Fraunhofer-Institut für Toxikologie und Experimentelle Medizin
Fraunhofer-Institut für Toxikologie und Experimentelle Medizin

Publikationen des Fraunhofer ITEM

 

»Fraunhofer-Publica«

Die Fraunhofer-Datenbank dokumentiert Publikationen und Patente aller Fraunhofer-Institute. Hier finden Sie Veröffentlichungen gezielt nach Stichwörtern oder Autoren. 

Hochschulschriften

Chronologie der Publikationen

Sie finden hier Hinweise auf Aufsätze, Konferenzbeiträge und Tagungsbände sowie Forschungsberichte, Studien, Hochschulschriften und Patente aus dem laufenden und den vergangenen Jahren.

© Adobe Stock

Aktuelle Publikationen

Hier finden Sie eine themenspezifische Sortierung der Publikationen des Fraunhofer ITEM.

Alle ausklappen Alle einklappen

FuE-Kompetenz »Lungenforschung«

  • Behr, J., Prasse, A., Wirtz, H., Koschel, D., Pittrow, D., Held, M., Klotsche, J., Andreas, S., Claussen, M., Grohe, C., Wilkens, H., Hagmeyer, L., Skowasch, D., Meyer, J. F., Kirschner, J., Glaser, S., Neurohr, C., Schwaiblmair, M., Buschulte, K., Veit, T., Frankenberger, M., Ryerson, C. J., Johannson, K. A., Marcoux, V., Fisher, J. H., Assayag, D., Manganas, H., Khalil, N., Kolb, M., Kreuter, M. (2026). "Risk stratification as a guide to goal-oriented management of patients with fibrotic interstitial lung disease: a registry-based analysis." ERJ Open Res 12(1). doi: 10.1183/23120541.00570-2025 - Open Access
  • Carstensen-Aureche, S., Litzenburger, T., De Sousa, D., Sailer, R., Benediktus, E., Delic, D., Müller, F., Müller, M., Hohlfeld, J. M. (2026). "Safety, tolerability, pharmacokinetics and pharmacodynamics of the spleen tyrosine kinase inhibitor BI 894416 in healthy volunteers and patients with asthma." British Journal of Pharmacology [Epub ahead of print]. doi: 10.1111/bph.70329  - Open Access
  • Christian, L., Yilmaz, H., Ruwisch, J., Giercke, L., Seeliger, B., Kamp, J. C., Bayraktar, S., Ewen, R., Graalmann, T., Fuge, J., Greer, M., Ius, F., Welte, T., Liao, S. Y., Yang, I. V., Hohlfeld, J. M., Hoeper, M. M., Gottlieb, J., Kaminski, N., Prasse, A., Jonigk, D., Li, Y., Falk, C., Neubert, L., Schupp, J. C. (2026). "Spatial Transcriptomics Uncovers Hybrid, Pro-Inflammatory and Pro-Fibrotic Cellular Niches in Pulmonary Granuloma of Patients with Chronic Sarcoidosis." American Journal of Respiratory and Critical Care Medicine [Epub ahead of print]. doi: 10.1093/ajrccm/aamaf089  - Open Access
  • Gentemann, L., Ropken, F., Mroch, P. J., Noltemeyer, N., Donath, S., Seidler, A. E., Werlein, C., Zardo, P., Neubert, L., Jonigk, D., Fieguth, H. G., Heisterkamp, A., Sewald, K., Kalies, S. (2026). "Live imaging of human airway epithelial repair in precision-cut lung slices after targeted cell damage." Biochem Biophys Rep 45: 102470. doi: 10.1016/j.bbrep.2026.102470  - Open Access
  • Glandorf, J., Klein, M. M., Klimes, F., Kern, A. L., Gutberlet, M., Hohlfeld, J. M., Hoeper, M. M., Olsson, K. M., Wacker, F., Vogel-Claussen, J., Voskrebenzev, A. (2026). "Analysis of Pulsatile Vessel Expansion in Healthy, COPD-and PH-Patients Using Dynamic Vessel Segmentation in Free-Breathing Lung MRI." Journal of Magnetic Resonance Imaging [Epub ahead of print]. doi: 10.1002/jmri.70249  - Open Access
  • Gress, C., Müller, M., Hohlfeld, J. M. (2026). "Proteomic profiling of bronchoalveolar lavage following human segmental endotoxin challenge-a potential exacerbation model." Scientific Reports 16(1): 6145. doi: 10.1038/s41598-026-39528-x - Open Access
  • Hildebrand, C. B., Ozturk, S., Ye, J. L., Wedekind, D., Maus, U. A., Bär, C., Muhlfeld, C., Brandenberger, C. (2026). "Telomere damage-mediated senescence in alveolar epithelial type II cells but not in macrophages aggravates inflammation in acute lung injury." Respiratory Research 27(1). doi: 10.1186/s12931-026-03627-0  - Open Access 
  • Höflich, C., Badorrek, P., Gress, C., Müller, M., Straff, W., Hohlfeld, J. M. (2026). "Threshold Concentration of Ragweed Pollen for Inducing Allergic Symptoms: Initial Data Using an Allergen Challenge Chamber." International Archives of Allergy and Immunology [Epub ahead of print]: 1-8. doi: 10.1159/000551344 https://karger.com/iaa/article/doi/10.1159/000551344/949235/Threshold-Concentration-of-Ragweed-Pollen-for - Open Access
  • Kayser, T., Struss, N., Pflock, R., Heusser, K., Kern, A. L., Voskrebenzev, A., Behrendt, L., Kaireit, T. F., Badorrek, P., Tank, J., Andreas, S., Jordan, J., Vogel-Claussen, J., Hohlfeld, J. M. (2026). "Acute and 14-day effects of tiotropium/olodaterol on cardiopulmonary function in COPD." ERJ Open Res 12(3). doi: 10.1183/23120541.01282-2025 https://publications.ersnet.org/content/erjor/12/3/01282-2025 - Open Access
