Press releases

As part of the portfolio conference held by the Institute for Biomedical Translation (IBT) on November 27, 2024, a distinguished jury selected Inhale+ to receive €1.3 million in funding. We are immensely proud that this groundbreaking technology, developed at Fraunhofer ITEM, now reaches patients.

In July 2024, the Technical Rule for Hazardous Substances 529 (TRGS 529) was revised. TRGS 529 applies to all activities related to the production of biogas as well as the operation of biogas plants. It also regulates the handling of additives and auxiliary materials, including special safety measures required when using cobalt and nickel, as both heavy metals are considered carcinogenic.

Electronic cigarettes, or vapes, are commonly viewed as less harmful to people’s health than tobacco cigarettes. And yet, they are not without health drawbacks. For many ingredients, it is unknown how they will behave when heated. Since the temperatures inside e-cigarettes vary widely, different products can be released during thermal decomposition. This makes it more difficult to gauge the potential risks of these tobacco alternatives. Until now, there has been no testing system that could be used to test the ingredients used across the entire relevant temperature range. Now, with EVape, the Fraunhofer Institute for Toxicology and Experimental Medicine ITEM has developed a prototype device for controlled vaporization of e-liquids in a broad temperature range. The emissions released during the process can then be analyzed and subjected to a toxicological assessment. The findings are generally valid, regardless of which e-cigarette the liquid is used in.

Initiation of Phase Ia/Ib1 with the first human administration of the intranasal form of OM-85, a bacterial lysate and immune system modulator, already approved in oral form for the prevention of recurrent respiratory tract infections. Trial aims to deepen and understanding of OM-85-Intranasal (IN) and explore its potential impact on asthma management when administered as a nasal spray. (Geneva) OM Pharma, a global Geneva-based biotech and leader in bacterial lysate products, in collaboration with Fraunhofer Institute for Toxicology and Experimental Medicine ITEM announce the dosing of the first participant in a Phase Ia/Ib clinical trial evaluating the safety and tolerability of OM-85-Intranasal (IN) in 27 healthy volunteers during Phase Ia and 14 patients with mild asthma during Phase Ib.

The BIOSYNTH project is funded by the Fraunhofer-Gesellschaft and aims to develop a new microchip platform that enables efficient and digitally controllable cell-free biosynthesis. The Fraunhofer Institute for Photonic Microsystems IPMS leads the consortium and collaborates with the Fraunhofer Institute for Toxicology and Experimental Medicine ITEM and the Fraunhofer Institute for Cell Therapy and Immunology, part of Bioanalytics and Bioprocesses IZI-BB, on technologies that can be used in the future for mass data storage with very high storage density or in pollutant screening in human toxicology.

Every year, around half a million people in Germany are diagnosed with cancer. Despite the existence of effective treatment options for many types of cancer, many questions about the development of the disease remain unanswered. Why does a tumor develop? What factors promote the growth of cancer cells? Why do metastases spread to other organs over time? The animal models mainly in use to date only represent the actual processes in the human body to a limited extent. The Fraunhofer Institute for Material and Beam Technology IWS in Dresden has developed special microsystems in collaboration with the Fraunhofer Institute for Toxicology and Experimental Medicine ITEM in Hanover and the University of Regensburg. They are now using them to examine tissue sections of tumors under realistic conditions.

With the aim of developing a new technology for brain regeneration, the EU project REGENERAR kicks off on March 22, 2024. Fraunhofer ITEM is one of seven research partners, led by the University of Coimbra, seeking to create better therapies for patients with neurodegenerative diseases or stroke using this technology.

A research team from the Fraunhofer Institute for Toxicology and Experimental Medicine ITEM and the Hannover Medical School (MHH) have made significant progress in developing a new antiviral therapy. The drug, which is inhaled, uses RNAi to target and deactivate parainfluenza viruses before they multiply.

The European Chemicals Agency (ECHA) has contracted a consortium led by the Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, coordinated together with Michabo Health Science and BASF Metabolome Solutions, to conduct scientific studies on the reliability and relevance of new approach methodologies (NAMs) as alternatives to animal studies and to promote the use of such methods in the future. The aim of the contract is to get additional NAMs accepted by regulatory authorities, focusing on OMICS technologies and toxicokinetics, and therewith further reduce the number of animal studies conducted as part of safety assessments for chemical substances. The contract will run for six years for a total value of 4.2 million euros in ECHA funding. Other partners include the department for experimental toxicology and ecology at BASF, the University of Birmingham, and the biotech companies BioClavis, and Novogene Europe.