Project archive

The Fraunhofer project FibroPaths® aims to enable rapid and safe development of antifibrotic drugs.

With the help of a novel nanoparticle transfer system, messenger RNA (mRNA) encoding green fluorescent protein (GFP) can be delivered into human cardiomyocytes.

Fraunhofer ITEM researchers use the ex-vivo model of the isolated perfused rat lung (IPL). In this alternative model, they studied the transition of a fluorescence-labeled substance into the perfusate, which served as blood substitute in this model. Two different methods were used to generate aerosols with different droplet sizes.

The aim of the MyCellFight project is to develop a fully automated immune chip able to predict the specific immune responses of individuals.

Fraunhofer ITEM scientists help develop effective new strategies for the fight against resistant pathogens and novel antimicrobial medications and inhalable antibiotics.

Primary and secondary tumors of the central nervous system (CNS) continue to be associated with an unfavorable prognosis. The aims of this project are, firstly, to define pre-analytical standards for biomarker studies with CSF and, secondly, to develop molecular genetic tests based on panel sequencing, i.e. sequencing of a set of clinically relevant genes.

The aim of the toxicokinetic study conducted at Fraunhofer ITEM was to determine whether and to what extent carbon black can be absorbed in the body or systemically distributed.

The foodstuffs will be screened for unknown halogenated organic chemicals by using a non-targeted screening strategy. Experts from Fraunhofer ITEM are working to establish targeted detection limits based on the toxicity of the substances.

The aim of the 3Rs principle is to avoid animal experiments altogether (replacement), to reduce the number of animals per experiment (reduction) and to keep animal distress to an absolute minimum (refinement).

Respiratory syncytial virus (RSV) usually causes mild airway infections in healthy adults. Fraunhofer ITEM scientists have established a model that mimics the viral infection ex vivo in viable human lung tissue (precision-cut lung slices – PCLS for short).