  • Leuschner, G., Prasse, A., Klotsche, J., Kreuter, M., Wirtz, H., Pittrow, D., Frankenberger, M., Behr, J. (2026). "Sex Differences in IPF: Data from the German INSIGHTS Registry." Respiration [Epub ahead of print]: 1-10. doi: 10.1159/000550309
  • Li, D., Vinado, A. C., Garcia-Olloqui, P., Montesi, S. B., Shea, B. S., Christian, L., Vazquez-Urio, I., Aguirre-Ruiz, P., Ariceta, B., Neubert, M., Tripathy, A., Barua, N., Valera, P. S., Vera, L., Petri, E., Prasse, A., Seeliger, B., Vilas, A., Martin, P. S., Calasanz, M. J., Prosper, F., Miller, P. G., Seeger, W., Heidel, F. H., Schupp, J. C., Saez, B., Pardo-Saganta, A. (2026). "Clonal Hematopoiesis Instructs Maladaptive Tissue Repair to Promote Fibrosis." bioRxiv [Epub ahead of print]. doi: 10.64898/2026.03.24.710438 https://www.biorxiv.org/content/10.64898/2026.03.24.710438v1 - Preprint Open Access
  • Meinecke A, S. B., Schupp JC, Skripuletz T, Gödecke V, Holzer M-T, Ernst D and Witte T (2026). "Antibodies against Ro52 in idiopathic inflammatory myopathies are associated with objective sicca symptoms." Frontiers in Immunology [Epub ahead of print]. doi: 10.3389/fimmu.2026.1841969/full https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1841969/full - Open Access
  • Ruwisch, J., Cazes, A., Leiber, L. M., Borie, R., Neubert, L., Christian, L., Thomas de Montpreville, V., Szmul, A., Moussa, F., Verleden, S. E., Gaedcke, S., Hegermann, J., Fuge, J., Ballmaier, M., Kamp, J. C., Greer, M., Braubach, P., Werlein, C., Ius, F., Graalmann, T., Aburahma, K., De Sadeleer, L. J., Egashira, R., Ackermann, M., Yamada, D., Hoeper, M. M., Falk, C., Gottlieb, J., Schiller, H. B., Vanaudenaerde, B., Seeliger, B., Debray, M. P., Bernaudin, J. F., Knudsen, L., Bergot, E., Jacob, J., Mal, H., Jonigk, D., Dettmer, S., Mordant, P., Prasse, A., Fadel, E., Wuyts, W. A., Crestani, B., Kaminski, N., Justet, A., Schupp, J. C. (2026). "The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosis." Sci Adv 12(19): eaeb5967. doi: 10.1126/sciadv.aeb5967 https://www.science.org/doi/10.1126/sciadv.aeb5967 - Open Access
  • Struss, N., Badorrek, P., Schwarz, K., Windt, H., Straff, W., Hoflich, C., Hohlfeld, J. M. (2026). "Determining the Threshold Concentration of Birch Pollen for Inducing Allergic Symptoms Using an Allergen Challenge Chamber." International Archives of Allergy and Immunology 187(2): 103-112. doi: 10.1159/000545509 - Open Access
  • Vaso, M., Dukic, M., Pennitz, P., Manukyan, A., Collum, S., Lin, W., Winder, C. L., Dunn, W. B., Schupp, J. C., Braubach, P., Wygrecka, M., Ren, D., Suarez, E. E., Huang, H. J., Hussain, R., Patel, B., Karmouty-Quintana, H., Akalin, A., Landthaler, M., Nouailles, G., Ochs, M., Lopez-Rodriguez, E., Giambelluca, S. (2026). "Altered cholesterol immunometabolism activates the macrophage NLRP3-inflammasome in lung fibrosis." American Journal of Respiratory Cell and Molecular Biology [Epub ahead of print]. doi: 10.1093/ajrcmb/aanag029  - Open Access
  • Voskrebenzev, A., Kaireit, T. F., Klein, M. M., Kern, A. L., Behrendt, L., Klimeš, F., Müller, R. A., Kayser, T., Wacker, F., Vogel-Claussen, J., Hohlfeld, J. M. (2026). "Phase-resolved functional lung MRI detects single-dose and sustained bronchodilator responses in COPD in a randomized crossover trial." European Radiology [Epub ahead of print]. doi: 10.1007/s00330-026-12604-6 https://link.springer.com/article/10.1007/s00330-026-12604-6 - Open Access
  • Voskrebenzev, A., Pohler, G. H., Klimes, F., Klein, M. M., Muller, R. A., Wacker, F., Hohlfeld, J. M., Vogel-Claussen, J. (2026). "Accelerating PREFUL MRI: Comparison of Registration Methods and Impact of Time Series Reduction." NMR in Biomedicine 39(5): e70283. doi: 10.1002/nbm.70283 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/nbm.70283 - Open Access
  • Zoller, M., Mastalerz, M., Dick, E., Merl-Pham, J., Hennen, E., Prakki, S. R. S., Chakraborty, A., Nakayama, M., Klotz, M., Marchi, H., LeGleut, R., De Sadeleer, L. J., Wuyts, W. A., Vanaudenaerde, B. M., Jeridi, A., Prasse, A., Jager, B., Santofimia-Castano, P., Stoleriu, M. G., Hilgendorff, A., Hauck, S. M., Yildirim, A. O., Schiller, H., Staab-Weijnitz, C. A. (2026). "Nuclear protein 1 is a cell death regulator in primary human airway epithelial cells and reduced in idiopathic pulmonary fibrosis." Scientific Reports 16(1). doi: 10.1038/s41598-026-51510-1 https://www.nature.com/articles/s41598-026-51510-1

