Jenny Irwan, Nelly Simetska, Matthias Wehr, Rupert Kellner, Sylvia E. Escher, 2024 Read-Across Application for Food or Feed Ingredients. EFSA supporting publication 2024: 21(7):EN-8811. 77 pp. doi:10.2903/sp.efsa.2024.EN-8811
Zobl W, Bitsch A, Blum J, Boei JJWA, Capinha L, Carta G, Castell J, Davoli E, Drake C, Fisher CP, Heldring MM, Islam B, Jennings P, Leist M, Pellegrino-Coppola D, Schimming JP, Snijders KE, Tolosa L, van de Water B, van Vugt-Lussenburg BMA, Walker P, Wehr MM, Wijaya LS, Escher SE. Protectiveness of NAM-based hazard assessment - which testing scope is required? ALTEX. 2024;41(2):302-319. doi: 10.14573/altex.2309081. Epub 2023 Dec 4. PMID: 38048429.
Drake C, Wehr MM, Zobl W, Koschmann J, De Lucca D, Kühne BA, Hansen T, Knebel J, Ritter D, Boei J, Vrieling H, Bitsch A, Escher SE. Substantiate a read-across hypothesis by using transcriptome data-A case study on volatile diketones. Front Toxicol. 2023 May 3;5:1155645. doi: 10.3389/ftox.2023.1155645. PMID: 37206915; PMCID: PMC10188990.
Wehr MM, Sarang SS, Rooseboom M, Boogaard PJ, Karwath A, Escher SE. RespiraTox - Development of a QSAR model to predict human respiratory irritants. Regul Toxicol Pharmacol. 2022 Feb;128:105089. doi: 10.1016/j.yrtph.2021.105089. Epub 2021 Nov 30. PMID: 34861320.
DOI: 10.2903/sp.efsa.2022.EN-7341
Escher SE, Partosch F, Konzok S, Jennings P, Luijten M, Kienhuis A, de Leeuw V, Reuss R, Lindemann K-M, Hougaard Bennekou S, 2022. Development of a Roadmap for Action on New Approach Methodologies in Risk Assessment. 19(6): 153 pp. doi:10.2903/sp.efsa.2022.EN-7341
Escher SE, Aguayo-Orozco A, Benfenati E, Bitsch A, Braunbeck T, Brotzmann K, Bois F, van der Burg B, Castel J, Exner T, Gadaleta D, Gardner I, Goldmann D, Hatley O, Golbamaki N, Graepel R, Jennings P, Limonciel A, Long A, Maclennan R, Mombelli E, Norinder U, Jain S, Capinha LS, Taboureau OT, Tolosa L, Vrijenhoek NG, van Vugt-Lussenburg BMA, Walker P, van de Water B, Wehr M, White A, Zdrazil B, Fisher C. Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action. Toxicol In Vitro. 2022 Mar;79:105269. doi: 10.1016/j.tiv.2021.105269. Epub 2021 Oct 29. PMID: 34757180.
Rovida C, Escher SE, Herzler M, Bennekou SH, Kamp H, Kroese DE, Maslankiewicz L, Moné MJ, Patlewicz G, Sipes N, Van Aerts L, White A, Yamada T, Van de Water B. NAM-supported read-across: From case studies to regulatory guidance in safety assessment. ALTEX. 2021;38(1):140-150. doi: 10.14573/altex.2010062. PMID: 33452529.
Jain S, Norinder U, Escher SE, Zdrazil B. Combining In Vivo Data with In Silico Predictions for Modeling Hepatic Steatosis by Using Stratified Bagging and Conformal Prediction. Chem Res Toxicol. 2021 Feb 15;34(2):656-668. doi: 10.1021/acs.chemrestox.0c00511. Epub 2020 Dec 21. PMID: 33347274; PMCID: PMC7887803.
Rovida C, Barton-Maclaren T, Benfenati E, Caloni F, Chandrasekera PC, Chesné C, Cronin MTD, De Knecht J, Dietrich DR, Escher SE, Fitzpatrick S, Flannery B, Herzler M, Hougaard Bennekou S, Hubesch B, Kamp H, Kisitu J, Kleinstreuer N, Kovarich S, Leist M, Maertens A, Nugent K, Pallocca G, Pastor M, Patlewicz G, Pavan M, Presgrave O, Smirnova L, Schwarz M, Yamada T, Hartung T. Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology. ALTEX. 2020;37(4):579-606. doi: 10.14573/altex.1912181. Epub 2020 Apr 30. PMID: 32369604; PMCID: PMC9201788.
Sadekar N, Behrsing HP, Hansen T, Patel V, Paulo H, Rae A, Ritter D, Schwarz K, Api AM. A Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods. Toxics. 2025 Jan 4;13(1):35. doi: 10.3390/toxics13010035. PMID: 39853033; PMCID: PMC11769436.
Ritter D, Knebel J, Hansen T, Zifle A, Fuchs A, Fautz R, Schwarz K. Development of a non-target strategy for evaluation of potential biological effects of inhalable aerosols generated during purposeful room conditioning using an in vitro inhalation model. Inhal Toxicol. 2023 Oct-Nov;35(11-12):271-284. doi: 10.1080/08958378.2023.2267618. Epub 2023 Dec 7. PMID: 37853720.
Ritter D, Knebel J, Niehof M, Loinaz I, Marradi M, Gracia R, Te Welscher Y, van Nostrum CF, Falciani C, Pini A, Strandh M, Hansen T. In vitro inhalation cytotoxicity testing of therapeutic nanosystems for pulmonary infection. Toxicol In Vitro. 2020 Mar;63:104714. doi: 10.1016/j.tiv.2019.104714. Epub 2019 Nov 6. PMID: 31706036.