Publikationen des Fraunhofer ITEM

Publikationen 2020

  • Ambjorner, S. E. B., Wiese, M., Kohler, S. C., Svindt, J., Lund, X. L., Gajhede, M., Saaby, L., Brodin, B., Rump, S., Weigt, H., Brunner, N., Stenvang, J. (2020). "The Pyrazolo[3,4-d]pyrimidine derivative, SCO-201, deverses multidrug resistance mediated by ABCG2/BCRP." Cells 9(3): doi: 10.3390/cells9030613 
    https://www.mdpi.com/2073-4409/9/3/613/htm– Open Access
  • Baerlecken, N., Pursche, N., Witte, T., Kniesch, K., Höpfner, M., Ernst, D., Moosig, F., Seeliger, B., Prasse, A. (2020). "Presence of antibodies binding to negative elongation factor E in sarcoidosis." J Clin Med 9(3): doi: 10.3390/jcm9030715
    https://www.mdpi.com/2077-0383/9/3/715/htm – Open Access
  • Behr, J., Günther, A., Bonella, F., Dinkel, J., Fink, L., Geiser, T., Geißler, K., Gläser, S., Handzhhiev, S., Jonigk, D., Koschel, D., Kreuter, M., Leuschner, G., Markart, P., Prasse, A., Schonfeld, N., Schupp, J. C., Sitter, H., Müller-Quernheim, J., Costabel, U. (2020). "S2K-Leitlinie zur Diagnostik der idiopathischen Lungenfibrose. [German Guideline for Idiopathic Pulmonary Fibrosis]." Pneumologie [Epub ahead of print]. doi: 10.1055/a-1120-3531
  • Bernstein, D. M., Toth, B., Rogers, R. A., Kling, D. E., Kunzendorf, P., Phillips, J. I., Ernst, H. (2020). "Evaluation of the dose-response and fate in the lung and pleura of chrysotile-containing brake dust compared to TiO2, chrysotile, crocidolite or amosite asbestos in a 90-day quantitative inhalation toxicology study - Interim results Part 2: Histopathological examination, Confocal microscopy and collagen quantification of the lung and pleural cavity." Toxicology and Applied Pharmacology 387: 114847. doi: 10.1016/j.taap.2019.114847 https://www.sciencedirect.com/science/article/pii/S0041008X19304557?via%3Dihub - Open Access
  • Bernstein, D. M., Toth, B., Rogers, R. A., Kling, D. E., Kunzendorf, P., Phillips, J. I., Ernst, H. (2020). "Evaluation of the exposure, dose-response and fate in the lung and pleura of chrysotile-containing brake dust compared to TiO2, chrysotile, crocidolite or amosite asbestos in a 90-day quantitative inhalation toxicology study - Interim results Part 1: Experimental design, aerosol exposure, lung burdens and BAL." Toxicology and Applied Pharmacology 387: 114856. doi: 10.1016/j.taap.2019.114856 https://www.sciencedirect.com/science/article/pii/S0041008X19304648?via%3Dihub - Open Access
  • Blazquez, R., Rietkotter, E., Wenske, B., Wlochowitz, D., Sparrer, D., Vollmer, E., Muller, G., Seegerer, J., Sun, X., Dettmer, K., Barrantes-Freer, A., Stange, L., Utpatel, K., Bleckmann, A., Treiber, H., Bohnenberger, H., Lenz, C., Schulz, M., Reimelt, C., Hackl, C., Grade, M., Buyuktas, D., Siam, L., Balkenhol, M., Stadelmann, C., Kube, D., Krahn, M. P., Proescholdt, M. A., Riemenschneider, M. J., Evert, M., Oefner, P. J., Klein, C. A., Hanisch, U. K., Binder, C., Pukrop, T. (2020). "LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancer." International Journal of Cancer 146(11): 3170-3183. doi:  10.1002/ijc.32742
    https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijc.32742 – Open Access
  • Bogorodskiy, A. O., Bolkhovitina, E. L., Gensch, T., Troyanova, N. I., Mishin, A. V., Okhrimenko, I. S., Braun, A., Spies, E., Gordeliy, V. I., Sapozhnikov, A. M., Borshchevskiy, V. I., Shevchenko, M. A. (2020). "Murine intraepithelial dendritic cells interact with phagocytic cells during aspergillus fumigatus-induced inflammation." Frontiers in Immunology 11: Article 298. doi:  10.3389/fimmu.2020.00298