FuE-Kompetenz »Toxikologie«

  • Billat, P. A., Hansen, T., De Bruijn, V., Boufalaas, R., Stefano, S., Sosnowska, A., Kohl, Y., Verstraelen, S., Camassa, L. M. A., Spanig, M., Gabriel, C., Sarigiannis, D., Kratschmer, K., Raitano, G., Bulawska, N., Ratier, A., Zienolddiny-Narui, S., Chary, A., Serchi, T., Viegas, S., Mollerup, S., Escher, S. E., Staal, Y. C. M. (2026). "NAMs for closing knowledge gaps in assessment of respiratory uptake - a PARC project." Front Toxicol 8: 1764276. doi: 10.3389/ftox.2026.1764276 https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2026.1764276/abstract - Open Access
  • Bruer, G. G., Janssen, P., Schaudien, D., Ramazanoglu, M., Kryjewska, M., Hansen, T., de Aquino, E. L. S., Creutzenberg, O. (2026). "Identification of diniobium pentaoxide as a novel nuisance dust in a 90-day nose-only inhalation study." Inhalation Toxicology [Epub ahead of print]: 1-11. doi: 10.1080/08958378.2026.2625804 - Open Access
  • Clerbaux, L. A., Alb, M., Fogal, B., Hartung, T., Hench, V. K., Morgan, H., Gavins, F. N. E., Lindeman, B., Margiotta-Casaluci, L., Ostaszewski, M., Reiche, K., Sachana, M., Wittwehr, C., Sewald, K. (2026). "Filling the mechanistic and methodological gaps for predicting cytokine release syndrome in humans." Frontiers in Pharmacology 17: 1839092. doi: 10.3389/fphar.2026.1839092 https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1839092/full - Open Access
  • Djuari, M. A., Londenberg, A., Bassan, A., Cross, K., Elenschneider, L., Escher, S. E., Fahrer, J., Fangmann, J., Felske, C., Frotschl, R., Haas, B., Johnson, G. E., Vogel, M., Whomsley, R., Ziemann, C. (2026). "The in vitro alkaline comet assay with liver models as a complementary tool for genotoxicity assessment of N-nitrosamines." Archives of Toxicology [Epub ahead of print]. doi: 10.1007/s00204-026-04457-1 https://link.springer.com/article/10.1007/s00204-026-04457-1 - Open Access
  • Ghaffari, M. H., Stoschus, A., Diesing, L. E., Schuchardt, S., Hammon, H. M. (2026). "Effect of weaning duration (3 vs. 6 weeks) on plasma acylcarnitine and free fatty acid profiles in ad libitum-fed dairy calves." Journal of Dairy Science [Epub ahead of print]. doi: 10.3168/jds.2026-28522 https://www.sciencedirect.com/science/article/pii/S0022030226029243?via%3Dihub – Open Access
  • Ghaffari, M. H., Stoschus, A., Diesing, L. E., Schuchardt, S., Hammon, H. M. (2026). "Plasma bile acid dynamics during 3- and 6-week weaning transitions in ad libitum milk replacer-fed calves." Journal of Dairy Science [Epub ahead of print]. doi: 10.3168/jds.2026-28947 https://www.sciencedirect.com/science/article/pii/S002203022603081X?via%3Dihub – Open Access
  • Hadrup, N., Sorli, J. B., Frederiksen, M., Sharma, A. K., Kafert-Kasting, S., Schuchardt, S., Bitsch, A., Clausen, P. A., Saber, A. T., Vogel, U., Hougaard, K. S. (2026). "Oil mists and vapours: A review of exposure and toxicity, with dose descriptors from inhalation studies." Toxicology 519: 154314. doi: 10.1016/j.tox.2025.154314  - Open Access
  • Henning, T., Goerdeler, C., El-Khatib, A. H., Meyer, K., Bruer, G. G., Abraham, K., Monien, B. H. (2026). "Characterization and quantitation of urinary metabolites of 3-monochloropropane-1,2-diol (3-MCPD) in rats." Archives of Toxicology [Epub ahead of print]. doi: 10.1007/s00204-026-04318-x  - Open Access
  • Irwan, J., Kass, G. E. N., Kellner, R., Nathanail, A. V., Simetska, N., Wehr, M. M., Escher, S. E. (2025). "Bridging the gap in chemical risk assessment: Leveraging metabolite similarity for enhanced read-across applications." Altex [Epub ahead of print]. doi: 10.14573/altex.2508271  - Open Access
  • Jordan, M., Stucki-Koch, A., Schinke, M., Willmer, L., Senne, I., Abbas, N., Bentele, M., Oldenkott, D., Lachmann, N., Feldbrugge, L., Puffert, R., Fangmann, J., Ramm, R., Thum, T., Sewald, K., Schmidt, K., Fiedler, J. (2026). "Preclinical evaluation of cysteine protease-inhibitor aloxistatin (E64d) for heart failure therapy." Journal of Molecular Medicine (Berlin, Germany) 104(1). doi: 10.1007/s00109-026-02695-5 https://link.springer.com/article/10.1007/s00109-026-02695-5 - Open Access
