Clinical Research Center Hannover (CRC Hannover):
- State-of-the-art facility
- 6000 m2 of floor space
- 24/7 operations
- 30 intensive-monitoring beds (for clinical trials of phases I and IIa)
- 20 beds for study participants not requiring intensive monitoring
- 15 rooms for special diagnostics
- Outpatient section for screening visits
- Facilities for study participants, incl. cinema, gym, and cafeteria
- Ability to house study participants for several weeks
- Telemetric observation
- Attendance of an anesthesiologist when required by protocol
- Full set of emergency equipment and medication
Fraunhofer Allergen Challenge Chambers:
Four challenge chambers for proof-of-concept studies with sophisticated study designs, using natural pollen (grass, birch), allergen extracts (e.g. cat, house dust mite), or ozone.
Inhaled allergen challenge:
Induction of early and late-phase asthmatic reactions in patients with asthma, enabling efficacy testing of novel asthma treatments. A German multicenter network with the same high quality level across all participatory sites is available for expedited recruitment.
Segmental challenge by bronchoscopy:
Localized pulmonary inflammation (endotoxin, allergen) for the assessment of anti-inflammatory drugs or sampling of human material (under well-defined conditions).
Exercise testing (ergospirometry):
Ergospirometry for efficacy testing of bronchodilators in patients with COPD.
Blood samples, cells, and lung tissue collected according to standardized procedures from well-characterized patients can be used for validation of drug candidates. Biological materials can be stored in our biobank at ultra-low temperatures.
Analysis of a wide range of biomarkers from blood, sputum, and lavage fluid in our state-of-the-art immunological laboratory (incl. flow cytometry, chip cytometry, MSD multiplex platform). Standardized induced sputum sampling and processing allows centralized analyses in multicenter trials that guarantee the highest level of quality.
Non-invasive MRI techniques for quantitative assessment of pulmonary inflammation.
Handling of investigational medicinal products and production of final intravenous dosage forms in our in-house GMP unit.
Patient/volunteer database and professional recruitment:
Large database of pre-screened patients and healthy volunteers and a professional recruitment unit guarantee rapid recruitment and reliable timelines in our clinical trials.