    https://www.frontiersin.org/articles/10.3389/fimmu.2020.00298/full – Open Access
  • Delgado, S. J., Dehmel, S., Twisterling, E., Wichmann, J., Jonigk, D., Warnecke, G., Braubach, P., Fieguth, H. G., Wilkens, L., Dahlmann, F., Kaup, F. J., Eggel, A., Knauf, S., Sewald, K., Braun, A. (2020). "Disruptive anti-IgE inhibitors prevent mast cell-dependent early airway response in viable atopic lung tissue." Journal of Allergy and Clinical Immunology 145(2): 719-722.e711. doi: 10.1016/j.jaci.2019.11.002 https://www.sciencedirect.com/science/article/abs/pii/S009167491931485X?via%3Dihub
  • Escher, S. E., Mangelsdorf, I., Hoffmann-Doerr, S., Partosch, F., Karwath, A., Schroeder, K., Zapf, A., Batke, M. (2020). "Time extrapolation in regulatory risk assessment: The impact of study differences on the extrapolation factors." Regulatory Toxicology and Pharmacology [Epub ahead of print]: 104584. doi: 10.1016/j.yrtph.2020.104584 https://www.sciencedirect.com/science/article/abs/pii/S0273230020300106?via%3Dihub
  • Falciani, C., Zevolini, F., Brunetti, J., Riolo, G., Gracia, R., Marradi, M., Loinaz, I., Ziemann, C., Cossío, U., Llop, J., Bracci, L., Pini, A. (2020). "Antimicrobial peptide-loaded nanoparticles as inhalation therapy for Pseudomonas aeruginosa infections." International Journal of Nanomedicine Volume 15: 1117-1128. doi: 10.2147/ijn.S218966
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034994/ – Open Aceess
  • Franken, A., Honisch, E., Reinhardt, F., Meier-Stiegen, F., Yang, L., Jaschinski, S., Esposito, I., Alberter, B., Polzer, B., Huebner, H., Fasching, P. A., Pancholi, S., Martin, L. A., Ruckhaeberle, E., Schochter, F., Tzschaschel, M., Hartkopf, A. D., Mueller, V., Niederacher, D., Fehm, T., Neubauer, H. (2020). "Detection of ESR1 Mutations in Single Circulating Tumor Cells on Estrogen Deprivation Therapy but Not in Primary Tumors from Metastatic Luminal Breast Cancer Patients." J Mol Diagn 22(1): 111-121. doi: 10.1016/j.jmoldx.2019.09.004 https://www.ncbi.nlm.nih.gov/pubmed/31669227
    https://www.sciencedirect.com/science/article/abs/pii/S1525157819304027?via%3Dihub
  • George, L., Taylor, A. R., Esteve-Codina, A., Soler Artigas, M., Thun, G. A., Bates, S., Pavlidis, S., Wagers, S., Boland, A., Prasse, A., Boschetto, P., Parr, D. G., Nowinski, A., Barta, I., Hohlfeld, J., Greulich, T., van den Berge, M., Hiemstra, P. S., Timens, W., Hinks, T., Wenzel, S., Siddiqui, S., Richardson, M., Venge, P., Heath, S., Gut, I., Tobin, M. D., Edwards, L., Riley, J. H., Djukanovic, R., Auffray, C., De-Meulder, B., Erik-Dahlen, S., Adcock, I. M., Chung, K. F., Ziegler-Heitbrock, L., Sterk, P. J., Singh, D., Brightling, C. E. (2020). "Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma." Allergy 75(2): 370-380. doi: 10.1111/all.14016 
    https://onlinelibrary.wiley.com/doi/full/10.1111/all.14016 – Open Aceess
  • Holz, O., DeLuca, D. S., Roepcke, S., Illig, T., Weinberger, K. M., Schudt, C., Hohlfeld, J. M. (2020). "Smokers with COPD Show a Shift in Energy and Nitrogen Metabolism at Rest and During Exercise." International Journal of Chronic Obstructive Pulmonary Disease 15: 1-13. doi: 10.2147/copd.S217474 https://www.dovepress.com/smokers-with-copd-show-a-shift-in-energy-and-nitrogen-metabolism-at-re-peer-reviewed-fulltext-article-COPD - Open Access