  • Luijten, M., Herzler, M., Affourtit, F., Allen, D., Ashraf, M. W., Ball, N., Berggren, E., Berndt, S., Billat, P. A., Collen, E., Colbourne, J., Marco, M., Currie, R., Diemar, M. G., Dirven, H., Dreser, N., Escher, S. E., Gardner, I., Gozalbes, R., Hahn, S., Heiland, A., Hempt, C., Hendriks, G., Henschel, O., Husoy, T., Islam, B., Jensen, K. A., Kamp, H., Karakitsios, S., Kass, G. E. N., Kumar, V., Landsiedel, R., Loret, T., Lundquist, P., Mahony, C., Marx-Stoelting, P., Mone, M. J., Ottenbros, I., Ouedraogo, G., Pastor, M., Sachana, M., Schmeisser, S., Scholz, S., Schutte, K., Sullivan, K., Tangianu, S., Tristram, A., Turner, J., Vinken, M., Vlaanderen, J., van de Water, B., White, A., Leist, M. (2026). "Stakeholder input towards further refinement and consolidation of the alternative safety profiling algorithm (ASPA) for next generation risk assessment (NGRA)." Altex [Epub ahead of print]. doi: 10.14573/altex.2603121 https://www.altex.org/index.php/altex/article/view/3164 - Open Access
  • Marx-Stoelting, P., Ritz, V., Herzler, M., Kneuer, C., Aiello-Holden, K., Brescia, S., Escher, S. E., Feustel, S., Fritsche, E., Gebel, J., Kenny, E. F., Landsiedel, R., Sanders, P., Schwarz, M., Streitz, M., Testai, E., van Ravenzwaay, B., Waetjen, W., Wend, K., Wilks, M., Luch, A., Tralau, T., Hensel, A. (2026). "Regulation of chemicals demands assessment of risks rather than identification of hazards only." Archives of Toxicology [Epub ahead of print]. doi: 10.1007/s00204-026-04307-0  - Open Access
  • Moller, P., Ladeira, C., Ziemann, C., Knasmueller, S., Misik, M., Louro, H., Silva, M. J., Olsen, A. K., Azqueta, A., Langie, S. A. S., Bonassi, S., Dusinska, M., Gajski, G., Collins, A. (2026). "Towards a validation of the standard and enzyme-linked comet assay: a retrospective variability analysis." Archives of Toxicology 100(4): 1275-1300. doi: 10.1007/s00204-026-04317-y -
  • Ravi Shankar, A. L., Irwan, J., Spaenig, M., Carlier, M., Hansen, T., Zumbulte, N., Islam, B., Lundquist, P., Svensson, R., Gouin, T., Hamers, T., Escher, S. E. (2026). "Extrapolation of in vitro effect concentrations to in vivo bioavailable concentrations using PBK modelling in humans for two classes of persistent and mobile compounds: triazoles and triazines." Archives of Toxicology [Epub ahead of print]. doi: 10.1007/s00204-025-04268-w  - Open Access
  • Schaudien, D., Cohen, S. M., Dunmore, H. M., Bosseler, L., Rinke, M., Crabbs, T. A. (2026). "Carcinogenicity in the 21st Century: Challenges of New Methodologies, Strategies, and Their Impact on Pathologists-Session 1." Toxicologic Pathology [Epub ahead of print]: 1926233261430673. doi: 10.1177/01926233261430673  https://journals.sagepub.com/doi/10.1177/01926233261430673 - Open Access
  • Spaenig, M., Ashraf, M. W., Bouhifd, M., Drake, C., Sobanski, T., Escher, S. E. (2026). "Applicability of next-generation risk assessment generic PBK models and their performance within the chemical domain." Archives of Toxicology [Epub ahead of print]. doi: 10.1007/s00204-026-04443-7 https://link.springer.com/article/10.1007/s00204-026-04443-7 - Open Access
  • Spaenig, M., Vogel, M., Hansen, T., Elenschneider, L., Londenberg, A., Whomsley, R., Deppenmeier, U., Escher, S. E. (2026). "Estimation of bioavailable concentration of endogenously formed N-nitrosamines by physiologically based kinetic modelling." Altex 43(1): 49-64. doi: 10.14573/altex.2412061 - Open Access
  • Sündermann, J., Reamon-Buettner, S. M., Wilde, S., Bitsch, A., Ziemann, C. (2026). "The nitrovinyl moiety determines the cyto- and genotoxic profiles of beta-nitrostyrene derivatives: evidence from in silico and in vitro evaluation." Archives of Toxicology [Epub ahead of print]. doi: 10.1007/s00204-026-04349-4  - Open Access
  • Wagner, A., Schulz, F., Meyer-Plath, A., Dahlmann, F., Rittinghausen, S., Schaudien, D. (2026). "Impact of carbon-based fibers morphologies on their carcinogenic potential." Particle and Fibre Toxicology [Epub ahead of print]. doi: 10.1186/s12989-026-00663-y  - Open Access  
  • Weber, K., Hayes, A. W., Schaudien, D., de Miguel, R. (2025). "Editorial: Advances in non-clinical and translational studies: cutting-edge study designs, special technologies, routine pitfalls, background findings and control data." Front Vet Sci 12: 1743861. doi: 10.3389/fvets.2025.1743861 - Open Access
  • Yamano, S., Schaudien, D., Umeda, Y. (2026). "The Pneumoconiosis Renaissance: Revisiting the Pulmonary Pathology of Poorly Soluble Low Toxicity Particles: Insights from Rodent Inhalation Studies on Titanium Dioxide Nanoparticles." Nanomaterials (Basel) 16(4). doi: 10.3390/nano16040230  - Open Access
  • Ye, L., Wegner, F., Smandzich, N. J., Rudtke, O., Efe, G. D., Hollerhage, M., Schneidereit, I. V., Greten, S., Schuchardt, S., Klietz, M. (2026). "Metabolomic Cerebrospinal Fluid Biomarkers for the Diagnosis of Atypical Parkinsonian Syndromes." Int J Mol Sci 27(7). doi: 10.3390/ijms27073270 https://www.mdpi.com/1422-0067/27/7/3270 - Open Access

