Wir freuen uns darauf, beim Jahreskongress der Society of Toxicology und der ToxExpo in San Diego, Kalifornien (USA) unsere toxikologische Forschung zu präsentieren.
Besuchen Sie uns an unserem Stand (Standnummer: 1235) oder treffen Sie uns an unseren Postern oder in unserer Exhibitor-hosted Session. Wir freuen uns auf Sie!
„Strategic Concepts in Regulatory Inhalation Toxicology: Fraunhofer ITEM’s Comprehensive Approach"
Dienstag, 24. März 2026, 10:45-11:45 Uhr, Raum 23B, San Diego Convention Center
Redner*innen: Dr. Katharina Schwarz, Dr. Gustav Bruer, Dr. Florian Schulz
The session will present Fraunhofer ITEM’s concept-driven testing strategies for regulatory inhalation toxicology, developed over many years of research. It will highlight validated in-vivo study designs and exposure concepts tailored to complex aerosols such as bitumen fumes, synthetic fibers, and biopersistent particles.
Participants will gain insights into how Fraunhofer ITEM integrates aerosol generation, analytical characterization, and study design into robust, reproducible approaches that meet evolving regulatory requirements and support concept-based risk assessment.
"NAM In Vitro Assessment of Intestinal Metabolism to Inform PBK Modeling of Bioavailability and Systemic Exposure"
Mittwoch, 25. März 2026, 8:00-10:45 Uhr, Ballroom 6F, San Diego Convention Center
Chair: John Wambaugh, US EPA
Co-Chair: Max Spänig, Fraunhofer ITEM
Next-Generation chemical risk assessment (NGRA) aims to replace and expand on traditional toxicity testing with new approach methodologies (NAMs). One central aspect in NGRA is the assessment of toxicokinetic properties to estimate the bioavailable concentration of the dosed compounds and/or potentially toxicologically relevant metabolites. This question is also relevant to address interspecies differences or route-to-route extrapolation.
The development of NGRA framework needs a joint effort, and several projects are advancing this field like ASPIS (Animal-Free Safety Assessment of Chemicals), the EFSA ADME4NGRA and PARC (Partnership for the Assessment of Risks from Chemicals). This session will highlight recent advances from these projects to fill methodological, as well as knowledge, gaps.
San Diego, Kalifornien (USA)
22. März 2026 - 25. März 2026
Englisch
Safety evaluation of hair straightening products containing glyoxylic acid with respect to formaldehyde release
3326: Poster Board - F466
Autor*innen: R. Justiniano, J. Diller, A. Fuchs, R. Fautz, N. Hewitt, C. Schmidt, S. Langhoff, C. Goebel, K. Schwarz, K. Bluemlein, and G. von Bölcsházy
Safe-by-Design Assessment of Aerosolized Hair-Care Products Using an In Vitro Inhalation Model
3518: Poster Board - J670
Autor*innen: K. Schwarz, D. Ritter, T. Hansen, and H. Assaf Vandecasteele
Precision-Cut Liver Slices provide a human, immune-competent tissue model for mechanistic assessment of immune-related Drug-Induced Liver Injury
3686: Poster Board - A114
Autor*innen: S. Dehmel, K. Schmidt, F. Dahlmann, J. Fiedler, C. Hesse, H. Aselmann, J. Fangmann, S. Escher, and K. Sewald
Complementary cardiotoxicity screening pipeline from 2D hiPSC-cardiomyocytes towards complex 3D cardiac organoids and living myocardial slices
4239: Poster Board - K731
Autor*innen: E. Mohr, M. Jordan, N. Hoffmann, I. Riedel, A. Gietz, S. Chatterjee, K. Schmidt, F. Schmieder, A. Stucki-Koch, C. Polk, C. Hansen, J. Philipp, S. Behrens, T. Nicke, R. Ramm, F. Sonntag, C. Bär, and J. Fiedler
Implementation of an hOGG1-Enhanced In Vivo Comet Assay to Identify Particle-Induced DNA Damage in Rat Lung Tissue Following Instillation issue Following Instillation
4328: Poster Board - M826
Autor*innen: G. Bruer, H. Angelov, H. Brockmeyer, M. Djuari, M. Engelke, C. Müller, J. Wabra, M. Winkler, and C. Ziemann
Sponsor: S. Escher
Metabolism of Selected N-Nitrosamine Drug Substance-Related Impurities: Insights from the MUTAMIND Project
4389: Poster Board - A142
Autor*innen: K. P. Cross, S. Greco, A. Bassan, J. Irwan, A. Londenberg, D. Palazzotti, and S. E. Escher
Improved cryopreservation of human Precision-Cut Lung Slices supports tissue integrity
4741: Poster Board - G532
Autor*innen: H. Obernolte, K. Grieger, S. Metzger, V. Neuhaus, F. Ihmig, F. Sonntag, F. Schmieder, J. Neubauer, I. Meiser, and K. Sewald
Fraunhofer ITEM
Fraunhofer-Institut für Toxikologie und Experimentelle Medizin