  • Huppertz, C., Jäger, B., Wieczorek, G., Engelhard, P., Oliver, S. J., Bauernfeind, F. G., Littlewood-Evans, A., Welte, T., Hornung, V., Prasse, A. (2020). "The NLRP3 inflammasome pathway is activated in sarcoidosis and involved in granuloma formation." European Respiratory Journal [Epub ahead of print]. doi: 10.1183/13993003.00119-2019 https://erj.ersjournals.com/content/early/2020/01/03/13993003.00119-2019.long
  • Jimenez-Delgado, S., Dehmel, S., Twisterling, E., Wichmann, J., Jonigk, D., Warnecke, G., Braubach, P., Fieguth, H. G., Wilkens, L., Dahlmann, F., Kaup, F. J., Eggel, A., Knauf, S., Sewald, K., Braun, A. (2020). "Disruptive anti-IgE inhibitors prevent mast cell-dependent early airway response in viable atopic lung tissue." Journal of Allergy and Clinical Immunology 145(2): 719-722.e711. doi: 10.1016/j.jaci.2019.11.002 
  • Kern, A. L., Gutberlet, M., Moher Alsady, T., Welte, T., Wacker, F., Hohlfeld, J. M., Vogel-Claussen, J. (2020). "Investigating short-time diffusion of hyperpolarized (129) Xe in lung air spaces and tissue: A feasibility study in chronic obstructive pulmonary disease patients." Magnetic Resonance in Medicine [Epub ahead of print]. doi: 10.1002/mrm.28264
    https://onlinelibrary.wiley.com/doi/full/10.1002/mrm.28264 – Open Access
  • Lange, L., Hoffmann, D., Schwarzer, A., Ha, T. C., Philipp, F., Lenz, D., Morgan, M., Schambach, A. (2020). "Inducible Forward Programming of Human Pluripotent Stem Cells to Hemato-endothelial Progenitor Cells with Hematopoietic Progenitor Potential." Stem Cell Reports 14(1): 122-137. doi: 10.1016/j.stemcr.2019.11.005 https://www.sciencedirect.com/science/article/pii/S2213671119304084?via%3Dihub - Open Access
  • Metzenmacher, M., Varaljai, R., Hegedus, B., Cima, I., Forster, J., Schramm, A., Scheffler, B., Horn, P. A., Klein, C. A., Szarvas, T., Reis, H., Bielefeld, N., Roesch, A., Aigner, C., Kunzmann, V., Wiesweg, M., Siveke, J. T., Schuler, M., Lueong, S. S. (2020). "Plasma Next Generation Sequencing and Droplet Digital-qPCR-Based Quantification of Circulating Cell-Free RNA for Noninvasive Early Detection of Cancer." Cancers 12(2). doi: 10.3390/cancers12020353 https://www.mdpi.com/2072-6694/12/2/353 - Open Access
  • Metzler, M., Bitsch, A., Degen, G. H. (2020). "The life of Hans-Günter Neumann and his contributions to chemical carcinogenesis." Archives of Toxicology [Epub ahead of print]. doi: 10.1039/c9em00369j
  • Oltmanns, J., Licht, O., Bohlen, M. L., Schwarz, M., Escher, S. E., Silano, V., MacLeod, M., Noteborn, H., Kass, G. E. N., Merten, C. (2020). "Potential emerging chemical risks in the food chain associated with substances registered under REACH." Environ Sci Process Impacts 22(1): 105-120. doi: 10.1039/c9em00369j https://pubs.rsc.org/en/content/articlelanding/2020/EM/C9EM00369J#!divAbstract
  • Quercini, L., Brunetti, J., Riolo, G., Bindi, S., Scali, S., Lampronti, I., D'Aversa, E., Wronski, S., Pollini, S., Gentile, M., Lupetti, P., Rossolini, G. M., Falciani, C., Bracci, L., Pini, A. (2020). "An antimicrobial molecule mitigates signs of sepsis in vivo and eradicates infections from lung tissue." FASEB Journal 34(1): 192-207. doi: 10.1096/fj.201901896RR https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.201901896RR
  • Ritter, D., Knebel, J., Niehof, M., Loinaz, I., Marradi, M., Gracia, R., Te Welscher, Y., van Nostrum, C. F., Falciani, C., Pini, A., Strandh, M., Hansen, T. (2020). "In vitro inhalation cytotoxicity testing of therapeutic nanosystems for pulmonary infection." Toxicology in Vitro 63: 104714. doi: 10.1016/j.tiv.2019.104714 https://www.sciencedirect.com/science/article/pii/S0887233319302309?via%3Dihub - Open Access