FuE-Kompetenz »Tumorfoschung«

  • Alves-de-Lima, J., Pukrop, T., Blazquez, R. (2026). "Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection." J Vis Exp227 [Epub ahead of print](227). doi: 10.3791/69415  - Open Access
  • Böttcher, M., Reemts, L., Hengeveld, P. J., Bottcher-Loschinski, R., Bhuria, V., Lu, J., Materna-Reichelt, S., Das, D., Stojanovic Guzvic, N., Bruns, H., Huber, W., Zenz, T., Schanze, D., Zenker, M., Dietrich, S., Langerak, A. W., Mougiakakos, D. (2026). "Immunoglobulin heavy-chain status and stromal interactions shape ferroptosis sensitivity in chronic lymphocytic leukemia." Signal Transduct Target Ther 11(1): 3. doi: 10.1038/s41392-025-02535-x  - Open Access
  • Harrer, D. C., Lüke, F., Pukrop, T., Ghibelli, L., Reichle, A., Heudobler, D. (2026). "Genome agnostic, multi-level non-oncogene addiction-based systems pharmacology for rescuing metastatic relapsed/refractory neoplasias." Frontiers in Pharmacology 17: 1629187. doi: 10.3389/fphar.2026.1629187  - Open Access
  • Harrer, D. C., Lüke, F., Pukrop, T., Reichle, A., Heudobler, D. (2026). "Genome Agnostic Reprogramming of Acute Myelocytic Leukemia Hallmarks by Targeting Non-Oncogene Addictions with Azacitidine Plus Pioglitazone and All-Trans Retinoic Acid." Int J Mol Sci 27(2). doi: 10.3390/ijms27021067 - Open Access
  • Jovel, J., Polzer, B., Patterson, J., Yong, H., Vasquez, C., O'Keefe, S., Pink, D., Li, G., Fairey, A., Adam, B., Teitelbaum, J., Salimi, A., Kirsh, S., Alberter, B., Lowes, L., Carpenter, E., Kolinsky, M., Zhu, Z., Zhou, Q., Venner, P., Venner, C., Williams, D., Allan, A., Boutros, P. C., Klein, C. A., Wong, G., Lewis, J. D. (2026). "Single-cell genomic analysis of cancer cells from one treatment-naive patient with metastatic prostate cancer." BMC Genom Data [Epub ahead of print]. doi: 10.1186/s12863-026-01435-5 https://link.springer.com/article/10.1186/s12863-026-01435-5 - Open Access
  • Komljenovic, D., Bauerle, T., Alves-de-Lima, J., Trigueros, L., Dietz, C., Winter, Z., Araceli, T., Strotzer, Q., Wendl, C., Brendel, M., Proescholdt, M. A., Harter, P. N., Evert, K., Pukrop, T., Blazquez, R. (2026). "Local metastatic expansion versus secondary intra-organ dissemination: two causes of neurological death explained by fundamentally different metastatic colonization patterns." Molecular Cancer 25(1): 17. doi: 10.1186/s12943-026-02574-0  - Open Access
  • Reichle, A., Harrer, D. C., Lüke, F., Pukrop, T., Ghibelli, L., Heudobler, D. (2026). "Editorial: Exploiting non-oncogene addiction for overcoming drug resistance in metastatic tumors." Frontiers in Pharmacology 17: 1798268. doi: 10.3389/fphar.2026.1798268 - Open Access
  • Treitschke, S., Weidele, K., Klein, C., Werno, C. (2026). "Funktionelle Präzisionsonkologie als Chance für personalisierte Therapienbeim malignen Melanom." Journal Onkologie 6: 5 p. https://www.journalonko.de/dermatologische-tumoren/malignes-melanom/funktionelle-praezisionsonkologie-personalisierte-therapien
  • Weidele, K., Werno, C., Treitschke, S., Botteron, C., Hoffmann, M., Scheitler, S., Wohrl, L., Czyz, Z., Feliciello, G., Weber, F., Ravikumar Varadarajan, A., Warfsmann, J., Materna-Reichelt, S., Katzer, M., Schreieder, L., Mohammadi, P., Hosseini, H., Honarnejad, K., Haferkamp, S., Werner-Klein, M., Klein, C. A. (2026). "Micrometastasis-derived models enable drug testing for early-stage, high-risk melanoma patients." EMBO Molecular Medicine 18(1): 297-324. doi: 10.1038/s44321-025-00339-8 - Open Access 

FuE-Kompetenz »Medizin-und Pharmatechnologie«

  • Nguyen, M.-H., Singla, P., Dann, A., Tran, T. H., Sündermann, J., Kreienmeyer, M., Schmitt, H., Butterbrodt, T., Schwarz, T., Schwieger, J., Scheper, V., Peeters, M., Wagner, P., Warnecke, A., Kaulen, C., Körner, J., Lenarz, T., Doll, T. (2026). "Intra-cochlear detection of Interleukin-6 using nanoMIPs embedded in a biodegradable matrix." Sensing and Bio-Sensing Research 51. doi: 10.1016/j.sbsr.2026.100990 - Open Access 
  • Rahim, M. I., Baseer, S., Paasch, D., Steglich, M., Waqas, S. F. H., Lachmann, N., Falk, C. S., Stiesch, M. (2026). "Commensal microflora coating endows implants with biofilm-repellent, immunomodulatory and osteogenic properties." Acta Biomater [Epub ahead of print]. doi: 10.1016/j.actbio.2026.01.017  - Open Access  
  • Steinke, J. A., Destruel, P. L., Weiche, B., Dengl, S., Schwach, G., Pohlmann, G., Hinner, M. J. (2026). "Minimizing Aggregates when Nebulizing Antibody Fab Fragments: High Thermostability and High Concentration are Key." European Journal of Pharmaceutical Sciences [Epub ahead of print]: 107446. doi: 10.1016/j.ejps.2026.107446  - Open Access 

