-2936-5

Microfluidic enrichment, isolation and characterization of disseminated melanoma cells from lymph node samples.
Weidele, K., Stojanovic, N., Feliciello, G., Markiewicz, A., Scheitler, S., Alberter, B., Renner, P., Haferkamp, S., Klein, C. A., Polzer, B. (2018). International Journal of Cancer [Epub ahead of print]. doi: 10.1002/ijc.32092
https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32092

Differentiation of aneugens and clastogens in the in vitro micronucleus test by kinetochore scoring using automated image analysis.
Wilde, S., Queisser, N., Holz, C., Raschke, M., Sutter, A. (2018). Environmental and Molecular Mutagenesis [Epub ahead of print]. doi: 10.1002/em.22259
https://onlinelibrary.wiley.com/doi/10.1002/em.22259