  • Schaudien, D., Creutzenberg, O., Wagner, A., Dahlmann, F., Rittinghausen, S. (2020). "Malignant myoepithelioma of the parotid gland in a rat." Journal of Comparative Pathology 176: 162-164. doi: 10.1016/j.jcpa.2020.03.004
  • Schochter, F., Werner, K., Köstler, C., Faul, A., Tzschaschel, M., Alberter, B., Müller, V., Neubauer, H., Fehm, T., Friedl, T. W. P., Polzer, B., Janni, W., Rack, B., Wiesmuller, L. (2020). "53BP1 accumulation in circulating tumor cells identifies chemotherapy-responsive metastatic breast cancer patients." Cancers 12(4): 930. doi: 10.3390/cancers12040930
    https://www.mdpi.com/2072-6694/12/4/930/htm – Open Access
  • Schuermann, D., Ziemann, C., Barekati, Z., Capstick, M., Oertel, A., Focke, F., Murbach, M., Kuster, N., Dasenbrock, C., Schär, P. (2020). "Assessment of genotoxicity in human cells exposed to modulated electromagnetic fields of wireless communication devices." Genes (Basel) 11(4). doi: 10.3390/genes11040347
    https://www.mdpi.com/2073-4425/11/4/347/htm – Open Access
  • Schupp, J. C., Prasse, A., Erythropel, H. C. (2020). "[E-Cigarettes - Operating Principle, Ingredients, and Associated Acute Lung Injury].
    E-Zigaretten – Funktionsweise, Inhaltsstoffe und die Vaping-assoziierte akute Lungenschädigung." Pneumologie [Epub ahead of print]. doi: 10.1055/a-1078-8126
    https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1078-8126 - Open Access
  • Struß, N., Badorrek, P., Mattern, C., Mattern, U., Hohlfeld, J. M. (2020). "The Effect of a Thixotropic Nasal Gel on Nasal Symptoms and Inflammatory Biomarkers in Seasonal Allergic Rhinitis." International Archives of Allergy and Immunology [Epub ahead of print]: 1-10. doi: 10.1159/000506129
  • Tentschert, J., Laux, P., Jungnickel, H., Brunner, J., Estrela-Lopis, I., Merker, C., Meijer, J., Ernst, H., Ma-Hock, L., Keller, J., Landsiedel, R., Luch, A. (2020). "Organ burden of inhaled nanoceria in a 2-year low-dose exposure study: dump or depot?" Nanotoxicology 14(4): 554-576. doi: 10.1080/17435390.2020.1736355
    https://www.tandfonline.com/doi/full/10.1080/17435390.2020.1736355 – Open Access
  • Vollmann-Zwerenz, A., Leidgens, V., Feliciello, G., Klein, C. A., Hau, P. (2020). "Tumor cell invasion in glioblastoma." Int J Mol Sci 21(6). doi: 10.3390/ijms21061932
  • Watz, H., Hohlfeld, J. M., Singh, D., Beier, J., Diamant, Z., Liu, J., Hua, S., Abd-Elaziz, K., Pinot, P., Jones, I., Tillmann, H. C. (2020). "Letter to the editor: indacaterol/glycopyrronium/mometasone furoate compared with salmeterol/fluticasone propionate in patients with asthma: a randomized controlled cross-over study." Respiratory Research 21(1): 87. doi: 10.1186/s12931-020-01349-5
  • Wilde, S., Queisser, N., Sutter, A. (2020). "Image analysis of mechanistic protein biomarkers for the characterization of genotoxicants: aneugens, clastogens and ROS inducers." Environmental and Molecular Mutagenesis [Epub ahead of print]. doi: 10.1002/em.22374
  • Zimmermann, F., Roessler, J., Schmidt, D., Jasina, A., Schumann, P., Gast, M., Poller, W., Leistner, D., Giral, H., Kränkel, N., Kratzer, A., Schuchardt, S., Heimesaat, M. M., Landmesser, U., Haghikia, A. (2020): "Impact of the Gut Microbiotica on Atorvastatin Mediated Effects on Blood Lipids." Journal of Clinical Medicine. doi: 10.3390/jcm9051596
    https://www.mdpi.com/2077-0383/9/5/1596/htm - Open Access