FuE-Kompetenz »Bioinformatik«

  • Christian, L., Yilmaz, H., Ruwisch, J., Giercke, L., Seeliger, B., Kamp, J. C., Bayraktar, S., Ewen, R., Graalmann, T., Fuge, J., Greer, M., Ius, F., Welte, T., Liao, S. Y., Yang, I. V., Hohlfeld, J. M., Hoeper, M. M., Gottlieb, J., Kaminski, N., Prasse, A., Jonigk, D., Li, Y., Falk, C., Neubert, L., Schupp, J. C. (2026). "Spatial Transcriptomics Uncovers Hybrid, Pro-Inflammatory and Pro-Fibrotic Cellular Niches in Pulmonary Granuloma of Patients with Chronic Sarcoidosis." American Journal of Respiratory and Critical Care Medicine [Epub ahead of print]. doi: 10.1093/ajrccm/aamaf089  - Open Access
  • Ghaffari, M. H., Sadri, H., Hemmert, K. J., Ostendorf, C. S., Schuchardt, S., Koch, C., Sauerwein, H. (2026). "Longitudinal characterization of fecal lipids in dairy heifers from birth to first calving." Journal of Dairy Science 109(3): 3011-3033. doi: 10.3168/jds.2025-27816  - Open Access
  • Gress, C., Müller, M., Hohlfeld, J. M. (2026). "Proteomic profiling of bronchoalveolar lavage following human segmental endotoxin challenge-a potential exacerbation model." Scientific Reports 16(1): 6145. doi: 10.1038/s41598-026-39528-x - Open Access
  • Harrer, D. C., Lüke, F., Pukrop, T., Ghibelli, L., Reichle, A., Heudobler, D. (2026). "Genome agnostic, multi-level non-oncogene addiction-based systems pharmacology for rescuing metastatic relapsed/refractory neoplasias." Frontiers in Pharmacology 17: 1629187. doi: 10.3389/fphar.2026.1629187  - Open Access
  • Irwan, J., Kass, G. E. N., Kellner, R., Nathanail, A. V., Simetska, N., Wehr, M. M., Escher, S. E. (2025). "Bridging the gap in chemical risk assessment: Leveraging metabolite similarity for enhanced read-across applications." Altex [Epub ahead of print]. doi: 10.14573/altex.2508271  - Open Access
  • Jacobs, M., Goudarzi, S., Stucke, J., Rohm, R., Kanninen, T., Oinonen, T., Ritter, P., Schirner, M., Prasser, F., Bhagwagar, A., Matzenbach, B., Schultze, H., Schultze, J., Goschl, M., Matthies, H., Evans, K. R., Dharsee, M., Stephan, C., Belz, M., Gribbon, P., Herzog, K., Chen, C., Ruau, D., Dayan, I., Sannyasi, A., Kranzlmuller, D., Zhou, N., Warfsmann, J., Hoffmann, M., Schmidt, R., Hofmann-Apitius, M. (2026). "Selecting medical research data platforms for translational biomedical research: a five-tier overview and requirement-weighted assessment framework." Front Digit Health 8: 1814015. doi: 10.3389/fdgth.2026.1814015 https://www.frontiersin.org/journals/digital-health/articles/10.3389/fdgth.2026.1814015/full - Open Access
  • Ravi Shankar, A. L., Irwan, J., Spaenig, M., Carlier, M., Hansen, T., Zumbulte, N., Islam, B., Lundquist, P., Svensson, R., Gouin, T., Hamers, T., Escher, S. E. (2026). "Extrapolation of in vitro effect concentrations to in vivo bioavailable concentrations using PBK modelling in humans for two classes of persistent and mobile compounds: triazoles and triazines." Archives of Toxicology [Epub ahead of print]. doi: 10.1007/s00204-025-04268-w  - Open Access
  • Spaenig, M., Vogel, M., Hansen, T., Elenschneider, L., Londenberg, A., Whomsley, R., Deppenmeier, U., Escher, S. E. (2026). "Estimation of bioavailable concentration of endogenously formed N-nitrosamines by physiologically based kinetic modelling." Altex 43(1): 49-64. doi: 10.14573/altex.2412061 - Open Access
  • Sündermann, J., Reamon-Buettner, S. M., Wilde, S., Bitsch, A., Ziemann, C. (2026). "The nitrovinyl moiety determines the cyto- and genotoxic profiles of beta-nitrostyrene derivatives: evidence from in silico and in vitro evaluation." Archives of Toxicology [Epub ahead of print]. doi: 10.1007/s00204-026-04349-4  - Open Access
  • Tawadros, D., Yang, W., Wiese, L., Meyer, V. (2026). Optimizing Classification Accuracy with Simulated Annealing in k-Anonymity. Database Engineered Applications. IDEAS 2025. Lecture Notes in Computer Science. G., B., P., E., Y., M. et al. Newcastle upon Tyne, 14 July 2025 - 16 July 2025, Springer, Cham. 15928: 71-84 10.1007/978-3-032-06744-9_6 
  • Xu, M., Wiese, L. (2026). Constrained Adaptive Partial Training for Federated Learning on Heterogeneous Clients. Algorithmic Aspects of Cloud Computing. ALGOCLOUD 2025. Lecture Notes in Computer Science. D., G., D., C., Springer, Cham. 16349: 43-57 10.1007/978-3-032-13744-9_4

FuE-Kompetenz »Immunologie und Infektionsforschung«

  • Babl, S., Seidel, J. M., Kugler, F., Silberhorn, E., Ludwig, A., Abel, J., Winklbauer, S., Schaub, N., Materna-Reichelt, S., Honarnejad, K., Stojanovic Guzvic, N., Langst, G. (2026). "SARS-CoV-2 nucleocapsid protein variants have differential RNA chaperone activity." FEBS J 293(9): 2579-2598. doi: 10.1111/febs.70329 https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.70329 - Open Access
  • Clerbaux, L. A., Alb, M., Fogal, B., Hartung, T., Hench, V. K., Morgan, H., Gavins, F. N. E., Lindeman, B., Margiotta-Casaluci, L., Ostaszewski, M., Reiche, K., Sachana, M., Wittwehr, C., Sewald, K. (2026). "Filling the mechanistic and methodological gaps for predicting cytokine release syndrome in humans." Frontiers in Pharmacology 17: 1839092. doi: 10.3389/fphar.2026.1839092 https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1839092/full - Open Access
  • Gross, C., Chatterjee, S., Nilsson-Payant, B. E., Stojanovic, S. D., Kefalakes, H., Bär, C., Thum, T., Pietschmann, T., Bauersachs, J., Amanakis, G. (2026). "SARS-CoV-2-infected cardiomyocytes exhibit upregulated necroptosis, but no evidence of mitochondrial permeability transition." J Mol Cell Cardiol Plus 15: 100833. doi: 10.1016/j.jmccpl.2025.100833  - Open Access 
  • Hildebrand, C. B., Ozturk, S., Ye, J. L., Wedekind, D., Maus, U. A., Bär, C., Muhlfeld, C., Brandenberger, C. (2026). "Telomere damage-mediated senescence in alveolar epithelial type II cells but not in macrophages aggravates inflammation in acute lung injury." Respiratory Research 27(1). doi: 10.1186/s12931-026-03627-0  - Open Access 
  • La Rocca, V., Filipponi, C., Diesendorf, V., De Carli, A., Sciandrone, G., Nottoli, S., Plicanti, E., Fonnesu, R., Iacono, E., Mengozzi, A., Masi, S., Lenzi, P., Fornai, F., Sewald, K., Obernolte, H., Angelini, R., Bodem, J., Freer, G., Pistello, M., Lai, M. (2026). "N-Acylethanolamine Acid Amidase Inhibition Reduces SARS-CoV-2 Infection in Human Precision Cut-Lung Slices and Downregulates NF-KBB Signalling." Journal of Medical Virology 98(2): e70819. doi: 10.1002/jmv.70819
  • Paasch, D., Schevel, H., Riehle, A., Costa, B., Toufaili, H., Gehnen, T., Dahlmann, J., Pavlou, A., Neehus, A. L., Nguyen, A. H. H., Schiering, E., Buchegger, T., Bustamante, J., Hansen, G., Kalinke, U., Gulbins, E., Grassme, H., Lachmann, N. (2026). "Immune activation and response dynamics of human iPSC-derived macrophages in tuberculosis infection models." Clin Transl Immunology 15(1): e70071. doi: 10.1002/cti2.70071   - Open Access
  • Perkins, E., Cooper, C., Lund, E., Alb, M., Morgan, H., Fogal, B., Hewitt, P., Mazein, A., Ostaszewski, M., Sewald, K. (2025). "Perspective of using in vitro models to understand immunotherapy-induced cytokine release syndrome." Frontiers in Immunology 16: 1732193. doi: 10.3389/fimmu.2025.1732193 - Open Access
  • Schmitz, B., Garbsch, R., Schafer, H., Bär, C., Chatterjee, S., Riemekasten, G., Schulze-Forster, K., Heidecke, H., Schultheiss, C., Binder, M., Mooren, F. C. (2026). "Autonomic dysfunction and vasoregulation in long COVID-19 are linked to anti-GPCR autoantibodies." Journal of Allergy and Clinical Immunology 157(3): 722-738 e727. doi: 10.1016/j.jaci.2025.10.034  - Open Access
  • Schreckenberg, R., Woitasky, N., Itani, N., Czech, L., Windhorst, A. C., Juchem, M., Bär, C., Thum, T., Ferdinandy, P., Schulz, R. (2026). "mRNA-based SARS-CoV-2 vaccines: intracellular processing and aggregation of the encoded spike protein as a mechanistic contributor to cardiac cellular stress." Frontiers in Immunology 17: 1635478. doi: 10.3389/fimmu.2026.1635478 - Open Access
  • Vaso, M., Dukic, M., Pennitz, P., Manukyan, A., Collum, S., Lin, W., Winder, C. L., Dunn, W. B., Schupp, J. C., Braubach, P., Wygrecka, M., Ren, D., Suarez, E. E., Huang, H. J., Hussain, R., Patel, B., Karmouty-Quintana, H., Akalin, A., Landthaler, M., Nouailles, G., Ochs, M., Lopez-Rodriguez, E., Giambelluca, S. (2026). "Altered cholesterol immunometabolism activates the macrophage NLRP3-inflammasome in lung fibrosis." American Journal of Respiratory Cell and Molecular Biology [Epub ahead of print]. doi: 10.1093/ajrcmb/aanag029  - Open Access
  • Wronski, S., Obernolte, H., Schaudien, D., Braun, A., Sewald, K., Vaslin Chessex, A., Baulier, E., Pasquali, C. (2026). "Prophylactic intranasal administration of bacterial lysate OM-85 mitigates human rhinovirus (RV-A1b) lung infection and inflammation in mice." Antiviral Research [Epub ahead of print]: 106362. doi: 10.1016/j.antiviral.2026.106362  - Open Access  

FuE-Kompetenz »RNA-Technologien«

  • Babl, S., Seidel, J. M., Kugler, F., Silberhorn, E., Ludwig, A., Abel, J., Winklbauer, S., Schaub, N., Materna-Reichelt, S., Honarnejad, K., Stojanovic Guzvic, N., Langst, G. (2026). "SARS-CoV-2 nucleocapsid protein variants have differential RNA chaperone activity." FEBS J 293(9): 2579-2598. doi: 10.1111/febs.70329 https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.70329 - Open Access
  • Costa, A., Bär, C. (2026). "piRNA-mediated RNA oxidation as a new route to heart regeneration." Cardiovascular Research [Epub ahead of print]. doi: 10.1093/cvr/cvag005  - Open Access
  • Hilbold, E. A., Costa, A., Cushman, S., Fuchs, M., Jansen, K., Selich, A., Huang, C. K., Haubner, B. J., Thum, T., Bär, C. (2026). "Loss of lncRNA H19 impairs neonatal cardiac regeneration." American Journal of Physiology: Cell Physiology [Epub ahead of print]. doi: 10.1152/ajpcell.00002.2026 https://journals.physiology.org/doi/abs/10.1152/ajpcell.00002.2026 - Open Access
  • Kiselev, E., Agyapong, W., Jurgens, B., Mohr, E., Chatterjee, S., Hunkler, H. J., Salman, J., Cipriano, G., Bentele, M., Liu, J., Specht, J., Menge, K. S., Waleczek, F. J. G., Haas, J. A., Derda, A. A., Sonnenschein, K., Gietz, A., Neumuller, S., Pfanne, A., Beetz, O., Pflaum, M., Wiegmann, B., Psaras, Y., Toepfer, C., Zweigerdt, R., Radocaj, A., Kraft, T., Zeug, A., Ponimaskin, E., Korte, W., Horke, A., Ruhparwar, A., Fuchs, M., Xiao, K., Bär, C., Weber, N., Thum, T. (2026). "Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy." British Journal of Pharmacology 183(5): 1122-1139. doi: 10.1111/bph.70247 - Open Access 

FuE-Kompetenz »Stammzelltechnologien«

  • Fleischauer, J., John-Neek, P., Ha, T. C., Mansel, F., Kosanke, M., Selich, A., Hagedorn, M., Bastone, A. L., Schinke, M., Dziadek, V., Dittrich-Breiholz, O., von Kaisenberg, C., Schambach, A., Rothe, M. (2026). "Ex vivo long-term expansion of human hematopoietic stem and progenitor cells as a tool for modeling vector integration sites and clonality." Journal of Translational Medicine 24(1). doi: 10.1186/s12967-026-07700-6   - Open Access
  • Jung, M., Schmidt, A., Sansonetti, M., Al Soodi, B., Thum, S., Pfanne, A., Just, A., Xiao, K., Huang, C. K., Erschow, S., Ricke-Hoch, M., Oehlsen, L., Agyapong, W., Jansen, K., Blume, J., Buchler, G., Hilbold, E., Bär, C., Weber, N., Schinke, M., Nguyen, A. H. H., Wollert, K. C., Thackeray, J. T., Bengel, F., Lachmann, N., Thum, T. (2026). "Macrophage-specific circular RNA circHIPK2, inflammation, and fibrosis after myocardial infarction." European Heart Journal [Epub ahead of print]. doi: 10.1093/eurheartj/ehaf1116  - Open Access
  • Jung, M., Schmidt, A., Sansonetti, M., Al Soodi, B., Thum, S., Pfanne, A., Just, A., Xiao, K., Huang, C. K., Erschow, S., Ricke-Hoch, M., Oehlsen, L., Agyapong, W., Jansen, K., Blume, J., Buchler, G., Hilbold, E., Bär, C., Weber, N., Schinke, M., Nguyen, A. H. H., Wollert, K. C., Thackeray, J. T., Bengel, F., Lachmann, N., Thum, T. (2026). "Macrophage-specific circular RNA circHIPK2, inflammation, and fibrosis after myocardial infarction." European Heart Journal [Epub ahead of print]. doi: 10.1093/eurheartj/ehaf1116  - Open Access
  • Paasch, D., Schevel, H., Riehle, A., Costa, B., Toufaili, H., Gehnen, T., Dahlmann, J., Pavlou, A., Neehus, A. L., Nguyen, A. H. H., Schiering, E., Buchegger, T., Bustamante, J., Hansen, G., Kalinke, U., Gulbins, E., Grassme, H., Lachmann, N. (2026). "Immune activation and response dynamics of human iPSC-derived macrophages in tuberculosis infection models." Clin Transl Immunology 15(1): e70071. doi: 10.1002/cti2.70071   - Open Access
  • Saleh, F., Valdivia Malqui, E. E., Gensch, I., Schinke, M., Kappelhoj, M., Nikolouli, E., Nguyen, A. H. H., Jang, M. S., Basilio-Queiros, D., Lachmann, N. (2026). "Harnessing intermediate-scale bioreactors for next-generation macrophage production and application." Nature Protocols [Epub ahead of print]. doi: 10.1038/s41596-025-01313-x
  • Schinke, M., Gensch, I., Rietschel, T., Nguyen, A. H. H., Slevogt, H., Jansch, L., Lachmann, N. (2026). "Defined culture conditions improve functional properties of mature iPSC-derived macrophages for therapeutic screening." Stem Cell Research & Therapy 17(1). doi: 10.1186/s13287-026-05009-1 https://link.springer.com/article/10.1186/s13287-026-05009-1

Ihre Ansprechpartnerin

Petra Wiedemeier

Contact Press / Media

Petra Wiedemeier

Leiterin Informationsmanagement

Telefon +49 511 5350-327